Table S4 Interaction analysis results obtained using the Model-Based Multifactor Dimensionality Reduction approach proposed by Calle et al. (2010)
SNP1 / SNP2 / NH / WH / PH / NL / WL / PL / MIN.P / p*rs195990 / rs2111699 / 2 / 6.947 / 0.008 / 1 / 3.493 / 0.062 / 0.008 / 0.0056
rs1770345 / rs3789327 / 1 / 4.032 / 0.045 / 2 / 6.870 / 0.009 / 0.009 / 0.0094
rs16902632 / rs3789327 / 1 / 6.147 / 0.013 / 1 / 3.432 / 0.064 / 0.013 / 0.0118
rs649392 / rs2069762 / 1 / 5.717 / 0.017 / 0 / - / - / 0.017 / 0.0128
rs16902632 / rs6214 / 1 / 2.890 / 0.089 / 1 / 5.651 / 0.017 / 0.017 / 0.0122
rs1800566 / rs2069762 / 1 / 5.188 / 0.023 / 0 / - / - / 0.023 / 0.0109
rs12626475 / rs1799930 / 1 / 4.890 / 0.027 / 0 / - / - / 0.027 / 0.0141
rs1549854 / rs1800896 / 1 / 4.661 / 0.031 / 0 / - / - / 0.031 / 0.0234
rs1770345 / rs1625525 / 0 / - / - / 1 / 4.439 / 0.035 / 0.035 / 0.0281
rs649392 / rs4073 / 1 / 4.434 / 0.035 / 0 / - / - / 0.035 / 0.0274
rs1799930 / rs6214 / 1 / 4.381 / 0.036 / 0 / - / - / 0.036 / 0.0253
rs1062935 / rs282070 / 1 / 4.372 / 0.037 / 0 / - / - / 0.037 / 0.0193
rs11066301 / rs1800566 / 1 / 4.338 / 0.037 / 0 / - / - / 0.037 / 0.0242
rs649392 / rs1770345 / 0 / - / - / 1 / 4.305 / 0.038 / 0.038 / 0.0345
rs135539 / rs870995 / 1 / 3.461 / 0.063 / 1 / 4.236 / 0.040 / 0.040 / 0.0286
rs1800566 / rs4073 / 1 / 4.065 / 0.044 / 0 / - / - / 0.044 / 0.0254
rs282070 / rs1800896 / 1 / 4.042 / 0.044 / 0 / - / - / 0.044 / 0.0304
rs135539 / rs7614 / 1 / 4.022 / 0.045 / 1 / 3.629 / 0.057 / 0.045 / 0.037
rs1800896 / rs1799787 / 0 / - / - / 1 / 3.962 / 0.047 / 0.047 / 0.0382
NH, NL: the number of multi locus genotypes classified as high and low risk, respectively.
WH, WL: Wald statistic for the high and low risk categories, respectively.
PH, PL: unadjusted P-value for the high and low risk categories, respectively
MIN.P: The minimum between PH and PL.
p*: simulated p-values obtained calling the mbmdr.PermTest function of the mbmdr package (10000 permutations)