Authors

Jennifer Murphy, Ph.D. (Department of Neurology, UCSF, primary and corresponding author); Pam Factor-Litvak, Ph.D. (Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center (CUMC), co-PI and planning, statistical analyses as well as analyses of biomarkers, exposures, and cognition. She also prepared drafts of the manuscript); Raymond R Goetz, Ph.D. (Department of Psychiatry, New York State Psychiatric Institute & CUMC, lead general statistical analyses in addition to preparing drafts of the manuscript); Cathy Lomen-Hoerth, M.D., Ph.D. (Department of Neurology, UCSF, site investigator for the University of California San Francisco and planning the study, data collection, and reviewing the manuscript); Peter L. Nagy, M.D. Ph.D. (Columbia University Medical Center (CUMC), analyses of biomarkers in addition to reviewing the manuscript);

Jon Hupf, MA (Eleanor and Lou Gehrig MD/ALS Research Center, Department of Neurology, CUMC, planning and coordination of the study, data collection, and reviewing the manuscript); Jess Singleton, MA (Eleanor and Lou Gehrig MD/ALS Research Center, Department of Neurology, CUMC, coordination of the study, data collection, and reviewing the manuscript);Susan Woolley, Ph.D. (California Pacific Medical Center, San Francisco, CA, planning of the cognitive analyses and in reviewing the manuscript); Howard Andrews, Ph.D. (Departments of Biostatistics and Psychiatry, Mailman School of Medicine, CUMC,data management for the entire study and reviewing the manuscript); DaraghHeitzman, M.D. (Texas Neurology, P.A., Dallas, TX, site investigator at Texas Neurology in Dallas, Texas and planning the study, patient evaluations, data collection and data analysis and serving as the Databank and Biobank Committee Chairperson); Richard S. Bedlack, M.D. Ph.D. M.S. (Duke University, Durham, NC, site investigator for DukeUniversity, and planning the study, data collection, and reviewing the manuscript); Jonathan S. Katz, M.D. (California Pacific Medical Center, San Francisco, CA and site investigator at California Pacific Medical Center and reviewing the manuscript); Richard J. BarohnM.D., Ph.D. (Department of Neurology, University of Kansas, site investigator for the University of Kansas and planning of the study, data collection, and reviewing the manuscript); Eric J. Sorenson, M.D. (Mayo Clinic, Rochester, MN,site investigator for Mayo clinic, Rochester, and planning of the study, data collection,statistical analysis and reviewing the manuscript); BjörnOskarsson, M.D. (University of California, Davis, Sacramento, CA,site investigator for University of California, Davis, and planning of the study, data collection,statistical analysis and reviewing the manuscript); J Americo M. FernandesFilho, M.D. (University of Nebraska Medical Center, Omaha, NE, publication committee of the project and reviewed the manuscript); Edward J. Kasarskis, M.D. Ph.D. (University of Kentucky, Lexington, KY,site investigator for University of Kentucky and planning the study, data collection, and reviewing the manuscript); TahseenMozaffar, M.D. Ph.D. (University of California, Irvine, Orange, CA,site investigator for University of California, Irvine and data collection and reviewing the manuscript); Yvonne Rollins, M.D., Ph.D. (University of Colorado Denver, Aurora, site investigator, data collection); Sharon P. Nations, M.D. (University of Texas - Southwestern, Dallas, TX, site investigator for University of Texas, Southwestern and planning of the study, data collection, and reviewing the manuscript);Andrea J. Swenson, M.D. (University of Iowa, Iowa City, IA, site investigator for University of Iowa Hospitals and Clinics and subject recruitment); Boguslawa A. Koczon-Jaremko, M.D. (Hospital for Special Care, New Britain, CT,site investigator for Hospital for Special Care, New Britain, CT, and data collection, and reviewing the manuscript); Hiroshi Mitsumoto, M.D. (Eleanor and Lou Gehrig MD/ALS Research Center, Department of Neurology, CUMC, served as the primary investigator for this study. He was involved in all stages of this project, data collection, analyses, and preparing the draft of the manuscript).

ALS COSMOS Study Group: Co-Investigators

Christa Campanella, B.S. (Columbia University Coordinating Center, New York, NY,Co-Investigator), David Merle, BS (Columbia University Coordinating Center, New York, NY,Co-Investigator), Tejal Shah, BS (Columbia University Coordinating Center, New York, NY,Co-Investigator), Meredith Pasmantier Kim, B.A. (Columbia University Coordinating Center, New York, NY,Co-Investigator), Yei-Won Lee, B.A. (Columbia University Coordinating Center, New York, NY,Co-Investigator), Georgia Christodoulou, M.A. (Columbia University Coordinating Center, New York, NY,Co-Investigator), Kate Dalton, M.S. (Columbia University Coordinating Center, New York, NY,Co-Investigator), RD, Jessica Kidd, B.A. (Columbia University Coordinating Center, New York, NY,Co-Investigator), Erin Gilbert, B.A. (Columbia University Coordinating Center, New York, NY,Co-Investigator), Mary Kilty, MBA, MPH (Columbia University Coordinating Center, New York, NY,Co-Investigator);Wendy Rodriguez, NRCMA (Texas Neurology, P.A., Dallas, TX,Co-Investigator), Shari Hand, B.S., CCRC (Texas Neurology, P.A., Dallas, TX,Co-Investigator), Michelle Washington, NRCMA (Texas Neurology, P.A., Dallas, TX,Co-Investigator), Brent Spears, B.S., CCRC (Texas Neurology, P.A., Dallas, TX,Co-Investigator), Brandie Burson, NRCMA (Texas Neurology, P.A., Dallas, TX,Co-Investigator);. Karen Grace, RN, BSN (Duke University, Durham, NC,Co-Investigator), Candace Boyette, RN, FNP (Duke University, Durham, NC,Co-Investigator); Robert G. Miller, M.D. (California Pacific Medical Center, San Francisco, CA,Co-Investigator), Dallas Forshew, RN, BSN (California Pacific Medical Center, San Francisco, CA,Co-Investigator), Joni Beemsterboer, M.P.H. (California Pacific Medical Center, San Francisco, CA,Co-Investigator), Will Harris, B.A. (California Pacific Medical Center, San Francisco, CA,Co-Investigator), Shelley McCoy, B.S. (California Pacific Medical Center, San Francisco, CA,Co-Investigator), Thaïs Zayas-Bazan, B.A. (California Pacific Medical Center, San Francisco, CA,Co-Investigator), Chow Saephanh, B.A. (California Pacific Medical Center, San Francisco, CA,Co-Investigator);April L. McVey, M.D. (University of Kansas, Kansas City, KS,Co-Investigator), Mazen M. Dimachkie, M.D., (University of Kansas, Kansas City, KS,Co-Investigator),MamathaPasnoor, M.D. (University of Kansas, Kansas City, KS,Co-Investigator), Yunxia Wang, M.D. (University of Kansas, Kansas City, KS,Co-Investigator), Lowell L. Tilzer, M.D., Ph.D., (University of Kansas, Kansas City, KS,Co-Investigator) Maureen Walsh, B.S. (University of Kansas, Kansas City, KS,Co-Investigator), Laura Herbelin, B.S., CCRP (University of Kansas, Kansas City, KS,Co-Investigator), Christian Pearson, B.S. (University of Kansas, Kansas City, KS,Co-Investigator), Joe Sibinski, B.A. (University of Kansas, Kansas City, KS,Co-Investigator), Kristy Anderson (University of Kansas, Kansas City, KS,Co-Investigator); Sherry Klingerman, CCRP (Mayo Clinic, Rochester, MN,Co-Investigator), Delana Weis, LPN, CCRP (Mayo Clinic, Rochester, MN,Co-Investigator);Nanette Joyce, D.O, M.A.S. (University of California, Davis, Sacramento, CA,Co-Investigator), Steffany Lim, B.S., CCRP (University of California, Davis, Sacramento, CA,Co-Investigator), Michelle Cregan, CRA (University of California, Davis, Sacramento, CA,Co-Investigator);Kathie Vanderpool, RN, B.S. (University of Kentucky, Lexington, KY,Co-Investigator), Deborah Taylor, M.S. (University of Kentucky, Lexington, KY,Co-Investigator), Samantha Thomas, M.S. (University of Kentucky, Lexington, KY,Co-Investigator), Jason King, M.S. (University of Kentucky, Lexington, KY,Co-Investigator), Robert Wells, CCRP (University of Kentucky, Lexington, KY,Co-Investigator);Y-Nhy Duong, B.A. (University of California, San Francisco, San Francisco, CA,Co-Investigator), Dennis Robins, B.A. (University of California, San Francisco, San Francisco, CA,Co-Investigator), Claudia Villerme, M.Ed. (University of California, San Francisco, San Francisco, CA,Co-Investigator);Yvonne D. Rollins, M.D., Ph.D. (University of Colorado Denver, Aurora, CO,Co-Investigator), Steven P. Ringel, M.D. (University of Colorado Denver, Aurora, CO,Co-Investigator), Dianna Quan, M.D. (University of Colorado Denver, Aurora, CO,Co-Investigator), Elizabeth Whitethorn, B.S. (University of Colorado Denver, Aurora, CO,Co-Investigator);Annabel K. Wang, M.D. (University of California, Irvine, Orange, CA,Co-Investigator), Veronica Martin, B.A. (University of California, Irvine, Orange, CA,Co-Investigator), Brian Minton, B.S., B.A. (University of California, Irvine, Orange, CA,Co-Investigator), Patricia Tully, FNP (University of California, Irvine, Orange, CA,Co-Investigator), Denise Davis (University of California, Irvine, Orange, CA,Co-Investigator);PariwatThaisetthawatkul, M.D. (University of Nebraska Medical Center, Omaha, NE,Co-Investigator), Cindy Cowardin, RN, BSN, CCRP (University of Nebraska Medical Center, Omaha, NE,Co-Investigator), Russell Herstein, B.A., (University of Nebraska Medical Center, Omaha, NE,Co-Investigator)Carolyn Peterson, BSN, RN, CCRC (University of Nebraska Medical Center, Omaha, NE,Co-Investigator);DeconteeJimmeh-Fletcher, M.D. (University of Iowa, Iowa City, IA,Co-Investigator),HeenaOlalde, RN, MSN (University of Iowa, Iowa City, IA,Co-Investigator), Jeri Sieren, RN (University of Iowa, Iowa City, IA,Co-Investigator);Jeffrey Elliott, M.D. (University of Texas - Southwestern, Dallas, TX,Co-Investigator), Jaya Trivedi, M.D., (University of Texas - Southwestern, Dallas, TX,Co-Investigator) Nina Gorham, CCRP (University of Texas - Southwestern, Dallas, TX,Co-Investigator); Jeremy M. Shefner, M.D., Ph.D. (SUNY - Upstate Medical University, Syracuse, NY,Co-Investigator), Mary Lou Watson, B.A., RRT, CCRP (SUNY - Upstate Medical University, Syracuse, NY,Co-Investigator), Jennifer Moore (SUNY - Upstate Medical University, Syracuse, NY,Co-Investigator), Katie Markis, B.A., CCRP (SUNY - Upstate Medical University, Syracuse, NY,Co-Investigator), Megan Grosso, RPA-C, DPT, PT (SUNY - Upstate Medical University, Syracuse, NY,Co-Investigator);Jinsy A. Andrews, M.D. (Hospital for Special Care, New Britain, CT,Co-Investigator), M.S., Agnes Koczon-Jaremko, M.D., (Hospital for Special Care, New Britain, CT,Co-Investigator) Janet Bowen, B.A., CRT (Hospital for Special Care, New Britain, CT,Co-Investigator).