The Classification Systems of Secondary Active Transporters

Supplemental information Table S1

The classification systems of secondary active transporters

Emelie Perland and Robert Fredriksson

Department of Pharmaceutical Bioscience, Molecular Neuropharmacology, Uppsala University, Uppsala SE 7512, Sweden

*Correspondence:

Table S1. Detailed list of how each SLC is classified according to the various systems

There are 429 unique secondary active transporter sequences, of which 30 are newly identified (listed in red at the end of the table). Proteins that were detected when searched for MFS and APC proteinsusing Pfam hidden Markov modelsare listed in the first column, together with the specific accession numbers (Ensemble version 84 [1]). The following columns represent information about human sequences, collected from the classification systems discussed in the main article: HGNC [2], SLC tables [3], Phylogenetic analyses [4, 5], Atypical SLCs [6, 7], TCDB [8] and Pfam [9]. There are additional 26 known SLC pseudogenes, which are not included. Colours represent the ones used in figure 1.

Human classification systems / Multi-organism classification systems
Our search / HGNC
[2] / SLC Tables [3] / Phylogeny
[4, 5] / Atypical SLCs
[6, 7] / TCDB human
[8] / TCDB
Superfamily/
Transporter family/Subfamily / Pfam Clan [9] / Pfam member family
SLC1A1 / X / 2.A.23.2.3 / /DAACS / SDF
SLC1A2 / X / 2.A.23.2.7 / /DAACS / SDF
SLC1A3 / X / 2.A.23.2.6 / /DAACS / SDF
SLC1A4 / X / 2.A.23.3.1 / /DAACS / SDF
SLC1A5 / X / 2.A.23.3.3 / /DAACS / SDF
SLC1A6 / X / 2.A.23.2.8 / /DAACS / SDF
SLC1A7 / X / 2.A.23.2.5 / /DAACS / SDF
SLC2A1_ENSP00000361578 / SLC2A1 / X / α [4, 5] / 2.A.1.1.28 / MFS/MFS/
sugar porters / MFS (CL0015) / sugar and other transporter
SLC2A2_ENSP00000323568 / SLC2A2 / X / α [4, 5] / 2.A.1.1.29 / MFS/MFS/
sugar porters / MFS (CL0015) / sugar and other transporter
SLC2A3_ENSP00000440750 / SLC2A3 / X / α [4, 5] / 2.A.1.1.91 / MFS/MFS/
sugar porters / MFS (CL0015) / sugar and other transporter
SLC2A4_ENSP00000396887 / SLC2A4 / X / α [4, 5] / 2.A.1.1.80 / MFS/MFS/
sugar porters / MFS (CL0015) / sugar and other transporter
SLC2A5_ENSP00000467840 / SLC2A5 / X / α [4, 5] / 2.A.1.1.13 / MFS/MFS/
sugar porters / MFS (CL0015) / sugar and other transporter
SLC2A6_ENSP00000360964 / SLC2A6 / X / α [4, 5] / 2.A.1.1.88 / MFS/MFS/
sugar porters / MFS (CL0015) / sugar and other transporter
SLC2A7_ENSP00000383698 / SLC2A7 / X / α [4, 5] / 2.A.1.1.37 / MFS/MFS/
sugar porters / MFS (CL0015) / sugar and other transporter
SLC2A8_ENSP00000391213 / SLC2A8 / X / α [4, 5] / 2.A.1.1.89 / MFS/MFS/
sugar porters / MFS (CL0015) / sugar and other transporter
SLC2A9_ENSP00000426800 / SLC2A9 / X / α [4, 5] / 2.A.1.1.72 / MFS/MFS/
sugar porters / MFS (CL0015) / sugar and other transporter
SLC2A10_ENSP00000352216 / SLC2A10 / X / α [4, 5] / 2.A.1.1.59 / MFS/MFS/
sugar porters / MFS (CL0015) / sugar and other transporter
SLC2A11_ENSP00000342542 / SLC2A11 / X / α [4, 5] / 2.A.1.1.44 / MFS/MFS/
sugar porters / MFS (CL0015) / sugar and other transporter
SLC2A12_ENSP00000275230 / SLC2A12 / X / α [4, 5] / 2.A.1.1.87 / MFS/MFS/
sugar porters / MFS (CL0015) / sugar and other transporter
SLC2A13_ENSP00000370239 / SLC2A13 / X / α [4, 5] / 2.A.1.1.25 / MFS/MFS/
sugar porters / MFS (CL0015) / sugar and other transporter
SLC2A14_ENSP00000442402 / SLC2A14 / X / α [4, 5] / 2.A.1.1.90 / MFS/MFS/
sugar porters / MFS (CL0015) / sugar and other transporter
SLC3A1 / X / 8.A.9.1.2 / /rBAT / Tim barrel glycosyl hydrolase superfamily
(CL0058) / Alpha-Amylase
SLC3A2 / X / 8.A.9.2.2 / /rBAT / Tim barrel glycosyl hydrolase superfamily
(CL0058) / Alpha-Amylase
SLC4A1_ENSP00000262418 / SLC4A1 / X / 2.A.31.1.1 / APC/AE / APC (CL0062) / HCO3_cotransp
SLC4A2_ENSP00000419412 / SLC4A2 / X / 2.A.31.1.2 / APC/AE / APC (CL0062) / HCO3_cotransp
SLC4A3_ENSP00000273063 / SLC4A3 / X / 2.A.31.1.3 / APC/AE / APC (CL0062) / HCO3_cotransp
SLC4A4_ENSP00000393557 / SLC4A4 / X / 2.A.31.2.12 / APC/AE / APC (CL0062) / HCO3_cotransp
SLC4A5_ENSP00000366861 / SLC4A5 / X / 2.A.31.2.8 / APC/AE / APC (CL0062) / HCO3_cotransp
SLC4A7_ENSP00000390394 / SLC4A7 / X / 2.A.31.2.11 / APC/AE / APC (CL0062) / HCO3_cotransp
SLC4A8_ENSP00000405812 / SLC4A8 / X / 2.A.31.2.4 / APC/AE / APC (CL0062) / HCO3_cotransp
SLC4A9_ENSP00000427661 / SLC4A9 / X / 2.A.31.2.13 / APC/AE / APC (CL0062) / HCO3_cotransp
SLC4A10_ENSP00000393066 / SLC4A10 / X / 2.A.31.2.14 / APC/AE / APC (CL0062) / HCO3_cotransp
SLC4A11_ENSP00000369399 / SLC4A11 / X / 2.A.31.4.1 / APC/AE / APC (CL0062) / HCO3_cotransp
SLC5A1_ENSP00000266088 / SLC5A1 / X / 2.A.21.3.1 / APC/SSS / APC (CL0062) / SSF
SLC5A2_ENSP00000327943 / SLC5A2 / X / 2.A.21.3.16 / APC/SSS / APC (CL0062) / SSF
SLC5A3_ENSP00000370543 / SLC5A3 / X / 2.A.21.3.14 / APC/SSS / APC (CL0062) / SSF
SLC5A4_ENSP00000266086 / SLC5A4 / X / 2.A.21.3.18 / APC/SSS / APC (CL0062) / SSF
SLC5A5_ENSP00000222248 / SLC5A5 / X / 2.A.21.5.1 / APC/SSS / APC (CL0062) / SSF
SLC5A6_ENSP00000310208 / SLC5A6 / X / 2.A.21.5.7 / APC/SSS / APC (CL0062) / SSF
SLC5A7_ENSP00000387346 / SLC5A7 / X / 2.A.21.8.2 / APC/SSS / APC (CL0062) / SSF
SLC5A8_ENSP00000461697 / SLC5A8 / X / 2.A.21.5.3 / APC/SSS / APC (CL0062) / SSF
SLC5A9_ENSP00000236495 / SLC5A9 / X / 2.A.21.3.17 / APC/SSS / APC (CL0062) / SSF
SLC5A10_ENSP00000379008 / SLC5A10 / X / 2.A.21.3.15 / APC/SSS / APC (CL0062) / SSF
SLC5A11_ENSP00000289932 / SLC5A11 / X / 2.A.21.3.6 / APC/SSS / APC (CL0062) / SSF
SLC5A12_ENSP00000379326 / SLC5A12 / X / 2.A.21.5.6 / APC/SSS / APC (CL0062) / SSF
SLC6A1 / X / 2.A.22.3.2 / APC/NSS / APC (CL0062) / SNF
SLC6A2 / X / 2.A.22.1.2 / APC/NSS / APC (CL0062) / SNF
SLC6A3 / X / 2.A.22.1.3 / APC/NSS / APC (CL0062) / SNF
SLC6A4 / X / 2.A.22.1.1 / APC/NSS / APC (CL0062) / SNF
SLC6A5 / X / 2.A.22.2.10 / APC/NSS / APC (CL0062) / SNF
SLC6A6 / X / 2.A.22.3.3 / APC/NSS / APC (CL0062) / SNF
SLC6A7 / X / 2.A.22.2.11 / APC/NSS / APC (CL0062) / SNF
SLC6A8 / X / 2.A.22.3.11 / APC/NSS / APC (CL0062) / SNF
SLC6A9 / X / 2.A.22.2.12 / APC/NSS / APC (CL0062) / SNF
Not found / SLC6A10
SLC6A11 / X / 2.A.22.3.9 / APC/NSS / APC (CL0062) / SNF
SLC6A12 / X / 2.A.22.3.1 / APC/NSS / APC (CL0062) / SNF
SLC6A13 / X / 2.A.22.3.10 / APC/NSS / APC (CL0062) / SNF
SLC6A14 / X / 2.A.22.2.3 / APC/NSS / APC (CL0062) / SNF
SLC6A15 / X / 2.A.22.6.7 / APC/NSS / APC (CL0062) / SNF
SLC6A16 / X / 2.A.22.6.5 / APC/NSS / APC (CL0062) / SNF
SLC6A17 / X / 2.A.22.6.6 / APC/NSS / APC (CL0062) / SNF
SLC6A18 / X / 2.A.22.6.4 / APC/NSS / APC (CL0062) / SNF
SLC6A19 / X / 2.A.22.6.3 / APC/NSS / APC (CL0062) / SNF
SLC6A20 / X / 2.A.22.6.8 / APC/NSS / APC (CL0062) / SNF
SLC7A1_ENSP00000370128 / SLC7A1 / X / β[5] / 2.A.3.3.9 / APC/APC/CAT / APC (CL0062) / AA_permease_2
SLC7A2_ENSP00000004531 / SLC7A2 / X / β[5] / 2.A.3.3.8 / APC/APC/CAT / APC (CL0062) / AA_permease_2
SLC7A3_ENSP00000363417 / SLC7A3 / X / β[5] / 2.A.3.3.10 / APC/APC/CAT / APC (CL0062) / AA_permease_2
SLC7A4_ENSP00000384278 / SLC7A4 / X / β[5] / 2.A.3.3.6 / APC/APC/CAT / APC (CL0062) / AA_permease_2
SLC7A5_ENSP00000261622 / SLC7A5 / X / β[5] / 2.A.3.8.25 / APC/APC/LAT / APC (CL0062) / AA_permease_2
SLC7A6_ENSP00000219343 / SLC7A6 / X / β[5] / 2.A.3.8.23 / APC/APC/LAT / APC (CL0062) / AA_permease_2
SLC7A7_ENSP00000285850 / SLC7A7 / X / β[5] / 2.A.3.8.22 / APC/APC/LAT / APC (CL0062) / AA_permease_2
SLC7A8_ENSP00000320378 / SLC7A8 / X / β[5] / 2.A.3.8.20 / APC/APC/LAT / APC (CL0062) / AA_permease_2
SLC7A9_ENSP00000464822 / SLC7A9 / X / β[5] / 2.A.3.8.19 / APC/APC/LAT / APC (CL0062) / AA_permease_2
SLC7A10_ENSP00000253188 / SLC7A10 / X / β[5] / 2.A.3.8.21 / APC/APC/LAT / APC (CL0062) / AA_permease_2
SLC7A11_ENSP00000280612 / SLC7A11 / X / β[5] / 2.A.3.8.18 / APC/APC/LAT / APC (CL0062) / AA_permease_2
SLC7A13_ENSP00000297524 / SLC7A13 / X / β[5] / 2.A.3.8.24 / APC/APC/LAT / APC (CL0062) / AA_permease_2
SLC7A14_ENSP00000231706 / SLC7A14 / X / β[5] / X [6] / 2.A.3.3.7 / APC/APC/CAT / APC (CL0062) / AA_permease_2
SLC8A1 / X / δ [4, 5] / 2.A.19.3.4 / CDF/CaCA / Na_Ca_Exsuperfamily
SLC8A2 / X / δ [4, 5] / 2.A.19.3.5 / CDF/CaCA / Na_Ca_Ex superfamily
SLC8A3 / X / δ [4, 5] / 2.A.19.3.3 / CDF/CaCA / Na_Ca_Ex superfamily
SLC8B1 (SLC24A6) / X / δ [5] / 2.A.19.4.4 / CDF/CaCA / Na_Ca_Ex superfamily
SLC9A1 / X / γ[5] / 2.A.36.1.13 / /CPA1 / CPA/AT (CL0064) / Na_H_Exchanger
SLC9A2 / X / γ[5] / 2.A.36.1.17 / /CPA1 / CPA/AT (CL0064) / Na_H_Exchanger
SLC9A3 / X / γ[5] / 2.A.36.1.15 / /CPA1 / CPA/AT (CL0064) / Na_H_Exchanger
SLC9A4 / X / γ[5] / 2.A.36.1.18 / /CPA1 / CPA/AT (CL0064) / Na_H_Exchanger
SLC9A5 / X / γ[5] / 2.A.36.1.16 / /CPA1 / CPA/AT (CL0064) / Na_H_Exchanger
SLC9A6 / X / γ[5] / 2.A.36.1.14 / /CPA1 / CPA/AT (CL0064) / Na_H_Exchanger
SLC9A7 / X / γ[5] / 2.A.36.1.3 / /CPA1 / CPA/AT (CL0064) / Na_H_Exchanger
SLC9A8 / X / γ[5] / 2.A.36.1.9 / /CPA1 / CPA/AT (CL0064) / Na_H_Exchanger
SLC9A9 / X / γ[5] / 2.A.36.1.19 / /CPA1 / CPA/AT (CL0064) / Na_H_Exchanger
SLC9B1 / X / 2.A.36.2.3 / /CPA1 / CPA/AT (CL0064) / Na_H_Exchanger
SLC9B2 / X / 2.A.36.2.2 / /CPA1 / CPA/AT (CL0064) / Na_H_Exchanger
SLC9C1 / X / 2.A.36.7.5 / /CPA1 / CPA/AT (CL0064) / Na_H_Exchanger
SLC9C2 / X / 2.A.36.7.4 / /CPA1 / CPA/AT (CL0064) / Na_H_Exchanger
SLC10A1 / X / γ[5] / 2.A.28.1.8 / BART/BASS / CPA/AT (CL0064) / SBF
SLC10A2 / X / γ[5] / 2.A.28.1.2 / BART/BASS / CPA/AT (CL0064) / SBF
SLC10A3 / X / γ[5] / 2.A.28.1.8 / BART/BASS / CPA/AT (CL0064) / SBF
SLC10A4 / X / γ[5] / 2.A.28.1.7 / BART/BASS / CPA/AT (CL0064) / SBF
SLC10A5 / X / γ[5] / 2.A.28.1.6 / BART/BASS / CPA/AT (CL0064) / SBF
SLC10A6 / X / γ[5] / X [6] / 2.A.28.1.4 / BART/BASS / CPA/AT (CL0064) / SBF
SLC10A7 / X / 2.A.28.3.1 / BART/BASS / CPA/AT (CL0064) / SBF
SLC11A1_ENSP00000233202 / SLC11A1 / X / 2.A.55.2.3 / APC/Nramp / APC (CL0062) / Nramp
SLC11A2_ENSP00000449200 / SLC11A2 / X / 2.A.55.2.1 / APC/Nramp / APC (CL0062) / Nramp
SLC12A1_ENSP00000379822 / SLC12A1 / X / β[5] / 2.A.30.1.2 / APC/CCC / APC (CL0062) / AA_permease
SLC12A2_ENSP00000262461 / SLC12A2 / X / β[5] / 2.A.30.3.1 / APC/CCC / APC (CL0062) / AA_permease
SLC12A3_ENSP00000402152 / SLC12A3 / X / β[5] / 2.A.30.4.2 / APC/CCC / APC (CL0062) / AA_permease
SLC12A4_ENSP00000395983 / SLC12A4 / X / β[5] / 2.A.30.5.5 / APC/CCC / APC (CL0062) / AA_permease
SLC12A5_ENSP00000387694 / SLC12A5 / X / β[5] / 2.A.30.5.6 / APC/CCC / APC (CL0062) / AA_permease
SLC12A6ENSP00000454168 / SLC12A6 / X / β[5] / 2.A.30.5.3 / APC/CCC / APC (CL0062) / AA_permease
SLC12A7_ENSP00000264930 / SLC12A7 / X / β[5] / 2.A.30.5.4 / APC/CCC / APC (CL0062) / AA_permease
SLC12A8_ENSP00000404243 / SLC12A8 / X / β[5] / 2.A.30.3.4 / APC/CCC / APC (CL0062) / AA_permease
SLC12A9_ENSP00000275730 / SLC12A9 / X / β[5] / 2.A.30.3.3 / APC/CCC / APC (CL0062) / AA_permease
SLC13A1 / X / 2.A.47.1.16 / IT/DASS / IT (CL0182) / Na_sulph_symp
SLC13A2 / X / 2.A.47.1.17 / IT/DASS / IT (CL0182) / Na_sulph_symp
SLC13A3 / X / IT (CL0182) / Na_sulph_symp
SLC13A4 / X / 2.A.47.1.14 / IT/DASS / IT (CL0182) / Na_sulph_symp
SLC13A5 / X / 2.A.47.1.9 / IT/DASS / IT (CL0182) / Na_sulph_symp
Not found / SLC13A6 [6]
SLC14A1 / SLC14A1_UT-B1 / 1.A.28.1.5 / UT/UT / UT
Not found / SLC14A1_UT-B2
SLC14A2 / SLC14A2_UT-A1 / 1.A.28.1.6 / UT/UT / UT
Not found / SLC14A2_UT-A2
Not found / SLC14A2_UT-A3
Not found / SLC14A2_UT-A4
Not found / SLC14A2_UT-A5
Not found / SLC14A2_UT-A6
SLC15A1_ENSP00000365686 / SLC15A1 / X / α [5] / 2.A.17.4.9 / MFS/PRT / MFS (CL0015) / PTR2
SLC15A2_ENSP00000418704 / SLC15A2 / X / α [5] / 2.A.17.4.8 / MFS/PRT / MFS (CL0015) / PTR2
SLC15A3_ENSP00000441559 / SLC15A3 / X / α [5] / 2.A.17.3.9 / MFS/PRT / MFS (CL0015) / PTR2
SLC15A4_ENSP00000365930 / SLC15A4 / X / α [5] / 2.A.17.3.11 / MFS/PRT / MFS (CL0015) / PTR2
SLC15A5_ENSP00000340402 / SLC15A5 / α [5] / X [6] / 2.A.17.3.10 / MFS/PRT / MFS (CL0015) / PTR2
SLC16A1_ENSP00000358640 / SLC16A1 / X / α [4, 5] / 2.A.1.13.1 / MFS/MFS/
Sugar porter / MFS (CL0015) / MFS_1
SLC16A2_ENSP00000465734 / SLC16A2 / X / α [4, 5] / 2.A.1.13.10 / MFS/MFS
/Sugar porter / MFS (CL0015) / MFS_1
SLC16A3_ENSP00000376150 / SLC16A3 / X / α [4, 5] / 2.A.1.13.6 / MFS/MFS/
Sugar porter / MFS (CL0015) / MFS_1
SLC16A4_ENSP00000394790 / SLC16A4 / X / α [4, 5] / 2.A.1.13.7 / MFS/MFS/
Sugar porter / MFS (CL0015) / MFS_1
SLC16A5_ENSP00000463931 / SLC16A5 / X / α [4, 5] / 2.A.1.13.11 / MFS/MFS/
Sugar porter / MFS (CL0015) / MFS_1
SLC16A6_ENSP00000319991 / SLC16A6 / X / α [4, 5] / 2.A.1.13.15 / MFS/MFS/
Sugar porter / MFS (CL0015) / MFS_1
SLC16A7_ENSP00000449547 / SLC16A7 / X / α [4, 5] / 2.A.1.13.5 / MFS/MFS/
Sugar porter / MFS (CL0015) / MFS_1
SLC16A8_ENSP00000321735 / SLC16A8 / X / α [4, 5] / 2.A.1.13.9 / MFS/MFS/
Sugar porter / MFS (CL0015) / MFS_1
SLC16A9_ENSP00000378756 / SLC16A9 / X / α [4, 5] / 2.A.1.13.16 / MFS/MFS/
Sugar porter / MFS (CL0015) / MFS_1
SLC16A10_ENSP00000399601 / SLC16A10 / X / α [4, 5] / 2.A.1.13.8 / MFS/MFS/
Sugar porter / MFS (CL0015) / MFS_1
SLC16A11_ENSP00000394449 / SLC16A11 / X / α [4, 5] / 2.A.1.13.13 / MFS/MFS/
Sugar porter / MFS (CL0015) / MFS_1
SLC16A12_ENSP00000360855 / SLC16A12 / X / α [4, 5] / X [6] / 2.A.1.13.14 / MFS/MFS/
Sugar porter / MFS (CL0015) / MFS_1
SLC16A13_ENSP00000309751 / SLC16A13 / X / α [4, 5] / 2.A.1.13.17 / MFS/MFS/
Sugar porter / MFS (CL0015) / MFS_1
SLC16A14_ENSP00000395775 / SLC16A14 / X / α [4, 5] / 2.A.1.13.12 / MFS/MFS/
Sugar porter / MFS (CL0015) / MFS_1
SLC17A1_ENSP00000244527 / SLC17A1 / X / α [4, 5] / 2.A.1.14.27 / MFS/MFS/ACS / MFS (CL0015) / MFS_1
SLC17A2_ENSP00000367081 / SLC17A2 / X / α [4, 5] / 2.A.1.14.29 / MFS/MFS/ACS / MFS (CL0015) / MFS_1
SLC17A3_ENSP00000353873 / SLC17A3 / X / α [4, 5] / 2.A.1.14.28 / MFS/MFS/ACS / MFS (CL0015) / MFS_1
SLC17A4_ENSP00000380266 / SLC17A4 / X / α [4, 5] / 2.A.1.14.24 / MFS/MFS/ACS / MFS (CL0015) / MFS_1
SLC17A5_ENSP00000348019 / SLC17A5 / X / α [4, 5] / 2.A.1.14.10 / MFS/MFS/ACS / MFS (CL0015) / MFS_1
SLC17A6_ENSP00000263160 / SLC17A6 / X / α [4, 5] / 2.A.1.14.31 / MFS/MFS/ACS / MFS (CL0015) / MFS_1
SLC17A7_ENSP00000221485 / SLC17A7 / X / α [4, 5] / 2.A.1.14.30 / MFS/MFS/ACS / MFS (CL0015) / MFS_1
SLC17A8_ENSP00000376715 / SLC17A8 / X / α [4, 5] / 2.A.1.14.32 / MFS/MFS/ACS / MFS (CL0015) / MFS_1
SLC17A9_ENSP00000388215 / SLC17A9 / X / α [4, 5] / 2.A.1.14.21 / MFS/MFS/ACS / MFS (CL0015) / MFS_1
SLC18A1_ENSP00000413361 / SLC18A1 / X / α [4, 5] / 2.A.1.2.12 / MFS/MFS/DHA1 / MFS (CL0015) / MFS_1
SLC18A2_ENSP00000298472 / SLC18A2 / X / α [4, 5] / 2.A.1.2.29 / MFS/MFS/DHA1 / MFS (CL0015) / MFS_1
SLC18A3_ENSP00000363229 / SLC18A3 / X / α [4, 5] / 2.A.1.2.28 / MFS/MFS/DHA1 / MFS (CL0015) / MFS_1
SLC18B1_ENSP00000275227 / SLC18B1 / X / α [5] / 2.A.1.2.57 / MFS/MFS/DHA1 / MFS (CL0015) / MFS_1
SLC19A1_ENSP00000441772 / SLC19A1 / X / α [5] / 2.A.48.1.1 / MFS/RFC / MFS (CL0015) / Folate carrier
SLC19A2_ENSP00000356778 / SLC19A2 / X / α [5] / 2.A.48.2.1 / MFS/RFC / MFS (CL0015) / Folate carrier
SLC19A3_ENSP00000397393 / SLC19A3 / X / α [5] / 2.A.48.2.3 / MFS/RFC / MFS (CL0015) / Folate carrier
SLC20A1 / X / 2.A.20.2.7 / /PiT / PHO4
SLC20A2 / X / 2.A.20.2.3 / /PiT / PHO4
SLCO2A1_ENSP00000420028 / SLCO2A1 / X / α [5] / 2.A.60.1.19 / MFS/OAT / MFS (CL0015) / OATP
SLCO4A1_ENSP00000217159 / SLCO4A1 / X / α [5] / 2.A.60.1.9 / MFS/OAT / MFS (CL0015) / OATP
SLCO5A1_ENSP00000432676 / SLCO5A1 / X / α [5] / 2.A.60.1.16 / MFS/OAT / MFS (CL0015) / OATP
SLCO3A1_ENSP00000320634 / SLCO3A1 / X / α [5] / 2.A.60.1.18 / MFS/OAT / MFS (CL0015) / OATP
SLCO6A1_ENSP00000421339 / SLCO6A1 / X / α [5] / 2.A.60.1.17 / MFS/OAT / MFS (CL0015) / OATP
SLCO1A2_ENSP00000438348 / SLCO1A2 / X / α [5] / 2.A.60.1.14 / MFS/OAT / MFS (CL0015) / OATP
SLCO2B1_ENSP00000432889 / SLCO2B1 / X / α [5] / 2.A.60.1.20 / MFS/OAT / MFS (CL0015) / OATP
SLCO1B1_ENSP00000256958 / SLCO1B1 / X / α [5] / 2.A.60.1.5 / MFS/OAT / MFS (CL0015) / OATP
SLCO1B3 / X / α [5] / 2.A.60.1.12 / MFS/OAT / MFS (CL0015) / OATP
SLCO4C1_ENSP00000309741 / SLCO4C1 / X / α [5] / MFS (CL0015) / OATP
SLCO1C1_ENSP00000438665 / SLCO1C1 / X / α [5] / 2.A.60.1.15 / MFS/OAT / MFS (CL0015) / OATP
SLCO1B7_ENSP00000394168 / SLCO1B7 / α [5] / SLC21A21
[6] / MFS (CL0015) / OATP
SLC22A1_ENSP00000439274 / SLC22A1 / X / α [4, 5] / 2.A.1.19.29 / MFS/MFS/OCT / MFS (CL0015) / Sugar and other transporter
SLC22A2_ENSP00000355919 / SLC22A2 / X / α [4, 5] / 2.A.1.19.30 / MFS/MFS/OCT / MFS (CL0015) / Sugar and other transporter
SLC22A3_ENSP00000275300 / SLC22A3 / X / α [4, 5] / 2.A.1.19.24 / MFS/MFS/OCT / MFS (CL0015) / MFS_1
SLC22A4_ENSP00000200652 / SLC22A4 / X / α [4, 5] / 2.A.1.19.2 / MFS/MFS/OCT / MFS (CL0015) / Sugar and other transporter
SLC22A5_ENSP00000402760 / SLC22A5 / X / α [4, 5] / 2.A.1.19.3 / MFS/MFS/OCT / MFS (CL0015) / Sugar and other transporter
SLC22A6_ENSP00000404441 / SLC22A6 / X / α [4, 5] / 2.A.1.19.31 / MFS/MFS/OCT / MFS (CL0015) / Sugar and other transporter
SLC22A7_ENSP00000393836 / SLC22A7 / X / α [4, 5] / 2.A.1.19.25 / MFS/MFS/OCT / MFS (CL0015) / MFS_1
SLC22A8_ENSP00000398548 / SLC22A8 / X / α [4, 5] / 2.A.1.19.34 / MFS/MFS/OCT / MFS (CL0015) / Sugar and other transporter
SLC22A9_ENSP00000279178 / SLC22A9 / X / α [4, 5] / 2.A.1.19.18 / MFS/MFS/OCT / MFS (CL0015) / MFS_1
SLC22A10_ENSP00000433048 / SLC22A10 / X / α [4, 5] / 2.A.1.19.27 / MFS/MFS/OCT / MFS (CL0015) / MFS_1
SLC22A11_ENSP00000366804 / SLC22A11 / X / α [4, 5] / 2.A.1.19.10 / MFS/MFS/OCT / MFS (CL0015) / Sugar and other transporter
SLC22A12_ENSP00000366795 / SLC22A12 / X / α [4, 5] / 2.A.1.19.11 / MFS/MFS/OCT / MFS (CL0015) / Sugar and other transporter
SLC22A13_ENSP00000310241 / SLC22A13 / X / α [4, 5] / 2.A.1.19.17 / MFS/MFS/OCT / MFS (CL0015) / Sugar and other transporter
SLC22A14_ENSP00000273173 / SLC22A14 / X / α [4, 5] / 2.A.1.19.22 / MFS/MFS/OCT / MFS (CL0015) / Sugar and other transporter
SLC22A15_ENSP00000358515 / SLC22A15 / X / α [4, 5] / 2.A.1.19.32 / MFS/MFS/OCT / MFS (CL0015) / Sugar and other transporter
SLC22A16_ENSP00000416310 / SLC22A16 / X / α [4, 5] / 2.A.1.19.12 / MFS/MFS/OCT / MFS (CL0015) / Sugar and other transporter
SLC22A17_ENSP00000380437 / SLC22A17 / X / α [4, 5] / 2.A.1.19.8 / MFS/MFS/OCT / MFS (CL0015) / Sugar and other transporter
SLC22A18_ENSP00000433019 / SLC22A18 / X / α [4, 5] / 2.A.1.2.53 / MFS/MFS/DHA1 / MFS (CL0015) / MFS_1
SLC22A20_ENST00000525437 / SLC22A20 / X / α [4, 5] / 2.A.1.19.35 / MFS/MFS/OCT / MFS (CL0015) / MFS_1
SLC22A23_ENSP00000369653 / SLC22A23 / X / α [4, 5] / 2.A.1.19.28 / MFS/MFS/OCT / MFS (CL0015) / Sugar and other transporter
SLC22A24_ENSP00000321549 / SLC22A24 / X / α [4, 5] / 2.A.1.19.21 / MFS/MFS/OCT / MFS (CL0015) / MFS_1
SLC22A25_ENSP00000432242 / SLC22A25 / X / α [4, 5] / 2.A.1.19.33 / MFS/MFS/OCT / MFS (CL0015) / MFS_1
SLC22A31_ENSP00000474621 / SLC22A31 / X / α [4, 5] / 2.A.1.19.23 / MFS/MFS/OCT / MFS (CL0015) / MFS_1
SLC23A1_ENSP00000302851 / SLC23A1 / X / 2.A.40.6.5 / APC/NAT / APC (CL0062) / Xan_ur_permease
SLC23A2_ENSP00000344322 / SLC23A2 / X / 2.A.40.6.2 / APC/NAT / APC (CL0062) / Xan_ur_permease
SLC23A3_ENSP00000406546 / SLC23A3 / X / 2.A.40.6.4 / APC/NAT / APC (CL0062) / Xan_ur_permease
SLC24A1 / X / δ [4, 5] / 2.A.19.4.9 / CDF/CaCA / Na_Ca_Ex superfamily
SLC24A2 / X / δ [4, 5] / 2.A.19.4.11 / CDF/CaCA / Na_Ca_Ex superfamily
SLC24A3 / X / δ [4, 5] / 2.A.19.4.10 / CDF/CaCA / Na_Ca_Ex superfamily
SLC24A4 / X / δ [4, 5] / 2.A.19.4.5 / CDF/CaCA / Na_Ca_Ex superfamily
SLC24A5 / X / δ [4, 5] / 2.A.19.4.6 / CDF/CaCA / Na_Ca_Ex superfamily
SLC25A1 / X / 2.A.29.7.2 / MC/MC / Mito_carr
SLC25A2 / X / 2.A.29.19.1 / MC/MC / Mito_carr
SLC25A3 / X / 2.A.29.4.2 / MC/MC / Mito_carr
SLC25A4 / X / 2.A.29.1.2 / MC/MC / Mito_carr
SLC25A5 / X / 2.A.29.1.1 / MC/MC / Mito_carr
SLC25A6 / X / 2.A.29.1.10 / MC/MC / Mito_carr
UCP1 / SLC25A7 / 2.A.29.3.2 / MC/MC / Mito_carr
UCP2 / SLC25A8 / 2.A.29.3.4 / MC/MC / Mito_carr
UCP3 / SLC25A9 / 2.A.29.3.5 / MC/MC / Mito_carr
SLC25A10 / X / 2.A.29.2.7 / MC/MC / Mito_carr
SLC25A11 / X / 2.A.29.2.13 / MC/MC / Mito_carr
SLC25A12 / X / 2.A.29.14.1 / MC/MC / Mito_carr
SLC25A13 / X / 2.A.29.14.2 / MC/MC / Mito_carr
SLC25A14 / X / 2.A.29.24.1 / MC/MC / Mito_carr
SLC25A15 / X / 2.A.29.19.2 / MC/MC / Mito_carr
SLC25A16 / X / 2.A.29.12.3 / MC/MC / Mito_carr
SLC25A17 / X / 2.A.29.20.1 / MC/MC / Mito_carr
SLC25A18 / X / 2.A.29.14.5 / MC/MC / Mito_carr
SLC25A19 / X / 2.A.29.16.1 / MC/MC / Mito_carr
SLC25A20 / X / 2.A.29.8.3 / MC/MC / Mito_carr
SLC25A21 / X / 2.A.29.2.4 / MC/MC / Mito_carr
SLC25A22 / X / 2.A.29.14.3 / MC/MC / Mito_carr
SLC25A23 / X / 2.A.29.23.5 / MC/MC / Mito_carr
SLC25A24 / X / 2.A.29.23.8 / MC/MC / Mito_carr
SLC25A25 / X / 2.A.29.23.1 / MC/MC / Mito_carr
SLC25A26 / X / 2.A.29.18.3 / MC/MC / Mito_carr
SLC25A27 / X / 2.A.29.24.3 / MC/MC / Mito_carr
SLC25A28 / X / 2.A.29.5.8 / MC/MC / Mito_carr
SLC25A29 / X / 2.A.29.8.9 / MC/MC / Mito_carr
SLC25A30 / X / 2.A.29.24.4 / MC/MC / Mito_carr
SLC25A31 / X / 2.A.29.1.8 / MC/MC / Mito_carr
SLC25A32 / X / 2.A.29.10.2 / MC/MC / Mito_carr
SLC25A33 / X / 2.A.29.10.7 / MC/MC / Mito_carr
SLC25A34 / X / 2.A.29.15.3 / MC/MC / Mito_carr
SLC25A35 / X / 2.A.29.15.2 / MC/MC / Mito_carr
SLC25A36 / X / 2.A.29.10.6 / MC/MC / Mito_carr
SLC25A37 / X / 2.A.29.5.7 / MC/MC / Mito_carr
SLC25A38 / X / 2.A.29.5.6 / MC/MC / Mito_carr
SLC25A39 / X / 2.A.29.14.8 / MC/MC / Mito_carr
SLC25A40 / X / 2.A.29.14.6 / MC/MC / Mito_carr
SLC25A41 / X / 2.A.29.23.6 / MC/MC / Mito_carr
SLC25A42 / X / 2.A.29.12.2 / MC/MC / Mito_carr
SLC25A43 / X / 2.A.29.23.7 / MC/MC / Mito_carr
SLC25A44 / X / 2.A.29.14.7 / MC/MC / Mito_carr
SLC25A45 / X / 2.A.29.8.7 / MC/MC / Mito_carr
SLC25A46 / X / 2.A.29.30.1 / MC/MC / Mito_carr
SLC25A47 / X / 2.A.29.8.10 / MC/MC / Mito_carr
SLC25A48 / X / 2.A.29.8.8 / MC/MC / Mito_carr
MTCH1 / SLC25A49 / 2.A.29.25.1 / MC/MC / Mito_carr
MTCH2 / SLC25A50 / 2.A.29.25.2 / MC/MC / Mito_carr
SLC25A51 / X / 2.A.29.2.14 / MC/MC / Mito_carr
SLC25A52 / X / 2.A.29.2.12 / MC/MC / Mito_carr
SLC25A53 / X / Mito_carr
SLC26A1_ENSP00000354721 / SLC26A1 / X / 2.A.53.2.16 / APC/SuLP / APC (CL0062) / Sulfate_transp
SLC26A2_ENSP00000286298 / SLC26A2 / X / 2.A.53.2.1 / APC/SuLP / APC (CL0062) / Sulfate_transp
SLC26A3_ENSP00000345873 / SLC26A3 / X / 2.A.53.2.18 / APC/SuLP / APC (CL0062) / Sulfate_transp
SLC26A4_ENSP00000265715 / SLC26A4 / X / 2.A.53.2.17 / APC/SuLP / APC (CL0062) / Sulfate_transp
SLC26A5_ENSP00000377328 / SLC26A5 / X / 2.A.53.2.19 / APC/SuLP / APC (CL0062) / Sulfate_transp
SLC26A6_ENSP00000378920 / SLC26A6 / X / 2.A.53.2.7 / APC/SuLP / APC (CL0062) / Sulfate_transp
SLC26A7_ENSP00000309504 / SLC26A7 / X / 2.A.53.2.6 / APC/SuLP / APC (CL0062) / Sulfate_transp
SLC26A8_ENSP00000417638 / SLC26A8 / X / 2.A.53.2.14 / APC/SuLP / APC (CL0062) / Sulfate_transp
SLC26A9_ENSP00000341682 / SLC26A9 / X / 2.A.53.2.15 / APC/SuLP / APC (CL0062) / Sulfate_transp
SLC26A10_ENSP00000320217 / SLC26A10 / X / 2.A.53.2.13 / APC/SuLP / APC (CL0062) / Sulfate_transp
SLC26A11_ENSP00000355384 / SLC26A11 / X / 2.A.53.1.10 / APC/SuLP / APC (CL0062) / Sulfate_transp
SLC27A1 / X / 4.C.1.1.9 / /FAT / ANL (CL0378) / AMP-binding
SLC27A2 / X / 4.C.1.1.5 / /FAT / ANL (CL0378) / AMP-binding
SLC27A3 / X / 4.C.1.1.12 / /FAT / ANL (CL0378) / AMP-binding
SLC27A4 / X / 4.C.1.1.10 / /FAT / ANL (CL0378) / AMP-binding
SLC27A5 / X / 4.C.1.1.13 / /FAT / ANL (CL0378) / AMP-binding
SLC27A6 / X / 4.C.1.1.11 / /FAT / ANL (CL0378) / AMP-binding
SLC28A1 / X / 2.A.41.2.3 / /CNT / Nucleos_tra2_C
SLC28A2 / X / 2.A.41.2.4 / /CNT / Nucleos_tra2_C
SLC28A3 / X / 2.A.41.2.8 / /CNT / Nucleos_tra2_C
SLC29A1_ENSP00000377424 / SLC29A1 / X / α[5] / 2.A.57.1.1 / MFS/ENT / MFS (CL0015) / Nucleoside_tran
SLC29A2_ENSP00000440329 / SLC29A2 / X / α[5] / 2.A.57.1.8 / MFS/ENT / MFS (CL0015) / Nucleoside_tran
SLC29A3_ENSP00000362285 / SLC29A3 / X / α[5] / 2.A.57.1.6 / MFS/ENT / MFS (CL0015) / Nucleoside_tran
SLC29A4_ENSP00000385845 / SLC29A4 / X / α[5] / 2.A.57.1.5 / MFS/ENT / MFS (CL0015) / Nucleoside_tran
SLC30A1 / X / 2.A.4.2.6 / CDF/CDF / Cation_efflux
SLC30A2 / X / 2.A.4.3.6 / CDF/CDF / Cation_efflux
SLC30A3 / X / 2.A.4.3.2 / CDF/CDF / Cation_efflux
SLC30A4 / X / 2.A.4.3.7 / CDF/CDF / Cation_efflux
SLC30A5 / X / 2.A.4.4.3 / CDF/CDF / Cation_efflux
SLC30A6 / X / 2.A.4.4.4 / CDF/CDF / Cation_efflux
SLC30A7 / X / 2.A.4.4.5 / CDF/CDF / Cation_efflux
SLC30A8 / X / 2.A.4.3.5 / CDF/CDF / Cation_efflux
SLC30A9 / X / 2.A.4.6.1 / CDF/CDF / Cation_efflux
SLC30A10 / X / X [6] / 2.A.4.2.5 / CDF/CDF / Cation_efflux
SLC31A1 / X / 1.A.56.1.2 / /TRAP-T / Ctr
SLC31A2 / X / 1.A.56.1.9 / /TRAP-T / Ctr
SLC32A1_ENSP00000217420 / SLC32A1 / X / β [4, 5] / 2.A.18.5.4 / APC/AAAP / APC (CL0062) / Aa_trans
SLC33A1_ENSP00000419165 / SLC33A1 / X / 2.A.1.25.1 / MFS/MFS/
Actan / MFS (CL0015) / Acatn
SLC34A1 / X / 2.A.58.1.5 / TOG/PNaS / Na_Pi_cotrans
SLC34A2 / X / 2.A.58.1.4 / TOG/PNaS / Na_Pi_cotrans
SLC34A3 / X / 2.A.58.1.3 / TOG/PNaS / Na_Pi_cotrans
SLC35A1 / X / 2.A.7.12.11 / DMT/DMT/CSA / DMT (CL0184) / Nuc_sug_transp
SLC35A2 / X / 2.A.7.12.6 / DMT/DMT/CSA / DMT (CL0184) / Nuc_sug_transp
SLC35A3 / X / 2.A.7.12.7 / DMT/DMT/CSA / DMT (CL0184) / Nuc_sug_transp
SLC35A4 / X / 2.A.7.12.12 / DMT/DMT/CSA / DMT (CL0184) / Nuc_sug_transp
SLC35A5 / X / 2.A.7.12.14 / DMT/DMT/CSA / DMT (CL0184) / Nuc_sug_transp
SLC35B1 / X / 2.A.7.11.1 / DMT/DMT/UGA / DMT (CL0184) / UAA
SLC35B2 / X / 2.A.7.11.3 / DMT/DMT/UGA / DMT (CL0184) / UAA
SLC35B3 / X / 2.A.7.11.5 / DMT/DMT/UGA / DMT (CL0184) / UAA
SLC35B4 / X / 2.A.7.10.2 / DMT/DMT/UAA / DMT (CL0184) / UAA
SLC35C1 / X / 2.A.7.16.1 / DMT/DMT/GFT / DMT (CL0184) / TPT
SLC35C2 / X / 2.A.7.9.16 / DMT/DMT/TPT / DMT (CL0184) / TPT
SLC35D1 / X / 2.A.7.15.4 / DMT/DMT/UGnT / DMT (CL0184) / TPT
SLC35D2 / X / 2.A.7.15.1 / DMT/DMT/UGnT / DMT (CL0184) / TPT
SLC35D3 / X / 2.A.7.15.5 / DMT/DMT/UGnT / DMT (CL0184)
SLC35E1 / X / 2.A.7.9.9 / DMT/DMT/TPT / DMT (CL0184) / TPT
SLC35E2 / X / DMT (CL0184) / TPT
SLC35E2B / 2.A.7.9.7 / DMT/DMT/TPT / DMT (CL0184) / TPT
SLC35E3 / X / 2.A.7.9.15 / DMT/DMT/TPT / DMT (CL0184) / TPT
SLC35E4 / X / 2.A.7.9.11 / DMT/DMT/TPT / DMT (CL0184) / TPT
SLC35F1 / X / 2.A.7.24.9 / DMT/DMT/TPPT / DMT (CL0184) / SLC35F
SLC35F2 / X / 2.A.7.24.10 / DMT/DMT/TPPT / DMT (CL0184) / SLC35F
SLC35F3 / X / 2.A.7.24.8 / DMT/DMT/TPPT / DMT (CL0184) / EamA
SLC35F4 / X / 2.A.7.24.14 / DMT/DMT/TPPT / DMT (CL0184)
SLC35F5 / X / 2.A.7.24.6 / DMT/DMT/TPPT / DMT (CL0184)
SLC35F6 / X / DMT (CL0184) / SLC35F
SLC35G1 / X / 2.A.7.28.8 / DMT/DMT/
SLC35G / DMT (CL0184) / EamA
SLC35G2 / X / 2.A.7.28.2 / DMT/DMT/
SLC35G / DMT (CL0184) / EamA
SLC35G3 / X / 2.A.7.28.7 / DMT/DMT/
SLC35G / DMT (CL0184) / EamA
SLC35G4 / X / 2.A.7.28.4 / DMT/DMT/
SLC35G / DMT (CL0184)
SLC35G5 / X / 2.A.7.28.5 / DMT/DMT/
SLC35G / DMT (CL0184)
SLC35G6 / X / 2.A.7.28.6 / DMT/DMT/
SLC35G / DMT (CL0184)
SLC36A1_ENSP00000428140 / SLC36A1 / X / β [4, 5] / 2.A.18.8.7 / APC/AAAP / APC (CL0062) / Aa_trans
SLC36A2_ENSP00000334223 / SLC36A2 / X / β [4, 5] / 2.A.18.8.6 / APC/AAAP / APC (CL0062) / Aa_trans
SLC36A3_ENSP00000366942 / SLC36A3 / X / β [4, 5] / 2.A.18.8.4 / APC/AAAP / APC (CL0062) / Aa_trans
SLC36A4_ENSP00000317382 / SLC36A4 / X / β [4, 5] / 2.A.18.8.5 / APC/AAAP / APC (CL0062) / Aa_trans
SLC37A1_ENSP00000344648 / SLC37A1 / X / α [4, 5] / 2.A.1.4.7 / MFS/MFS/OPA / MFS (CL0015) / MFS_1
SLC37A2_ENSP00000384407 / SLC37A2 / X / α [4, 5] / 2.A.1.4.8 / MFS/MFS/OPA / MFS (CL0015) / MFS_1
SLC37A3_ENSP00000417449 / SLC37A3 / X / α [4, 5] / 2.A.1.4.9 / MFS/MFS/OPA / MFS (CL0015) / MFS_1
SLC37A4_ENSP00000476176 / SLC37A4 / X / α [4, 5] / 2.A.1.4.5 / MFS/MFS/OPA / MFS (CL0015) / MFS_1
SLC38A1_ENSP00000449756 / SLC38A1 / X / β [4, 5] / 2.A.18.6.14 / APC/AAAP / APC (CL0062) / Aa_trans
SLC38A2_ENSP00000256689 / SLC38A2 / X / β [4, 5] / APC/AAAP / APC (CL0062) / Aa_trans
SLC38A3_ENSP00000479737 / SLC38A3 / X / β [4, 5] / 2.A.18.6.3 / APC/AAAP / APC (CL0062) / Aa_trans
SLC38A4_ENSP00000389843 / SLC38A4 / X / β [4, 5] / 2.A.18.6.17 / APC/AAAP / APC (CL0062) / Aa_trans
SLC38A5_ENSP00000366073 / SLC38A5 / X / β [4, 5] / 2.A.18.6.15 / APC/AAAP / APC (CL0062) / Aa_trans
SLC38A6_ENSP00000346959 / SLC38A6 / X / β [4, 5] / 2.A.18.6.11 / APC/AAAP / APC (CL0062) / Aa_trans
SLC38A7_ENSP00000454646 / SLC38A7 / X / β [4, 5] / 2.A.18.6.13 / APC/AAAP / APC (CL0062) / Aa_trans
SLC38A8_ENSP00000299709 / SLC38A8 / X / β [4, 5] / 2.A.18.6.12 / APC/AAAP / APC (CL0062) / Aa_trans
SLC38A9_ENSP00000380074 / SLC38A9 / X / β [4, 5] / 2.A.18.9.1 / APC/AAAP / APC (CL0062) / Aa_trans
SLC38A10_ENSP00000363891 / SLC38A10 / X / β [4, 5] / 2.A.18.6.16 / APC/AAAP / APC (CL0062) / Aa_trans
SLC38A11_ENSP00000387345 / SLC38A11 / X / β [4, 5] / 2.A.18.6.18 / APC/AAAP / APC (CL0062) / Aa_trans
SLC39A1 / X / 2.A.5.3.2 / /Zip / DMT (CL0184) / Zip
SLC39A2 / X / 2.A.5.3.1 / /Zip / DMT (CL0184) / Zip
SLC39A3 / X / 2.A.5.3.3 / /Zip / DMT (CL0184) / Zip
SLC39A4 / X / 2.A.5.4.1 / /Zip / DMT (CL0184) / Zip
SLC39A5 / X / 2.A.5.4.10 / /Zip / DMT (CL0184) / Zip
SLC39A6 / X / 2.A.5.4.13 / /Zip / DMT (CL0184) / Zip
SLC39A7 / X / 2.A.5.4.3 / /Zip / DMT (CL0184) / Zip
SLC39A8 / X / 2.A.5.4.15 / /Zip / DMT (CL0184) / Zip
SLC39A9 / X / 2.A.5.6.1 / /Zip / DMT (CL0184) / Zip
SLC39A10 / X / 2.A.5.4.6 / /Zip / DMT (CL0184) / Zip
SLC39A11 / X / 2.A.5.5.2 / /Zip / DMT (CL0184) / Zip
SLC39A12 / X / 2.A.5.4.14 / /Zip / DMT (CL0184) / Zip
SLC39A13 / X / 2.A.5.4.12 / /Zip / DMT (CL0184) / Zip
SLC39A14 / X / 2.A.5.4.5 / /Zip / DMT (CL0184) / Zip
SLC40A1_ENSP00000413549 / SLC40A1 / X / 2.A.100.1.4 / MFS/FpN / MFS (CL0015) / FPN1
SLC41A1 / X / 1.A.26.2.1 / TOG/MgtE / MgtE
SLC41A2 / X / 1.A.26.2.2 / TOG/MgtE / MgtE
SLC41A3 / X / 1.A.26.2.3 / TOG/MgtE / MgtE
RHAG / SLC42A1 / 1.A.11.4.3 / /Amt / Ammonium_transp
RHBG / SLC42A2 / 1.A.11.4.2 / /Amt / Ammonium_transp
RHCG / SLC42A3 / 1.A.11.4.1 / /Amt / Ammonium_transp
SLC43A1_ENSP00000435673 / SLC43A1 / X / α [5] / 2.A.1.44.1 / MFS/MFS/
LAT3 / MFS (CL0015) / MFS_1
SLC43A2_ENSP00000371582 / SLC43A2 / X / α [5] / 2.A.1.44.2 / MFS/MFS/
LAT3 / MFS (CL0015) / MFS_1
SLC43A3_ENSP00000434515 / SLC43A3 / X / α [5] / 2.A.1.44.3 / MFS/MFS/
LAT3 / MFS (CL0015) / MFS_1
SLC44A1 / X / 2.A.92.1.6 / /CLT / Choline_transpo
SLC44A2 / X / 2.A.92.1.4 / /CLT / Choline_transpo
SLC44A3 / X / 2.A.92.1.3 / /CLT / Choline_transpo
SLC44A4 / X / 2.A.92.1.7 / /CLT / Choline_transpo
SLC44A5 / X / 2.A.92.1.5 / /CLT / Choline_transpo
SLC45A1_ENSP00000289877 / SLC45A1 / X / α [5] / 2.A.2.4.10 / MFS/GPH / MFS (CL0015) / MFS_1
SLC45A2_ENSP00000296589 / SLC45A2 / X / α [5] / 2.A.2.4.9 / MFS/GPH / MFS (CL0015) / MFS_2
SLC45A3_ENSP00000356113 / SLC45A3 / X / α [5] / 2.A.2.4.8 / MFS/GPH / MFS (CL0015) / MFS_1
SLC45A4_ENSP00000429059 / SLC45A4 / X / α [5] / 2.A.2.4.7 / MFS/GPH / MFS (CL0015) / MFS_2
SLC46A1_ENSP00000480703 / SLC46A1 / X / α [4, 5] / 2.A.1.50.1 / MFS/MFS/
PCFT / MFS (CL0015) / MFS_1
SLC46A2_ENSP00000474847 / SLC46A2 / X / α [4, 5] / 2.A.1.50.2 / MFS/MFS/
PCFT / MFS (CL0015) / MFS_1
SLC46A3_ENSP00000370192 / SLC46A3 / X / α [4, 5] / 2.A.1.50.3 / MFS/MFS/
PCFT / MFS (CL0015) / MFS_1
SLC47A1 / X / 2.A.66.1.14 / MOP/MOP/
MATE / MviN, MATE (CL0222) / MatE
SLC47A2 / X / 2.A.66.1.20 / MOP/MOP/
MATE / MviN, MATE (CL0222) / MatE
SLC48A1 / X / 2.A.110.1.1 / HRG/HRG / HRG
MFSD7_ENSP00000424556 / MFSD7 / SLC49A1 / 2.A.1.28.2 / MFS/MFS/
FLVCR / MFS (CL0015) / MFS_1
FLVC1_ENSP00000414680 / FLVCR1 / SLC49A2 / 2.A.1.28.1 / MFS/MFS/
FLVCR / MFS (CL0015) / MFS_1
FLVC2_ENSP00000452453 / FLVCR2 / SLC49A3 / MFS/MFS/
FLVCR / MFS (CL0015) / MFS_1
DIRC2 / SLC49A4 / 2.A.1.28.6 / MFS/MFS/
FLVCR
SLC50A1 / X / 2.A.123.1.4 / TOG/
MtN3_slv / MtN3-like, vesicle-trafficking cargo-receptor (CL0141) / MtN3_slv
SLC51A / X / 2.A.82.1.2 / TOG/OST / Solute_Trans_a/OSTAlpha
SLC51B / X / 2.A.82.1.2 / TOG/OST / Solute_Trans (OSTBeta)
SLC52A1 / X / 2.A.125.1.1 / /E-RFT / DUF1011
SLC52A2 / X / 2.A.125.1.3 / /E-RFT / DUF1011
SLC52A3 / X / 2.A.125.1.2 / /E-RFT / DUF1011
OCA2_ENST00000354638 / OCA2 / 2.A.45.2.1 / IT/ArsB / IT (CL0182) / CitMHS
CLN3_ENSP00000454229 / CLN3 / 2.A.57.5.1 / MFS/ENT / CLN3 protein
TMEM104_ENSP00000461922 / TMEM104 / APC (CL0062) / aa_trans
SPNS1_ENSP00000455429 / SPNS1 / 2.A.1.49.2 / MFS/MFS/
Spinster / MFS (CL0015) / MFS_1
SPNS2_ENSP00000333292 / SPNS2 / 2.A.1.49.6 / MFS/MFS/
Spinster / MFS (CL0015) / MFS_1
SPNS3_ENSP00000347721 / SPNS3 / MFS (CL0015) / MFS_1
SV2A_ENSP00000358142 / SV2A / α [4] / MFS (CL0015) / Sugar and other transprters / MFS_1
SV2B_ENSP00000332818 / SV2B / α [4] / MFS (CL0015) / Sugar and other transprters / MFS_1
SV2C_ENSP00000316983 / SV2C / α [4] / MFS (CL0015) / Sugar and other transprters / MFS_1
SVOP_ENSP00000479104 / SVOP / α [4] / 2.A.1.82.3 / MFS/MFS/
Pl-Cu-UP / MFS (CL0015) / MFS_1
SVOPL_ENSP00000417018 / SVOPL / α [4] / MFS (CL0015) / MFS_1
MFSD1_ENSP00000376560 / MFSD1 / X [6] / MFS (CL0015) / MFS_1
MFSD2A_ENSP00000391261 / MFSD2A / 2.A.2.3.8 / MFS/GPH / MFS (CL0015) / MFS_2
MFSD2B_ENSP00000342501 / MFSD2B / MFS (CL0015) / MFS_1
MFSD3_ENSP00000301327 / MFSD3 / 2.A.1.25.4 / MFS/MFS/
PAT / MFS (CL0015) / MFS_1
MFSD4_ENSP00000445329 / MFSD4A / MFS (CL0015) / MFS_1
MFSD4B_ENSP00000357840 / MFSD4B / MFS (CL0015) / MFS_1
MFSD5_ENSP00000442688 / MFSD5 / X [6, 7] / MFS (CL0015) / MFS_5
MFSD6_ENSP00000400131 / MFSD6 / X [6] / 2.A.1.65.6 / MFS/MFS/
UMF14 / MFS (CL0015) / MFS_1_like
MFS6L_ENSP00000330051 / MFSD6L / 2.A.1.65.10 / MFS/MFS/
UMF14 / MFS (CL0015) / MFS_1
MFSD8_ENSP00000296468 / MFSD8 / 2.A.1.2.56 / MFS/MFS/
DHA1 / MFS (CL0015) / MFS_1
MFSD9_ENSP00000413641 / MFSD9 / α [4] / X [6] / 2.A.1.2.72 / MFS/MFS/
DHA1 / MFS (CL0015) / MFS_1
MFSD10_ENSP00000423402 / MFSD10 / α [4] / X [6] / 2.A.1.2.73 / MFS/MFS/
DHA1 / MFS (CL0015) / MFS_1
MFSD11_ENSP00000348225 / MFSD11 / X [7] / 2.A.1.58.3 / MFS/MFS/
NAG-T / MFS (CL0015) / Unc-93
MFSD12_ENSP00000465302 / MFSD12 / MFS (CL0015) / MFS_2
MFSD13A_ENSP00000238936 / MFSD13A / MFS (CL0015) / MFS_2
MFSD14A_ENSP00000411185 / MFSD14A / X [6] / MFS (CL0015) / MFS_1
MFSD14B_ENSP00000405909 / MFSD14B / X [6] / 2.A.1.2.30 / FS/MFS/
DHA1 / MFS (CL0015) / MFS_1
UNC93A_ENSP00000355794 / Unc93a / 2.A.1.58.2 / MFS/MFS/
NAG-T / MFS (CL0015) / Unc-93
UNC93B1_ENST00000227471 / Unc93b1 / 2.A.1.58.7 / MFS/MFS/
NAG-T / MFS (CL0015) / Unc-93

Supplemental references

S1 Cunningham, F., et al. (2015) Ensembl 2015. Nucleic acids research 43, D662-669

S2 Gray, K.A., et al. (2016) A review of the new HGNC gene family resource. Human genomics 10, 6

S3 SLC tables (2016) SLC Tables.

S4 Fredriksson, R., et al.(2008) The solute carrier (SLC) complement of the human genome: phylogenetic classification reveals four major families. FEBS letters 582, 3811-3816

S5 Hoglund, P.J., et al. (2011) The solute carrier families have a remarkably long evolutionary history with the majority of the human families present before divergence of Bilaterian species. Molecular biology and evolution 28, 1531-1541

S6 Sreedharan, S., et al. (2011) Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters. Gene 478, 11-18

S7 Perland, E., et al. (2016) The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis. PloS one 11, e0156912

S8 Saier, M.H., Jr., et al. (2014) The transporter classification database. Nucleic acids research 42, D251-258

S9 Finn, R.D., et al. (2016) The Pfam protein families database: towards a more sustainable future. 44, D279-285

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