Splementary Material

Splementary material

Table S1. Genes with expression changes of at least 1.5 fold in Mycobacterium tuberculosis H37Rvexposed to linezolid.

Functional category / ORF no. a / Gene / Product or putative function / Fold changeb / P valueb
Amino acid biosynthesis / Rv3708c / asd / Aspartate-semialdehyde dehydrogenase / 2.61 / 0.020626
Rv3670 / ephE / Epoxide hydrolase ephe / 1.61 / 0.003761
Rv2773c / dapB / Dihydrodipicolinate reductase / -1.69 / 5.55E-04
Rv2539c / aroK / Shikimate kinase / 1.62 / 0.044995
Rv2537c / aroD / 3-dehydroquinate dehydratase / -1.72 / 0.001324
Rv1656 / argF / Ornithine carbamoyltransferase / 1.58 / 0.021385
Rv1653 / argJ / Bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein / 1.66 / 0.049588
Rv1605 / hisF / Imidazole glycerol phosphate synthase subunit hisf / 1.72 / 0.001574
Rv1202 / dapE / Succinyl-diaminopimelate desuccinylase / 1.77 / 0.001408
Biosynthesis of cofactors, prosthetic groups, and carriers / Rv3582c / ispD / 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase / -1.54 / 0.044081
Rv3090 / - / Hypothetical protein / 1.59 / 0.047693
Rv3041c / - / ABC transporter ATP-binding protein / 1.56 / 0.006348
Rv2991 / - / Hypothetical protein / 1.73 / 0.001421
Rv2678c / hemE / Uroporphyrinogen decarboxylase / 1.62 / 0.044869
Rv2421c / nadD / Nicotinic acid mononucleotide adenylyltransferase / 1.65 / 0.000861
Rv2071c / cobM / Precorrin-4 C11-methyltransferase cobm / 1.51 / 0.001264
Rv2065 / cobH / Precorrin-8X methylmutase / 1.63 / 0.000664
Rv1681 / moeX / Molybdopterin biosynthesis protein moex / -2.02 / 0.027913
Rv1405c / - / Putative methyltransferase / 1.60 / 0.040813
Rv1092c / coaA / Pantothenate kinase / 1.57 / 1.58E-04
Rv0866 / moaE2 / Molybdenum cofactor biosynthesis protein E2 / 1.71 / 0.007807
Rv0510 / hemC / Porphobilinogen deaminase / 2.13 / 0.03261
Rv0260c / - / Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein / -1.56 / 0.02319
Rv0255c / cobQ1 / Cobyric acid synthase / -1.64 / 0.026915
Rv2236c / cobD / Cobalamin biosynthesis protein / 1.61 / 0.046709
Cell envelope / Rv3921c / - / Putative inner membrane protein translocase component yidc / -1.56 / 0.034517
Rv3823c / mmpL8 / Integral membrane transport protein / -2.08 / 0.001029
Rv3806c / - / Phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase / -2.41 / 0.048252
Rv3779 / - / Transmembrane protein alanine and leucine rich / 1.55 / 0.000556
Rv3730c / - / Hypothetical protein / 2.47 / 0.001885
Rv3464 / rmlB / Dtdp-glucose 4,6-dehydratase RMLB / -1.55 / 0.024375
Rv3377c / - / Cyclase / -1.56 / 0.022742
Rv3306c / amiB1 / Amidohydrolase amib1 / 1.55 / 0.000617
Rv2957 / - / Glycosyl transferase / -1.67 / 0.005968
Rv2729c / - / Hypothetical protein / -1.72 / 0.021604
Rv2672 / - / Secreted protease / 1.95 / 0.013026
Rv1980c / mpt64 / Immunogenic protein MPT64 (antigen MPT64/MPB64) / -1.51 / 0.035781
Rv1903 / - / Hypothetical protein / -2.11 / 0.003271
Rv1881c / lppE / Lipoprotein lppe / -1.55 / 0.000854
Rv1648 / - / Transmembrane protein / -1.84 / 0.011572
Rv1565c / - / Hypothetical protein / -1.55 / 0.028729
Rv1431 / - / Hypothetical protein / -1.74 / 0.032997
Rv1363c / - / Hypothetical protein / 1.51 / 0.001791
Rv1362c / - / Hypothetical protein / -1.59 / 0.009592
Rv1227c / - / Hypothetical protein / 1.79 / 0.001063
Rv1183 / mmpL10 / Transmembrane transport protein mmpl10 / -1.60 / 0.000531
Rv1101c / - / Hypothetical protein / -1.71 / 0.028937
Rv1018c / glmU / UDP-N-acetylglucosamine pyrophosphorylase glmu / -1.71 / 0.014103
Rv0955 / - / Integral membrane protein / -2.12 / 0.000618
Rv0869c / moaA / Molybdenum cofactor biosynthesis protein A / -1.55 / 0.037998
Rv0625c / - / Transmembrane protein / 2.23 / 0.00428
Rv0588 / yrbE2B / Integral membrane protein yrbe2b / -1.55 / 0.018941
Rv0585c / - / Integral membrane protein / -2.17 / 0.000708
Rv0476 / - / Transmembrane protein / 1.75 / 0.000866
Rv0450c / mmpL4 / Transmembrane transport protein mmpl4 / -1.76 / 0.035046
Rv0236c / - / Transmembrane protein / -1.54 / 0.001622
Rv0177 / - / MCE associated protein / -1.61 / 0.000629
Rv0168 / yrbE1B / Integral membrane protein YRBE1B / -2.26 / 0.012908
Rv0167 / yrbE1A / Integral membrane protein YRBE1A / -1.78 / 0.018402
Rv0115 / hddA / D-alpha-D-heptose-7-phosphate kinase / -1.74 / 0.001275
Rv0113 / gmhA / Phosphoheptose isomerase / -1.60 / 0.00061
Rv0085 / hycP / Hydrogenase hycp / 1.86 / 0.001451
Rv0039c / - / Transmembrane protein / 2.56 / 0.014781
Rv0024 / - / Putative secreted protein P60-related protein / 1.51 / 0.001171
MT3745 / - / Hypothetical protein / 1.63 / 0.001504
MT1954 / - / Hypothetical protein / -2.33 / 0.000576
MT0524 / cma2 / Cyclopropane-fatty-acyl-phospholipid synthase 2 / -1.69 / 0.041473
Cellular processes / Rv3846 / sodA / Superoxide dismutase [Fe] SODA / -2.32 / 0.000716
Rv3817 / - / Phosphotransferase / 1.63 / 0.000694
Rv3496c / mce4D / MCE-family protein MCE4D / -1.64 / 0.04954
Rv3479 / - / Hypothetical protein / -1.66 / 0.035416
Rv3358 / - / Hypothetical protein / 1.62 / 0.000749
Rv3226c / - / Hypothetical protein / 1.77 / 0.001475
Rv3092c / - / Integral membrane protein / -3.74 / 0.017299
Rv3077 / - / Hydrolase / 1.60 / 0.001023
Rv2946c / pks1 / Polyketide synthase PKS1 / -1.59 / 0.00051
Rv2936 / drrA / Daunorubicin-DIM-transport ATP-binding protein ABC transporter drra / -1.54 / 0.04946
Rv2759c / - / Hypothetical protein / 1.85 / 0.000985
Rv2150c / ftsZ / Cell division protein ftsz / -1.69 / 0.000869
Rv1894c / - / Hypothetical protein / -2.42 / 0.049345
Rv1687c / - / ABC transporter ATP-binding protein / 1.90 / 0.00383
Rv1062 / - / Hypothetical protein / -1.68 / 0.000931
Rv1010 / ksgA / Dimethyladenosine transferase / -1.81 / 0.000783
Rv0634c / - / Glyoxalase II / -1.59 / 0.044806
Rv0590A / - / MCE family-like protein / -2.21 / 0.045685
Rv0590 / mce2B / MCE-family protein MCE2B / -1.68 / 0.011445
Rv0522 / gabP / GABA permease gabp / -1.77 / 0.00074
Rv0325 / - / Hypothetical protein / 1.98 / 0.020516
Rv0174 / mce1F / MCE-family protein MCE1F / -1.99 / 7.90E-04
Rv0173 / lprK / MCE-family lipoprotein lprk / -2.45 / 0.016429
MT2593 / - / Hypothetical protein / 1.73 / 0.003018
MT2042 / - / Rrna adenine N-6-methyltransferase, putative / -1.56 / 0.018726
Central intermediary metabolism / Rv3487c / lipF / Esterase/lipase lipf / -1.80 / 0.005524
Rv3432c / gadB / Glutamate decarboxylase gadb / 1.61 / 0.000853
Rv3198A / - / Glutaredoxin protein / -2.74 / 0.001713
Rv3171c / hpx / Non-Heme haloperoxidase Hpx / 1.55 / 0.000619
Rv2922A / acyP / Acylphosphatase / 1.64 / 0.001919
Rv2775 / - / Hypothetical protein / -1.90 / 0.027434
Rv2402 / - / Hypothetical protein / -1.61 / 0.018767
Rv2263 / - / Short chain dehydrogenase / -1.54 / 0.000645
Rv2002 / fabG3 / 20-beta-hydroxysteroid dehydrogenase / 1.85 / 0.000907
Rv1990A / - / Dehydrogenase / 1.51 / 0.000676
Rv1544 / - / Ketoacyl reductase / -3.50 / 0.042114
Rv1377c / - / Putative transferase / 1.74 / 0.001489
Rv1317c / alkA / Bifunctional methylated-DNA--protein-cysteine methyltransferase/O-6-methylguanine-DNA transcription regulator / 1.57 / 0.000754
Rv0765c / - / Short chain dehydrogenase / 2.04 / 0.005997
Rv0694 / lldD1 / L-lactate dehydrogenase (cytochrome) lldd1 / -3.60 / 0.001319
Rv0484c / - / Short-chain type oxidoreductase / 1.77 / 0.001515
Rv0449c / - / Hypothetical protein / -4.10 / 0.001088
Rv0261c / narK3 / Integral membrane nitrite extrusion protein nark3 / -2.23 / 0.000805
Rv0247c / - / Fumarate reductase iron-sulfur subunit / -1.54 / 0.031843
Rv0228 / - / Integral membrane acyltransferase / 1.73 / 0.00223
Rv0223c / - / Aldehyde dehydrogenase / -1.62 / 0.00067
MT3561 / - / Hypothetical protein / -1.63 / 0.00494
MT2819 / ftsK / Cell division protein ftsk / 1.64 / 0.002448
MT2740 / - / Truncated IS1081 transposase / -2.04 / 0.041343
MT1743 / - / Catechol-O-methyltransferase / -1.53 / 0.000747
MT0721 / - / FMN-dependent alpha-hydroxy acid dehydrogenase family protein / -3.52 / 0.033712
Rv2800 / - / Hydrolase / 1.72 / 0.000971
Conserved Hypothetical proteins / Rv2653c / - / Phirv2 prophage protein / 1.72 / 0.002076
Rv2628 / - / Hypothetical protein / -3.12 / 0.005636
Rv2032 / acg / Hypothetical protein / -3.08 / 0.003638
Rv1733c / - / Transmembrane protein / 2.01 / 0.018573
MT3994 / - / Hypothetical protein / 1.71 / 0.000785
Rv3916c / - / Hypothetical protein / 1.52 / 0.003004
Rv3909 / - / Hypothetical protein / -1.71 / 0.001358
Rv3900c / - / Hypothetical protein / 1.54 / 8.09E-04
Rv3876 / - / Hypothetical protein / -1.62 / 0.000736
Rv3865 / - / Hypothetical protein / -1.54 / 0.000545
Rv3851 / - / Hypothetical protein / 2.07 / 0.004555
Rv3850 / - / Hypothetical protein / 1.54 / 0.042394
Rv3847 / - / Hypothetical protein / -1.56 / 0.027424
Rv3845 / - / Hypothetical protein / 1.55 / 0.000999
Rv3839 / - / Hypothetical protein / -2.04 / 0.001301
Rv3819 / - / Hypothetical protein / -1.71 / 0.026792
Rv3802c / - / Hypothetical protein / -1.94 / 0.032816
Rv3760 / - / Hypothetical protein / -1.85 / 0.000552
Rv3747 / - / Hypothetical protein / 2.09 / 0.001636
Rv3615c / - / Hypothetical protein / -1.72 / 0.027607
Rv3572 / - / Hypothetical protein / -2.30 / 0.010599
Rv3541c / - / Hypothetical protein / 1.54 / 0.000639
Rv3527 / - / Hypothetical protein / -1.79 / 0.039531
Rv3491 / - / Hypothetical protein / -1.63 / 0.024348
Rv3482c / - / Hypothetical protein / 1.50 / 0.025397
Rv3439c / - / Hypothetical protein / 1.90 / 0.002839
Rv3412 / - / Hypothetical protein / -1.62 / 0.023631
Rv3395c / - / Hypothetical protein / 1.63 / 0.001347
Rv3289c / - / Transmembrane protein / -2.33 / 0.00056
Rv3259 / - / Hypothetical protein / 2.18 / 0.001659
Rv3221A / - / Anti-sigma factor / 1.70 / 0.000718
Rv3195 / - / Hypothetical protein / 1.64 / 0.048327
Rv3165c / - / Hypothetical protein / 1.51 / 0.008844
Rv3143 / - / Response regulator / 1.57 / 0.046911
Rv3134c / - / Hypothetical protein / -1.64 / 0.014355
Rv3131 / - / Hypothetical protein / -2.08 / 0.00158
Rv3127 / - / Hypothetical protein / -3.77 / 0.003414
Rv3123 / - / Hypothetical protein / 2.07 / 0.010011
Rv3076 / - / Hypothetical protein / -1.80 / 0.000686
Rv2970A / - / Hypothetical protein / -1.62 / 0.024947
Rv2927c / - / Hypothetical protein / -1.50 / 0.041789
Rv2663 / - / Hypothetical protein / -1.82 / 0.034217
Rv2629 / - / Hypothetical protein / -2.03 / 0.011579
Rv2627c / - / Hypothetical protein / -5.29 / 0.002526
Rv2623 / TB31.7 / Hypothetical protein / -2.54 / 0.002011
Rv2514c / - / Hypothetical protein / 2.66 / 0.009699
Rv2513 / - / Hypothetical protein / 1.56 / 0.047214
Rv2375 / - / Hypothetical protein / -1.53 / 0.022441
Rv2319c / - / Hypothetical protein / -1.67 / 0.002302
Rv2252 / - / Diacylglycerol kinase / 2.31 / 0.001831
Rv2227 / - / Hypothetical protein / -1.70 / 0.038665
Rv2180c / - / Integral membrane protein / -1.56 / 0.019909
Rv2164c / - / Hypothetical protein / -2.41 / 0.044351
Rv2036 / - / Hypothetical protein / -1.54 / 0.01343
Rv2016 / - / Hypothetical protein / 2.41 / 0.004315
Rv2005c / - / Hypothetical protein / -2.16 / 0.003564
Rv2004c / - / Hypothetical protein / -2.23 / 0.034541
Rv1996 / - / Hypothetical protein / -2.39 / 0.014733
Rv1993c / - / Hypothetical protein / 2.90 / 0.008573
Rv1989c / - / Hypothetical protein / -1.73 / 0.0007
Rv1957 / - / Hypothetical protein / 1.52 / 0.000693
Rv1929c / - / Hypothetical protein / -1.79 / 0.001602
Rv1794 / - / Hypothetical protein / -1.60 / 0.001365
Rv1775 / - / Hypothetical protein / 1.52 / 0.021864
Rv1738 / - / Hypothetical protein / -3.71 / 0.013776
Rv1645c / - / Hypothetical protein / -1.77 / 0.040918
Rv1597 / - / Hypothetical protein / -1.93 / 0.001259
Rv1583c / - / Phirv1 phage protein / 2.07 / 0.001579
Rv1572c / - / Hypothetical protein / 2.10 / 0.011814
Rv1560 / - / Hypothetical protein / -1.82 / 0.001173
Rv1546 / - / Hypothetical protein / 1.72 / 0.002476
Rv1507c / - / Hypothetical protein / -1.94 / 0.001439
Rv1429 / - / Hypothetical protein / 1.71 / 0.007057
Rv1360 / - / Oxidoreductase / -1.52 / 0.04608
Rv1343c / lprD / Lipoprotein lprd / -1.60 / 0.000522
Rv1278 / - / Hypothetical protein / 2.04 / 0.001841
Rv1241 / - / Hypothetical protein / 1.51 / 0.028212
Rv1159A / phhB / Pterin-4-alpha-carbinolamine dehydratase / -1.57 / 0.007757
Rv1155 / - / Hypothetical protein / -1.59 / 0.000545
Rv1125 / - / Hypothetical protein / 1.77 / 0.001521
Rv1113 / - / Hypothetical protein / 1.69 / 0.001123
Rv1100 / - / Hypothetical protein / -1.53 / 0.018488
Rv0991c / - / Putative serine rich protein / 2.16 / 0.002018
Rv0990c / - / Hypothetical protein / 3.40 / 0.008647
Rv0965c / - / Hypothetical protein / 1.72 / 0.032937
Rv0961 / - / Integral membrane protein / -1.79 / 0.036989
Rv0786c / - / Hypothetical protein / 1.52 / 0.001521
Rv0713 / - / Transmembrane protein / 1.67 / 0.029079
Rv0692 / - / Hypothetical protein / -1.73 / 0.02523
Rv0690c / - / Hypothetical protein / -2.59 / 7.15E-04
Rv0656c / - / Hypothetical protein / 1.53 / 0.037795
Rv0572c / - / Hypothetical protein / -2.57 / 0.043703
Rv0493c / - / Hypothetical protein / 1.95 / 0.022987
Rv0470A / - / Hypothetical protein / -2.13 / 0.000643
Rv0455c / - / Hypothetical protein / -1.55 / 0.016674
Rv0444c / - / Hypothetical protein / -1.68 / 0.040601
Rv0441c / - / Hypothetical protein / -1.67 / 0.004164
Rv0366c / - / Hypothetical protein / -1.51 / 0.001547
Rv0341 / iniB / Isoniazid inductible gene protein INIB / 1.55 / 0.043941
Rv0331 / - / Dehydrogenase/reductase / 1.51 / 0.001637
Rv0299 / - / Hypothetical protein / 1.51 / 0.023559
Rv0293c / - / Hypothetical protein / -1.60 / 0.016722
Rv0272c / - / Hypothetical protein / -1.52 / 0.037642
Rv0250c / - / Hypothetical protein / -2.13 / 0.038115
Rv0249c / - / Succinate dehydrogenase membrane anchor subunit / -1.70 / 0.000937
Rv0201c / - / Hypothetical protein / 1.66 / 0.042696
Rv0178 / - / Mce associated membrane protein / -1.51 / 0.001254
Rv0123 / - / Hypothetical protein / 1.58 / 0.01115
MT3846 / - / Hypothetical protein / 1.71 / 0.007996
MT3762 / - / Hypothetical protein / 1.95 / 0.002312
MT3042 / - / Hypothetical protein / 1.82 / 0.00243
MT2950 / - / Hypothetical protein / 1.69 / 0.000856
MT2919 / - / PE_PGRS family protein / 1.58 / 0.001628
MT2205 / - / Hypothetical protein / -1.72 / 2.87E-04
MT2168 / - / Hypothetical protein / -1.76 / 0.001398
MT2035 / - / Hypothetical protein / 2.01 / 0.001452
MT1932 / - / Hypothetical protein / -1.73 / 0.001325
MT1924 / - / Hypothetical protein / 1.55 / 0.005418
MT1622 / - / Hypothetical protein / 1.57 / 0.029154
MT1468 / - / Hypothetical protein / -1.59 / 0.024751
MT0810 / - / Hypothetical protein / 1.61 / 0.0029
MT0595 / - / Hypothetical protein / -1.53 / 0.004619
MT0415 / - / Hypothetical protein / 1.66 / 0.01324
Disrupted reading frame / MT2544 / - / Hypothetical protein / -1.68 / 0.023056
MT0817 / - / Mercuric reductase/transcriptional regulator, fusion / 1.64 / 0.023642
DNA metabolism / Rv3886c / mycP2 / Alanine and proline rich membrane-anchored mycosin / -1.88 / 0.025318
Rv3752c / - / Cytidine/deoxycytidylate deaminase / 1.60 / 0.001846
Rv3733c / - / Hypothetical protein / 1.78 / 0.01902
Rv3505 / fadE27 / Acyl-coa dehydrogenase FADE27 / 1.78 / 0.00278
Rv3037c / - / Hypothetical protein / 1.65 / 0.04503
Rv3014c / ligA / NAD-dependent DNA ligase liga / 1.51 / 0.049454
Rv2528c / mrr / Restriction system protein mrr / 1.57 / 0.012964
Rv2413c / - / Hypothetical protein / 1.79 / 0.005366
Rv2315c / - / Hypothetical protein / -1.78 / 0.034951
Rv1629 / polA / DNA polymerase I / 1.70 / 0.01689
Rv1574 / - / Phirv1 phage related protein / 1.64 / 0.002642
Rv1547 / dnaE / DNA polymerase III subunit alpha / -1.51 / 0.048835
Rv1259 / - / Hypothetical protein / -1.65 / 0.000513
Rv1107c / xseB / Exodeoxyribonuclease VII small subunit / 1.61 / 0.001294
Rv0235c / - / Transmembrane protein / -2.20 / 0.001601
Rv0007 / - / Hypothetical protein / -1.68 / 0.000869
Rv0002 / dnaN / DNA polymerase III subunit beta / -1.86 / 0.000523
MT2948 / - / Phosphatidate cytidylyltransferase, putative / -1.68 / 0.02563
Energy metabolism / Rv3829c / - / Dehydrogenase / 1.61 / 0.001663
Rv3534c / - / 4-hydroxy-2-ketovalerate aldolase / 2.75 / 0.024544
Rv3490 / otsA / Alpha,alpha-trehalose-phosphate synthase / -2.09 / 0.0388
Rv3317 / sdhD / Succinate dehydrogenase hydrophobic membrane anchor subunit sdhd / -2.12 / 0.044527
Rv3307 / deoD / Purine nucleoside phosphorylase / 1.93 / 0.001844
Rv3280 / accD5 / Propionyl-coa carboxylase beta chain / 1.61 / 0.000708
Rv3230c / - / Oxidoreductase / 1.72 / 0.000902
Rv3157 / nuoM / NADH dehydrogenase subunit M / -2.37 / 0.036587
Rv3045 / adhC / NADP-dependent alcohol dehydrogenase ADHC / -1.51 / 0.043252
Rv2951c / - / Oxidoreductase / -1.54 / 0.018199
Rv2780 / ald / Secreted L-alanine dehydrogenase ALD (40 kda antigen) (TB43) / -1.57 / 0.032224
Rv2713 / sthA / Soluble pyridine nucleotide transhydrogenase / -1.71 / 0.030131
Rv2391 / sirA / Ferredoxin-dependent sulfite reductase SIRA / -1.55 / 0.001577
Rv2345 / - / Transmembrane protein / 1.66 / 0.004464
Rv2332 / mez / Malate dehydrogenase / 1.77 / 0.013266
Rv2200c / ctaC / Transmembrane cytochrome C oxidase subunit II ctac / 1.52 / 0.042412
Rv1824 / - / Hypothetical protein / -1.99 / 0.033787
Rv1771 / - / Oxidoreductase / -1.52 / 0.011913
Rv1737c / narK2 / Nitrate/nitrite transporter nark2 / -2.43 / 0.043145
Rv1732c / - / Hypothetical protein / -1.51 / 0.023077
Rv1400c / lipI / Lipase liph / -1.53 / 0.03419
Rv1394c / cyp132 / Cytochrome P450 132 / -1.63 / 0.000709
Rv1260 / - / Hypothetical protein / -1.58 / 0.000707
Rv1257c / - / Oxidoreductase / 1.56 / 0.015811
Rv1245c / - / Short-chain type dehydrogenase/reductase / 1.61 / 0.001293
Rv0913c / - / Dioxygenase / -2.13 / 0.031219
Rv0896 / gltA / Type II citrate synthase / -1.80 / 0.037912
Rv0771 / - / 4-carboxymuconolactone decarboxylase / -1.55 / 0.047531
Rv0763c / - / Ferredoxin / 1.90 / 0.004461
Rv0753c / mmsA / Methylmalonate-semialdehyde dehydrogenase / -1.51 / 0.011515
Rv0568 / cyp135B1 / Cytochrome P450 135B1 / 1.63 / 0.007548
Rv0547c / - / Short chain dehydrogenase / 1.66 / 0.027727
Rv0310c / - / Hypothetical protein / 1.93 / 0.004594
Rv0252 / nirB / Nitrite reductase large subunit / -2.42 / 0.032254
Rv0197 / - / Oxidoreductase / -1.69 / 0.000519
Rv0089 / - / Methyltransferase/methylase / 1.63 / 0.00211
MT3131 / - / Hypothetical protein / -1.66 / 0.031642
MT1834 / - / P450 heme-thiolate protein / 1.71 / 0.016176
Rv0097 / - / Oxidoreductase / -1.62 / 0.001724
Fatty acid and phospholipid metabolism / Rv3523 / ltp3 / Acetyl-coa acetyltransferase / -1.69 / 0.014519
Rv3392c / cmaA1 / Cyclopropane-fatty-acyl-phospholipid synthase 1 CMAA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 1) / -1.91 / 5.67E-04
Rv3089 / fadD13 / Chain-fatty-acid-coa ligase / 1.56 / 0.001089
Rv2950c / fadD29 / Acyl-coa synthetase / -1.68 / 0.032791
Rv2928 / tesA / Thioesterase TESA / -1.68 / 0.00118
Rv2045c / lipT / Carboxylesterase lipt / -1.90 / 0.000566
Rv0914c / - / Acetyl-coa acetyltransferase / -1.60 / 0.026866
Rv0859 / fadA / Acetyl-coa acetyltransferase / 2.43 / 0.023314
Rv0503c / cmaA2 / Cyclopropane-fatty-acyl-phospholipid synthase 2 CMAA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 2) (mycolic acid trans-cyclopropane synthetase) / -1.63 / 0.022912
Rv0499 / - / Hypothetical protein / 1.58 / 0.00123
Rv0436c / pssA / CDP-diacylglycerol--serine O-phosphatidyltransferase / -2.07 / 0.027968
MT3139 / - / Glutaredoxin nrdh, putative / -1.58 / 0.014206
MT2941 / - / Hypothetical protein / -1.54 / 0.034821
MT1218 / mas-1 / Mycocerosic acid synthase / -1.55 / 0.025658
Hypothetical proteins / Rv3654c / - / Hypothetical protein / 2.02 / 0.002855
Rv3252c / alkB / Transmembrane alkane 1-monooxygenase alkb / -1.60 / 0.04874
MT4037 / - / Soj family protein / -1.53 / 0.042241
MT3972 / - / Hypothetical protein / -1.62 / 0.016179
Rv3861 / - / Hypothetical protein / 2.71 / 0.004272
Rv3613c / - / Hypothetical protein / -1.51 / 0.028053
Rv3416 / whiB3 / Transcriptional regulatory protein WHIB-like WHIB3 / -1.55 / 0.013884
Rv3344c / PE_PGRS49 / PE-PGRS family protein / 2.33 / 0.031602
Rv3108 / - / Hypothetical protein / -2.83 / 0.007588
Rv2908c / - / Hypothetical protein / 1.66 / 0.042627
Rv2767c / - / Hypothetical protein / -3.18 / 0.00087
Rv2736c / recX / Recombination regulator recx / 1.88 / 0.001972
Rv2568c / - / Hypothetical protein / -2.50 / 0.040498
Rv1987 / - / Chitinase / -1.73 / 0.011868
Rv1810 / - / Hypothetical protein / -1.58 / 0.024162
Rv1545 / - / Hypothetical protein / 1.54 / 0.008304
Rv1434 / - / Hypothetical protein / 2.17 / 0.002728
Rv0833 / PE_PGRS13 / PE-PGRS family protein / 1.62 / 0.006214
Rv0801 / - / Hypothetical protein / 2.13 / 0.003734
Rv0454 / - / Hypothetical protein / 1.58 / 5.20E-04
Rv0114 / gmhB / D-alpha,beta-D-heptose-1,7-biphosphate phosphatase / -1.67 / 0.034523
Rv0061 / - / Hypothetical protein / -1.74 / 0.001235
Rv0040c / mtc28 / Secreted proline rich protein MTC28 (proline rich 28 kda antigen) / -1.57 / 0.000806
MT3867 / - / Hypothetical protein / -1.82 / 0.032268
MT3866 / - / Amino acid ABC transporter, amino acid-binding protein, putative / -1.83 / 0.034194
MT3858 / - / Hypothetical protein / 1.64 / 0.012598
MT3796 / - / Hypothetical protein / -1.52 / 0.047294
MT3786 / - / Cysteine synthase/cystathionine beta-synthase family protein / -1.84 / 0.000779
MT3679 / - / Tetr family transcriptional regulator / -1.59 / 0.006292
MT3523 / - / RNA polymerase sigma factor sigd / 1.68 / 0.001658
MT3495 / - / PE_PGRS family protein / 2.98 / 4.62E-04
MT3357 / - / Hypothetical protein / 1.93 / 0.002095
MT3347 / - / Hypothetical protein / -1.78 / 2.27E-04
MT3290 / - / ABC transporter, ATP-binding protein, putative / 1.52 / 0.000874
MT3280 / - / Hypothetical protein / -1.51 / 0.01419
MT3275 / - / Hypothetical protein / 2.55 / 0.002717
MT3229 / - / Hypothetical protein / 1.61 / 0.003046
MT3210 / - / Hypothetical protein / -2.85 / 0.008453
MT3191 / - / Hypothetical protein / -2.53 / 0.014961
MT3174 / - / Substrate--coa ligase / 1.61 / 0.001932
MT3144 / - / Tetr family transcriptional regulator / -1.61 / 0.034102
MT3080 / - / ABC transporter, ATP-binding protein / 1.68 / 0.001741
MT2962 / xerC / Site-specific tyrosine recombinase xerc / -2.73 / 0.040108
MT2947 / - / Hypothetical protein / 1.63 / 0.000941
MT2885 / - / Hypothetical protein / -1.86 / 0.043875
MT2845 / - / Acetyltransferase / -1.68 / 0.042385
MT2424 / - / Hypothetical protein / -1.54 / 0.040431
MT2421 / - / Hypothetical protein / -1.73 / 0.020987
MT2283 / - / Hypothetical protein / 2.00 / 0.001235
MT2235 / - / Hypothetical protein / -1.74 / 0.031823
MT2165 / - / Hypothetical protein / 2.71 / 0.00199
MT2160 / - / Hypothetical protein / 1.71 / 0.020846
MT2159 / - / PE family-related protein / 1.57 / 0.002019
MT2079 / - / Hypothetical protein / 1.70 / 0.01193
MT2015 / - / Hypothetical protein / 2.32 / 0.006894
MT1975 / - / Hypothetical protein / -2.02 / 0.002751
MT1858 / - / Hypothetical protein / -1.70 / 0.03046
MT1759 / - / Hypothetical protein / 2.14 / 0.008467
MT1747 / - / Hypothetical protein / 2.48 / 0.042478
MT1548 / - / Hypothetical protein / -1.63 / 0.030753
MT1266 / - / Hypothetical protein / -1.59 / 0.00052
MT1213 / - / Hypothetical protein / -2.14 / 0.001515
MT1190 / - / Hypothetical protein / 1.66 / 0.001506
MT1181 / - / Hypothetical protein / 2.00 / 0.001919
MT1166 / - / Hypothetical protein / 1.56 / 0.02228
MT1075 / - / Hypothetical protein / 1.53 / 0.025243
MT0974 / - / Hypothetical protein / 1.55 / 0.024729
MT0774 / - / Hypothetical protein / 1.81 / 0.042088
MT0655 / - / Hypothetical protein / 1.92 / 0.001516
MT0653 / - / Hypothetical protein / 2.26 / 0.031056
MT0645 / - / Hypothetical protein / 2.39 / 0.019369
MT0600 / - / Hypothetical protein / -2.17 / 0.015289
MT0540 / - / Hypothetical protein / -1.57 / 0.042493
MT0471 / - / Hypothetical protein / -1.59 / 0.014131
MT0470 / - / Hypothetical protein / -1.51 / 0.000539
MT0036 / - / Hypothetical protein / 1.95 / 0.002873
Main Role Amino acid biosynthesis / MT3680 / - / Laci family transcription regulator / 1.53 / 0.00062
Main Role Biosynthesis of cofactor prosthetic groups and carriers / MT1196 / phhB / Pterin-4-alpha-carbinolamine dehydratase / -1.72 / 0.041749
MT0573 / menB / Naphthoate synthase / 2.47 / 0.009155
Mobile and extrachromosomal element functions / Rv3827c / - / Transposase / 1.91 / 0.035239
Rv3770A / - / Hypothetical protein / 1.86 / 0.038687
Rv2894c / xerC / Site-specific tyrosine recombinase xerc / -2.55 / 0.002112
Rv2820c / - / Hypothetical protein / 3.29 / 0.005138
Rv2792c / - / Resolvase / 1.67 / 0.028486
Rv2177c / - / Transposase / -1.61 / 0.000709
Rv1042c / - / IS like-2 transposase / 1.74 / 0.017569
Rv0920c / - / Transposase / -1.68 / 0.001045
MT2846 / - / Oxidoreductase / 1.68 / 0.001145
Protein fate / Rv3421c / - / Hypothetical protein / 1.83 / 0.004244
Rv3418c / groES / Co-chaperonin groes / 2.76 / 0.029805
Rv2674 / - / Hypothetical protein / -1.50 / 0.032746
Rv2586c / secF / Preprotein translocase subunit secf / -1.52 / 0.030993
Rv2110c / prcB / Proteasome (beta subunit) prcb / -2.03 / 0.010462
Rv2030c / - / Hypothetical protein / -5.72 / 0.00101
Rv1539 / lspA / Lipoprotein signal peptidase / 1.72 / 0.01838
Rv0950c / - / Hypothetical protein / -1.52 / 0.01344
Rv0693 / pqqE / Coenzyme PQQ synthesis protein E / -4.23 / 0.041212
Rv0457c / - / Peptidase / -1.81 / 0.000748
Rv0419 / lpqM / Lipoprotein peptidase lpqm / 1.75 / 0.000811
Rv0384c / clpB / Endopeptidase ATP binding protein / 1.50 / 0.039034
Rv3660c / - / Hypothetical protein / 1.86 / 0.002317
Rv3593 / lpqF / Lipoprotein lpqf / -1.72 / 0.000811
Rv2916c / ffh / Signal recognition particle protein / 1.87 / 0.001671
Protein synthesis / Rv3917c / parB / Chromosome partitioning protein parb / 1.56 / 0.001252
Rv3459c / rpsK / 30S ribosomal protein S11 / -1.89 / 0.037286
Rv2882c / frr / Ribosome recycling factor / -1.72 / 0.001339
Rv2118c / - / RNA methyltransferase / 1.98 / 0.036638
Rv2058c / rpmB / 50S ribosomal protein L28 / -1.50 / 0.041059
Rv2056c / rpsN / 30S ribosomal protein S14 / -1.60 / 0.033433
Rv1711 / - / Hypothetical protein / 1.58 / 0.035909
Rv1643 / rplT / 50S ribosomal protein L20 / -1.72 / 0.004904
Rv1536 / ileS / Isoleucyl-trna synthetase / -2.15 / 0.000755
Rv1530 / adh / Alcohol dehydrogenase adh / 2.98 / 0.012873
Rv1479 / moxR1 / Transcriptional regulatory protein MOXR1 / -1.78 / 0.011509
Rv1406 / fmt / Methionyl-trna formyltransferase / 1.97 / 0.003141
Rv0709 / rpmC / 50S ribosomal protein L29 / 1.80 / 0.020636
Rv0706 / rplV / 50S ribosomal protein L22 / 1.63 / 0.001954
Rv0703 / rplW / 50S ribosomal protein L23 / -1.56 / 0.046133
Rv0651 / rplJ / 50S ribosomal protein L10 / 1.81 / 0.014037
Rv0640 / rplK / 50S ribosomal protein L11 / -1.95 / 0.006204
Rv1640c / lysS / Lysyl-trna synthetase / -1.65 / 0.000937
Purines, pyrimidines, nucleosides, and nucleotides / MT0596 / - / Ribonucleoside-diphosphate reductase, alpha subunit, putative / -3.18 / 0.025902
Rv3313c / add / Adenosine deaminase / -1.71 / 0.000651
Rv3309c / upp / Uracil phosphoribosyltransferase / 1.93 / 0.00182
Rv3242c / - / Hypothetical protein / 1.64 / 0.00189
Rv3051c / nrdE / Ribonucleotide-diphosphate reductase subunit alpha / -2.51 / 0.018534
Rv2764c / thyA / Thymidylate synthase / -2.15 / 0.045304
Rv2716 / - / Hypothetical protein / -1.72 / 0.014975
Rv0570 / nrdZ / Ribonucleoside-diphosphate reductase large subunit nrdz / -3.64 / 0.029519
Rv0382c / pyrE / Orotate phosphoribosyltransferase / 1.69 / 0.002627
Regulatory functions / Rv3840 / - / Transcriptional regulatory protein / -1.75 / 0.039781
Rv3583c / - / Transcription factor / -1.77 / 0.012808
Rv3578 / arsB2 / Arsenical PUMP integral membrane protein arsb2 / 1.59 / 0.006062
Rv3575c / - / Transcriptional regulatory protein laci-family / 1.51 / 0.001568
Rv3454 / - / Integral membrane protein / -1.59 / 0.000878
Rv2884 / - / Transcriptional regulatory protein / -1.64 / 0.003274
Rv2745c / - / Transcriptional regulatory protein / 1.59 / 0.032808
Rv2374c / hrcA / Heat-inducible transcription repressor / 1.76 / 0.003094
Rv1719 / - / Transcriptional regulatory protein / 2.04 / 0.00204
Rv1534 / - / Transcriptional regulator / -1.90 / 0.000749
Rv0890c / - / Luxr family transcriptional regulator / 1.61 / 0.001085
Rv0757 / phoP / Two component system response transcriptional positive regulator PHOP / 1.56 / 0.002613
Rv0581 / - / Hypothetical protein / 1.94 / 0.018113
Rv0474 / - / Transcriptional regulatory protein / -1.78 / 0.015897
Rv0348 / - / Transcriptional regulatory protein / 2.04 / 0.04741
Rv0275c / - / Tetr family transcriptional regulator / 1.61 / 0.001059
Rv0238 / - / Tetr family transcriptional regulator / -1.91 / 0.000819
Rv0158 / - / Tetr family transcriptional regulator / -1.54 / 0.01312
Rv0144 / - / Tetr family transcriptional regulator / -1.53 / 0.021836
Rv0117 / oxyS / Oxidative stress response regulatory protein OXYS / 1.78 / 0.002679
Rv0081 / - / Transcriptional regulatory protein / -2.57 / 0.003658
MT3876 / - / Hypothetical protein / 1.57 / 0.001624
MT3612 / - / PE_PGRS family protein / 2.63 / 0.002452
MT3591 / - / Esterase / -1.86 / 0.001348
MT3135 / - / Hypothetical protein / -1.58 / 0.020356
MT1062 / trcR / DNA-binding response regulator trcr / 1.51 / 0.000837
MT0709 / - / Transcriptional regulator, putative / 1.52 / 0.000552
Rv3911 / sigM / RNA polymerase sigma factor sigm / 1.58 / 0.047633
Rv2640c / - / Arsr family transcriptional regulator / -1.51 / 0.037913
Rv0775 / - / Hypothetical protein / -1.68 / 0.029837
Transcription / Rv3920c / - / Hypothetical protein / -1.68 / 0.000715
Rv3414c / sigD / RNA polymerase sigma factor sigd / 2.00 / 0.022717
Rv3287c / rsbW / Anti-sigma factor rsbw (sigma negative effector) / 1.69 / 0.03769
Rv1297 / rho / Transcription termination factor Rho / -1.82 / 0.000684
MT3483 / - / Hypothetical protein / 1.61 / 0.001199
MT1435 / - / DNA-directed RNA polymerase subunit omega / -1.69 / 0.027823
Transport and binding proteins / Rv3758c / proV / Osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter PROV / -1.68 / 0.000745
Rv3728 / - / Hypothetical protein / 2.51 / 0.004356
Rv3253c / - / Cationic amino acid transport integral membrane protein / 1.67 / 0.003083
Rv2938 / drrC / Daunorubicin-DIM-transport integral membrane protein ABC transporter drrc / -2.23 / 0.032608
Rv2937 / drrB / Daunorubicin-DIM-transport integral membrane protein ABC transporter drrb / -1.72 / 0.036331
Rv2920c / amt / Ammonium transporter / -1.72 / 0.043647
Rv2564 / glnQ / Glutamine-transport ATP-binding protein ABC transporter glnq / 1.83 / 0.035511
Rv2510c / - / Hypothetical protein / 1.54 / 0.027225
Rv2459 / - / Integral membrane transport protein / -1.92 / 0.027309
Rv2399c / cysT / Sulfate-transport integral membrane protein ABC transporter cyst / -2.29 / 0.036733
Rv2320c / rocE / Cationic amino acid transport integral membrane protein roce / -1.51 / 0.037825
Rv2287 / yjcE / Integral membrane transport protein yjce / 1.56 / 0.001499
Rv2040c / - / Sugar-transport integral membrane protein ABC transporter / -2.63 / 0.000592
Rv1997 / ctpF / Metal cation transporter P-type atpase A ctpf / -2.21 / 0.030973
Rv1986 / - / Integral membrane protein / -1.59 / 0.000611
Rv1819c / - / Drugs-transport transmembrane ATP-binding protein ABC transporter / -1.78 / 0.017238
Rv1704c / cycA / D-serine/alanine/glycine transporter protein cyca / -2.25 / 0.047484
Rv1250 / - / Drug-transport integral membrane protein / 1.52 / 0.003418
Rv1218c / - / Tetronasin-transport ATP-binding protein ABC transporter / 1.86 / 0.002298
Rv0986 / - / Adhesion component transport ATP-binding protein ABC transporter / -1.51 / 0.048237
Rv0934 / pstS1 / Periplasmic phosphate-binding lipoprotein PSTS1 (PBP-1) (PSTS1) / -1.57 / 0.025778
Rv0362 / mgtE / Mg2+ transport transmembrane protein mgte / 1.55 / 0.040687
Rv0126 / treS / Trehalose synthase TRES / -1.60 / 0.034199
Rv0103c / ctpB / Cation-transporter P-type atpase B / -1.75 / 0.001335
MT3817 / - / Hypothetical protein / 2.89 / 6.53E-04
MT3279 / - / Hypothetical protein / 1.53 / 0.001007
MT3022 / - / Hypothetical protein / -1.77 / 0.006185
Unclassified Role category not yet assigned / Rv3874 / esxB / 10 kda culture filtrate antigen esxb / -1.51 / 0.049504
Rv3873 / PPE68 / PPE family protein / -1.54 / 0.046929
Rv3824c / papA1 / Polyketide synthase associated protein / -2.12 / 0.023874
Rv3822 / - / Hypothetical protein / -1.57 / 0.000591
Rv3793 / embC / Integral membrane indolylacetylinositol arabinosyltransferase embc (arabinosylindolylacetylinositol synthase) / 1.83 / 0.027487
Rv3783 / rfbD / O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter rfbd / -1.75 / 0.000745
Rv3759c / proX / Osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein PROX / -1.65 / 0.036157
Rv3745c / - / Hypothetical protein / 1.52 / 0.000995
Rv3738c / PPE66 / PPE family protein / -1.69 / 0.00081
Rv3684 / - / Lyase / -1.60 / 0.035616
Rv3653 / PE_PGRS61 / PE-PGRS family-related protein / 2.23 / 0.010465
Rv3623 / lpqG / Lipoprotein lpqg / 1.72 / 0.003113
Rv3620c / esxW / Putative ESAT-6 like protein ESXW (ESAT-6 like protein 10) / -1.50 / 0.001287
Rv3590c / PE_PGRS58 / PE-PGRS family protein / 2.81 / 0.032588
Rv3545c / cyp125 / Cytochrome P450 125 / -1.52 / 0.001523
Rv3518c / cyp142 / Cytochrome P450 monooxygenase 142 / -1.86 / 0.046637
Rv3516 / echA19 / Enoyl-coa hydratase / 1.51 / 0.002352
Rv3514 / PE_PGRS57 / PE-PGRS family protein / 2.73 / 0.013242
Rv3510c / - / Hypothetical protein / 1.60 / 0.042524
Rv3508 / PE_PGRS54 / PE-PGRS family protein / 1.86 / 0.001176
Rv3504 / fadE26 / Acyl-coa dehydrogenase FADE26 / 1.66 / 0.015518
Rv3478 / PPE60 / PE family protein / -1.69 / 0.039526
Rv3429 / PPE59 / PPE family protein / -1.73 / 0.048083
Rv3388 / PE_PGRS52 / PE-PGRS family protein / 3.07 / 0.009725
Rv3374 / echA18.1 / Enoyl-coa hydratase / 1.50 / 0.000727
Rv3364c / - / Hypothetical protein / -1.70 / 0.046649
Rv3295 / - / Tetr family transcriptional regulator / -1.55 / 0.018703
Rv3290c / lat / L-lysine aminotransferase / -2.91 / 0.014266
Rv3278c / - / Transmembrane protein / 2.45 / 0.037843
Rv3249c / - / Tetr family transcriptional regulator / -1.74 / 0.017302
Rv3229c / - / Linoleoyl-coa desaturase / -1.92 / 0.04069
Rv3209 / - / Hypothetical protein / 1.68 / 0.000918
Rv3194c / - / Hypothetical protein / 1.57 / 0.001096
Rv3193c / - / Hypothetical protein / -1.50 / 0.033914
Rv3158 / nuoN / NADH dehydrogenase subunit N / -1.76 / 0.007151
Rv3155 / nuoK / NADH dehydrogenase subunit K / -3.14 / 0.000883
Rv3152 / nuoH / NADH dehydrogenase subunit H / -5.54 / 0.025969
Rv3150 / nuoF / NADH dehydrogenase I chain F / -2.69 / 0.046978
Rv3145 / nuoA / NADH dehydrogenase subunit A / -2.77 / 0.048435
Rv3133c / devR / Two component transcriptional regulatory protein devr / -3.61 / 7.25E-04
Rv3130c / tgs1 / Triacylglycerol synthase / -4.62 / 0.014554
Rv3088 / - / Hypothetical protein / 1.58 / 0.014822
Rv3084 / lipR / Acetyl-hydrolase/esterase lipr / 2.55 / 0.031192
Rv3075c / - / Hypothetical protein / 2.34 / 0.021444
Rv3064c / - / Integral membrane protein / -1.68 / 0.001382
Rv3053c / nrdH / Glutaredoxin electron transport protein nrdh / -1.68 / 0.024255
Rv3036c / TB22.2 / Hypothetical protein / -1.71 / 0.047651
Rv3016 / lpqA / Lipoprotein lpqa / -1.50 / 0.012836
Rv2958c / - / Glycosyl transferase / 2.42 / 0.011343
Rv2956 / - / Hypothetical protein / -1.84 / 0.040594
Rv2949c / - / Hypothetical protein / -2.03 / 0.048098
Rv2945c / lppX / Lipoprotein lppx / -1.84 / 0.03955
Rv2940c / mas / Multifunctional mycocerosic acid synthase membrane-associated MAS / 1.57 / 0.014802
Rv2935 / ppsE / Phenolpthiocerol synthesis type-I polyketide synthase PPSE / -2.47 / 0.025132
Rv2931 / ppsA / Phenolpthiocerol synthesis type-I polyketide synthase PPSA / -1.73 / 0.033808
Rv2912c / - / Tetr family transcriptional regulator / 1.92 / 0.00469
Rv2879c / - / Hypothetical protein / 1.56 / 0.01915
Rv2875 / mpt70 / Major secreted immunogenic protein MPT70 / -1.99 / 0.01051
Rv2873 / mpt83 / Cell surface lipoprotein mpt83 (lipoprotein P23) / -2.41 / 0.011667
Rv2853 / PE_PGRS48 / PE-PGRS family protein / 1.56 / 0.014543
Rv2741 / PE_PGRS47 / PE-PGRS family protein / 1.96 / 0.01561
Rv2691 / ceoB / TRK system potassium uptake protein CEOB / -1.85 / 0.000981
Rv2676c / - / Hypothetical protein / -1.64 / 0.005916
Rv2638 / - / Hypothetical protein / 1.68 / 0.005696
Rv2634c / PE_PGRS46 / PE-PGRS family protein / 2.60 / 0.005012
Rv2630 / - / Hypothetical protein / -2.98 / 0.000515
Rv2626c / - / Hypothetical protein / -2.31 / 0.000674
Rv2616 / - / Hypothetical protein / 1.52 / 0.001549
Rv2608 / PPE42 / PPE family protein / -2.89 / 0.001363
Rv2600 / - / Integral membrane protein / -2.57 / 0.001418
Rv2590 / fadD9 / Fatty-acid-coa ligase / -1.70 / 3.66E-04
Rv2519 / PE26 / PE family protein / -2.09 / 0.000747
Rv2498c / citE / Citrate (Pro-3S)-lyase beta subunit / 2.05 / 0.031718
Rv2497c / pdhA / Pyruvate dehydrogenase E1 component alpha subunit pdha / 1.52 / 0.017054
Rv2495c / pdhC / Branched-chain alpha-keto acid dehydrogenase subunit E2 / -1.70 / 0.000779
Rv2411c / - / Hypothetical protein / -1.65 / 0.012486
Rv2409c / - / Hypothetical protein / -1.91 / 0.019311
Rv2393 / - / Hypothetical protein / -1.62 / 0.000603
Rv2392 / cysH / Phosphoadenosine phosphosulfate reductase / -1.71 / 0.029732
Rv2378c / mbtG / Lysine-N-oxygenase MBTG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase) / 1.73 / 0.002062
Rv2371 / PE_PGRS40 / PE-PGRS family protein / 1.83 / 0.001192
Rv2331 / - / Hypothetical protein / -1.56 / 0.022582
Rv2328 / PE23 / PE family protein / 1.79 / 0.002457
Rv2307c / - / Hypothetical protein / 1.93 / 0.001122
Rv2268c / cyp128 / Cytochrome P450 128 / -2.35 / 0.000952
Rv2238c / ahpE / Peroxiredoxin ahpe / 1.63 / 0.019989
Rv2229c / - / Hypothetical protein / 1.65 / 0.00613
Rv2221c / glnE / Glutamate-ammonia-ligase adenylyltransferase GLNE (glutamine-synthetase adenylyltransferase) / 1.62 / 0.024205
Rv2140c / TB18.6 / Hypothetical protein / -1.65 / 0.000899
Rv2127 / ansP1 / L-asparagine permease ansp1 / -1.68 / 0.037682
Rv2102 / - / Hypothetical protein / 1.52 / 0.000637
Rv2047c / - / Hypothetical protein / -2.30 / 0.000855
Rv2031c / hspX / Heat shock protein hspx / -3.21 / 0.018209
Rv2022c / - / Hypothetical protein / -2.91 / 0.000829
Rv1988 / - / Methyltransferase / -1.86 / 0.00163
Rv1945 / - / Hypothetical protein / 1.94 / 0.001795
Rv1866 / - / Hypothetical protein / -2.13 / 0.027511
Rv1818c / PE_PGRS33 / PE-PGRS family protein / 1.82 / 0.000922
Rv1816 / - / Transcriptional regulatory protein / -2.42 / 0.000793
Rv1813c / - / Hypothetical protein / -2.33 / 0.016214
Rv1809 / PPE33 / PPE family protein / -1.66 / 0.025613
Rv1808 / PPE32 / PPE family protein / -1.65 / 0.000797
Rv1802 / PPE30 / PPE family protein / -2.20 / 0.016639
Rv1787 / PPE25 / PPE family protein / -1.53 / 0.001283
Rv1785c / cyp143 / Cytochrome P450 143 / 1.76 / 0.027769
Rv1759c / wag22 / PE-PGRS family protein / 2.15 / 0.002121
Rv1753c / PPE24 / PPE family protein / -1.51 / 0.034921
Rv1749c / - / Integral membrane protein / 1.60 / 0.045481
Rv1706c / PPE23 / PPE family protein / -1.97 / 0.018651
Rv1705c / PPE22 / PPE family protein / -2.36 / 0.026875
Rv1703c / - / Catechol-o-methyltransferase / -1.52 / 0.037761
Rv1631 / coaE / Dephospho-coa kinase/unknown domain fusion protein / -1.57 / 0.006021
Rv1615 / - / Hypothetical protein / -1.57 / 0.026177
Rv1593c / - / Hypothetical protein / -1.86 / 0.007695
Rv1466 / - / Hypothetical protein / 1.50 / 0.040207
Rv1450c / PE_PGRS27 / PE-PGRS family protein / 1.78 / 0.027752
Rv1425 / - / Hypothetical protein / -1.56 / 0.000771
Rv1397c / - / Hypothetical protein / -1.81 / 0.019711
Rv1396c / PE_PGRS25 / PE-PGRS family protein / 2.37 / 0.002356
Rv1393c / - / Monoxygenase / -1.63 / 0.028715
Rv1325c / PE_PGRS24 / PE-PGRS family protein / 2.15 / 0.008767
Rv1305 / atpE / F0F1 ATP synthase subunit C / -1.78 / 0.014587
Rv1243c / PE_PGRS23 / PE-PGRS family protein / 3.22 / 0.030319
Rv1238 / sugC / Sugar-transport ATP-binding protein ABC transporter sugc / -1.82 / 0.044208
Rv1185c / fadD21 / Acyl-coa synthetase / -2.18 / 0.033359
Rv1184c / - / Hypothetical protein / -1.88 / 0.019482
Rv1182 / papA3 / Polyketide synthase associated protein papa3 / -1.74 / 0.020518
Rv1181 / pks4 / Polyketide beta-ketoacyl synthase PKS4 / -1.58 / 0.015304
Rv1173 / fbiC / FO synthase / -1.64 / 0.0276
Rv1148c / - / Hypothetical protein / 1.73 / 0.003033
Rv1117 / - / Hypothetical protein / 1.59 / 0.000626
Rv1095 / phoH2 / Phoh-like protein phoh2 (phosphate starvation-inducible protein psih) / -1.53 / 0.027281
Rv1091 / PE_PGRS22 / PE-PGRS family protein / 2.36 / 0.017532
Rv1087 / PE_PGRS21 / PE-PGRS family protein / 1.52 / 0.009571
Rv1067c / PE_PGRS19 / PE-PGRS family protein / 1.97 / 0.022209
Rv1039c / PPE15 / PPE family protein / 1.69 / 0.00427
Rv1017c / prsA / Ribose-phosphate pyrophosphokinase / -1.55 / 0.000617
Rv0975c / fadE13 / Acyl-coa dehydrogenase FADE13 / 2.00 / 0.001789
Rv0937c / - / Hypothetical protein / -1.70 / 0.001186
Rv0888 / - / Hypothetical protein / -1.76 / 0.00187
Rv0880 / - / Marr family transcriptional regulator / 2.11 / 0.020008
Rv0872c / PE_PGRS15 / PE-PGRS family protein / 1.66 / 0.001094
Rv0868c / moaD2 / Molybdenum cofactor biosynthesis protein D / -1.50 / 0.020226
Rv0834c / PE_PGRS14 / PE-PGRS family protein / 1.54 / 0.047795
Rv0792c / - / Gntr family transcriptional regulator / 1.57 / 0.016167
Rv0747 / PE_PGRS10 / PE-PGRS family protein / 2.22 / 0.016009
Rv0671 / lpqP / Lipoprotein lpqp / 1.69 / 0.039742
Rv0661c / - / Hypothetical protein / -1.62 / 0.000738
Rv0571c / - / Hypothetical protein / -2.89 / 0.001228
Rv0567 / - / Methyltransferase/methylase / -2.21 / 0.000958
Rv0566c / - / Putative nucleotide-binding protein / 1.62 / 0.001994
Rv0549c / - / Hypothetical protein / 1.74 / 0.001173
Rv0536 / galE3 / UDP-glucose 4-epimerase / 1.93 / 0.001263
Rv0529 / ccsA / Cytochrome C-type biogenesis protein ccsa / -1.93 / 0.000709
Rv0501 / galE2 / UDP-glucose 4-epimerase / -1.57 / 0.029996
Rv0458 / - / Aldehyde dehydrogenase / 2.57 / 0.044619
Rv0413 / mutT3 / 7,8-dihydro-8-oxoguanine-triphosphatase / 3.68 / 0.031014
Rv0351 / grpE / GRPE protein (HSP-70 cofactor) / 1.54 / 0.026624
Rv0350 / dnaK / Molecular chaperone dnak / 1.52 / 0.042999
Rv0346c / ansP2 / L-asparagine ABC transporter permease / -1.74 / 0.012812
Rv0335c / PE6 / PE family protein / 1.60 / 0.002486
Rv0297 / PE_PGRS5 / PE-PGRS family protein / 2.07 / 0.021707
Rv0286 / PPE4 / PPE family protein / -1.92 / 0.033344
Rv0284 / - / Hypothetical protein / -1.58 / 0.036283
Rv0280 / PPE3 / PPE family protein / -1.69 / 0.036383
Rv0253 / nirD / Nitrite reductase [NAD(P)H] small subunit nird / -1.63 / 0.027261
Rv0229c / - / Hypothetical protein / -2.00 / 0.004096
Rv0221 / - / Hypothetical protein / -1.59 / 0.001319
Rv0172 / mce1D / MCE-family protein MCE1D / -4.22 / 0.010223
Rv0171 / mce1C / MCE-family protein MCE1C / -2.33 / 0.000578
Rv0131c / fadE1 / Acyl-coa dehydrogenase FADE1 / -2.16 / 0.046563
Rv0118c / oxcA / Putative oxalyl-coa decarboxylase / -1.71 / 0.001417
Rv0112 / gca / GDP-mannose 4,6-dehydratase / -2.36 / 0.030343
Rv0110 / - / Integral membrane protein / -1.68 / 0.002521
Rv0100 / - / Hypothetical protein / 1.72 / 0.000801
Rv0044c / - / Oxidoreductase / -2.04 / 0.000743
Rv0016c / pbpA / Penicillin-binding protein pbpa / -1.61 / 0.026429
Unknown function / Rv3919c / gidB / 16S rrna methyltransferase gidb / 1.65 / 0.039178
Rv3892c / PPE69 / PPE family protein / 1.58 / 0.001849
Rv3755c / - / Hypothetical protein / -1.75 / 0.029033
Rv3669 / - / Transmembrane protein / -1.51 / 0.039556
Rv3638 / - / Transposase / 2.03 / 0.001398
Rv3547 / - / Hypothetical protein / -2.20 / 0.049825
Rv3362c / - / ATP/GTP-binding protein / -1.72 / 0.016488
Rv3320c / - / Hypothetical protein / -1.74 / 0.033815
Rv3260c / whiB2 / Transcriptional regulatory protein WHIB-like WHIB2 / 1.60 / 0.008219
Rv2966c / - / Methyltransferase (methylase) / -1.66 / 0.001246
Rv2923c / - / Hypothetical protein / 1.60 / 0.000615
Rv2602 / - / Hypothetical protein / -1.58 / 0.026382
Rv2566 / - / Hypothetical protein / -3.07 / 0.000735
Rv2431c / PE25 / PE family protein / -1.81 / 0.010882
Rv2267c / - / Hypothetical protein / -2.05 / 0.001001
Rv2166c / - / Cell division protein mraz / -2.05 / 0.049779
Rv2120c / - / Integral membrane protein / -1.58 / 0.001028
Rv2117 / - / Hypothetical protein / 1.74 / 0.00099
Rv2111c / - / Hypothetical protein / 1.58 / 0.010144
Rv1804c / - / Hypothetical protein / -2.64 / 0.030081
Rv1798 / - / Hypothetical protein / -1.60 / 0.030501
Rv1670 / - / Hypothetical protein / 1.57 / 0.000842
Rv1619 / - / Hypothetical protein / -3.27 / 0.001736
Rv1262c / - / HIT-like protein / -1.68 / 0.001236
Rv1242 / - / Hypothetical protein / 1.93 / 0.013045
Rv1112 / - / GTP-dependent nucleic acid-binding protein engd / 1.76 / 0.002484
Rv1099c / glpX / Fructose 1,6-bisphosphatase II / -1.71 / 0.003111
Rv1078 / pra / Proline-rich antigen / 2.01 / 0.010208
Rv0839 / - / Hypothetical protein / -1.79 / 0.04666
Rv0726c / - / Hypothetical protein / -1.57 / 0.002528
Rv0617 / - / Hypothetical protein / 1.52 / 0.034807
Rv0440 / groEL / Chaperonin groel / 3.19 / 0.024069
Rv0379 / secE2 / Protein transport protein / 1.57 / 0.001058
Rv0281 / - / Hypothetical protein / -1.55 / 0.011983
Rv0140 / - / Hypothetical protein / -1.51 / 0.047267
MT3583 / - / Hypothetical protein / -2.28 / 0.001928
MT3413 / - / Hypothetical protein / -1.85 / 0.045867
MT2867 / - / Hypothetical protein / 1.78 / 0.002098
MT2096 / - / Hypothetical protein / -1.61 / 0.006466
MT1839 / - / PPE family protein / 1.57 / 0.003931
MT1300 / - / HIT family protein / -1.90 / 0.00082
MT0311 / - / PE_PGRS family protein / 2.28 / 0.016215
MT0292 / - / PPE family protein / -1.72 / 0.034063
MT0132 / - / PE_PGRS family protein / 3.02 / 0.029847

aFold change refers to expression increases or decreases for upregulated or downregulated genes, respectively.