College of Engineering and Science Updated: November, 2013
RESUME Frank Alexis, Ph.D.
PERSONAL DATA
Assistant Professor
Department of Bioengineering
203 Rhodes Engineering Research Center
Clemson University
Clemson, SC 29634
864-656-5003
October 09, 1976
Pointe-Noire
Congo
France
EDUCATION
Ph.D., Nanyang Technological University, 2005, Materials Science Engineering.
M.S., Technological University of Montpellier, 2000, Materials Science and Interfaces.
B.S., Technological University of Montpellier, 1999, Chemistry.
PROFESSIONAL EXPERIENCE
Clemson University, 2009-, Assistant Professor of Bioengineering
Massachusetts Institute of Technology, 2006-2009, Research Associate, Department of Health Science and Technology.
Brigham and Women’s Hospital, 2006-2009, PostdocFellow, Laboratory of Biomaterials and Nanomedicine.
CONSULTING EXPERIENCE
Stericoat Inc., Cambridge, Massachusetts (2008), assisted for the development of novel implant coatings.
MEMBERSHIPS
Member, Society For Biomaterials, SFB (2009- )
Member, American Chemical Society, ACS (2008-2012)
Member, Society of Chemical Industry, SCI (2004- )
PROFESSIONAL ACTIVITIES
Singapore A*Star Government Scholarship, Assessor (2004)
Singapore Science and Engineering Fair, Judge (2003)
Encyclopedia of Biomaterials and Biomedical Engineering, G. E Wneck and G.L Bowlin. Marcel Dekker, NY, Reviewer (2005).
ASM International, Reviewer (2006)
Molecular Pharmaceutics, Reviewer (2008- )
Biomacromolecules, Reviewer (2008- )
Cancer Epidemiology, Reviewer (2008- )
Cancer Research, Reviewer (2008- )
Nano Science and Technology Institute Conference, Reviewer (2008- ).
Molecular Cancer Therapeutics, Reviewer (2009- )
Bioconjugates Chemistry, Reviewer (2009- )
Cancer Epidemiology, Reviewer (2009- )
Journal of Biomedical Materials Research: Part A, Reviewer (2009- )
Journal of Biomaterial Science: Polymer Edition, Reviewer (2009- )
US Army Medical Research and Materiel Command (USAMRMC) Grant, Reviewer (2009- )
Ocular Pharmacology and Therapeutics, Reviewer (2010- )
Royal Society for Chemistry, Reviewer (2010- )
Therapeutic Delivery, Reviewer (2010- )
Trends in Molecular Medicine, Reviewer (2010- )
Advanced Functional Materials, Reviewer (2010-)
Chemical Papers, Reviewer (2010-)
Chemistry an Asian Journal, Reviewer (2010-)
ORAU Grant, Reviewer (2010- )
Biomedical Engineering Society Conference, Reviewer (2011-)
ChemPhysChem, Reviewer (2011-)
Journal of Biomedical Materials Research: Part B, Reviewer (2011- )
European Journal of Pharmaceutics and Biopharmaceutics, Reviewer (2011- )
Advanced Materials, Reviewer (2011-)
National Conference for Undergraduate Research, Biomedical Engineering Society Conference, Reviewer (2011-)
Nanomedicine, Reviewer (2012-)
Small, Reviewer (2012-)
Acta Biomateriala, Reviewer (2012-)
Langmuir, Reviewer (2012-)
Expert Opinion in Drug Delivery, Reviewer (2012-)
Journal of Nanotechnology, Reviewer (2012-)
Journal of Visualized Experiments, Reviewer (2012-)
NSF-MRI Grant, Reviewer (2012-)
Singapore-MIT Alliance for Research and Technology Innovation Grant, Reviewer (2012-)
Fonds recherche Québec - Nature et technologies (FRQNT), Reviewer (2012-)
Clemson’s Biomaterials Day-Society For Biomaterials, Organizer (2012)
Materials, Reviewer (2012-)
Chemistry and Asian Journal., Reviewer (2012-)
Polymer Degradation and Stability, Reviewer (2012-)
International Organizing Committee of the IUPAC MacroMolecular Complexes Conference, MMC-15:2013, Committee Member (2012)
American Association for the Advancement of Science (AAAS), INDO-US SCIENCE & TECHNOLOGY Grant, Reviewer (2012).
Military Medicine, Reviewer (2012-)
ACSNano, Reviewer (2013-)
Advanced Eng. Mat., Reviewer (2013-)
Advanced Healthcare Mat., Reviewer (2013-)
Drug Discovery Today, Reviewer (2013-)
Expert Reviews Medical Devices., Reviewer (2013-)
Open Journal of Biomedical Research., Reviewer (2013-)
SCIKNOW, Reviewer (2013-)
Tissue Engineering, Reviewer (2013-)
DoD-PRMRP Grant, Reviewer (2013-)
Nanyang Technological University-Singapore-Internal Grant, Reviewer (2013-)
CRC Book, Reviewer (2013)
Future Science, E-Book, Reviewer (2013)
CITATION INDEX: 1439
H-Index: 12
PUBLICATIONS
Book Chapter (N=7)
Kolishetti, N., Alexis, F., Pridgen, E., Farokhzad, O. C., Nanoplatform-Based Molecular Imaging, 1st edition (2011), John Wiley and Sons, Inc., Hoboken, NJ.
Rosen, Y., Mattix, Rao A., Alexis, F. Nanomedicine in Health and Disease, 1st edition (2011), Taylor and Francis Group, LLC, Boca Raton, FL.
Moore, T., Graham, E., Mattix, B., Alexis, F., Biomaterials Science: An Integrated Clinical and Engineering Approach, 1st edition (2012), Taylor and Francis Group, LLC, Boca Raton, FL.
Venkatraman, S.; Keith, K.; Rosen, Y.; Huang, Y.; Steele, T.W.J.; Alexis, F., Polymers for Vascular and Urogenital Applications, 1st edition (2012), Taylor and Francis Group, LLC, Boca Raton, FL.
Prior to Clemson:
Alexis, F.; Zeng, J.; Wang, S., Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual, 1st edition (2007) , Cold Spring Harbor Laboratory Press, New York, NY.
Pridgen, E.; Alexis, F.; Farokhzad, O. C.; Langer, R., Methods in Bioengineering Book Series Nanoscale Bioengineering and Nanomedicine, 1st edition (2009), Artech House , Boston, MA.
Alexis, F.; Pridgen, E.; Langer, R.; Farokhzad, O. C., Handbook of Experimental Pharmacology 197, 1st edition (2010), Springer, Berlin, Germany.
Referred Journal Publications (N=39)
Loo, S.C.J., Moore, T., Banik, B., Alexis, F., “Biomedical Applications of Hydroxyapatite Nanoparticles”, Current Pharmaceutical Biotechnology 11, 333-342 (2010).
Zha, L., Banik, B., Alexis, F., “Stimuli Responsive Nanogels”, Soft Matter 7, 5908-5916 (2011).
Stone, R., Willi, T.J., Mefford, T., Rosen, Y., Alexis, F., “Targeted Magnetic Hyperthermia”, Therapeutic Delivery 2, 815-838 (2011).
Votruba, A.R., Mattix, B., Alexis, F., Bao, X., Michna, E., Janfaza, D., Farokhzad, O.C., Ross, E., “Nanotechnology and chronic pain management: small drug carriers with large implications for future pain treatments”, Editorial for Pain, Submitted (2011).
Banik, B., Alexis, F., “Spatial Functionalization of Polymeric Films”, Cover page of Biomaterials Forum 33, 3, (2011).
Xiao, Z., Levy-Nissenbaum, E., Alexis, F., Lupták, A., Teply, B.A., Chan, J.M., Shi, J., Digga, E., Cheng, J., Langer, R., Farokhzad, O.C., “Engineering of Targeted Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake Selection”, ACS Nano 6, 696-704 (2012).
Chen, H., Colvin, D. C., Qi, B., Moore, T., He, J., Mefford, O. T., Alexis, F., Gore, J. C., Anker, J. N., “Magnetic and optical properties of multifunctional core-shell radioluminescence nanoparticles”, J. Mat. Chem. 22, 12802-12809 (2012).
Chen, H., Moore, T.; Qi, B.; Colvin, D.C.; Jelen, E.; Hitchcock, D.A.; He, J.O.; Mefford, T.; Gore, J.C.; Alexis, F.; Anker, J.N. “Monitoring pH-triggered Drug Release from Radioluminescent Nanocapsules with X-ray Excited Optical Luminescence.” ACS Nano, 7, 1178-1187 (2013).
Podila, R.; Moore, T.; Alexis, F.; Rao, M.A. “Graphene coatings for enhanced hemo-compatibility of nitinol stents”. RSC Advances , 3, 1660-1665 (2013).
Podila, R.; Moore, T.; Alexis, F.; Rao, M.A. “Graphene Coatings for Biomedical Implants”. Journal of Visualized Experiments, 73, e50276 (2013)
Moore, T.L., Pitzer, J., Podila, R., Wang, X., Lewis, R.L., Grimes S.W., Wilson, J.R., Skjervold, E., Brown, J., Rao, A., Alexis, F., “Polymer Coated Carbon Nanotubes to Safely Deliver Drugs”, Particles and Particle Systems Characterization, 30, 299 (2013).
Moore, T.L., Pitzer, J., Podila, R., Wang, X., Lewis, R.L., Grimes S.W., Wilson, J.R., Skjervold, E., Brown, J., Rao, A., Alexis, F. Cover Art in Particles and Particle Systems Characterization, Vol 30 (2013).
Chi, A.; Clayton, K.; Burrow, T.J.; Lewis, R.; Luciano, D.; Alexis, F.; D’hers, S.; Elman, NM; “Intelligent drug-delivery devices based on micro- and nanotechnologies”. Therapeutic Delivery, 4, 77-94 (2013)
Mattix, B.; Olsen, T.R.; Moore, T; Casco, M.; Simionescu, D.; Visconti, R; Alexis, “Accelerated Iron Oxide Nanoparticle Degradation Mediated by Polyester Encapsulation for Tissue Engineering Into Cellular Spheroids”. Adv. Funct. Mat., In Press (2013)
Chen, H.; Qi, B.; Moore, T.; Colvin, D.C.; Gore, J.C.; Alexis, A.; Mefford, O.T.; and Anker, J.N.” Synthesis of brightly luminescent magnetic up-conversion nanophosphors for dual MRI and deep tissue imaging. Small (In Press, 2013).
Mattix, B.; Olsen, T.R.; Gu, Y.; Casco, M.; Herbst, A.; Simionescu, D., Visconti, R. P., Kornev, K.G.; and Frank Alexis, “Biological Magnetic Cellular Spheroids as Building Blocks for Tissue Engineering”, Acta Biomateriala, In Press (2013).
Pridgen, E.M., Alexis, F., Kuo, T.T., Levy-Nissenbaum, E., Blumberg, R.S., Langer, R., Farokhzad, O.C., “Transepithelial Transport of Fc-Targeted Nanoparticles Across the Intestinal Epithelium Barrier by the Neonatal Fc Receptor for Oral Delivery”, Science Translational Medicine, Accepted (2013).
Mattix, B.; Olsen, T.R.; Casco, M.; Reese, L.; Poole, L.T.; Zhang, J.; Visconti, R.; Simionescu, A.; Simionescu, D.; Alexis, F. “Janus Magnetic Cellular Spheroids for Vascular Tissue Engineering”, Biomaterials, In press (2013).
Mattix, B.; Poole, T.; Casco, M.; Uvarov, O; Visconti, R. P.; Simionescu, D.; and Alexis F. “Small Diameter Vascular Grafts: Replacement Strategies, Maturation Techniques, and Challenges”, Journal of Tissue Science & Engineering, In Press (2013).
Moore, T.L.; Grimes, S.W.; Lewis, R.L.; Alexis, F.“Multilayered Coated Carbon Nanotube to Deliver Dasatinib”. Mol. Pharm., Accepted (2013).
Moore, T.; Chen, H.; Morrison, R.; Wang, F.; Anker, J.N., Alexis, F. “Nanotechnologies for Non-invasive Measurement of In Vivo Drug Release”. Mol. Pharma., Accepted (2013)
Mattix, B., Moore, T., Uvarov, O., Pollard, S., O'Donnell, L., Park, K., Horne, D., Dhulekar, J., Olsen, T., Duong, N.; Burg, K.; Kraveka , J., Alexis, F. “Effects of Polymeric Nanoparticle Surface Properties on Interaction with Brain Tumor Environment for Drug Delivery Applications”. NanoLife, Accepted (2013)
Ilyinskii, P.O., Roy, C.J.; O’Neil, C.P.; Browning, E.A.; Pittet, L.A.; Altreuter, D.H.; Alexis, F.; Tonti, E.; Shi, J.; Basto, P.A., Radovic-Moreno, A.F.; Iannacone, Langer, R.S., Farokhzad, O.C.; von Andrian,U.H.; Johnston, L.P.M.; and Kishimoto, T.K. “Adjuvant-Carrying Synthetic Vaccine Particles Augment the Immune Response to Encapsulated Antigen and Exhibit Strong Local Immune Activation without Inducing Systemic Cytokine Release”. Submitted (2013)
Chen, H.; Moore, T.; Qi, B.; Mefford, O.T.; Alexis, F.; and Anker, J.N. “Improving X-Ray and Up-Conversion Nanophosphor Cristallinity and Luminescence Intensity via a Confined Flux Method”. Submitted (2013)
Alexis, A.; and Anker, J.N.”Theranostic nanotechnologies: moving beyond imaging the localization of the drug”. Therapeutic Delivery (Editorial), Accepted (2013).
Prior to Clemson:
Alexis, F., Rath, S. K., Boey, F.Y.C., Venkatraman, S.,"Study of the Initial Stages of Drug Release from a Degradable Matrix of Poly (d,l-lactide-co- glycolide)", Biomaterials 25, 813-821 (2004).
Alexis, F., Rath, S. K, Venkatraman, S., “In Vitro Study of Release Mechanisms of Paclitaxel and Rapamycin from Drug-Incorporated Biodegradable Stent”, Journal of Controlled Release 98, 67-74 (2004).
Alexis, F., Rath, S. K., Boey, F.Y.C., Venkatraman, S., “Controlled drug release of bioerodible polymers: effect of drug type and composition”, Journal of Controlled Release 102, 333-344 (2005).
Alexis, F., "Factors Affecting Degradation and Drug Release Mechanisms of Bioerodible Polymers", Polymer International 54, 36-46 (2005).
Tang, G.P., Zeng, S., Alexis, F., Yang, Y.Y., Wang, S., “Low Molecular Weight Polyethylenimine Copolymerized with B-cyclodextrin for Gene Delivery”, Journal of Gene Medicine 8, 736-744 (2006).
Alexis, F., Rath, S. K., Gan, L-H., Venkatraman, S.,”Some Insight into Hydrolytic Scissions Mechanisms in Bioerodible Polyesters”, Journal of Applied Polymer Science 102, 3111-3117 (2006).
Alexis, F., Lo, S.L., Wang, S., “Covalent Attachment of Low Molecular Weight Polyethylenimine Improves Tat-Peptide Mediated Gene Delivery", Advanced Materials 18, 2174-2178 (2006).
Zhang, L., Radovic-Moreno, A., Alexis, F., Gu, F.X., Basto, P., Langer, R, Farokhzad, O. C., “Co-Delivery of Hydrophobic and Hydrophilic Drugs from Nanoparticle-Aptamer Bioconjugates”, ChemMedChem. 2, 1268-1271 (2007).
Gu, F.X., Karnik, R., Wang, A. Z., Alexis, F., Levy-Nissenbaum, E., Hong, S., Langer, R., Farokhzad, O. C.,” Targeted Nanoparticles for Cancer Therapy”, NanoToday 2, 14-21 (2007).
Alexis, F., Basto, P., Levy-Nissenbaum, E., Radovic-Moreno, A., Zhang, L., Langer, R., Molnar, L., Farokhzad, O. C.,”HER-2 Targeted Nanoparticle-Affibody Bioconjugates for Breast Cancer Therapy“, ChemMedChem. 3, 1839-1843 (2008).
Zhang, L., Chan, J. M., Gu, F.X., Rhee, J-W., Wang, A.Z., Radovic-Moreno, A., Alexis, F., Langer, R, Farokhzad, O. C., “Self-Assembled Lipid-Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform”, ACS Nano 2, 1696-1702 (2008).
Alexis, F., Radovic-Moreno, A., Rhee, J-W, Richie, J. P., Langer, R., Farokhzad, O. C., "New Frontiers in Nanotechnology for Cancer Treatment", Journal of Urological Oncology 26. 74-85 (2008).
Wang, A. Z., Bagalkot, V., Vasilliou, C., Gu, F.X., Alexis, F., Zhang, L., Shaikh M., Yuet, K. , Cima, M., Langer, R., Farokhzad, O. C., Kantoff, P.W., Bander, N.H., Jon, S., Farokhzad, O. C., "Superparamagnetic Iron Oxide Nanoparticle-Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy”, ChemMedChem. 9, 1311-1315 (2008).
Alexis, F., Pridgen, E., Langer, R., Farokhzad, O. C., "Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles", Molecular Therapeutics 5, 505-515 (2008).
Conference Proceedings: (Peer Reviewed N=22))
Banik, B.L., Rogers, M., Dhulekar, J., Moore, T.L., Alexis, F., “Synthesis and Testing of Biomolecules to Target Bone”, Proceedings of the National Conference of Undergraduate Research, Ithaca College, Ithaca, NY, (2011).
Banik, B.L., Rogers, M., Dhulekar, J., Moore, T.L., Alexis, F., “Synthesis and Testing of Biomolecules to Target Bone”, Proceedings of the ACC Meetings of Minds, University of Miami, Miami, FL, (2011).
Keith, K., Mattison, S., Collier, M., Lewis, R., Alexis, F. “Testing Chemotherapeutic Drugs for Synergistic Toxicity Using Several Cancer Cell Lines”, Proceedings of the ACC Meetings of Minds, University of Miami, Miami, FL, (2011).
Wright-Walker, C. J., DesJardins, J. D., Alexis, F., LaBerge, M., “Tribological Evaluation of a Drug Enriched Ultra-High Molecular Weight Polyethylene for Enhanced Total Joint Replacement Bearing Surface Functionality”, Proceedings of the Society For Biomaterials Meeting, Orlando, FL, (2011).
Mattix, B., Reese, L., Pollard, S., Anderson, J., Carpenter, K., Davda, L., Breece, J., Alexis, F.”Effects of Polymeric Nanoparticle Surface Properties on Interaction with Brain Cancer Cells”, Proceedings of the Southeast Regional IDeA Meeting, New Orleans, LA, (2011).
Mattix, B., Uvarov, O., Willi, T., Reese, L., Pollard, S., Frankel, B., Alexis, F. “ Effects of Polymeric Nanoparticle Surface Properties on Interaction with Brain Tumor Environment”, Proceedings of the SC INBRE Scientific Symposium, Columbia, SC, (2012).
Mattix, B., Reese, L., Poole, T., Visconti, R., Simionescu, D., Simionescu, A., Jenkins, L., Bruce, T., Alexis, F. “Assembly of Engineered Blood Vessels Using Magnetic Forces.” Proceedings of the SC Project for Organ Biofabrication Scientific Symposium, Columbia, SC, (2012).
Poole, T., Mattix, B, Reese, L., Alexis, F. “Magnetic Spheroids For Tissue Engineering Applications.” Proceedings of the National Conference on Undergraduate Research, Weber State University, Ogden, Utah, (2012).
Wright-Walker, C. J.; Golightly, C. E.; Alexis, F.; DesJardins, J. D.; LaBerge, M.; “Tribological Evaluation of a Drug Enriched Ultra-High Molecular Weight
Polyethylene for Enhanced Total Joint Replacement Bearing Surface Functionality”;
Proceedings of the Society For Biomaterials Conference, New Orleans, (2012).
Moore, T. L.; Stoner, B.; Morrison, R.; Simionescu, A.; Simionescu, D.; Recknor, C.; Alexis, F.; “Targeted, Multifunctional Nanoparticles for Controlled Delivery of Anabolic Bone Therapy Drugs”. Proceedings of the Society For Biomaterials Conference, New Orleans, (2012).
Mattix, B.; Poole, T.; Casco1, M.; Visconti, R.; Simionescu, D.; Simionescu, A.;
Alexis, F.; “Spatial Control of Magnetic Nanoparticles Integrated with Cellular Spheroids as Tissue Engineered Building Blocks”. Proceedings of the Society For Biomaterials Conference, New Orleans, (2012).