Table 1. Summary of clinical information, EEG findings, AMT PET findings and surgery
Tubers with The number of tubers Surgery
Patient No. /Sex Seizure semiology Medication Interictal EEG Ictal EEG AMT uptake ratio with AMT uptake ratio (Outcome. Follow-up period)
/Age spiking activity onset greater than 0.98 lower than 0.98
1 / female CPS, sGTC. vigabatrin Rt P-T Rt P-T 5 at Rt P-T 31 Rt P-T resection
7yr 11mo (eye deviation to the Lt side.) lamotrigine Rt F 1 at Lt P (seizure free. 28 months.)
Lt F-T
2 /female CPS, sGTC. vigabatrin Lt T Not obtained 1 at Lt T 26 Considering epilepsy surgery
3yr 10mo (motionless staring clonazepam 1 at Rt P
Rt hemiconvulsion.) lamotrigine
phenobarbital
ethosuximide
3 /female CPS, myoclonic seizures, vigabatrin Lt T-P Lt T-P 1 at Lt T 13 Lt T-P resection
6yr 10mo atonic seizures, sGTC. clonazepam Rt F-T 1 at Lt P (worthwhile improvement.
phenobarbital Generalized 1 at Lt O 20 months.)
ketogenic diet 1 at Rt O
1 at Rt F
4 /male CPS. valproate Rt T Rt T-O 1 at Rt T 17 Not being considered
3yr 1mo (motionless staring Lt T-P 1 at Rt O
falling.) Generalized 1 at Lt T-O
5 /male CPS. vigabatrin Lt F-T Lt F-T 1 at Lt T 16 Not being considered
1yr 7mo (staringautomatism.) carbamazepine Rt T
6 /female CPS, sGTC. valproate Lt T Not obtained None 5 Considering epilepsy surgery
16yr 2mo (motionless staring.) gabapentin Generalized
7 /male CPS, sGTC. carbamazepine Rt T Not obtained None 25 Not being considered
6yr 11mo (fussstaring, lamotrigine Lt F-P
body jerking.) Generalized
8 /male CPS, sGTC. tiagabine Rt T Rt T 1 at Rt F 14 Rt T resection
2yr (behavioral arrest (Dysplastic cortex next (seizure free. 3 months.)
Lt arm stiffening, to Rt T tuber showed
version to the Lt side.) increased AMT uptake.)
9 /male CPS, atonic seizures, clonazepam Generalized Lt P-T None 13 Lt P-T resection
9yr 5mo sGTC. (motionless staring lamotrigine (A subependymal nodule (seizure free. 14 months.)
eye blinking, version to acetazolamide at Lt P-T showed
the Rt side.) increased AMT uptake.)
10 /female CPS, sGTC. vigabatrin Rt F Bilateral F-P 1 at Rt P 6 Not being considered
1yr 6mo (eyelid fluttering and clonazepam Rt T 1 at Lt T
bout of laughter.) lamotrigine Generalized
phenobarbital
11 /female infantile spasms. vigabatrin Lt T Lt T 1 at Lt T 7 Considering epilepsy surgery
0yr 7mo (Rt hand jerkingspasms.) valproate Rt T 1 at Lt T-P
pyridoxine
12 /male CPS. (behavioral arrest vigabatrin Rt T-P Rt T-P 1 at Rt T 6 Not being considered
0yr 7mo Lt arm jerking, version carbamazepine Lt P 1 at Lt P
to the Lt side.) Lt F-T 1 at Lt T
13 /female CPS, sGTC. clonazepam Lt T-P Lt posterior 1 at Lt P-T 11 Lt P-T-F resection
1yr 1mo (crying topiramate quadrant 1 at Lt P (seizure free. 4 months.)
asymmetric tonic posture.) 1 at Rt F-P
14 /female CPS, sGTC. carbamazepine Rt F-T Rt F-P 1 at Rt F 19 Rt F resection
2yr 10mo (Lt arm jerking, eye Lt F-T (worthwhile improvement.
deviation to the Lt side.) 23 months.)
15 /female CPS, sGTC. carbamazepine Rt T-P Rt posterior 1 at Rt O-P 4 Considering epilepsy surgery
2yr 2mo (erratic eye movement phenobarbital Lt T-P quadrant 1 at Rt P
eye deviation to the Lt side.) topiramate 2 at Rt F
1 at Lt F
16 /female CPS, sGTC. valproate Rt T Rt T 2 at Rt T 3 Rt T resection
9yr 2mo (staring Lt F-T 2 at Rt P (seizure free. 24 months.)
asymmetric tonic posture.) Generalized
17 /male CPS, sGTC. vigabatrin Rt F-P Rt F-P None (An adjacent 2 Considering epilepsy surgery
5yr 6mo (behavioral arresteye carbamazepine cortex posterior to Rt F
blinking, twitching of topiramate tuber showed increased
Lt face and arm.) AMT uptake.)
18 /male CPS. vigabatrin Lt T-P Lt T-P 1 at Lt T-P-O 1 Considering epilepsy surgery
2yr 9mo (staringRt arm jerking.) carbamazepine