The association of SNAP25 gene polymorphisms in attentiondeficit hyperactivity disorder: a systematic review and meta-analysis

Yun-Sheng Liu1, Xuan Dai1, Wei Wu2, Fang-fen Yuan1, Xue Gu1, Jian-Guo Chen3,4, Ling-Qiang Zhu3,5, Jing Wu1

1Key Laboratory of Environment and Health, Ministry of Education & Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P.R.China

2Department of Pediatics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

3Key lab of neurological disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P. R. China

4Department of Pharmacology, School of Basic Medicine, Tongji Medical College, HuazhongUnivresity of Science and Technology, Wuhan, 430030, China

5Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

Yun-Sheng Liu, Xuan Dai andWei Wu contributed equally to this paper.

Corresponding Author: Jing Wu, and Ling-Qiang Zhu,

Supplementary Files

Supplementary Fig.1Meta-analysis literature selection flow chart

Supplementary Fig.2 Themetastatistical analysis flow chart

Supplementary Table 1Sensitivity Analysis ofAssociation Studies between the rs3746544, rs1051312, rs362549 and ADHD

Study Omitted / Pooled Results After Omission of Study
OR / 95%CI / I2(%)
rs3756544 / Barr CL, 2000 / 1.185 / (1.023, 1.371) / 46.409
Brophy K, 2002 / 1.179 / (1.020, 1.362) / 46.650
Kustanovich V, 2003 / 1.160 / (0.998, 1.349) / 45.401
Mill J, 2004 / 1.168 / (1.007, 1.356) / 46.994
Feng Y, 2005(1) / 1.196 / (1.034, 1.383) / 43.284
Feng Y, 2005(2) / 1.181 / (1.022, 1.365) / 46.465
Kim JW, 2007 / 1.170 / (1.003, 1.364) / 46.805
Hawi Z, 2013 / 1.213 / (1.078, 1.364) / 9.408
Choi TK, 2007 / 1.163 / (1.008, 1.342) / 45.678
Gao XP, 2009 / 1.127 / (0.993, 1.278) / 30.050
Sarkar K, 2012 / 1.182 / (1.020, 1.368) / 46.817
Galvez JM, 2014 / 1.117 / (0.992, 1.259) / 23.472
rs1051312 / Barr CL, 2000 / 1.000 / (0.826, 1.212) / 44.620
Brophy K, 2002 / 0.917 / (0.805, 1.045) / 0.009
Kustanovich V, 2003 / 0.978 / (0.767, 1.247) / 59.275
Mill J, 2004 / 0.922 / (0.766, 1.109) / 41.437
Feng Y, 2005(1) / 0.984 / (0.798, 1.215) / 56.564
Feng Y, 2005(2) / 0.956 / (0.753, 1.214) / 60.860
Kim JW, 2007 / 0.958 / (0.750, 1.223) / 59.813
Sarkar K, 2012 / 0.960 / (0.769, 1.198) / 60.442
Galvez JM, 2014 / 1.001 / (0.833, 1.203) / 40.158
rs362549 / Feng Y, 2005(1) / 1.193 / (0.968, 1.417) / 29.811
Feng Y, 2005(2) / 1.021 / (0.841, 1.239) / 0.001
Kim JW, 2007 / 1.083 / (0.731, 1.603) / 64.560
Zhang H, 2011 / 1.103 / (0.780, 1.558) / 68.581

SupplementaryFig. 3Funnel plots of publication biasof the association between ADHD and SNPsaThe single study and funnel plot of publication bias of the association between ADHD and rs3746544 b The single study and funnel plot of publication bias of the association between ADHD and rs1051312