Demographic and Neurpsychiatric Characteristics of AD Alone and AD + LB Patients

Table (E) 1

Demographic and neurpsychiatric characteristics of AD alone and AD + LB patients

AD alone (%) / AD + LB (%) / χ2/t-test
Number of cases: / 125 / 142
Age: / 73.4 + 9.3 / 71.7 + 7.3
Male/female: / 42/72 / 5/6 / 2.49
Education Level, in years: / 12.6 + 3.0 / 12.2 + 3.1 / .76
Time from onset of symptoms to initial visit, in years: / 3.7 + 2.1 / 4.0 + 2.3 / -1.16
Time from initial visit to death, in years: / 5.5 + 3.2 / 6.1 + 3.4 / -1.61
Time from the last formal psychiatric evaluation to death, in years / 2.5 + 1.9 / 2.6 + 1.9 / -1.81
Mini-MentalState Examination:
Baseline:
At last Psychiatric evaluation: / 18.4 + 5.4
10.9 + 7.3 / 17.3 + 4.7
9.3 + 6.4 / 1.62
1.60
Mattis Dementia Rating Scale* / 106.9 + 20.3 / 106.5 + 19.0 / .13
Blessed Dementia Rating Scale for Activities of daily living* / 6.0 + 3.8 / 6.7 + 4.0 / -1.25
Hamilton Depression Scale* / 6.5 + 3.9 / 6.8 + 4.7 / -.68
Hachinski Rating Scale* / 2.9 + 2.2 / 2.5 + 2.1 / 1.57
NYU scale for parkinsonism* / 11.8 + 12.7 / 12.0 + 13.7 / .14

* Baseline measures

Table (E) 2

Baseline clinical characteristics and psychiatric medication use,

and other relevant neuropathological findings

AD alone (%) / AD + LB (%) / χ2/t-test
Extrapyramidal signs / 82 (66) / 97 (68) / .22
Delusions / 46 (37) / 59 (41.5) / .62
Visual hallucinations / 19 (15) / 26 (18) / .45

Medication use

Antidepressant use / 28 (23) / 28 (20) / .32
Antipsychotic use / 14 (11) / 21 (15) / .70
Sedative/hypnotic use / 14 (11) / 13 (9) / .33
Cholinesterase inhibitors use: / 7 (6) / 8 (6) / .00

Systemic disorders

Hypertension / 49 (39) / 44 (31) / 1.97
Diabetes mellitus / 6 (5) / 6 (4) / .05
Heart disease / 43 (34) / 43 (30) / .51
Other relevant neuropathological findings
Ischemic lesions / 54 (49) / 40 (29) / 6.28*
Cerebral hemorrhages / 4 (3) / 4 (3) / .03
Cerebral metastasis / 3 (2) / 6 (4) / .68

*AD alone different from AD + LB (p= .01)