Sung-Joon Lee, PhD
Professor,
Department of Biotechnology
Graduate School of Life Sciences and Biotechnology
Department of Food Bioscience and Technology
College of Life Sciences and Biotechnology
Korea University
5-Ga, Anam-dong, Seoungbuk-gu,
Bldg-EAST, Rm 410, College of Life Sciences & Biotechnology, Seoul 136-713, Korea
Tel: 02-3290-3029, Fax: 02-925-1970, email:
Homepage: http://nutritionalgenomics.co.kr
EDUCATION
Feb, 1991 Seoul National Univ. Food Science & Biotechnology, B.A.
Feb, 1993 Seoul National Univ. Food Science & Biotechnology,
Major in Enzyme Technology, M.A.
June, 2001 Harvard School of Public Health,
PhD Programs in Biological Sciences and Public Health, Department of Nutrition.
Nutritional Biochemistry Ph.D. Advisor: Dr. Frank M. Sacks
PROFESSIONAL EXPERIENCESTime / Institute / Position
2013.3-present / Korea University / Professor
2008.03-2013.02 / Korea University / Associate Professor
2004.03-2008.02 / Korea University / Assistant Professor
2014.02-2014.12 / Institute of Life Science & Natural Resources / Vice Director
2012.01-2013.12 / Korea University, Division of Food Bioscience and Biotechnology / Division Chair
2008.03-2008.08 / UC Berkeley, Department of Nutrition and Toxicology / Visiting Professor
2001.07-2004.02 / Stanford School of Medicine, Department of Medicine / Postdoctoral Scientist
2013.01- / Molecular Nutrition & Food Research / Board Member (SCI)
2004.01-2005.12
2008.01-2009.12
2011.01-Present / Korea Society of Food Science and Technology / Editor, Food Science and Biotechnology (SCIE)
2011.11-Present / The Korean Society for Applied Biological Chemistry / Editor, Journal of the Korean Society for Applied Biological Chemistry (SCIE)
2006.01-2007.12 / Korean Society of Food and Nutrition / Editor, Korean Journal of Food and Nutrition
2007.01-2008.12 / Korean Nutrition Society / Editor, The Korean Journal of Nutrition
2008.01-2008.12 / Korean Nutrition Society / Standing Committee Member
2013.01-2013.12 / Korean Society of Food Science and Technology / Secretary of Scientific Affairs
2011.01-2011.12 / Korean Society of Food Science and Technology / Treasurer
2006.07-2009.4 / Korean Medical Association / National Health Committee, Expert Advisor in Food Safety and Functional Food
2008.01-2009.12
2011.01-2011.12 / Korea Society of Food Science and Technology / Journal Committee Member, Journal of Food Science and Nutrition
2009.01-Present / Korean Nutrition Society / Conference Committee Member
2009.01-Present / Korea Society of Food Science and Technology / Secretary, Division of Functional Food
2008.05-2010.05 / Korea FDA / Expert Advisor Division of Nutrition and Functional Food
2011.11-Present / Korea FDA / Expert Advisor Division of New Biomaterials and Food
Research
Research Keywords: Cholesterol and Lipid Metabolism, Nuclear Receptors, Functional Foods, Nutraceuticals, Nutritional genomicsPublications (* correspondence)
2015
123. Hexacosanol reduces plasma and hepatic cholesterol by activation of AMPK and inhibition of SREBP2.In submission
122.Hyun-seok Oh, Tae Hyung Kim, Se Kwan Oh, Jum Seek Oh,Ji Hae Lee,Sung-Joon Lee*. Brown rice (Oriza sativa L. cv. Hiami) extract promotes cellular growth by upregulation gy GH and IGF-1 expression.Food Science & Biotechnology(Accepted)
121. Betaine reduces melanogenesis by inhibition of cyclic adenosine monophosphate dependent signaling pathways in B16F1 melanocytes.Phytotherapy Research(Revision, 20150810)
120.Se-Young Kim,Yeon-Ji Kim, Young Jae An, Hae-Jeung Lee, Sung-Hyen Lee, Jung-Bong Kim, Haeng-Ran Kim, andSung-Joon Lee*.Black rice (Oryza sativa, Heukmi) extracts stimulate osteogenesis but inhibitadipogenesis in mesenchymal C3H10T1/2 cells.Journal of Food Biochemistry(Accepted, 20150915)
119. Daniel Klionesky et al. Guidelines for the use and interpretation of assays for monitoring autophagy.Autophagy(In press)
118. No-Joon Song, Ui Jeong Yun, SungHee Yang,Chunyan Wu, Cho-Rang Seo, A-Ryeong Gwon, Sang-Ha Baik, Yuri Choi, Bo Youn Choi, Gahee Bahn, Suji Kim, So-Mi Kwon, Jin Su Park, Seung Hyun Baek, Tae Joo Park, Keejung Yoon, Byung-Joon Kim,Sung-Joon Lee, Dong-Gyu Jo, and Kye Won Park*.Notch1 deficiency decreases hepatic lipid accumulation by induction of fatty acid oxidation.Scientific Report(In press)
117.Yaoyao Jia, Chunyan Wu, Jiyoung Kim, Bobae Kim, Ji Hae Lee, Sung-Joon Lee*.Astaxanthin reduces hepatic lipid accumulations in high-fat-fed C57BL/6J mice via activation of peroxisome proliferator-activated receptor (PPAR) alpha and inhibition of gamma and AKT.Journal of Nutritional Biochemistry(2015) 28:9-18.
116. Woo-Duck Seo,Ji Hae Lee, Yaoyao Jia, Chunyan Wu, Sung-Joon Lee*.Saponarinactivates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5.Bioorganic & Medicinal Chemistry Letters(2015) 25(22):5237-42.
115.Ji Hae Lee, So Young Lee, Bonae Kim,Woo Duck Seo,Yaoyao Jia, Chunyan Wu, Hee-jin Jun, Sung-Joon Lee*. Barley sprout extract containing policosanols and polyphenols regulate AMPK, SREBP2 and ACAT2 activity and cholesterol and glucose metabolismin vitroandin vivo.Food Research International(2015) 72:174-183.
114.Minh-Hien Hoang, Yaoyao Jia, Boram Mok, Hee-jin Jun, Kwang-Yeon Hwang,Sung-Joon Lee*.Kaempferol ameliorates symptoms of metabolic syndrome by regulating activities of liver X receptor-β.Journal of Nutritional Biochemistry(2015) 26(8):868-875.
113.Chunyan Wu, Yaoyao Jia, Ji Hae Lee, Yeonji Kim, Sivakumar Sekharan, Victor S. Batista,Sung-Joon Lee*.Activation ofOR1A1suppresses PPAR-gamma expression by inducing HES-1 in cultured hepatocytes.International Journal of Biochemistry & Cell Biology(2015) 64:75-80.IF=4.046, 5Y IF=4.371
112.Xiang Hua Hana, Chul Lee, Jin Woo Lee, Qinghao Jin, Hari Jang, Hak Ju Lee, Dongho Lee,Sung-Joon Lee, Jin Tae Hong, Mi Kyeong Lee, and Bang Yeon Hwang*. Two new iridoids from the stem ofCatalpa ovata.Helvetica Chimica Acta(2015) 98:381-385.
111.Dae-Bang Seo, Hyun Woo Jeong, Donghyun Cho , Bum Jin Lee ,Ji-Hae Lee, Jae Young Choi , Il Hong Bae , andSung-Joon Lee*.Fermented green tea extract alleviated obesity and related complications and alters gut microbiota composition in diet-induced obese Mice.Journal of Medicinal Food(2015) 18(5):1-8.
110. Dong Hyun Jo#, Jeong Hun Kim#,Hee-Jin Jun, Jin Hyoung Kim, Quingcheng Wen, Ji Hae Lee, Minh Hien Hoang, Young Suk Yu,Sung-Joon Lee*.Gene expression analysis of primary retinal pigment epithelial cells from apolipoprotein E knockout and human apolipoprotein E2 transgenic mice.Genetics & Molecular Research(2015) 14(1):1855-67.
109.Sung-Joon Lee* and Yaoyao Jia.The effect of bioactive compounds in tea on lipid metabolism and obesity through regulation of peroxisome proliferator-activated receptors.Current Opinion in Lipidology(2015) 26(1):3-9. IF 5.656, 5Y IF=5.659
108. Seungbo Ryu, Hyun Ju You,Ye Won Kim, Ariel Lee, Gwang Pyo Ko,Sung-Joon Lee*,Moon Jung Song*,Inactivation of norovirus and surrogates by natural phytochemicals and bioactive substances.Molecular Nutrition & Food Research(2015)59(1):65–74.IF=4.603; 5Y IF=4.770
107.Minh-Hen Hoang, Ji-Young Kim,Ji Hae Lee,Sang Guan You*,Sung-Joon Lee*.Antioxidative, hypolipidemic and anti-inflammatory activities of sulfated polysaccharides frommonostroma nitidum.Food Science & Biotechnology(2015) 24(1):199-205.
106.Yaoyao Jia, Seyoung Kim, Jiyoung Kim, Bobae Kim, Chunyan Wu, Ji Hae Lee, Hee-jin Jun, Nahyun Kim, Dongho Lee,Sung-Joon Lee*.Ursolic acid improves lipid and glucose metabolism in high-fat-fed C57BL/6J mice by activating peroxisome proliferator-activated receptor alpha and hepatic autophagy.Molecular Nutrition & Food Research(2015) 59(2):344-354. IF=4.603; 5Y IF=4.770
105.Yaoyao Jia#, Jongho Kim#, Bora Nam, Jiyoung Kim, Ji Hae Lee, Kwang Yeon Hwang,Sung-Joon Lee*.The dipeptide H-Trp-Arg-OH (WR) is a PPARα agonist and reduceshepatic lipid accumulation in lipid-loaded H4IIE cells.Applied Biochemistry & Biotechnology(2015) 5(2):1211-1220.
2014
104.Ji Hae Lee, Yeojin Kim, Minh Hien Hoang, Hee-jin Jun, Sung-Joon Lee*. Rapid quantification of cellular flavonoid levels using the fluorescent probe
diphenylboric acid 2-amino ethyl ester.Food Science & Biotechnology(2014) 23(1): 75-79.
103.Ji Hae Lee, Jung Eun Lee,Yeojin Kim,Hou Joung Lee, andSung-Joon Lee*.Multidrug and toxic compound extrusion protein-1 (MATE01/SLC47A1) is a novel flavonoid transporter.Journal of Agricultural & Food Chemistry(2014)62(40):9690-9698.
102.Jong-Ho Kim, Yaoyao Jia, Jung-Gyu Lee, Bora Nam, Ji Hae Lee,Kwang-Soon Shin, Yong Ho Kim, Hyung Suk, Heo,Sung-Joon Lee*. Hypolipidemic and anti-inflammaion activities of fermented soybean fibers frommejuin C57BL/6J mice.PhytotherapyResearch(2014)28(9):1335-1341.
101. Mini Jeong, Jaewook Cho, Jong-Il Shin, Yong-Joon Jeon,Sung-Joon Lee,Eun-Soo Kim, Kyoungho Lee*.Hempseed oil induces reactive oxygen species- and C/EBP homologous protein-mediated apoptosis in MH7A human rheumatoid arthritis fibroblast-like synovial cells.Journal of Ethnopharmacology(2014) 154(3):745-752.
100.Hee-jin Jun, Jinyoung Kim, Yaoyao Jia,Kyoung Heon Kim, Eun Ju Yun, Kwang Yeon Hwang, andSung-Joon Lee*. Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome.Journal of Lipid Research(2014)55(6):1098-1110.
99.Chunyan Wu#, Minh Hien Hoang, Yaoyao Jia, Ji Hae Lee, Sung-Joon Lee*.Trans-caryophyllene is a natural agonistic ligand for peroxisome proliferator-activated receptor-α.Bioorganic & Medicinal Chemistry Letters(2014) 24(14):3168-3174.
98.Dae-Bang Seo#, Hyun Woo Jeong#, Sang-Jun Leeb*, andSung-Joon Lee*. Coumestrol induces mitochondrial biogenesis by activating Sirt1 in cultured skeletal muscle cells.Journal ofAgricultural & Food Chemistry(2014) 62(19):4298-4305.
97.Yaoyao Jia, Jong-Ho Kim, Bora Nam, Jiyoung Kim, Ji Hae Lee, Kwang-Yeon Hwang,Sung-Joon Lee*.The Dipeptide H-Trp-Glu-OH (WE) shows agonistic activity to peroxisome proliferator-activated protein-alpha and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells.Bioorganic & Medicinal Chemistry Letters24:2957-2962.
2013
96. Hwan-Ung Yong, Tae-Soo Lee, Jae-Sik Kim, Hyung-Hee Baek, Bong-Soo Noh,Sung-Jun Lee, Jong-Tae Park,Jae-Hoon Shim, Dan Li, In-Hee Hong, Dang Hai Dang Nguyen, Phuong Lan Tran, Thi Lan Huong Nguyen,Ershita Fitria Oktavina, Jung-Wan Kim, Hee-Kwon Kang, and Kwan-Hwa Park. Flavor characteristics of rice-grape wine with starch-hydrolyzing enzymes.Food Science & Biotechnology22(4):937-943
95. Dong-Hyun Lee, Sung-Sik Choi,Bo-Bae Kim, Se-Young Kim,Bo-Sik Kang,Sung-Joon Lee,Hyun-Jin Park∗.Effect of alcohol-free red wine concentrates on cholesterolhomeostasis: An in vitro and in vivo study.Process Biochemistry48:1964-1971.
94. Chul Lee, Jin Woo Lee, Qinghao Jin, Hak Ju Lee,Sung-Joon Lee, Dongho Lee, Myung Koo Lee, Chong Kil Lee, Jin Tae Hong, Mi Kyeong Lee, and Bang Yeon Hwang*. Anti-inflammatory Constituents from the Fruits of Vitex rotundifolia.Bioorg Med Chem Lett2013 23(21):6010-4.
93.Yaoyao Jia, Minh Hien Hoang, Hee-jin Jun, Ji Hae Lee, Sung-Joon Lee* .Cyanidin, a natural flavonoid, is a moderate agonist for liver X receptor alpha and beta and reduces cellular lipid accumulation in macrophages and hepatocytes.Bioorg Med Chem Lett2013 23(14):4185-90
92. A-Young Lee#,Siok-Koon Yeo#, Ji Hae Lee, Haewon Kim, Yaoyao Jia, Minh Hien Hoang, Hyun Chung, Young-Suk Kim*,Sung-Joon Lee*
Hypolipidemic effect of Goami-3 rice (Oryza sativa L. cv. Goami-3) on C57BL/6 mice is mediated by the regulation of peroxisome proliferator-activated receptor-alpha and -gamma.J Nutr Biochem2013 Nov;24(11):1991-2000
91.Hea-Won Lee#, A-Young Lee#,Siok Koon Yeo, Hyun Chung,Ji Hae Lee, Minh-Hien Hoang, Yaoyao Jia, Sea-Kwan Oh,Sung-Joon Lee*, Young-Suk Kim*. Metabolic profiling and biological mechanisms of body fat reduction in mice fed the ethanolic extracts of black-colored rice.Food Research International(#, authors contribute equally to the paper). 2013 53:373-390.
90. Chul Lee, Jin Woo Lee, Qinghao Jin, Dae Sik Jang,Sung-Joon Lee, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, and Bang Yeon Hwang*. Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages.Bioorg Med Chem Lett2013 (23): 4263-4266.
89. Kyeong Lee, Soo Hyun Cho, Jee Hyun Lee, Jail Goo, Sung Yoon Lee, Shanthaveerappa K. Boovanahalli,Siok Koon Yeo, Sung-Joon Lee, Young Kook Kim, Dong Hee Kim, Yongseok Choi*, Gyu-Yong Song*. Synthesis of a novel series of 2-alkylthio substituted naphthoquinones as potent acyl-CoA: Cholesterol acyltransferase (ACAT) inhibitors.Eur J Med Chem2013 62:515-525.
88. Woo Duck Seo, Heung Joo Yuk, Marcus J. Curtis-Long, Ki Chang Jang, Jin Hwan Lee, Sang-Ik Han,Hang Won Kang, Min Hee Nam,Sung-Joon Lee,Ji Hae Lee, and Ki Hun Park*. Effect of the growth stage and cultivar on policosanol profiles of barley sprouts and their adenosine 5′-monophosphate-activated protein kinase activation.J Agric Food Chem2013 61(5):1117-23..
87.Mastura Abd Malek , Minh-Hien Hoang , Yaoyao Jia, Ji Hae Lee, Hee-jin Jun,Dong-Ho Lee, Hal Ju Lee, Chul Lee, Myung Koo Lee, Bang Yeon Hwang*,Sung-Joon Lee*. Ombuine-3-O-beta-D-glcopyranoside from Gynostemma pentaphyllum is a dual ligand of peroxisome proliferator-activated receptor alpha and beta/delta.Biochem Biophys Res Copmmun2013 25;430(4):1322.
86.Yaoyao Jia, Jin-Young Kim, Hee-jin Jun,Sun-Joong Kim,Ji Hae Lee, Minh Hien Hoang,Hyo Ihl Chang, Kwang-Yeon Hwang, Soo-Jong Um,Sung-Joon Lee*. Cyanidin is an agonistic ligan for PPAR-alpha and reduces hepatic lipid accumulation by rewiring transcriptome profiling.BBA-Molecular & Cellular Biology of Lipids2013 1831(4):698-708..
85.Hee-jin Jun#, Minh Hien Hoang#, Siok Koon Yeo, Yaoyao Jia, Sung-Joon Lee*. Induction of ABCA1 and ABCG1 expression by the liver X receptormodulator cineole in RAW264.7 macrophage.Bioorg Med Chem Lett. 2013 15;23(2):579-83 (#, authors contribute equally to the paper).
2012
84.Hee Joon Cho, Soung-Jin Houng, Hee-jin Jun,Jae-Hoon Shim, Kwan-Hwa Park,Sung-Joon Lee*. Acute effect of high-dose isoflavones from Pueraria lobata (Willd.) Ohwi on lipid and bone metabolism in ovariectomized mice.Phytotherapy Res2012 26(12):1864-71
83. Mehdi Tabarsa,Sung-Joon Lee*, Sangguan You*. Structural analysis of immunostimulating sulfated polysaccharides from Ulva pertusa.Carbohydr Res2012 14:361C:141-147.
82.Minh-Hien Hoang, Yaoyao Jia, Ji Hae Lee, Hee-jin Jun,Soo-Jong Um, Boo-Yong Lee, Sang-Guan You,Sung-Joon Lee*. Fucosterol is a liver X receptor agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage, hepatocytes, and intestinal epithelium.J Agric Food Chem201260:(46):11567-75
81.Hee-jin Jun, Ji Hae Lee, Bo-Ram Cho, Woo-Duck Seo, Dong-Woo Kim, Kang-Jin Cho,Sung-Joon Lee*. p-Coumaric acid inhibition of CREB phosphorylation reduces cellular melanogenesis.Eur Food Res Technol2012 235(6):1207-11
80.Hee-jin Jun, Ji Hae Lee, Boram Cho,Kyoung Heon Kim, Hou Joung Lee,Minh-Hien Hoang, Sung-Joon Lee*. Dual Inhibition of γ-Oryzanol on Cellular Melanogenesis: Inhibition of Tyrosinase Activity and Reduction of Melanogenic Gene Expression by a Protein Kinase A-Dependent Mechanism .J Nat Prod2012 75(10):1706-11.
79.Hee-jin Jun#, Minh-Hien Hoang#,Jin Woo Lee,Jia Yaoyao, Ji-Hae Lee,Dong-Ho Lee, Hak-Ju Lee, Woo-Duck Seo, Bang-Yeon Hwang*,Sung-Joon Lee*. Iristectorigenin B isolated from Belamcanda chinensis is a live X receptor modulator that increases ABCA1 expression in macrophage RAW 264.7 cell.Biotechnol Lett2012 34(12):2213-21. (#, authors contribute equally to the paper)
78.Ji Hae Lee, Hee-jin Jun, Minh-Hien Hoang, Yaoyao Jia,Xiang Hua Han, Dong-Ho Lee, Hak Ju Lee, Bang Yeon Hwang*,Sung-Joon Lee*.Catalposide is a natural agonistic ligand of peroxisome proliferator-activated receptor-alpha.Biochem Biophys Res Commun(2012) 422:4:568-72.
77.Minh-Hien Hoang, Yaoyao Jia, Hee-jin Jun, Ji Hae Lee,Dong-Ho Lee, Bang-Yeon Hwang, Woo-Jin Kim, Hak-Ju Lee,Sung-Joon Lee*. Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells.Bioorg Med Chem Lett(2012) 22:12:4094-9.
76.Ji Hae Lee, Boram Cho, Hee-jin Jun,Woo-Duck Seo, Dong-Woo Kim, Kang-Jin Cho,Sung-Joon Lee*. Momilactone B inhibits protein kinase A signaling and reduces tyrosinase-related protein 1 and 2 wxpressions in melanocytes.Biotechnol Lett(2012) 34:5:805-12.
75.Yaoyao Jia, Jin-Young Kim, Hee-jin Jun,Seon-Jung Kim,Ji-Hae Lee, Minh Hien Hoang,Hyo-Il Chang, Kwang-Yeon Hwang, Su-Jong Eom,Sung-Joon Lee*. The natural carotenoid astaxanthin, a PPAR-alpha agonist and PPAR-gamma antagonist, reduces hepatic lipid accumulations by rewiring the transcriptome in lipid-loaded hepatocytes .Mol Nutr Food Res(2012) 56:6:878-8.
74.Minh Hien Hoang, Yaoyao Jia, Hee-jin Jun, Ji Hae Lee,Kwang-Yeon Hwang, Soo-Jong Um, Boo-Yong Lee, Sang-Guan You,Sung-Joon Lee*. Taurine is a liver X receptor ligand and activates genes in the reverse cholesterol transport without inducing hepatic lipogenesis.Mol Nurt Food Res(2012) 56:6:900-11