Role of FKBP5 in emotion processing: Results from a 25-year prospective study on amygdala activity, connectivity and volume
Brain Structure and Function
Nathalie Holz1, Arlette F. Buchmann1,Regina Boecker1, Dorothea Blomeyer1, Sarah Baumeister1, Isabella Wolf1,2, Marcella Rietschel3, Stephanie H. Witt3, Michael M. Plichta4, Andreas Meyer-Lindenberg4, Tobias Banaschewski1, Daniel Brandeis1, 5, Manfred Laucht1, 6
Central Institute of Mental Health, Medical Faculty Mannheim / Heidelberg University, J5, 68159 Mannheim, Germany, 1Department of Child and Adolescent Psychiatry and Psychotherapy, 2Department of Neuroimaging, 3Department of Genetic Epidemiology in Psychiatry, 4Department of Psychiatry and Psychotherapy; 5Department of Child and Adolescent Psychiatry, University of Zurich, Neumünsterallee 9, 8032 Zürich, Switzerland; 6Department of Psychology, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476 Potsdam OT Golm, Germany
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Supplemental Table 7.Functional connectivity between the right amygdala and the whole brain depending on the interaction involving FKBP5 genotype and different childhood adversity measures for the contrast faces > shapes (puncorr=.001, 5 adjacent voxels).
Region / BA / Hemisphere / Cluster Size / MNI coordinates / t-value / p (uncorr.)x / y / z
Decreasing coupling in TT genotype with increasing CTQ emotional neglect, opposite pattern in CC genotype
Calcarine / L / 10 / -14 / -56 / 6 / 3.37 / <.001a
Increasing coupling in TT genotype with increasing CTQ total, opposite pattern in CC genotype
Cerebellum / R / 52 / 20 / -62 / -42 / 3.91 / <.001b
R / 49 / 8 / -52 / -32 / 3.68 / <.001
Decreasing coupling in TT genotype with increasing CTQ total, opposite pattern in CC genotype
Thalamus / 47 / R / 91 / 2 / -12 / 14 / 3.75 / <.001c
Inferior Occipital Gyrus / 18 / R / 6 / 26 / -94 / -2 / 3.23 / .001
Decreasing coupling in TT genotype with increasing CFA, opposite pattern in CC genotype
Superior Temporal Gyrus / 38 / L / 6 / -50 / 12 / -22 / 3.33 / .001d
Precuneus / 31 / L / 62 / -14 / -64 / 34 / 3.28 / .001
Note: CTQ= Childhood Trauma Questionnaire, CFA= childhood family adversity
Exemplary figures showing the interaction patterns of a) FKBP5 x CTQ EN on amygdala-calcerine, b) FKBP5 x CTQ on amygdala-cerebellum, c)FKBP5 x CTQ on amygdala-thalamus, d) FKBP5 x CFA on amygdala-superior temporal gyrus coupling.
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d)