Table S1: Clinical Assessments

Name of Instrument / Quality Assessed / Publication / Category of Assessment / MCIC Assessment Name
Abnormal Involuntary Movement Scale (AIMS) / Facial and oral movements,
Extremity movements,
Trunk movements, and
Global judgment / National Institute of Mental Health. Abnormal Involuntary Movement Scale. In Guy, W., ed. (1976). ECDEU Assessment Manual. Washington DC, U.S. Department of Health, Education, and Welfare: 534. / Extrapyramidal symptoms data / Abnormal Involuntary Movement Scale (AIMS)
Annett Scale of Hand Preference / Handedness / Annett, M. (1970). A classification of hand preference by association analysis. British Journal of Psychology, 303-321. / Demographic data / Baseline Information Form (BIF) / Control Baseline Information Form (CBIF) / Comprehensive Assessment of Symptoms and History (CASH)
Barnes Akathisia Scale (BAS) / Awareness of restlessness, Distress related to restlessness, and Global clinical assessment of akathisia / Barnes, T.R. (1989). A rating scale for drug-induced akathisia. British Journal of Psychiatry, 154, 672-676. / Extrapyramidal symptoms data / Barnes Akathisia Scale (BAS)
Benton Visual Retention Test (BVRT) / Visual Memory / Sivan, A.B.. Benton Visual Retention Test (5th Edition). San Antonio, TX: The Psychological Corporation, 1992. / Neuropsychological data / Neuropsych. Data Collection Form
Calgary Depression Scale for Schizophrenia (CDSS) / Depression, Hopelessness
Self depreciation, Guilty ideas of reference, Pathological guilt, Morning depression, Early wakening, Suicide,
Observed depression / Addington, D., Addington, J., Maticka-Tyndale, E., & Joyce, J. (1992). Reliability and validity of a depression rating scale for schizophrenics. Schizophrenia Research, 6, 201-208. / Symptom Data / Calgary Depression Scale for Schizophrenia (CDSS)
California Computerized Assessment Battery (CalCap) / Processing Speed & Attention/Vigilance / Miller, E. N. (1990). California Computerized Assessment Battery (CalCAP). Los Angeles:
Norland Software. / Neuropsychological data / Neuropsych. Data Collection Form
Comprehensive Assessment of Symptoms and History (CASH) / Demographic Data, Treatment Data, and History of Onset / Andreasen NC, Flaum M, Arndt S. The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology. Arch Gen Psychiatry 1992; 49(8): 615-623. / Demographic data / Comprehensive Assessment of Symptoms and History (CASH)
The Delis–Kaplan Executive Function System (D-KEFS) Verbal Fluency Test: FAS / Verbal/Linguistic Ability / Delis DC, Kaplan E, Kramer J. Delis–Kaplan Executive Function System. San Antonio,
TX: The Psychological Corporation; 2001. / Neuropsychological data / Neuropsych. Data Collection Form
Grooved Pegboard / Motor / Ruff, R. M., & Parker, S. B. (1993). Sex- and age-specific changes in motor speed and eye hand coordination in adults: Normative values for the finger tapping and grooved pegboard tests. Perceptual and Motor Skills 76, 1219–1230. / Neuropsychological data / Neuropsych. Data Collection Form
Hollingshead-Redlich Scale / Parent Socioeconomic Status / Hollingshead and Redlich, 1958. A.B. Hollingshead and F.C. Redlich. Social Class and Mental Illness: A Community Sample, John Wiley and Sons, New York (1958). / Demographic data / Baseline Information Form (BIF) / Control Baseline Information Form (CBIF) / Comprehensive Assessment of Symptoms and History (CASH)
Hopkins Verbal Learning Test (HVLT): Immediate/Hopkins
Verbal Learning Test (HVLT): Delay / Verbal Declarative Memory / Brandt, J. (1991). The Hopkins Verbal Learning Test: Development of a new memory test with
six equivalent forms. The Clinical Neuropsychologist 5, 125-142. / Neuropsychological data / Neuropsych. Data Collection Form
Psychiatric Symptoms You Currently Have (PSYCH) / Treatment Summary and
Lifetime Diagnoses and Durations / Andreasen NC (1987): Psychiatric Symptoms You Currently Have—Baseline (PSYCH-BASE) Iowa City, Iowa: The University of Iowa. / Diagnostic data / Psychiatric Symptoms You Currently Have (PSYCH)
Scale for the Assessment of Negative Symptoms (SANS) / Negative symptoms associated with schizophrenia spectrum disorders / Andreasen NC. Scale for the Assessment of Negative Symptoms (SANS). University of Iowa: Iowa City, 1983. / Psychosis Symptom Data / Scale for the Assessment of Negative Symptoms (SANS) / Comprehensive Assessment of Symptoms and History (CASH)
Scale for Assessment of Positive (SAPS) / Positive symptoms associated with schizophrenia spectrum disorders / Andreasen NC. Scale for the Assessment of Positive Symptoms (SAPS). University of Iowa: Iowa City, 1984. / Psychosis Symptom Data / Scale for the Assessment of Positive Symptoms (SAPS) / Comprehensive Assessment of Symptoms and History (CASH)
Simpson Angus Scale (SAS) / Rigidity of major joints, Fixation of position or wrist rigidity, Leg pendulousness, Head dropping, Glabella tap, Tremor, Salivation, Gait, Balance, Akinesia, Akathisia, Addendum acute dsytonic reaction, Cooperativeness, Arm dropping, Shoulder shaking, Elbow rigidity, Cogwheeling / Simpson G.M., Angus, J.W.S. (1970). A rating scale for extrapyramidal side effects. Acta Psychiatry Scand (Suppl), 212, 11-19. / Extrapyramidal symptoms data / Simpson Angus Scale (SAS)
Structural Clinical Interview for DSM-IV-TR (SCID) / Diagnoses / First, Michael B., Spitzer, Robert L., Gibbon, Miriam, and Williams, Janet B.W.: "Structured Clinical Interview for DSM-IV Axis I Disorders -Patient Edition (SCID-I/P, Version 2.0, 8/98 revision)"
Biometrics Research Department
New York State Psychiatric Institute
722 West 168th Street
New York, New York 10032 / Diagnostic data / Psychiatric Symptoms You Currently Have (PSYCH) / Comprehensive Assessment of Symptoms and History (CASH)
Trail Making Test (TMT) / Problem Solving/ Executive / Reitan, R. M. (1958). Validity of the trail making test as indicator of organic brain damage.
Perceptual and Motor Skills 8, 271–276. / Neuropsychological data / Neuropsych. Data Collection Form
Tower of London (TOL) / Problem Solving/ Executive / Shallice, T. (1982). Specific impairments of planning. Phil. Trans Roy. Soc., 199–209. / Neuropsychological data / Neuropsych. Data Collection Form
Wechsler Adult Intelligence Scale (WAIS-3): Block Design, Similarities, Vocabulary, and Letter-Number Sequencing / Working Memory, Verbal Abstraction, and Current General Cognitive Functioning / Wechsler, D. (1997a). Wechsler Adult Intelligence Scale (3rd ed.). San Antonio, TX:
Psychological Corporation. / Neuropsychological data / Neuropsych. Data Collection Form
Wechsler Memory Scale-3 (WMS-3): Faces I
Wechsler Memory Scale-3 (WMS-3): Faces II-Delay / Visual Memory / Wechsler, D. (1997b). Wechsler Memory Scale (3rd ed.). San Antonio, TX: Psychological
Corporation. / Neuropsychological data / Neuropsych. Data Collection Form
Wechsler Memory Scale-3 (WMS-3): Logical Memory I
Wechsler Memory Scale-3 (WMS-3): Logical Memory II – Delay / Verbal Declarative Memory / Wechsler, D. (1997c). Wechsler Memory Scale (3rd ed.). San Antonio, TX: Psychological
Corporation. / Neuropsychological data / Neuropsych. Data Collection Form
Wide Range Achievement Test-3 (WRAT3RT) / Potential or Premorbid IQ / Wilkinson, G. (1993). Wide Range Achievement Test (3rd ed.). Wilmington, DE: Wide Range,
Inc. / Neuropsychological data / Neuropsych. Data Collection Form

Table S2: Chlorpromazine Equivalencies

Generic Name / Type / Chloropromazine Equivalency (mg)
Chlorpromazine / Typical / 100
Clozapine / Clozapine / 50
Fluphenazine / Typical / 2
Fluphenazine Decanoate / Typical / (1:1 equivalency with oral Fluphenazine)*
Fluphenazine Enanthate / Typical / (1:1 equivalency with oral Fluphenazine)*
Haloperidol / Typical / 2
Haloperidol Decanoate / Typical / (10:1 equivalency with oral Haloperidol)*
Perphenazine / Typical / 8
Thioridazine / Typical / 100
Thiothixene / Typical / 3
Triflupromazine / Typical / 30
Risperidone / Atypical / 2
Olanzapine / Atypical / 2
Quetiapine / Atypical / 100
Aripiprazole / Atypical / 5
Ziprasidone / Atypical / 80
Risperdal consta / Atypical / (2:1 for 25mg injection, 4:1 for 37.5 mg, and 6:1 for 50mg and 75 mg)*

For each antipsychotic drug (Generic name) administered to a subject, the category (Type) and the number of milligrams of that drug that would be required to obtain an equivalent treatment effect as a 100 mg dose of the drug Chlorpromazine (Chlorpromazine Equivalency) is given.

Atypical and Clozapine / Atypical and Typical / Atypical / Clozapine / Missing / None* / Typical / Total
All Sites
N / % / 5 / 3.1 / 7 / 4.3 / 109 / 67.7 / 13 / 8.1 / 7 / 4.3 / 9 / 5.6 / 11 / 6.8 / 161
A
N / % / 0 / 0 / 0 / 0 / 32 / 69.6 / 6 / 13 / 5 / 10.9 / 1 / 2.2 / 2 / 4.3 / 46
B
N / % / 0 / 0 / 2 / 4.5 / 30 / 68.2 / 3 / 6.8 / 1 / 2.3 / 4 / 9.1 / 4 / 9.1 / 44
C
N / % / 0 / 0 / 4 / 12.1 / 24 / 72.7 / 1 / 3 / 0 / 0 / 2 / 6.1 / 2 / 6.1 / 33
D
N / % / 5 / 13.2 / 1 / 2.6 / 23 / 60.5 / 3 / 7.9 / 1 / 2.6 / 2 / 5.3 / 3 / 7.9 / 38

Table S3: Patient use of antipsychotics by site and overall

Of those not currently on medication, 2 have a prior pharmacotherapy history.