Table e-1: Details of cases in Study 1

Case / Age (y) / Gender / PM delay (h) / Clinical Dx / Clinical
Stroke# / Hypertension / Diabetes / Other VRFs / Total Scheltens score / MRI scan interval (months) / Neuropathological findings
1 / 86 / F / 6 / Normal / days / Y / N / MI / 6 / 36 / Recent PCA infarct
2* / 81 / M / 3 / PSP / N / Y / N / N / 11 / 4 / PD; PSP
3 / 82 / F / 4 / AD / N / N / N / N / 23 / 78 / FTD
4 / 71 / F / 6 / FTD / N / N / N / N / 18 / 87 / FTD
5 / 60 / M / 14 / AD + DLB / N / N / N / N / 16 / 66 / AD
6* / 80 / F / 20 / CBD / N / N / N / N / 6 / 67 / CBD
7 / 60 / M / 24 / CBD / N / N / N / N / 14 / 73 / CBD; AD
8 / 84 / F / 4 / Normal / 5y / Y / Y / TIA, MI / 17 / 5 / Normal brain
9 / 73 / M / 13 / AD + PD / N / Y / N / N / 16 / 63 / DLB; AD
10 / 59 / M / 16 / AD / N / N / N / N / 5 / 64 / AD
11 / 68 / M / 6 / FTD / N / N / N / AAA / 15 / 37 / FTD
12* / 66 / F / 5 / FTD / N / N / N / N / 13 / 37 / FTD
13* / 88 / M / 6 / AD / N / N / N / N / 20 / 60 / AD; Multiple remote infarcts
14* / 63 / M / 15 / PSP / N / N / N / TIA, MI / 23 / 62 / PSP
15 / 79 / M / 24 / FTD / N / N / N / N / 17 / 69 / FTD
16 / 84 / F / 21 / Normal / N / N / N / MI / 14 / 16 / Normal brain
17 / 83 / M / 19 / Normal / 11y / Y / N / N / 9 / 4 / Remote infarct (basal ganglia)
18 / 74 / F / 4 / DLB / N / N / N / N / 18 / 37 / AD
19 / 67 / F / 6 / CBD / N / N / N / N / 9 / 72 / Tauopathy
20* / 94 / M / 44 / Normal / N / N / N / N / 22 / 26 / Normal brain
21 / 70 / F / 10 / AD / N / N / N / N / 13 / 79 / FTD
22 / 70 / M / 4 / CBD / N / Y / N / N / 13 / 38 / MSA
23* / 73 / M / 4 / AD + PD / 6y / Y / N / N / 21 / 76 / DLB; Remote infarct (occipital WM)

AAA abdominal aortic aneurysm; AD Alzheimer’s disease; CBD corticobasal degeneration; DLB dementia with Lewy bodies; Dx diagnosis; F female; FTD frontotemporal dementia; M male; MI myocardial infarct; MSA multiple systems atrophy; PCA posterior cerebral artery; PD Parkinson’s disease; PM postmortem; PSP progressive supranuclear palsy; TIA transient ischaemic attack; VRF vascular risk factors;WM white matter.

*Cases with positive APP staining; # time prior to death