Kolb, E. Anders March 6, 2014
Curriculum Vitae
Edward Anders Kolb, M.D.
Home Address:
804 Roberts Way
Kennett Square, PA 19348
Office Address:
Nemours Center for Cancer and Blood Disorders
Alfred I. duPont Hospital for Children
1600 Rockland Road
Wilmington, DE 19803
Education:
1988-1992 BA, University of Pennsylvania, Philadelphia, PA (Biological Basis of Behavior)
1992-1996 MD, Jefferson Medical College, Philadelphia, PA
Postgraduate Training and Fellowship Appointments:
1996-1999 Resident in Pediatrics, St. Christopher’s Hospital for Children, Philadelphia, PA
1999-2001 Fellow in Pediatric Hematology and Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY
2000-2002 Research Fellow in Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center, New York, NY
2001-2002 Chief Fellow, Pediatric Hematology and Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY
Faculty Appointments:
2002-2004 Memorial Sloan-Kettering Cancer Center, New York, NY
Clinical Instructor, Pediatric Hematology and Oncology
2004-2007 Albert Einstein College of Medicine, Bronx, NY
Assistant Professor, Pediatrics, Division of Hematology and Oncology
2004-2007 The Children’s Hospital at Montefiore, Bronx, NY
Assistant Professor, Pediatrics, Division of Pediatric Hematology and Oncology
2013-Present Associate Professor, Thomas Jefferson University, Jefferson Medical College
Hospital and Administrative Appointments:
2002-2004 Member, Pediatric Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY
2002-2004 Member, Pediatric Stem Cell Transplantation Service, Memorial Sloan-Kettering Cancer Center, New York, NY
2004-2007 Member, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY
2004-2007 Director, Pediatric Preclinical Chemotherapy Testing Laboratory, Albert Einstein College of Medicine, Bronx, NY
2004-2007 Director, Pediatric Stem Cell Transplantation, The Children’s Hospital at Montefiore, Bronx, NY
2004-2007 Director, Pediatric Leukemia and Lymphoma Service, The Children’s Hospital at Montefiore, Bronx, NY
2007-Present Nemours Alfred I. duPont Hospital for Children, Wilmington, DE
Attending Physician, Pediatrics, Nemours Center for Cancer and Blood Disorders
2007-Present Program Director, Blood and Bone Marrow Transplantation, Nemours Alfred I. duPont Hospital for Children, Wilmington, DE
2007-Present Head, Cancer Therapeutics Laboratory, Nemours Center for Childhood Cancer Research, Wilmington, DE
2011-Present Director, Nemours Center for Cancer and Blood Disorders, Nemours Alfred I. duPont Hospital for Children, Wilmington, DE
2012-Present Interim Director, Nemours Center for Childhood Cancer Research, Nemours Alfred I. duPont Hospital for Children, Wilmington, DE
2013-Present Chief, Division of Hematology and Oncology, Nemours Alfred I. duPont Hospital for Children, Wilmington, DE
Specialty Certification:
2003 - Present Pediatric Hematology-Oncology (American Board of Pediatrics),
Licensed Physician:
1996-2001 Pennsylvania (MT039273T)
2001-2008 New York (#214133)
2007-present Delaware (#C-10008378)
2012-present Pennsylvania (MD446009)
Awards, Honors and Membership in Honorary Societies:
1996 J. Woodrow Savacool Award in Medical Ethics, Jefferson Medical College
1996 Alfred I. duPont Award in Pediatrics, Alfred I duPont Institute
1996 The E. Harold Hinnman Memorial Prize, Jefferson Medical College
1999 The Nancy Elizabeth Barnhart Memorial Award, St. Christopher’s Hospital for Children
1999 David S. Smith Housestaff Teaching Award, St. Christopher’s Hospital for Children
2000 Revson Fellow for Biomedical Research, Memorial Sloan-Kettering Cancer Center
2002 Merit Award, American Society of Clinical Oncology
2007 Member, Society for Pediatric Research
2010 Nemours Alfred I. duPont Hospital for Children, Physician of the Year
2011 Nemours, Physician Award for Excellence in Scholarship
2011 Leukemia & Lymphoma Society, Man of the Year Candidate (Runner-up)
2012 Resident Educator of the Month (March)
Membership in Professional and Scientific Societies:
2001-present American Association of Cancer Research
2002-present Children’s Oncology Group
2007-present Society for Pediatric Research, Member
2007-present American Society for Blood and Marrow Transplantation
2013-present American Society of Hematology
Professional and Scientific Committees:
Local
1999-2002 Graduate Medical Education Committee, Memorial Sloan-Kettering Cancer Center
2001-2002 Quality Assessment Committee, Memorial Sloan-Kettering Cancer Center
2000-2004 Pediatric Pharmacy QA Subcommittee, Memorial Sloan-Kettering Cancer Center
2001-2004 Parent Bereavement Committee Member, Memorial Sloan-Kettering Cancer Center
2002-2004 Pediatric Day Hospital Committee Member, Memorial Sloan-Kettering Cancer Center
2003-2004 Junior Faculty Council Member, Memorial Sloan-Kettering Cancer Center
2004-2007 Residency Selection Committee, The Children’s Hospital at Montefiore
2004-2007 Chemotherapy Quality Assurance Committee, The Children’s Hospital at Montefiore
2004-2007 Stem Cell Transplant Medical Advisory Committee, The Children’s Hospital at Montefiore
2007-Present Bereavement Committee, Nemours Alfred I. duPont Hospital for Children
2007-Present Spirituality and Healing Committee, Nemours Alfred I. duPont Hospital for Children
2007-Present Cancer Committee, Nemours Alfred I. duPont Hospital for Children
2010-Present Member, Nemours Institutional Animal Care and Use Committee
2010-Present Member, Nemours Institutional Biosafety Committee
2010-Present Chair, Nemours Alfred I. duPont Hospital for Children, Pharmacy and Therapeutics Committee
2011-2012 Member, Nemours Nominating Committee for Physician Excellence Awards
2011-2012 Member, Nemours Search Committee for the Executive Director for Clinical Research Services
2011-Present Steering Committee, Delaware Bioinformatics Collaborative
2013-Present Member, Nemours Strategy Council
2013-Present Member, Nemours Guiding Council
National
2000-2002 American Society of Clinical Oncology, Scientific Program Committee Member
2000-2002 American Society of Clinical Oncology, Career Development Committee
2001-2003 Alliance for Childhood Cancer, ASCO representative
2004-2007 Children’s Oncology Group, Member, Tcell ALL Working Group
2004-present Children’s Oncology Group, AALL0434 Study Committee Member
2004-Present Member, Pediatric Preclinical Testing Program
2005-2007 Member of the Committee on Clinical Investigations, Albert Einstein College of Medicine (AECOM IRB)
2010-Present Chair, COG ADVL1014 Study Committee
2011-Present Member, Children’s Oncology Group Bone Tumor Committee
2011-Present Member, Children’s Oncology Group Ewing Sarcoma Working Group
2011-Present Member, Children’s Oncology Group Osteosarcoma Working Group
2012-Present Study Committee Member, Children’s Oncology Group AEWS1221
2012-Present Scientific Council Member, Children’s Oncology Group
2012-Present Sarcoma Alliance for Research through Collaboration, Concept Review Committee Member
2013-Present Chair, Myeloid Disease Committee, Children’s Oncology Group
2013-Present Study Committee Member, Children’s Oncology Group AOST1322
2013-Present Study Committee Member, Children’s Oncology Group AAML1331
2013-Present Data Safety and Monitoring Review Board, National Cord Blood Program, New York Blood Center
2013-Present Member-at-Large, Executive Committee, Pediatric Blood and Marrow Transplant Consortium.
Editorial Positions:
Editorial Board Member – Clinical Cancer Research (2011 – present)
Editorial Board Member – Frontiers in Pediatric Oncology (2011-present)
Invited to review manuscripts for Adolescent and Young Adult Oncology, Apoptosis, Blood, Cancer Research, Cell Biology and Toxicology, Clinical Cancer Research, Clinical Orthopaedics and Related Research, European Journal of Cancer, European Journal of Endocrinology, Expert Opinion on Drug Discovery, Expert Opinion on Investigational Drugs, Hematologica, Immunotherapy, International Journal of Cancer, Journal of Chemotherapy, Journal of Clinical Oncology, Journal of Orthopedic Research, Journal of Pediatric Hematology and Oncology, Leukemia, Molecular Cancer Therapeutics, Molecular Diagnosis and Therapy, Pediatric Blood and Cancer, Pediatric Drugs, The Pharmacogenomics Journal, PLoS Journal, Supportive Care in Cancer
Grant reviewer for: Congressionally Directed Medical Research Programs, Leukemia and Lymphoma Research UK, Cancer Research UK, Liddy Shriver Sarcoma Foundation, St. Baldricks Foundation, The Andrew McDonough B+ Foundation and the Bodhi Fund.
Major Teaching and Clinical Responsibilities:
Memorial Sloan-Kettering Cancer Center
2001-2002 Chief Fellow, Department of Pediatrics, Memorial Sloan-Kettering Cancer Center
Responsible for coordinating the educational program for Pediatric Hematology and Oncology Fellows.
2002-2004 Attending Physician on clinical service 9 weeks per year supervising residents and medical students.
The Children’s Hospital at Montefiore
2004-2007 Attending Physician on clinical service 12 weeks per year supervising residents and medical students.
2004-2007 Responsible for resident lectures on pediatric leukemia, lymphoma, immunodeficiencies, transfusion medicine, and bone marrow transplant.
Nemours Alfred I. duPont Hospital for Children
2007-Present Attending on Blood and Bone Marrow Transplantation Service at Nemours Alfred I. duPont Hospital for Children supervising Thomas Jefferson University (TJU) pediatric residents and medical students 40 weeks per year
2007-Present Attending on Hematology and Oncology Service at Nemours Alfred I. duPont Hospital for Children supervising TJU pediatric residents and medical students 6 weeks per year
2007-Present Responsible for resident lectures on pediatric immunodeficiencies and bone marrow transplant.
2007-Present Supervised resident and medical student research projects in the Cancer Therapeutics Laboratory
2008-Present Invited speaker for Hematology and Oncology Section of the annual Board Review Course
2009-Present Responsible for Bone Marrow Transplant Lectures for Gastroenterology, Critical Care, Pulmonary and Immunology Fellows
Lectures by Invitation:
2004 Grand Rounds Long Island College Hospital, “Alloimmune Thrombocytopenia in Fetuses and Neonates”
2004 Invited Speaker, The Children’s Hospital at Montefiore Alumni Day, “Hematopoietic Stem Cell Transplantation in Children”
2005 Grand Rounds Brookdale Hospital, “Hematopoietic Stem Cell Transplantation in Children”
2005 Grand Rounds Norwalk Health System “Leukemia and Hematopoietic Stem Cell Transplantation in Children”
2005 Grand Rounds Stamford Health System “Hematopoietic Stem Cell Transplantation in Children”
2006 Invited Keynote Speaker at the Annual Meeting of the New York Allergy and Asthma Society “Hematopoietic Stem Cell Transplantation in Children.”
2006 Co-Chaired a series of national teleconferences on Relapsed and Refractory Childhood ALL sponsored by Genzyme Oncology
2006 Hematology Grand Rounds, Montefiore Medical Center, “Diamond-Blackfan Anemia”
2006 Invited Speaker – New York Hematology and Oncology Consortium. “Preclinical Testing in Pediatrics.”
2007 Grand Rounds, Nemours Alfred I. duPont Hospital for Children– “Bone Marrow Transplantation in Children”
2008 Grand Rounds Riddle Memorial Hospital – “Bone Marrow Transplantation in Children”
2009 Invited Speaker, Pediatric Research Conference, Weill Cornell Medical College – “IGF1R signaling in Osteosarcoma”
2010 Invited Speaker, Alex’s Lemonade Stand Foundation, Childhood Cancer Symposium. “Bereavement Support”, Philadelphia, PA
2010 Invited Speaker, Lankenau Hospital, Department of Obstetrics and Gynecology Grand Rounds. “Public Cord Blood Banking”
2011 Invited Speaker, Solving Kids Cancer, Webinar, “Oncolytic Virus Therapy in Children.”
2011 Invited Speaker, Thomas Jefferson University, Department of Pediatrics Grand Rounds, “Cord Blood Banking: rationale and patient counseling”
2011 Invited Speaker, American College of Osteopathic Obstetricians and Gynecologist Annual Meeting, “Cord Blood Banking: rationale and patient counseling”
2011 Regional Meeting, Clinical Pediatric Oncology Nursing, “Cord Blood Banking: rationale and patient counseling.”
2012 Leukemia and Lymphoma Society, “Progress in Research for Leukemia and Lymphoma.”
2013 Invited Lecture: “Pediatric Leukemia and Bone Marrow Transplantation. del V Congreso Nacional de Oncología, III Taller de Patología y III Jornadas de Enfermería Oncológica
Bibliography:
Publications, Peer-Reviewed
1. Friedman D, Hu Z, Kolb EA, Gorfajn B, and Scotto KW. Ecteinascidin-743 inhibits activated but not constitutive transcription. Cancer Res. 2002 62: 3377-3381
2. Kolb EA, Kushner BH, Gorlick R, Laverdiere C, Healey JH, LaQuaglia MP, Huvos AG, Qin J, Vu T, Wexler L, Wolden S, and Meyers PA. Long-term event-free survival after intensive chemotherapy for Ewing's family of tumors in children and young adults. J Clin Oncology, 2003;21:3423-3430
3. Kolb EA, Steinherz PG. A new multidrug re-induction protocol with topotecan, vinorelbine, thiotepa, dexamethasone, and gemcitabine (TVTG) for relapsed or refractory acute leukemia. Leukemia, 2003;17:1967-1072.
4. Laverdiere C, Kolb EA, Supko JG, Gorlick R, Meyers PA, Maki RG, Wexler L, Demetri GD, Healey JG, Huvos AG, Goorin A, Bagatell R, Ruiz-Casado A, Guzman C, Jimeno J, Harmon D. Phase II study of Ecteinascidin 743 in heavily pretreated patients with recurrent osteosarcoma. Cancer, 2003;98:832-40.
5. Kolb EA, Pan Q, Ladanyi M, Steinherz PG. Imatanib mesylate in Philadelphia chromosome positive leukemia of childhood. Cancer, 2003;98:2643-50.
6. Hoang B, Kubo T, Healey JH, Yang R, Nathan SS, Kolb EA, Mazza R, Meyers PA, Gorlick RG. Dkk-3 Inhibits Invasion and Motility of Saos-2 Osteosarcoma Cells by Modulating the Wnt-Beta-Catenin Pathway. Cancer Res. 2004;64:2734-9
7. Berkowitz RL, Kolb EA, McFarland JG, Weisert M, Primani A, Lesser M, Bussel JB. Parallel randomized trials of risk-based therapy for fetal alloimmune thrombocytopenia. Obstetrics and Gynecology, 2006 Jan;107(1):91-6.
8. Houghton PJ, Morton CL, Tucker C, Payne D, Favours E, Gorlick R, Kolb EA, Zhang W, Lock R, Carol H, Tajbakhsh M, Reynolds CP, Maris JM, Courtright J, Keir ST, Friedman HS, Stopford C, Zeidner J, Wu1 J, Liu T, Billups CA, Khan J, Ansher S, Zhang J, Smith MA. The Pediatric Preclinical Testing Program: Description of Models and Early Testing Results. Pediatric Blood and Cancer, 2007 Dec;49(7):928-40.
9. Yang R, Kolb EA, Qin J, Chou A, Sowers R, Hoang B, Healey JH, Huvos AG, Meyers PA, Gorlick R. The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate. Clin Cancer Res. 2007 May 1;13(9):2557-67.
10. Garg V, Zhang WE, Kolb EA. ILX651 inhibits growth of pediatric sarcoma lines in vitro and in vivo. Clin Cancer Res. 2007 Sep 15;13(18):5446-54
11. Scheinfeld MH, Lui YW, Kolb EA, Engel HM, Gomes WA, Weidenheim KM, Bello JA. The neuroradiological findings in a case of Revesz syndrome. Pediatr Radiol. 2007 Nov;37(11):1166-70.
12. Houghton PJ, Morton CL, Tucker C, Payne D, Favours E, Gorlick R, Kolb EA, Zhang W, Lock R, Carol H, Tajbakhsh M, Reynolds CP, Maris JM, Courtright J, Keir ST, Friedman HS, Stopford C, Zeidner J, Wu1 J, Liu T, Billups CA, Khan J, Ansher S, Zhang J, Smith MA. Stage 1 Testing of the Proteasome Inhibitor Bortezomib by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer. 2008 Jan;50(1):37-45
13. Maris JM, Courtright J, Houghton PJ, Morton CL, Gorlick R, Kolb EA, Lock R, Tajbakhsh M, Reynolds CP, Keir ST, Wu J, Smith MA. Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2008 Mar;50(3):581-7
14. Tajbakhsh M, Houghton PJ, Morton CL, Kolb EA, Gorlick R, Maris JM, Keir ST, Wu J, Reynolds CP, Smith MA, Lock RB. .Initial testing of cisplatin by the pediatric preclinical testing program.
Pediatr Blood Cancer. 2008 May;50(5):992-1000
15. Houghton PJ, Morton CL, Kolb EA, Gorlick R, Lock R, Carol H, Reynolds CP Maris JM, Keir ST, Billups CA, Smith MA. Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program. Pediatr Blood Cancer. 2008 Apr;50(4):799-805
16. Kolb EA, Gorlick R, Houghton PJ, Morton CL, Lock RB, Tajbakhsh M, Reynolds CP Maris JM, Keir ST, Billips CA, Smith MA. Initial testing of dasatinib by the pediatric preclinical testing program. Pediatr Blood Cancer. 2008 Jun;50(6):1198-206.
17. Lock R, Carol H, Houghton PJ, Morton CL, Kolb EA, Gorlick R, Reynolds CP, Maris JM, Keir ST, Wu J, Smith M. Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2008 Jun;50(6):1181-9.
18. Kolb EA, Gorlick R, Houghton PJ, Morton CL, Lock RB, Hernan C, Reynolds CP Maris JM, Keir ST, Billips CA, Smith MA. Initial Testing (Stage 1) of a Monoclonal Antibody (SCH 717454) against the IGF-1 Receptor by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer. 2008 Jun;50(6):1190-7.
19. Smith MA, Morton CL, Phelps DA, Kolb EA, Lock R, Carol H, Reynolds CP, Maris JM, Keir ST, Wu J, Houghton. Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the pediatric preclinical testing program. Pediatr Blood Cancer. 2008 Jul;51(1):34-41