Table S1 Significant and near significant risk factors for engraftment and GVHD

Neutrophil engraftment / Platelet engraftment / aGVHD, grade II-IV / cGVHD, extensive
Variable subgroups† / RR* [95%CI] Signif. / RR [95%CI] Signif. / RR [95%CI] Signif. / RR [95%CI] Signif.
CD4/CD8 (G-BM): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 1.03[0.69-1.52] P=0.893 / 0.94[0.61-1.45] P=0.796 / 1.81[0.94-3.51] P=0.077 / 1.95[0.74-5.11] P=0.174
CD4 (G-BM): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 0.97[0.62-1.53] P=0.909 / 1.08[0.69-1.68] P=0.742 / 0.66[0.33-1.33] P=0.248 / 0.67[0.20-2.31] P=0.526
CD8 (G-BM): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 1.30[0.85-1.98] P=0.235 / 0.90[0.57-1.41] P=0.637 / 1.40[0.77-2.53] P=0.270 / 1.17[0.36-3.84] P=0.796
CD14 (G-BM): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 1.17[0.81-1.70] P=0.400 / 1.42 [0.96-2.10] P=0.077 / 1.38[0.77-2.45] P=0.278 / 0.95[0.37-2.41] P=0.908
CD34 (G-BM): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 1.02[0.71-1.47] P=0.914 / 1.19[0.80-1.77] P=0.380 / 0.75[0.42-1.31] P=0.306 / 1.46[0.55-3.90] P=0.451
CD4/CD8 (G-PB): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 0.97[0.66-1.41] P=0.860 / 1.09[0.73-1.62] P=0.671 / 1.11[0.61-2.01] P=0.730 / 2.06[0.76-5.58] P=0.156
CD4 (G-PB): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 0.90[0.55-1.47] P=0.673 / 0.94[0.58-1.52] P=0.815 / 0.66[0.33-1.31] P=0.239 / 1.74[0.57-5.37] P=0.330
CD8 (G-PB): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 0.92[0.58-1.48] P=0.736 / 1.08[0.68-1.73] P=0.741 / 1.55[0.78-3.08] P=0.214 / 1.56[0.54-4.53] P=0.411
CD14 (G-PB): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 1.02[0.72-1.46] P=0.896 / 0.95 [0.64-1.40] P=0.805 / 0.89[0.50-1.59] P=0.691 / 0.91[0.37-2.27] P=0.844
CD34 (G-PB): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 1.11[0.78-1.56] P=0.567 / 1.46[0.99-2.17] P=0.056 / 0.51[0.28-0.92] P=0.027 / 0.64[0.24-1.70] P=0.373
CD4/CD8 (Total): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 1.02[0.71-1.48] P=0.912 / 0.92[0.62-1.37] P=0.682 / 1.26[0.68-2.33] P=0.464 / 3.03[0.77-8.57] P=0.360
CD4 (Total): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 0.83[0.52-1.32] P=0.434 / 1.0 [0.63-1.58] P=0.995 / 0.65[0.34-1.24] P=0.188 / 1.43[0.49-4.16] P=0.509
CD8 (Total): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 0.92[0.59-1.41] P=0.695 / 0.96[0.62-1.47] P=0.836 / 1.62[0.83-3.18] P=0.159 / 1.63[0.60-4.46] P=0.340
CD14 (Total): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 1.08[0.77-1.53] P=0.650 / 1.21 [0.84-1.73] P=0.316 / 0.78[0.44-1.38] P=0.396 / 0.75[0.28-1.99] P=0.565
CD34 (Total): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 1.23 [0.87-1.73] P=0.239 / 1.69[1.15-2.47] P=0.007 / 1.25[0.67-2.32] P=0.464 / 1.11[0.39-3.14] P=0.845

Median value used as cut-point

*RR: hazard rate (risk) ratio with associated 95% Confidence Interval (CI) given in italics;the reference category for each variable is shown in the first line.

†G-BM=G-CSF primed Bone Marrow cells; G-PB=G-CSF primed peripheral blood stem cells; Total=Combination.

Table S2 Significant and near significant risk factors for relapse and treatment-related mortality [TRM], disease free survival[DFS], overall survival[OS]

Relapse / Treatment-related mortality / Disease free survival / Overall survival
Variable subgroups† / RR* [95%CI] Signif. / RR [95%CI] Signif. / RR [95%CI] Signif. / RR [95%CI] Signif.
CD4/CD8 (G-BM): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 3.85[0.78-19.04] P=0.089 / 2.65[0.96-7.27] P=0.06 / 3.28[1.33-8.06] P=0.010 / 3.20[1.26-8.16] P=0.015
CD4 (G-BM): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 0.37[0.07-2.03] P=0.251 / 0.67[0.23-1.97] P=0.461 / 0.63[0.24-1.64] P=0.341 / 0.58[0.21-1.58] P=0.287
CD8 (G-BM): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 3.00[0.63-14.32] P=0.168 / 0.99[0.37-2.67] P=0.983 / 1.32[0.56-3.11] P=0.525 / 1.09[0.44-2.73] P=0.850
CD14 (G-BM): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 0.61[0.17-2.12] P=0.435 / 1.02 [0.43-2.39] P=0.970 / 0.84[0.40-1.75] P=0.638 / 0.69[0.31-1.52] P=0.357
CD34 (G-BM): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 2.94[0.70-12.33] P=0.141 / 1.30[0.53-3.18] P=0.564 / 1.44[0.66-3.15] P=0.361 / 1.51[0.67-3.41] P=0.320
CD4/CD8 (G-PB): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 1.16[0.31-4.41] P=0.827 / 2.32[0.90-5.96] P=0.080 / 2.40[1.05-5.47] P=0.037 / 2.13[0.91-4.95] P=0.080
CD4 (G-PB): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 2.09[0.39-11.01] P=0.387 / 0.40 [0.12-1.30] P=0.128 / 0.58[0.21-1.58] P=0.288 / 0.71[0.25-2.00] P=0.519
CD8 (G-PB): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 0.80[0.15-4.22] P=0.792 / 1.55[0.48-5.04] P=0.469 / 1.35[0.49-3.73] P=0.560 / 1.43[0.50-4.10] P=0.501
CD14 (G-PB): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 1.08[0.29-3.99] P=0.906 / 1.19 [0.49-2.88] P=0.707 / 1.11[0.51-2.41] P=0.799 / 0.92[0.41-2.05] P=0.829
CD34 (G-PB): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 0.75[0.21-2.68] P=0.654 / 1.07[0.45-2.55] P=0.886 / 0.94[0.44-2.00] P=0.866 / 1.13[0.51-2.50] P=0.757
CD4/CD8 (Total): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 1.68[0.46-6.10] P=0.432 / 2.46[0.97-6.25] P=0.058 / 2.67[1.18-6.04] P=0.018 / 2.92[1.24-6.92] P=0.015
CD4 (Total): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 0.92[0.19-4.44] P=0.915 / 0.46[0.15-1.43] P=0.178 / 0.40[0.15-1.08] P=0.071 / 0.53[0.19-1.52] P=0.237
CD8 (Total): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 1.22[0.25-5.99] P=0.806 / 1.78[0.57-5.57] P=0.322 / 1.90[0.70-5.17] P=0.207 / 2.20[0.77-6.31] P=0.143
CD14 (Total): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 0.92[0.25-3.43] P=0.910 / 0.86 [0.35-2.07] P=0.733 / 0.84[0.39-1.81] P=0.649 / 0.72[0.32-1.62] P=0.427
CD34 (Total): <50 percentile / 1 / 1 / 1 / 1
≥50 percentile / 1.67 [0.46-6.10] P=0.432 / 1.26[0.53-3.02] P=0.599 / 1.48[0.70-3.15] P=0.308 / 1.33[0.60-2.95] P=0.480

Median value used as cut-point

*RR: hazard rate (risk) ratio with associated 95% Confidence Interval (CI) given in italics; the reference category for each variable is shown in the first line.

†G-BM=G-CSF primed Bone Marrow cells; G-PB=G-CSF primed peripheral blood stem cells; Total=Combination.