Supplementary Data Table 1Tests of Interaction between effects of Race andNMR-derived lipoproteins in multiple linear regression analysis of different measures of Pulse Wave Velocity

Supplementary Data Table 2Association between HDL subclasses and carotid-femoral, brachial-ankle and femoral-ankle pulse wave velocities after further adjusting for LDL-P

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Supplementary Data Table 1. Tests of Interaction between effects of Race and NMR-derived lipoproteins in multiple linear regression analysis of different measures of Pulse Wave Velocity (p-values for the test of interaction between race and respective NMR-lipoprotein)
VLDL / LDL / HDL
VLDL-P / Large VLDL-P / Medium VLDL-P / Small VLDL-P / LDL-P / Large LDL-P / Medium-Small LDL-P / Intermed-iate DL-P / HDL-P / Large HDL-P / Medium HDL-P / Small HDL-P
cfPWV / 0.925 / 0.926 / 0.988 / 0.879 / 0.609 / 0.784 / 0.513 / 0.151 / 0.049* / 0.099 / 0.103 / 0.553
baPWV / 0.162 / 0.914 / 0.125 / 0.625 / 0.985 / 0.127 / 0.815 / 0.326 / 0.005* / 0.104 / 0.090 / 0.360
faPWV / 0.200 / 0.554 / 0.087 / 0.766 / 0.833 / 0.031* / 0.220 / 0.981 / 0.289 / 0.619 / 0.717 / 0.508
Interaction tests were performed unadjusted for any other covariate in the study
*Indicates p<0.05

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Supplementary Data Table 2. Association between HDL subclasses and carotid-femoral, brachial-ankle and femoral-ankle pulse wave velocities after adjusting for LDL-P
Standardized coefficients (β)
cfPWV1 / p-value / baPWV1 / p-value / faPWV1 / p-value
Large HDL-P / 0.0013 / 0.9749 / -0.0136 / 0.7271 / -0.0177 / 0.6773
Medium HDL-P / 0.0077 / 0.8412 / 0.1093 / 0.0021 / 0.0527 / 0.01750
Small HDL-P / 0.0419 / 0.2770 / 0.1504 / <0.001 / 0.1676 / <0.0001
Total HDL-P / 0.0377 / 0.3450 / 0.1839 / <0.0001 / 0.1556 / 0.0001
HDL-C2 / -0.0053 / 0.8947 / 0.0245 / 0.5123 / 0.0001 / 0.9978
HDL Size / 0.0142 / 0.7468 / 0.0117 / 0.7744 / 0.0079 / 0.8587
1Linear regression derived beta (β) values
Table after adjusting for age, race, body-mass index, systolic blood pressure, glucose, smoking, alcohol intake and LDL-P.
2For HDL-C, estimate adjusted for LDL-C instead of LDL-P.
Cut-off p-value of p<0.01 was used for determining significance.
Unit for HDL-Pisµmol/L, unit for HDL-C is mg/dl
cfPWV = carotid-femoral pulse wave velocity, baPWV = brachial-ankle pulse wave velocity, faPWV = femoral-ankle pulse wave velocity
HDL-P = high-density lipoprotein particle number

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