Table S1 Primers used for quantitative RT-PCR

Genes / Sequences of primers / Production (bp) / Genbank
Agrn / F:GTGGCGGTACTTGAAAGGC / 107 / NM_021604.3
R:GGTTGTCGCAGATGAGGG
Ing2 / F:ATGACAAACGGGATTGACGA / 257 / NM_023503.3
R:CCCTTGGGTTTATAGGTGAGTG
Wisp1 / F:CAGCACCACTAGAGGAAACGA / 137 / NM_018865.2
R:CTGGGCACATATCTTACAGCAT
Hvcn1 / F:AGGAGCCGACTGAGGAAACT / 185 / NM_001042489.2
R:AAGAAGACCAGGATGGCAAAG
Aldh3a2 / F：GATTAAGGAAACGGTGAAGGAC / 180 / NM_007437.5
R：TCTGTAAGTATGGTTGGGGCTA
Irf8 / F:ATTACAATCAGGAGGTGGATGC / 127 / NM_001301811.1
R:CTCTTGTTCAGAGCACAGCGT
Aicda / F:CTTCTGTGAAGACCGCAAGG / 213 / NM_009645.2
R:TCGTACAAGGGCAAAAGGAT
Cd74 / F：TTACCAAGTACGGCAACAT / 217 / NM_001042605.1
R：GTGGGCTTCTTCTCCTCC
Bank / F:AGGGAAAGCTCCGAGAAC / 129 / NM_001033350.2
R:AGCAGTGCCTGGTCGTGGT
EGFr / F:ACCACACTGCTGGTGTTGCT / 172 / NM_007912.4
R:CCAAGTTCCCAAGGACCACT
Esr1 / F:CCTGAGACATGGACCCCTTT / 241 / NM_001302532.1
R:CGATGAAACGGGGTCACATC
Erbb2 / F: AAGAGGTCACAGCTGAGGAC / 171 / NM_001003817.1
R: AAAATGCCAGGCTCCCAAAG
Pgr / F:GAGCCATAGAGACTGTCGCT / 244 / NM_001302532.1
R: AGCTGGTCTGGTCTGAGAAC
Fos / F:GTTTCAACGCCGACTACGAG / 182 / NM_010234.2
R:TGTCACCGTGGGGATAAAGT
Rassf5 / F:ACCCCAACCTTGAACCAGA / 148 / NM_018750.3
R:TGTAGGTGCCATCTTCACTCAG
Cat / F:CAGCGACCAGATGAAGCAGT / 236 / NM_009804.2
R:CCTCAAAGTATCCAAAAGCACC
Gpx1 / F:GGAGAATGGCAAGAATGAAGAG / 135 / NM_008160.6
R:AGGAAGGTAAAGAGCGGGTG
Sod1 / F:GGGTTCCACGTCCATCAGTA / 128 / NM_011434.1
R:TTGCCCAGGTCTCCAACAT

Table S2the expressive pattern of genes within mouse breast exposure to DEHP in vivo

Gene symbol / Gene description / Fold change / p-value
Up-regulated
Trpm1 / transient receptor potential cation channel, subfamily M, member 1 / 9.854605 / 2.46175E-13
Nox1 / NADPH oxidase 1 / 6.563498 / 0.000105431
Pax3 / paired box gene 3 / 6.482013 / 0.174398959
1100001G20Rik / RIKEN cDNA1100001G20 gene / 6.042812 / 6.85456E-16
Bst2 / bone marrow stromal cell antigen 2 / 5.00981 / 2.41532E-22
Mmp16 / matrix metallopeptidase 16 / 4.592657 / 1.5662E-09
Csn1s2a / casein alpha s2-like A / 4.570852 / 5.63037E-10
Retsat / retinol saturase (all trans retinol 13,14 reductase) / 4.228556 / 1.05655E-17
I830012O16Rik / RIKEN cDNAI830012O16 gene / 4.16288 / 1.00476E-14
Krt15 / keratin 15 / 4.061802 / 1.10774E-13
Egfem1 / EGF-like and EMI domain containing 1 / 3.866837 / 2.71481E-10
Ctnna2 / catenin (cadherin associated protein), alpha 2 / 3.861502 / 2.80539E-06
Rsad2 / radical S-adenosyl methionine domain containing 2 / 3.8539 / 3.45273E-18
Gm14391 / predicted gene 14391 / 3.668827 / 1.67608E-05
Down-regulated
Bbc3 / BCL2 binding component 3 / -38.8692 / 0.011646274
Glycam1 / glycosylation dependent cell adhesion molecule 1 / -19.9301 / 4.52977E-25
Aldh3a2 / aldehyde dehydrogenase family 3, subfamily A2 / -15.4624 / 4.05563E-22
Hbq1b / hemoglobin, theta 1B / -11.6008 / 3.75922E-21
Igj / immunoglobulin joining chain / -11.3007 / 1.43131E-18
Cd19 / CD19 antigen / -11.2561 / 6.23088E-14
Htatsf1 / HIV TAT specific factor 1 / -10.6506 / 2.74801E-11
Spib / Spi-B transcription factor (Spi-1/PU.1 related) / -9.92829 / 1.12143E-11
Igj / immunoglobulin joining chain / -9.622 / 4.95114E-18
Vpreb3 / pre-B lymphocyte gene 3 / -9.32942 / 1.08915E-14
Blk / B lymphoid kinase / -9.12461 / 9.29472E-13
Fcer2a / Fc receptor, IgE, low affinity II, alpha polypeptide / -9.01991 / 8.91118E-14
Faim3 / Fas apoptotic inhibitory molecule 3 / -8.77626 / 2.85018E-16
Hrk / harakiri, BCL2 interacting protein (contains only BH3 domain) / -8.14162 / 0.073729552
Ms4a1 / membrane-spanning 4-domains, subfamily A, member 1 / -7.63498 / 1.33099E-23

The most differentially expressed genes

1