Appendix 1.
SEARCH TERMS
(thyroid (malignancy or tumor or carcinoma or cancer) or (well-differentiated or differentiated or papillary or follicular or Hurthle cell or poorly differentiated or medullary or anaplastic) thyroid cancer)
and
(SPECT-CT or SPECT/CT or SPECTCT or SPET-CT or SPET/CT or radioiodine scan or scintigraphy)
and
(surgery or neck dissection or histopathology or fine-needle aspiration biopsy or thyroglobulin)
and
(sensitivity or specificity or accuracy or predictive values or AUR or ROC or utility or benefits or limitations)
and
(US or MRI or CT)
DATABASES
Medline (OVID) – 1946 to current Feb, 2014
PubMed
Hand-search of references
SEARCH STRATEGY
Number One: March 1st, 2014 at 12:30 pm
1) thyroid gland or thyroid 153462
2) SPECT/CT or SPECT-CT or SPET/CT or SPET-CT or SPECTCT or hybrid or fusion 289203
3) 1 + 2 1883
4) restrict to date of first known SPET-CT article on thyroid cancer to present time 701
Of these 701 articles the titles were searched to reach a list of 78 papers for abstract review that were relevant for SPET-CT.
Number Two: March 1st, 2014 at 4:30pm.
P1) "thyroid cancer" or "thyroid neoplasm" or "thyroid tumor" 12,901
P2) "well-differentiated thyroid cancer" or "differentiated thyroid cancer" or "Hurthle cell thyroid cancer" or "poorly differentiated thyroid cancer" or "medullary thyroid cancer" or "anaplastic thyroid cancer"
3,182
P3) "well-differentiated" or "differentiated" or "Hurthle cell" or "poorly differentiated" or "medullary" or "anaplastic"
158,885
P1 or P3) 166,518
I1) "SPECT-CT" or "SPECT/CT" or "SPECTCT" or "SPET-CT" or "SPET/CT" or "radioiodine scan" or "scintigraphy"
33,679
C1) surgery or neck dissection or histopathology or thyroglobulin 872,996
O1) sensitivity or specificity or accuracy or "predictive values" or AUR or ROC or utility or benefits or limitations
1,665,044
T1) US or MRI or CT 6,842,275
PICOT CITATIONS
P = 166,518 PICO = 182
I = 33,679 PICOT = 93
C= 872,996 PIC = 507 à 66 yes/maybe à 19 YES
O = 1,665,044 PI = 1349
T = 6,842,275 P = 166,518
Of the title search of the 507 papers, there were 66 selected for abstract review and 19 for deemed relevant to SPET-CT. Augmentation with the PICOT search led to an additional 1 paper for abstract review, for a total of 79 papers.
Number Three: March 1st, 2014 at 7:30pm
Radioiodine SPECT-CT in PubMed
18 of 47 articles potentially relevant for abstract review were added by this search.
Hand-search of reference lists added 1 more article.
SEARCH RESULTS
Potentially Relevant 79 + 18 + 1 = 98
Based on their abstract these were divided into:
Reviews 22
Case reports, case series, letters, editorials 31
Miscellaneous 14
Relevant for full paper retrieval 30
Foreign Language 4
Hand-search of Reference lists 1
TOTAL of 31 FULL ARTICLE RETRIEVALS