Online Resource 2. Renal cell cancer risk and use of antihypertensive drugs with a history of hypertension, all five drug typesa in one model, by histologic subtype

All Histologies Clear Cell Papillary

(n=643 ca, 443 co) (n=357 ca, 443 co) (n=107 ca, 443 co)

Ca/Cob OR (95% CI)c Ca/Cob OR (95% CI)c Ca/Cob OR (95% CI)c

Ace Inhibitors

Never 314/236 1.0 176/236 1.0 43/236 1.0

Ever 271/157 1.2 (0.9-1.6) 152/157 1.2 (0.9-1.6) 54/157 1.7 (1.04-2.7)

<=5 years 164/90 1.4 (0.98-1.9) 92/90 1.3 (0.9-1.9) 31/90 1.8 (1.04-3.3)

6-15 years 71/48 1.0 (0.6-1.8) 39/48 1.0 (0.6-1.8) 16/48 1.6 (0.7-3.7)

16+ years 18/10 1.1 (0.5-2.9) 12/10 1.4 (0.5-3.9) 2/10 0.9 (0.2-3.8)

p-trend 0.99 0.80 0.43

p (difference in trends) = 0.53

Beta Blockers

Never 304/227 1.0 166/227 1.0 48/227 1.0

Ever 288/170 1.1 (0.8-1.5) 164/170 1.1 (0.8-1.6) 51/170 1.1 (0.6-1.8)

<=5 years 157/86 1.1 (0.8-1.6) 93/86 1.2 (0.8-1.8) 28/86 1.1 (0.6-2.2)

6-15 years 74/49 1.0 (0.6-1.6) 39/49 1.0 (0.6-1.6) 14/49 1.0 (0.5-2.3)

16+ years 34/19 1.3 (0.7-2.6) 17/19 1.2 (0.6-2.6) 7/19 1.9 (0.7-5.5)

p-trend 0.57 0.84 0.27

p (difference in trends) = 0.35

Calcium Channel

Blockers

Never 308/226 1.0 179/226 1.0 43/226 1.0

Ever 279/175 1.4 (1.02-1.8) 146/175 1.4 (1.005-1.9) 57/175 1.5 (0.9-2.4)

<=5 years 153/88 1.5 (1.1-2.2) 79/88 1.4 (0.95-2.2) 31/88 1.8 (1.1-3.1)

6-15 years 79/64 1.0 (0.6-1.7) 43/64 1.0 (0.6-1.9) 15/64 0.9 (0.4-2.1)

16+ years 25/14 2.0 (0.9-4.4) 11/14 2.0 (0.7-5.4) 8/14 3.4 (1.2-9.8)

p-trend 0.38 0.41 0.28

p (difference in trends) = 0.69

Diuretics

Never 223/138 1.0 132/138 1.0 31/138 1.0

Ever 380/268 0.8 (0.6-1.2) 203/268 0.8 (0.5-1.1) 70/268 1.2 (0.7-2.2)

<=5 years 164/144 0.7 (0.5-0.99) 97/144 0.7 (0.5-1.05) 24/144 0.7 (0.3-1.5)

6-15 years 102/72 0.8 (0.5-1.4) 57/72 0.7 (0.4-1.3) 18/72 1.1 (0.5-2.6)

16+ years 62/31 1.4 (0.9-2.4) 24/31 0.9 (0.6-5.1) 4/9 3.5 (1.6-7.5

p-trend 0.20 0.73 0.004

p (difference in trends) = 0.002

aACE inhibitors, beta blockers, calcium channel blockers, diuretics, and all other medications reported to have been taken for hypertension and heart problems

bCounts do not sum to the total population due to issues related to recall of drug type and/or duration of use.

cAdjusted for age (20-44, 45-54, 55-64, 65-74, 75+ years), race (white, black), sex, region, education (<12 years, high school graduate, some college, 4+ years of college), smoking status (never, occasional, regular former, regular current), body mass index (<25, 25-<30, 30-<35, 35+ kg/m2, unknown), family history of cancer (none, cancer other than kidney cancer, kidney cancer, unknown), and self-reported extent of hypertension control (always well controlled, usually well controlled, rarely well controlled, almost never controlled, unknown).

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