SUPPLEMENTARY APPENDIX (Online Resource 1)
Table 1: Private proton pump inhibitor (PPI) expenditures in Ontario by molecule
2000 / 2001 / 2002 / 2003 / 2004 / 2005 / 2006 / 2007 / 2008 / 2009 / SumRabeprazole Branded (Pariet®) / - / - / 404,004 / 3,684,443 / 7,353,540 / 11,327,327 / 15,348,215 / 18,319,755 / 2,377,181 / 925,540 / 59,740,005
Rabeprazole Generic / - / - / - / - / - / - / - / 6,851 / 13,392,855 / 15,564,123 / 28,963,828
Pantoprazole Branded (Tecta®/Pantoloc®) / 8,210,441 / 13,332,995 / 17,905,612 / 22,762,262 / 27,103,171 / 31,324,563 / 35,725,540 / 39,934,639 / 15,990,103 / 3,878,956 / 216,168,281
Pantoprazole Generic / - / - / - / - / - / - / - / - / 18,467,063 / 28,177,703 / 46,644,766
Lansoprazole Branded (Prevacid®) / 9,118,247 / 12,905,334 / 15,872,760 / 18,305,688 / 20,061,224 / 21,797,299 / 24,428,453 / 27,755,350 / 33,403,666 / 27,097,988 / 210,746,009
Lansoprazole Generic / - / - / - / - / - / - / - / - / - / 7,332,228 / 7,332,228
Omeprazole Branded (Losec®) / 46,776,589 / 55,425,481 / 60,487,764 / 61,772,480 / 58,298,030 / 53,656,175 / 40,904,944 / 9,399,063 / 8,078,605 / 6,921,550 / 401,720,681
Omeprazole Generic / - / - / - / - / 1,446,613 / 3,773,865 / 9,731,229 / 24,784,441 / 23,436,703 / 21,255,700 / 84,428,550
Esomeprazole Branded (Nexium®) / - / 1,043,848 / 11,472,458 / 20,546,281 / 30,688,704 / 36,773,043 / 44,073,090 / 50,225,304 / 57,867,065 / 63,358,384 / 316,048,177
Esomeprazole Generic / - / - / - / - / - / - / - / - / - / - / -
Sum / 64,105,277 / 82,707,658 / 106,142,599 / 127,071,153 / 144,951,281 / 158,652,273 / 170,211,472 / 170,425,403 / 173,013,241 / 174,512,171 / 1,371,792,527
Table 2: Private selective serotonin reuptake inhibitor (SSRI) expenditures in Ontario by molecule
2000 / 2001 / 2002 / 2003 / 2004 / 2005 / 2006 / 2007 / 2008 / 2009 / SumCitalopram Branded (Celexa®) / 6,227,548 / 12,735,944 / 19,880,877 / 27,217,131 / 18,657,158 / 2,335,280 / 1,619,301 / 1,316,728 / 1,149,901 / 1,054,430 / 92,194,297
Citalopram Generic / - / - / - / - / 9,006,531 / 21,112,160 / 21,918,121 / 23,074,875 / 24,158,717 / 23,513,171 / 122,783,574
Paroxetine Branded (Paxil®) / 23,082,669 / 27,536,776 / 32,108,231 / 34,747,078 / 14,616,324 / 5,316,119 / 5,279,417 / 5,483,025 / 4,782,924 / 4,253,083 / 157,205,646
Paroxetine Generic / - / - / - / 50,905 / 13,003,091 / 16,313,284 / 15,571,544 / 15,047,583 / 14,954,899 / 13,901,845 / 88,843,151
Sertraline Branded (Zoloft®) / 10,377,887 / 9,504,985 / 9,399,108 / 4,273,731 / 2,585,855 / 1,912,037 / 1,543,179 / 1,342,983 / 1,218,812 / 1,248,967 / 43,407,546
Sertraline Generic / 7,506,035 / 8,106,358 / 9,408,015 / 11,573,731 / 12,083,206 / 11,815,299 / 11,916,814 / 12,104,264 / 12,250,249 / 12,443,166 / 109,207,137
Escitalopram Branded (Cipralex®) / - / - / - / - / - / 2,587,209 / 8,509,032 / 13,928,309 / 18,852,202 / 24,413,812 / 68,290,564
Escitalopram Generic / - / - / - / - / - / - / - / - / - / - / -
Fluoxetine Branded (Prozac®) / 2,056,661 / 1,982,477 / 2,022,173 / 1,635,968 / 1,816,154 / 1,861,935 / 1,715,543 / 1,716,174 / 1,115,346 / 943,552 / 16,865,983
Fluoxetine Generic / 9,776,937 / 10,068,165 / 10,671,712 / 11,290,021 / 11,083,084 / 11,117,238 / 11,506,599 / 11,990,101 / 12,713,721 / 12,586,132 / 112,803,710
Fluvoxamine Branded (Luvox®) / 289,035 / 237,976 / 205,351 / 162,002 / 127,324 / 109,686 / 78,181 / 77,208 / 75,658 / 74,844 / 1,437,266
Fluvoxamine Generic / 1,415,616 / 1,383,655 / 1,430,313 / 1,434,019 / 1,385,093 / 1,360,184 / 1,309,176 / 1,269,346 / 1,256,236 / 1,159,663 / 13,403,302
Sum / 60,732,387 / 71,556,337 / 85,125,780 / 92,384,585 / 84,363,821 / 75,840,432 / 80,966,905 / 87,350,595 / 92,528,666 / 95,592,665 / 826,442,175
Table 3: Private angiotensin converting enzyme (ACE) inhibitor expenditures in Ontario by molecule
2000 / 2001 / 2002 / 2003 / 2004 / 2005 / 2006 / 2007 / 2008 / 2009 / SumRamipril Branded (Altace®) / 8,763,324 / 16,498,636 / 24,951,913 / 31,430,560 / 36,757,967 / 41,085,190 / 44,765,950 / 12,017,002 / 2,515,664 / 1,883,817 / 220,670,023
Ramipril Generic / - / - / - / - / - / - / - / 23,026,947 / 30,152,217 / 29,386,760 / 82,565,924
Perindopril Branded (Coversyl®) / 2,026,114 / 2,358,492 / 2,700,004 / 3,063,643 / 3,758,563 / 4,820,626 / 6,881,300 / 8,932,580 / 9,928,051 / 12,892,808 / 57,362,180
Perindopril Generic / - / - / - / - / - / - / - / 119,904 / 944,165 / 11,697 / 1,075,767
Lisinopril Branded (Zestril®/Prinivil®) / 6,790,159 / 4,402,342 / 1,652,845 / 1,187,327 / 860,216 / 618,194 / 1,362,056 / 4,637,686 / 1,009,538 / 605,926 / 23,126,289
Lisinopril Generic / 846,239 / 3,239,657 / 5,716,522 / 6,009,146 / 5,811,680 / 5,066,643 / 3,957,277 / 600,852 / 3,733,948 / 3,694,308 / 38,676,270
Quinapril Branded (Accupril®) / 3,264,241 / 3,645,716 / 3,944,819 / 4,087,494 / 4,184,459 / 4,094,240 / 3,989,621 / 3,797,604 / 3,539,261 / 3,182,397 / 37,729,852
Quinapril Generic / - / - / - / - / - / - / - / - / - / - / -
Enalapril Branded (Vasotec®) / 11,353,406 / 11,222,903 / 11,060,237 / 10,834,121 / 10,510,913 / 10,000,366 / 9,611,378 / 8,916,148 / 942,720 / 1,171,185 / 85,623,378
Enalapril Generic / 16,246 / 146 / - / - / 98 / - / - / 154,221 / 5,248,127 / 4,545,738 / 9,964,577
Fosinopril Branded (Monopril®) / 3,799,062 / 4,227,828 / 4,451,691 / 4,474,516 / 1,590,438 / 307,592 / 217,433 / 161,950 / 142,244 / 119,825 / 19,492,579
Fosinopril Generic / - / - / - / - / 1,676,122 / 2,151,259 / 2,022,152 / 1,850,007 / 1,703,802 / 1,485,511 / 10,888,854
Trandolapril Branded (Mavik®) / 430 / 910 / 197 / 171,957 / 762,101 / 1,267,981 / 1,648,927 / 2,068,921 / 2,510,977 / 2,665,624 / 11,098,027
Trandolapril Generic / - / - / - / - / - / - / - / - / - / - / -
Cilazapril Branded (Inhibace®) / 1,549,268 / 1,731,137 / 1,849,086 / 1,826,871 / 1,786,188 / 1,070,600 / 219,935 / 115,665 / 85,379 / 68,444 / 10,302,573
Cilazapril Generic / - / - / - / - / - / 412,944 / 861,986 / 774,241 / 710,772 / 622,372 / 3,382,314
Captopril Branded (Capoten®) / 91,900 / 69,452 / 54,539 / 48,557 / 36,467 / 28,250 / 22,546 / 14,178 / 11,363 / 8,302 / 385,555
Captopril Generic / 513,555 / 425,466 / 351,127 / 280,249 / 222,616 / 178,206 / 158,039 / 135,890 / 117,799 / 100,748 / 2,483,696
Benazepril Branded (Lotensin®) / 106,922 / 103,983 / 104,202 / 105,311 / 97,208 / 90,031 / 71,713 / 36,136 / 13,779 / 10,606 / 739,890
Benazepril Generic / - / - / - / - / - / - / 11,387 / 30,730 / 44,010 / 43,008 / 129,135
Sum / 39,120,867 / 47,926,667 / 56,837,180 / 63,519,753 / 68,055,037 / 71,192,121 / 75,801,701 / 67,390,661 / 63,353,816 / 62,499,077 / 615,696,882