University of Virginia School of Medicine

University of Virginia School of Medicine

PO Box 800739

Charlottesville, VA 22908-0739

(434) 924-5579

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Curriculum Vitae:

_

University of Vermont1989-1990

University of VirginiaB.A. 1990-1993Biology

University of VirginiaPh.D.1993-1999Neuroscience

University of Virginia1993-Medicine

Research Rotations:

Carl Haisch, M.D., University of Vermont (1990)

Federico Gonzalez-Fernandez M.D., Ph.D., University of Virginia (1992-1993)

Russell Foster, Ph.D., University of Virginia (1993)

Robert Grainger, Ph.D., University of Virginia (1994)

Federico Gonzalez-Fernandez, M.D., Ph.D., University of Virginia (1995-present)

Honors, Fellowships, and Awards:

Outstanding First-Year Student in General Biology, University of Vermont (1990)

Phi Beta Kappa (1993)

Richard D. Katz Undergraduate Research Symposium Prize,

University of Virginia (1993)

Bachelor of Arts with Distinction, University of Virginia (1993)

Samuel Miller Scholar Award in Biology, University of Virginia (1993)

Fight for Sight Student Fellowship in memory of Albert G. and Herman B. Mosler (1993)

Medical Scientist Training Program Fellowship (1993)

Merit Scholarship, University of Virginia School of Medicine (1993-1997)

Whitfield-Randolph Scholarship Award, University of Virginia (1996)

ARVO/Retina Research Foundation Joseph M. and Eula C. Lawrence Travel

Fellowship Grant (1999)

Ad hoc National Science Foundation reviewer, 1999.

Publications:

1.) _., Kittredge, K.L., Klinger, A.L., Briercheck, D.M., Braiman, M.S., and Gonzalez-

Fernandez, F. (1994). Expression and characterization of the fourth repeat of Xenopus

interphotoreceptor retinoid-binding protein in E. coli. Curr.Eye Res. 13, 391-400.

2.) Hessler, R.B., _., Bukelman, A., Kittredge, K.L., and Gonzalez-Fernandez, F. (1996).

Interphotoreceptor retinoid-binding protein (IRBP) - expression in the adult and

developing Xenopus retina. J.Comp.Neurol. 367, 329-341.

3.) _., Retief, J.D., Van Niel, E., Braiman, M.S., and Gonzalez-Fernandez, F. (1998). Soluble

expression in E. coli of a functional interphtoreceptor retinoid-binding protein module

fused to thioredoxin: Correlation of vitmain A binding regions with conserved domains

of C-terminal processing proteases. Exp.Eye Res. 66, 249-262..

4.) Gonzalez-Fernandez, F., _., Van Niel, E., Braiman, M.S., Okajima, T.L., and Pepperberg,

D.R. (1998). Fourth module of Xenopus interphotoreceptor retinoid-binding protein:

activity in retinoid transfer between the retinal pigment epithelium and rod

photoreceptors. Curr.Eye Res. 17, 1150-1157.

5.) _., Van Niel, E., Cronk, J.W., Kinter, M.T., Sherman, N.E., Braiman, M.S., and Gonzalez-

Fernandez, F. (1998). Arginine to glutamine substitutions in the fourth module of

Xenopus interphotoreceptor retinoid-binding protein. Mol.Vis. 4:30.

6.) _., Van Niel, E.E., Braiman, M., Bukelman, A., Retief, J.D., and Gonzalez-Fernandez, F.

Relationship of IRBP’s modules to retinoid binding. In revision.

7.) Gonzalez-Fernandez, F., _., Van Niel, E.E., Braiman, M., Bukelman, A., and Retief, J.D.

Xenopus interphotoreceptor retinoid-binding protein: Evolution and function. In revision.

8.) Gelderman, M.P., Gonzalez-Fernandez, F., _., Wiggert, B., Chan, C-C, Vistica, B.P., and

Gery, I. Xenopus IRBP, a phylogenetically remote protein, is uveitogenic in Lewis rats.

In preparation.

Abstracts:

1.) _, Kittredge, K.L., Gonzalez-Fernandez, F. (1993). Expression of the fourth repeat of

Xenopus IRBP in E. coli. Invest.Ophthal.Vis.Sci. 34, 831.

2.) Hessler, R.B., Wagenhorst, B., _., Gonzalez-Fernandez, F. (1993). Expression of

interphotoreceptor retinoid-binding protein (IRBP) in Xenopus and goldfish

photoreceptors. FASEB J. 7, A371.

3.) Van Niel, E.E., _., Cronk, J.W., Atwood, M., and Gonzalez-Fernandez, F. (1994). Functional

domains in IRBP. Invest.Ophthal.Vis.Sci. 35, 1704.

4.) Payman, R., Bukelman, A., _., Redick, J.A., Sheppard, B.L., Gonzalez-Fernandez, F. (1994)

Role of retinal pigment epithelium (RPE) in interphotoreceptor retinoid-binding protein

(IRBP) turnover. Invest.Ophthal.Vis.Sci. 35, 2061.

5.) Gonzalez-Fernandez, F., Baker, E.L., _., Okajima, T.L., Wiggert, B., and Pepperberg, D.R.

(1995). Recombinant IRBP 4th repeat. Invest.Ophthal.Vis.Sci. 36, S6.

6.) _., Yang, L., and Gonzalez-Fernandez, F. (1996). Light stimulates endocytosis of IRBP by

the RPE. Invest.Ophthal.Vis.Sci. 37, S909.

7.) Van Niel, E.E., _., Miller, V.L., Gonzalez-Fernandez, F. (1996) Comparison of expression

systems for recombinant interphotoreceptor retinoid-binding protein (IRBP).

Invest.Ophthal.Vis.Sci. 37, S801.

8.) _., Van Niel, E.E., Braiman, M.S., and Gonzalez-Fernandez, F. (1997). Truncational

mutagenesis of the fourth module of Xenopus IRBP. Invest.Ophthal.Vis.Sci. 38, S3.

9.) Van Niel, E., _., and Gonzalez-Fernandez, F. (1997). Structure/function studies of IRBP

modules expressed as thioredoxin fusion proteins in E. coli. Invest.Ophthal.Vis.Sci. 38,

S4..10.) _., Van Niel, E.E., Braiman, M, Gonzalez-Fernandez, F. (1998). Site-directed mutagenensis of the fourth module of Xenopus IRBP. Invest.Ophthal.Vis.Sci. 39, S422.

11.) Gelderman, M.P., Gonzalez-Fernandez, F., _., Wiggert, B., Chan, C.C., Vistica, B.P., Gery,

I. (1998). Uveitogenic and immunogenic properties of Xenopus IRBP in rats.

Invest.Ophthal.Vis.Sci. 39, S777.

12.) _., Van Niel, E.E., Braiman, M., Gonzalez-Fernandez, F. (1999). Relationship of IRBP’s

modules to retinoid binding. Invest.Ophthal.Vis.Sci. 40, S217.

13.) Casaletto, J.B., Vleugels, R.A., _., Van Niel, E.E., Gonzalez-Fernandez, F. (1999).

Expression of zebrafish interphotoreceptor retinoid-binding protein (IRBP) and its

individual modules in E. coli. 40, S217.

Community Service:

Big brother/little brother program (1993-present)

Hobbies:

Sailing, windsurfing, canoeing, hiking, guitar