Supporting Information.
Table S3. Regulation (up or down) of inflammation-related genes.
Gene Title / Gene Symbol / AZT 6 vs PBS6 / AZT24 vs PBS24 / SMM6 vs PBS6 / SMM24 vs PBS24 / AZT48 SMM6vs SMM6 / AZT72 SMM24 vs SMM24ADAM metallopeptidase domain 15 (metargidin) / ADAM15 / UP / DOWN / DOWN
ADAM metallopeptidase domain 28 / ADAM28 / UP
ADAM metallopeptidase with thrombospondin type 1 motif, 1 / ADAMTS1 / UP / DOWN / DOWN
adrenomedullin / ADM / UP / UP / UP / UP
adrenergic, beta-2-, receptor, surface / ADRB2 / UP / UP / DOWN
arachidonate 15-lipoxygenase / ALOX15 / DOWN
arachidonate 5-lipoxygenase / ALOX5 / UP
adhesion molecule with Ig-like domain 2 / AMIGO2 / DOWN / DOWN / DOWN
angiopoietin-like 4 / ANGPTL4 / UP / UP / DOWN
adaptor-related protein complex 2, beta 1 subunit / AP2B1 / UP
amphiregulin (schwannoma-derived growth factor) /// similar to Amphiregulin precursor (AR) (Colorectum cell-derived growth factor) (CRDGF) / AREG /// LOC727738 / UP / DOWN / UP / UP
ADP-ribosylation factor 4 / ARF4 / UP
arginase, type II / ARG2 / UP
Rho GDP dissociation inhibitor (GDI) alpha / ARHGDIA / UP / DOWN
rho/rac guanine nucleotide exchange factor (GEF) 2 / ARHGEF2 / UP
artemin / ARTN / UP
type 1 tumor necrosis factor receptor shedding aminopeptidase regulator / ARTS-1 / DOWN / UP
ATPase inhibitory factor 1 / ATPIF1 / DOWN
alpha-2-glycoprotein 1, zinc-binding / AZGP1 / DOWN / DOWN
B-cell receptor-associated protein 29 / BCAP29 / UP
B-cell CLL/lymphoma 10 / BCL10 / UP
BCL2-related protein A1 / BCL2A1 / DOWN / UP / UP / DOWN
B-cell CLL/lymphoma 3 / BCL3 / UP / UP
BH3 interacting domain death agonist / BID / UP
BCL2-interacting killer (apoptosis-inducing) / BIK / UP
baculoviral IAP repeat-containing 3 / BIRC3 / UP / UP
baculoviral IAP repeat-containing 5 (survivin) / BIRC5 / DOWN / DOWN
B-cell linker / BLNK / UP / UP
bone morphogenetic protein 2 / BMP2 / UP
BCL2/adenovirus E1B 19kDa interacting protein 3 / BNIP3 / UP
BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) / BUB1B / DOWN / DOWN
complement component 1, s subcomponent / C1S / UP / UP
chromosome 20 open reading frame 42 / C20orf42 / UP / DOWN / DOWN
carbonic anhydrase XII / CA12 / UP / UP
Calreticulin / CALR / DOWN / UP / UP
calcium/calmodulin-dependent protein kinase ID / CAMK1D / DOWN
calcium/calmodulin-dependent protein kinase II inhibitor 1 / CAMK2N1 / DOWN
calpain 13 / CAPN13 / UP
caspase 10, apoptosis-related cysteine peptidase / CASP10 / UP / UP
chromobox homolog 4 (Pc class homolog, Drosophila) / CBX4 / UP / UP / DOWN
chemokine (C-C motif) ligand 2 / CCL2 / UP
chemokine (C-C motif) ligand 20 / CCL20 / UP / DOWN / UP / UP / DOWN
CD24 molecule / CD24 / DOWN / UP
CD44 molecule (Indian blood group) /// mitogen-activated protein kinase 10 / CD44 /// MAPK10 / UP
CD46 molecule, complement regulatory protein / CD46 / UP
CD55 molecule, decay accelerating factor for complement (Cromer blood group) / CD55 / UP / UP / DOWN / DOWN
CD74 molecule, major histocompatibility complex, class II invariant chain / CD74 / UP
CD99 molecule / CD99 / UP / DOWN
cadherin 6, type 2, K-cadherin (fetal kidney) / CDH6 / DOWN / DOWN
cyclin-dependent kinase inhibitor 1A (p21, Cip1) / CDKN1A / UP / UP
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) / CEACAM1 / UP / UP / UP
CCAAT/enhancer binding protein (C/EBP), beta / CEBPB / UP
complement factor B / CFB / UP / UP
CASP8 and FADD-like apoptosis regulator / CFLAR / UP
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 / CHST2 / UP
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 / CHST4 / UP
claudin 1 / CLDN1 / UP / UP
claudin 10 / CLDN10 / DOWN / UP / DOWN / DOWN
C-type lectin domain family 2, member B /// CMT1A duplicated region transcript 15 pseudogene / CLEC2B /// CDRT15P / UP / UP
C-type lectin domain family 7, member A / CLEC7A / UP / DOWN / UP / UP
clusterin / CLU / DOWN / DOWN
CKLF-like MARVEL transmembrane domain containing 4 / CMTM4 / UP
Contactin 1 / CNTN1 / UP
contactin associated protein-like 3 /// contactin associated protein-like 3B /// similar to Contactin-associated protein-like 3 precursor (Cell recognition molecule Caspr3) / CNTNAP3 /// CNTNAP3B /// LOC728577 / DOWN
collagen, type XII, alpha 1 / COL12A1 / DOWN / DOWN / DOWN
collagen, type IV, alpha 6 / COL4A6 / DOWN
carboxypeptidase D / CPD / UP
carboxypeptidase E / CPE / DOWN
carboxypeptidase X (M14 family), member 2 / CPXM2 / UP / UP / UP
cysteine-rich protein 1 (intestinal) /// galactokinase 2 / CRIP1 /// GALK2 / DOWN / DOWN
cytokine receptor-like factor 1 / CRLF1 / DOWN / DOWN
colony stimulating factor 3 (granulocyte) / CSF3 / UP / UP / DOWN
connective tissue growth factor / CTGF / DOWN / UP / DOWN
catenin (cadherin-associated protein), alpha-like 1 / CTNNAL1 / DOWN
cathepsin A / CTSA / UP / UP / UP
cathepsin B / CTSB
cathepsin H / CTSH / UP
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) / CXCL1 / UP / UP
chemokine (C-X-C motif) ligand 14 / CXCL14 / DOWN
chemokine (C-X-C motif) ligand 16 / CXCL16 / UP
chemokine (C-X-C motif) ligand 2 / CXCL2 / UP / UP
chemokine (C-X-C motif) ligand 3 / CXCL3 / DOWN / UP / UP / DOWN
chemokine (C-X-C motif) ligand 5 / CXCL5 / UP / UP
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) / CXCL6 / DOWN / UP / UP / DOWN
chemokine (C-X-C motif) receptor 7 / CXCR7 / UP / UP
cytochrome P450, family 26, subfamily B, polypeptide 1 / CYP26B1 / UP / UP
D site of albumin promoter (albumin D-box) binding protein / DBP / UP
doublecortin domain containing 2 / DCDC2 / DOWN
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 / DDX58 / UP / UP
defensin, beta 1 / DEFB1 / UP / UP
defensin, beta 4 /// similar to Beta-defensin 2 precursor (BD-2) (hBD-2) (Defensin, beta 2) (Skin-antimicrobial peptide 1) (SAP1) / DEFB4 /// LOC728454 / UP / UP / DOWN
DnaJ (Hsp40) related, subfamily B, member 13 / DNAJB13 / DOWN
DnaJ (Hsp40) homolog, subfamily B, member 9 / DNAJB9 / UP / UP
DnaJ (Hsp40) homolog, subfamily C, member 10 / DNAJC10 / UP
DnaJ (Hsp40) homolog, subfamily C, member 12 / DNAJC12 / UP / UP
desmocollin 2 / DSC2 / UP
desmocollin 3 / DSC3 / DOWN / DOWN / DOWN
dual oxidase 2 / DUOX2 / UP / UP / DOWN
dual oxidase maturation factor 2 / DUOXA2 / UP / UP / DOWN / DOWN
dual specificity phosphatase 1 / DUSP1 / UP
dual specificity phosphatase 5 / DUSP5 / UP / UP / UP / UP
dual specificity phosphatase 6 / DUSP6 / UP / UP
Endothelin converting enzyme 1 / ECE1 / UP
endothelial cell growth factor 1 (platelet-derived) / ECGF1 / UP
extracellular matrix protein 1 / ECM1 / UP
epithelial cell transforming sequence 2 oncogene / ECT2 / DOWN
ER degradation enhancer, mannosidase alpha-like 1 / EDEM1 / UP
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 / EDG2 / UP / UP
EGF-like repeats and discoidin I-like domains 3 / EDIL3 / UP / UP
EF-hand domain (C-terminal) containing 1 / EFHC1 / DOWN / DOWN
ephrin-A1 / EFNA1 / UP / UP
Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) / EGFR / DOWN / UP / DOWN
egl nine homolog 3 (C. elegans) / EGLN3 / UP / UP / UP
eukaryotic translation initiation factor 5A / EIF5A / UP / UP / UP / DOWN
epithelial membrane protein 1 / EMP1 / UP / UP / DOWN
epoxide hydrolase 1, microsomal (xenobiotic) / EPHX1 / DOWN
epiregulin / EREG / UP / UP
ERO1-like (S. cerevisiae) / ERO1L / UP / UP
ERBB receptor feedback inhibitor 1 / ERRFI1 / UP / UP
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) / ETS1 / UP
coagulation factor III (thromboplastin, tissue factor) / F3 / DOWN / UP / DOWN
Fas (TNF receptor superfamily, member 6) / FAS / UP
F-box protein 2 / FBXO2 / UP
Fc fragment of IgG binding protein / FCGBP / UP / DOWN
fasciculation and elongation protein zeta 1 (zygin I) / FEZ1 / DOWN
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) / FGFR3 / UP / DOWN / DOWN
FK506 binding protein 11, 19 kDa / FKBP11 / DOWN / UP / DOWN
FK506 binding protein 1A, 12kDa / FKBP1A / DOWN
filamin A, alpha (actin binding protein 280) / FLNA / UP
fibronectin leucine rich transmembrane protein 2 / FLRT2 / DOWN / DOWN
fibronectin leucine rich transmembrane protein 3 / FLRT3 / DOWN / UP / DOWN
fibronectin 1 / FN1 / DOWN / DOWN / UP
v-fos FBJ murine osteosarcoma viral oncogene homolog / FOS / UP / UP / UP / DOWN
FOS-like antigen 1 / FOSL1 / UP / DOWN
FOS-like antigen 2 / FOSL2 / UP
ferritin, heavy polypeptide 1 / FTH1 / UP / UP
ferritin, light polypeptide / FTL / UP / UP / UP
fusion (involved in t(12;16) in malignant liposarcoma) / FUS / DOWN
fucosyltransferase 11 (alpha (1,3) fucosyltransferase) / FUT11 / UP
fucosyltransferase 2 (secretor status included) / FUT2 / UP / DOWN
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) / FUT3 / UP / UP
fucosyltransferase 6 (alpha (1,3) fucosyltransferase) / FUT6 / UP / UP
FYN binding protein (FYB-120/130) / FYB / DOWN / UP
GATA binding protein 3 / GATA3 / UP / DOWN
guanylate binding protein 1, interferon-inducible, 67kDa /// guanylate binding protein 1, interferon-inducible, 67kDa / GBP1 / UP
guanylate binding protein 2, interferon-inducible /// guanylate binding protein 2, interferon-inducible / GBP2 / UP
guanylate binding protein 3 / GBP3 / UP
GTP cyclohydrolase 1 (dopa-responsive dystonia) / GCH1 / UP / UP
growth differentiation factor 15 / GDF15 / UP / UP / UP / UP / UP
gap junction protein, alpha 1, 43kDa (connexin 43) / GJA1 / UP / UP
gap junction protein, beta 6 (connexin 30) / GJB6 / DOWN / UP / DOWN / DOWN
glycoprotein (transmembrane) nmb / GPNMB / UP / DOWN / UP / UP
glutathione S-transferase A3 / GSTA3 / DOWN / DOWN / DOWN
GULP, engulfment adaptor PTB domain containing 1 / GULP1 / UP / DOWN / UP / UP
hemoglobin, beta /// hemoglobin, beta / HBB / DOWN / DOWN
heparin-binding EGF-like growth factor / HBEGF / UP
histone deacetylase 9 / HDAC9 / UP
Helicase, lymphoid-specific / HELLS / DOWN
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) / HIF1A / UP / UP
hypoxia-inducible protein 2 / HIG2 / UP / UP
Homeodomain interacting protein kinase 2 / HIPK2 / UP
histone cluster 1, H2bc / HIST1H2BC / DOWN
histone cluster 1, H2bg / HIST1H2BG / DOWN / DOWN / DOWN
major histocompatibility complex, class II, DP beta 1 / HLA-DPB1
major histocompatibility complex, class II, DQ alpha 1 / HLA-DQA1 / DOWN / UP / UP
major histocompatibility complex, class II, DQ beta 1 /// major histocompatibility complex, class II, DQ beta 1 / HLA-DQB1 / UP / UP / UP / UP
major histocompatibility complex, class II, DR alpha / HLA-DRA / UP / UP
major histocompatibility complex, class II, DR beta 1 /// major histocompatibility complex, class II, DR beta 1 /// hypothetical protein LOC730415 /// hypothetical protein LOC730415 / HLA-DRB1 /// LOC730415 / UP / UP / UP
heme oxygenase (decycling) 1 / HMOX1 / UP
heat shock protein 90kDa beta (Grp94), member 1 / HSP90B1 / DOWN / UP
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) / HSPA5 / UP
heat shock 70kDa protein 6 (HSP70B') / HSPA6 / UP / DOWN
heat shock 27kDa protein 1 /// Meis1, myeloid ecotropic viral integration site 1 homolog 3 (mouse) / HSPB1 /// MEIS3 / DOWN
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor / ICAM1 / UP / UP / UP
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein / ID1 / UP / UP / DOWN / UP
immediate early response 3 / IER3 / UP / UP
interferon, gamma-inducible protein 16 / IFI16 / UP
interferon, gamma-inducible protein 30 / IFI30 / UP
interferon-induced protein with tetratricopeptide repeats 1 /// interferon-induced protein with tetratricopeptide repeats 1 / IFIT1 / DOWN / DOWN
interferon induced transmembrane protein 1 (9-27) / IFITM1 / UP
interferon induced transmembrane protein 2 (1-8D) / IFITM2 / UP
interferon induced transmembrane protein 3 (1-8U) / IFITM3 / UP
interferon gamma receptor 1 / IFNGR1 / UP / UP
interferon gamma receptor 2 (interferon gamma transducer 1) / IFNGR2 / UP / UP
Insulin-like growth factor 1 receptor / IGF1R / UP
insulin-like growth factor binding protein 3 / IGFBP3 / UP / UP / UP
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / IKBKB / UP
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon / IKBKE / UP
interleukin 13 receptor, alpha 1 / IL13RA1 / UP
interleukin 17C / IL17C / UP
interleukin 19 / IL19 / UP
interleukin 1, alpha / IL1A / UP / UP / DOWN / UP
interleukin 1, beta / IL1B / UP
interleukin 1 family, member 9 / IL1F9 / UP / UP
interleukin 1 receptor-like 1 / IL1RL1 / DOWN
interleukin 1 receptor antagonist / IL1RN / UP / UP / UP / UP
interleukin 32 /// interleukin 32 / IL32 / UP / UP
interleukin 4 receptor / IL4R / UP / UP
interleukin 6 (interferon, beta 2) / IL6 / UP / UP / UP
interleukin 6 signal transducer (gp130, oncostatin M receptor) / IL6ST / UP / UP / UP / UP
interleukin 7 / IL7 / DOWN / DOWN
interleukin 8 / IL8 / UP / UP / UP
indoleamine-pyrrole 2,3 dioxygenase / INDO / UP / UP / UP / UP
interleukin-1 receptor-associated kinase 2 / IRAK2 / UP
interleukin-1 receptor-associated kinase 3 / IRAK3 / UP / UP
interferon regulatory factor 1 / IRF1 / UP
interferon stimulated exonuclease gene 20kDa / ISG20 / UP
integrin, alpha 5 (fibronectin receptor, alpha polypeptide) / ITGA5 / UP
integrin, alpha 6 / ITGA6 / DOWN / DOWN / DOWN
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) / ITGAV / UP
integrin, beta 4 / ITGB4 / UP