Supplementary Table S1: List of All the Components Resulting from the Independent Component

Supplementary Table S1: List of all the components resulting from the Independent Component Analysis (ICA) for each rat strain.

Strain / Component # / Defining regional feature(s)
SD / 1 / Visual (medial secondary and primary monocular) and dygranular retrosplenial cortices, inferior colliculus (dorsal cortex and nucleus of the commissure)
2 / Piriform cortex, perirhinal cortex, temporal HPC (CA3, dentate gyrus),
substantia nigra
3 / PAG, dorsal raphe, visual cortex (primary and secondary), postrhinal cortex, postsubiculum, inferior colliculus (external cortex)
4 / Auditory cortex (primary and secondary), right primary somatosensory cortex, parietal cortex (posterior area)
5 / RSC (granular), anterior cingulate cortex, HPC (septal dentate gyrus)
6 / Visual cortex, inferior colliculus, subiculum
7 / Prelimbic cortex, orbital cortex
8 / Somatosensory cortex (right), left auditory cortex and medial geniculate
9 / Ventral tegmental area subregions, lateral entorhinal and piriform cortices, amygdala
10 / Anterior cingulate cortex, parietal association cortex (lateral and medial), somatomotor cortices
11 / Piriform cortex, amygdala, insula (granular, dysgranular, and posterior agranular), deep perirhinal cortex
12 / Thalamic nuclei (laterodorsal and lateroposterior), lateral habenula
13 / RSC (caudal), visual cortex, perirhinal/lateral entorhinal cortex
14 / Frontal cortex (prelimbic, orbital, and secondary motor)
15 / Visual cortex, caudal RSC (granular and dysgranular)
16 / Lateral hypothalamus, deep perirhinal cortex, temporal CA1, para- and subparafascicular thalamic nuclei, supramammillary nucleus, amygdala
17 / RSC, medial primary and secondary visual cortex, parietal cortex
18 / Rostral RSC, anterior cingulate, somatomotor, and somatosensory cortices
19 / Right amygdala and perihinal, lateral entorhinal, and piriform cortices
20 / Noise
WKY / 1 / Hypothalamus, amygdala, temporal hippocampus, geniculate nucleus, red nucleus, substantia nigra, parabrachial nucleus, paranigral nucleus
2 / Somatosensory and motor cortices,
3 / Left visual, postrhinal, and auditory cortices, intermediate HPC
4 / RSC, visual, and auditory cortices, PAG, superior colliculus
5 / Left piriform, perirhinal, auditory, and insular cortices; temporal HPC
6 / RSC, parietal, somatosensory, motor, and perirhinal cortices
7 / Dorsal thalamic nuclei, PAG, superior colliculus
8 / Somatomotor, anterior cingulate, RSC
9 / Right somatosensory, auditory, visual, and perirhinal cortices
10 / Left somatosensory, auditory, visual, and perirhinal cortices
11 / Prefrontal cortex (including prelimbic, infralimbic, orbital, insular, and anterior cingulate)
12 / Noise (due to last slice registration problems)
13 / PAG, raphe
14 / Piriform, insular, and perirhinal cortices, temporal HPC
15 / HPC, ACC, RSC
16 / Visual cortex, RSC
17 / Right somatosensory and insular cortices
18 / RSC, parietal cortex
19 / Right amygdala, piriform, perirhinal, and lateral entorhinal cortices
20 / Noise (motion)
SHR / 1 / Visual cortex, postsubiculum, colliculus, RSC
2 / RSC, ACC, parietal, visual, somatomotor, and somatosensory cortices
3 / PAG, colliculus, dorsal raphe
4 / Septum, medial striatum, ventromedial prefrontal cortex
5 / Lateral striatum, amygdala, insula, somatosensory cortex
6 / Somatosensory and somatomotor cortices
7 / Left somatosensory, parietal, auditory, and perirhinal cortices, HPC
8 / Right somatosensory, insular, and auditory cortices, HPC
9 / Orbitofrontal cortex, nucleus accumbens, amygdala
10 / Thalamus
11 / Noise
12 / RSC, parietal and visual cortices
13 / Prefrontal cortex, somatomotor cortex
14 / HPC, ACC, RSC
15 / Noise
16 / Noise (due to registration problems on last slice)
17 / Amygdala, perirhinal and entorhinal cortices, hippocampus, hypothalamus
18 / Somatomotor, and somatosensory cortices, RSC, ACC
19 / Amygdala, insula
20 / HPC, perirhinal cortex, substantial nigra, ventral tegmental area

HPC, hippocampus; ACC, anterior cingulate cortex; RSC, retrosplenial cortex; PAG, periaqueductal grey