Publications - Joyce Slingerland

Publications - Joyce Slingerland

PUBLICATIONS - Joyce M. Slingerland, M.D., Ph.D., Director, Braman Breast Cancer Institute, UM Sylvester Comprehensive Cancer Center

Books and Monographs

1.  Donovan, J., Slingerland, J.M., and Tannock I. (2004) Control of Cell Proliferation. In: 4rd Edition of Basic Science of Oncology. Editors: Ian Tannock and R.P. Hill, McGraw-Hill, New York, Chapter 10.

2.  Slingerland, J.M., and Tannock I. (1998) Control of Cell Proliferation and Cell Death. In: 3rd Edition of Basic Science of Oncology. Editors: Ian Tannock and R.P. Hill, McGraw-Hill, New York, Chapter 7, pp. 134-165.

3.  Slingerland, J.M. and Pagano, M. (1998) Regulation of the Cell Cycle by the Ubiquitin Pathway. In: Cell Cycle Control. Part of the Results and Problems in Cell Differentiation Series. Springer Verlag Publishers (Editor: M. Pagano), Chapter 6, pp. 133-147.

4.  Slingerland, J.M., Greisser H., Mak T.W., Minden M.D. (1988) The Structure and function of the T-cell antigen receptor in human malignancies. In: T.W. Mak (Ed.), The T-cell Receptor, New York: Plenum Press.

Refereed Journal Articles

1.  C. Catavelos, A. Alkarain, S. Bull, I. Andrulis, W. Hannah and J. M. Slingerland. p27 levels alone and in combination with Her-2/neu amplification are of important prognostic significance for node negative breast cancer. (2004) Manuscript in preparation for The New England Journal of Medicine. (2005) (Corresponding author, 100% effort).

2.  J. Liang, K. G. Koslowski, Hung, M. Larrea and J. M. Slingerland. Phosphorylation of Cdk2 by PKB (Akt) facilitates Cyclin-Cdk2 assembly and activation by CAK. Manuscript submitted. Molecular Cell (2005). (Corresponding author 100% effort).

3.  J Liang, S. Shao, K. Han, D. Dumont, J. M. Slingerland. Regulation of p27Kip1-mediated cyclin D1-cdk4 assembly by PKB through multisite phosphorylation. . In review, Genes and Development (2005) (Corresponding author, 100% effort).

4.  Laura J. Esserman, M.D., M.B.A., Elissa M. Ozanne, Ph.D., Mitch Dowsett, Ph.D., Joyce M. Slingerland, M.D., FRCP(C), Ph.D. Tamoxifen may not just prevent ER positive cancers: An alternate hypothesis. In revision, Breast Cancer Research. (Collaboration, 50% effort).

5.  Isabel Chu, Kimberly Blackwell, Susie Chen, and Joyce Slingerland The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with Tamoxifen to inhibit both cell proliferation and estrogen dependent gene expression in antiestrogen resistant breast cancer. (2005). Cancer Research, 65: (1) 18-25, January 1, 2005. (Collaboration, 70% effort from my lab).

6.  Charanjit Sandhu, Michael Connor, Thomas Kislinger, Joyce Slingerland, and Andrew Emili. Global Protein Shotgun Expression Profiling of Proliferationg MCF-7 Breast Cancer Cell. Journal of Proteome. In Press, 2005 (Collaboration, 20% effort).

7.  Sheng, W., Wang, G, Wang, Y, Liang, J, Wen, J Zheng, P, Wu, Y, Lee, V, Slingerland, J.M., Dumont, D and Yang, B. The Roles of Versican V1 Isoforms in Cell Proliferation and Apoptosis. Mol Biol Cell Jan 5; (2005). (Collaboration, 20% effort).

8.  Isabel Chu, Angel Arnaout, Jun Sun, Arun Seth, Chris McMahon, Kathy Chun, and Joyce Slingerland. Src cooperates with estrogen to activate ligand dependent ERα proteolysis in human breast cancer. (2005) In revision for Journal of Clinical Investigation. (Corresponding author, 100%).

9.  Connor, M., Kotchetkov, R., Carious, S., Resch, A., Lupetti, R., Beniston, R., Melchior, F., Hengst, L., Slingerland, J. (2003) Nuclear export of p27Kip1 is regulated by phosphorylation and by RanGTP/CRM1 binding. Molecular Biology of the Cell, 14: 201-213 (Corresponding author, 90% in my lab).

10.  Donovan, J., Milic, A. Rosenberg, J. and Slingerland, J. (2002) The requirement for p27 in G1 arrest by TGF-b becomes essential during progressive checkpoint loss in human cancers. Journal of Biological Chemistry, 277 (44): 41686-41692. (Corresponding author, 100% effort)

11.  Liang, J., Zubovitz, J., Petrocelli, T., Kotchetkov, R., Connor, M., Han, K., Lee, J.-W., Ciarallo, S., Catzavelos, C., Franssen, E., Beniston, R., Slingerland, J. (2002) Phosphorylation of p27Kip1 by PKB/Akt leads to p27Kip1 mislocalization and TGF-b resistance. Nature Medicine 8 (10): 1153-1160 (Corresponding author, 100% effort my lab)

12.  Ciarallo, S., Subramaniam V., Kotchetkov, R., Lee, J.H., Sandhu, C., Milic, A., Slingerland, J.M. (2002) Altered p27kip1 phosphorylation, localization and function in human mammary epithelial cells resistant to TGF-b mediated G1 arrest. Molecular and Cellular Biology, 22(9): 2993-3002 (Corresponding author, 100% effort from my lab).

13.  Gstaiger, M., Jordan, R., Lim, M., Catzavelos, C., Mestan, J., Slingerland, J., Krek, W. (2001) Skp2 is oncogenic and overexpressed in human cancers. Proceedings of the National Academy of Science (USA), April 24; 98(9):5043-5048 (Co-corresponding author, 50% effort my lab)

14.  Donovan JCH, Milic A, Slingerland J. (2001) Activation of p42/44 MAPK pathway leads to p27Kip1 deregulation and antiestrogen resistance in human breast cancer cells. Journal of Biological Chemistry, 276(44): 40888-40895 (Corresponding author, 100% effort)

15.  Petrocelli, T., Slingerland, J.M. (2001) PTEN deficiency: a role in mammary carcinogenesis. Breast Cancer Research, 3:356-360 (Corresponding author, 100% effort)

16.  Tsihlias, J., Zhang, W., Bhattacharya, N., Flanagan, M., Klotz, L., Slingerland, J. Involvement of p27Kip1 in G1 arrest by high dose 5a-dihydrotestosterone in LNCaP human prostate cancer cells. (2000) Oncogene 19:670-679. (Corresponding author, 100% effort in my lab)

17.  Sandhu, C., Peehl, D., Slingerland, J.M. (2000) p16INK4A mediates cyclin dependent kinast 4 and 6 inhibition in senescent prostate epithelial cells. Cancer Research 60:2616-2622. (Corresponding author, Collaboration, 90% effort from my lab)

18.  Tamir, A., Petrocelli, T., Stetler, K., Chu, W., Howard, J., St. Croix, B., Slingerland, J., Ben-David, Y. (2000) Stem cell factor inhibits erythroid differentiation by modulating the activity of G1-ccyclin-dependent kinase complexes: A role for p27 in erythroid differentiation coupled G1 arrest. Cell Growth & Differentiation 11(5):269-277. (Collaboration, 50% effort from my lab, my student is the co-first author)

19.  Cariou, S., Donovan, J.C.H., Flanagan, W.M., Milic, A., Bhattacharya, N., Slingerland, J.M. (2000) Downregulation of p21WAF1/Cip1 or p27K1p1 abrogates antiestrogen mediated G1 arrest in human breast cancer cells. Proceedings of the National Academy of Science (USA), 97(16):9042-9046. (Corresponding author, 100% effort in my lab)

20.  Petrocelli, T., Slingerland, J.M. (2000) UVB induced cell cycle checkpoints in an early stage melanoma line, WM35. Oncogene 19:4480-4490. (Corresponding author, 100% effort in my lab).

21.  Chappuis PO, Kapusta L, Begin LR, Wong N, Brunet JS, Narod SA, Slingerland J, Foulkes WD. (2000). Low p27Kip1 expression and BRCA1/2 germ-line mutations are associated and contribute to a poor outcome after breast cancer. Journal of Clinical Oncology, Dec 15;18(24):4045-52 (Collaborator, 50% effort in my lab).

22.  Sandhu C, Donovan J, Bhattacharya N, Stampfer M, Worland P, Slingerland JM. (2000) Reduction of Cdc25A contributes to cyclin E1-Cdk2 inhibition at senescence in human mammary epithelial cells. Oncogene 19:5314-5323. (Corresponding author, 100% effort in my lab).

23.  Florenes, V.A., Lu, C., Bhattacharya, N., Rak, J., Sheehan, C., Slingerland, J.M., Kerbel, R.S. (1999) Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma. Oncogene 18: 1023-1032. (Co-correspondent, collaboration 70% effort from my lab)

24.  Catzavelos, C., Tsao, M-S., DeBoer, G., Bhattacharya, N., Shepherd, F., Slingerland, J.M. (1999). Reduced expression of the cell cycle inhibitor p27Kip1 in non-small cell lung carcinoma: a potential prognostic factor independent of ras. Cancer Research 59: 684-688. (Corresponding author, 80% effort from my laboratory).

25.  Tsihlias, J., Kapusta, L.R., DeBoer, G., Morava-Protzner, I., Zbieranowski, I., Bhattacharya, N., Catzavelos, C., Klotz, L.H., Slingerland, J.M. (1998). Loss of cyclin dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma. Cancer Research, 58(3) 542-548. (100% effort from my laboratory).

26.  Jordan, R., Bradley, G. Slingerland, J.M. (1998) Reduced levels of the cell-cycle inhibitor p27Kip1 in epithelial dysplasia and carcinoma of the oral cavity. American Journal of Pathology, 152: 1-6. (Collaborator - 10% effort from my laboratory).

27.  St. Croix, B., Sheehan, C., Rak, J., Florenes, V.A., Slingerland, J.M. and Kerbel, R.S. (1998) E-cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27KIP1. Journal of Cellular Biology, 142:557-571. (Collaborator, 20% effort from my lab)

28.  Zhang, W., Kapusta, L.R., Klotz, L.H., Slingerland, J.M. (1998) Telomerase activity in prostate cancer, prostatic intraepithelial neoplasia and benign prostatic epithelium. Cancer Research 58:619-621. (Collaborator, 50% effort from my lab)

29.  Florenes, V.A., Maelandsmo, G.M., Kerbel, R.S., Slingerland, J.M., Nesland, J.M., Holm, R. (1998) Expression of the cell-cycle inhibitor p27 in malignant melanoma: Inverse correlation with disease-free survival. American Journal of Pathology, 153:305-312. (Collaborator, 50% effort from my lab).

30.  Lauper, N., Beck, A., Cariou, S., Richman, L., Hoffmann, K., Reither, W. Slingerland, J.M., Amati, B. (1998) Cyclin E2: a novel CDK2 partner in the last G1 and S phases of the mammalian cell cycle. Oncogene, 17:2637-43. (Collaborator, 40% effort from my lab).

31.  Catzavelos C., Bhattacharya N., Wilson J., Sandhu C., Roncari L., Shaw P., Yeger H., Morava-Protzner I., Kapusta L., Franssen E., Pritchard K.I., Ung Y., Slingerland J.M. (1997) Decreased levels of the cell cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer. Nature Medicine, 3: 227-230. (Corresponding author; project generated in my lab, 100% effort)

32.  Sandhu C., Garbe J., Bhattacharya N., Daksis J., Pan C-H., Yaswen P., Koh J., Slingerland J.M., Stampfer M.R. (1997) TGF-b stabilizes p15INK4B, increases p15INK4B/cdk4 complexes and inhibits cyclin D1/cdk4 association in human mammary epithelial cells. Molecular and Cellular Biology, 17(5):2458-2467. (Corresponding author; collaboration with 90% effort from my lab)

33.  Radeva G., Petrocelli T., Behrend E., Filmus J., Hannigan G., Slingerland J.M., Dedhar S. (1997) Overexpression of the Integrin Linked Kinase (ILK) promotes anchorage-independent cell cycle progression. Journal of Biological Chemistry. 272, 13937-13944, 1997. ( Collaboration with 30% effort from my laboratory)

34.  LaBaer, J., Garrett, M., Stevenson, L., Slingerland, J., Sandhu, C., Chou, H., Fattaey, Al, Harlow, E. (1997) New functional activities for the p21 family of CDK inhibitors. Genes & Development 11: 847-862. (Collaboration with 20% effort from my laboratory)

35.  Petrocelli T., Poon R., Drucker D.J., Slingerland J.M., and Rosen C.F. (1996) UVB radiation induces p21Cip1/WAF1 and mediates G1 and S phase checkpoints. Oncogene, 12:1387-1396. (Corresponding author; collaboration with Rosen lab, my lab contributed 70% effort)

36.  Florenes V.A., Bhattacharya N., Bani M.R., Ben-David Y., Kerbel R.S., Slingerland J.M. (1996) TGF-b mediated G1 arrest in a human melanoma cell line lacking p15INK4B: Evidence for cooperation between p21CIP1/WAF1 and p27KIP1. Oncogene, 13:2477-2457. (Corresponding author; 100 % effort from my laboratory)

37.  St. Croix B., Florenes V.A., Rak J.W., Flanagan M., Bhattacharya N., Slingerland J.M., Kerbel R.S. (1996) Impact of the cyclin dependent kinase inhibitor p27Kip1 on adhesion-dependent resistance of tumor cells to anticancer agents. Nature Medicine, 2:1204-1210. (Collaboration with 20% effort from my lab)

38.  Liu L., Lassam N.J., Slingerland J.M., Bailey D., Cole D., Jenkins R., and Hogg D. (1995) Germline p16INK4A mutation and protein dysfunction in a family with inherited melanoma. Oncogene 11:405-412. (Collaborator, 20% effort from my laboratory)

39.  Slingerland J.M., Hengst L., Pan C-H., Alexander D., Stampfer M.R., Reed S.I. (1994) A novel inhibitor of cyclin/cdk activity detected in TGF-b arrested epithelial cells. Molecular and Cellular Biology 14(6):3683-3694. ( Principal author, 100% effort)

40.  Hengst L., Dulic V., Slingerland J.M., Lees E., Reed S.I. (1994) A cell cycle regulated inhibitor of cyclin dependent kinases. Proceedings of the National Academy of Science (USA) 91:5291-5295. (Collaborator, 30% effort).

41.  Slingerland J.M., Jenkins J.R., Benchimol S. (1993) The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation. The EMBO Journal 12(3):1029-1037. (Principal author, 100% effort)

42.  Slingerland J.M., Minden M.D., Benchimol S. (1991) Mutation of the p53 gene in human acute myelogenous leukemia. Blood 77:1500-1507. (Principal author, 100% effort)

43.  Lishner M., Slingerland J.M., Barri J., Panzarella T., Degendorfer P., Sutcliffe S. (1991) Second malignant neoplasms in patients with non-Hodgkin's lymphoma. Hematologic Oncology 9:169-179. ( Collaborator, 50% effort)

44.  Slingerland J.M., Benchimol S. (1991) Transforming activity of mutant human p53 alleles. Journal of Cellular Physiology 148:391-395. (Principal author, 100% effort)

45.  Slingerland J.M., Grossman R., Chamberlain D., Tremblay C., Gauthier M.L. (1989) Pulmonary manifestations of tuberous sclerosis in first degree relatives. Thorax 44:212-214. (Principal author, 100% effort)

46.  Tiberius R.G., Sackin H.D., Slingerland J.M., Jubas K., Bell M., Matlow A. (1989) The influence of student evaluative feedback on the improvement of clinical teaching. Journal of Higher Education 60:665-681. (Collaborator, 20% effort)

Refereed Review Articles

1.  p27 Deregulation in Breast Cancer: Prognostic Significance and Implications for Therapy. A. Alkarain, R. Jordan, J. Slingerland. (2004) Journal of Mammary Gland Biology and Neoplasia. Vol. 9. 1:68-79.

2.  Deregulation of p27 by Oncogenic Signaling and its Prognostic Significance in Breast Cancer. A. Arnaout, J. Slingerland. (2003) Breast Cancer Research. 5:13-21.

3.  Liang, J., Slingerland J.M. (2003) Mulitiple Roles of the P13K/PKB (Akt) Pathway in Cell Cycle Progression. Cell Cycle 2:4, 339-345.

4.  Sandhu, C., Slingerland, J.M. (2000) p27, The Cell Cycle and Cancer. Cancer Detection and Prevention 24(2):107-118.

5.  Slingerland, J. and Pagano, M. (2000) Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiology 183:10-17.

6.  Donovan, J. and Slingerland, J.M. (2000) Cell cycle arrest by transforming growth factor-b and its disruption in cancer. Breast Cancer Research 2 (2):116-124.

7.  Slingerland, J. (2000) Transforming growth factor-beta and breast cancer: Introduction. Breast Cancer Research 2(2):91.

8.  Carious, S., Catzavelos, C., Slingerland, J.M. (1999) Prognostic implications of expression of the cell-cycle inhibitor p27Kip1 protein. Breast Cancer Treatment & Research.52 (1): 29-41. Special Issue on Prognostic variables in node negative and node positive breast cancer.

9.  Tshilias, J., Kapusta, L., Slingerland, J.M. (1999) Cyclin-Dependent Kinase Inhibitors and Cancer Prognosis. Annual Review of Medicine. 50: 401-423.

10.  Slingerland, J.M. (1997) Cancer Therapeutics: Experimental and Clinical Agents. Edited by Beverly A. Teicher. Book Review. Nature Medicine 3(5) 581-582.

11.  Reed SI, Bailly E., Bulic V., Hengst L., Resnitzky D., and Slingerland J.M. (1994) G1 control in mammalian cells. J. Cell Science Suppl. 18: 69-73.

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