BIOGRAPHICAL SKETCH

NAME
Mohamed Mosaad Salama / POSITION TITLE
Director
Experimental Neurology unit
Mansoura University
Mansoura, Egypt
Phone: ++201060556633
E-mail:

NATONALITY
Egyptian
DATE OF BIRTH
30 November 1975
EDUCATION/TRAINING
INSTITUTION / DEGREE / YEAR / FIELD OF STUDY
Mansoura University
Mansoura University
Mansoura University-(in collaboration with Philipps University Marburg, Germany-DAAD GERSS scholarship)
AUC (American University Cairo)
Suez Canal University / MBBCH=MD
MSc
MD= PhD
DTQM
DHPE / 1999
2006
2011
2008
2010 / Medicine
Toxicology
Neurotoxicology
Healthcare
Medical education

A. Positions and Honors

Positions and Employment

2011- Present Assistant Professor., Department of Toxicology Mansoura University. Mansoura, Egypt.

2011- Present Head of Experimental Neurology Unit- MERC

2011- Present International Coordinator- MERC

2012- Present Mansoura University Regenerative Medicine Programme (MURMP)- Coordinator

2013-Present Egyptian Network of Neurodegenerative Disorders

(ENND) - Coordinator

2013. Present Coordintor of project to study genetics of Parkinson’s disease (EGI PD)

2015- Present Academic Director of Neurotoxicology Fellowship of Mansoura University.

Honors

2009 Mansoura University Best Master Thesis

2010 DAAD Scholarship GERSS, BMFZ-Marburg- Germany

2010 German Egyptian Research Fund (GERF 2010)

2011 MERC Research Grants

2012 Best Neurology Poster (ISCOMS-2012, for my student Amr Ellaithy)

2012 Best National Student Research – Ministry of higher Education (2012)

[My student Basim Helmy]

2012 DAAD- German-Arab Research Partnerships – Al Tawasul

2013 Society of Toxicology [ SOT] Global Senior Scholar Awardee – 2013

2013 IBRO grant to organize a neuroscience school in Mansoura University" Epigenetics in Neurological disorders" October, 2014

2013 Establishment of Egyptian Network of Neurodegenerative Disorders (ENND)

2014 Movement Disorders Society (MDS), grant to organize Neuroscience school in Mansoura. Egypt

2014 International Society of Neurochemistry (ISN) grant

2014 IBRO-ARC Bursaries for short research fellows, Duke University, USA

2014 Science and Technology Development Fund SSE grants, Egypt

2014 Egyptian Young Academy of Science (EYAS) Membership

2014 International Society of Neurochemistry (ISN) CAEN 1A award

2014 Mansoura University competitive research projects-2014: Project a.

2014 Mansoura University competitive research projects-2014: Project b.

2014 MEK Foundation Prize for Best International Publication for year 2013

2014 Parkinson’s and movement disorders foundation (PMDF) research grant

2014 Science and Technology Development fund (STDF) Research Support

Grants.

2015 International Development Research Centre (IDRC) -Research Grant

2015 IBRO /WWN awards

2015 Movement Disorders Society (MDS) grant to organize School

2015 SOT Translational/Bridging Award, 2016

2015 DAAD- Cultural Dialogue with Islamic World- Gene Finder Project

2015 Mansoura University competitive research projects-2015

2015 JESOR grant; Academy of Scientific Research and Technology (ASRT)

2016 Science and Technology Development Fund (STDF), Basic and Applied

Research Grant

2016 Fulbright - Junior Faculty Development Program (2016-2017) Awardee

2016. Technical University of Munich (TUM) GLOBAL INCENTIVE GRANT

2016 International Parkinson’s and Movement Disorders Society Supported

Meetings.

Professional Memberships and Service

Member:

1.  Society of Toxicology (SOT)- U.S.A. - Neurotoxicology speciality section

2.  International Society of Neurochemistry (ISN)

3.  International Parkinson and Movement Disorders Society (MDS)

4.  International neurotoxicology association (INA)

5.  Egyptian Young Academy of Science (EYAS)

6.  Egyptian Network of Neurodegenerative Diseases (ENND)-Coordinator

7.  Index Copernicus scientists

8.  Egyptian society of natural toxins – Egypt

9.  Board of Quality Assurance Unit Mansoura School of Medicine

10.  Board of Medical Experimental Research Center Grant Committee –Mansoura- Egypt

11.  DAAD Alumni- Egypt

Ad-hoc reviewer for:

1. PLOS one

2. Nature Scientific Reports

3. Toxicology

4. Neuroscience Letters

5. CNS & Neurological Disorders-Drug Targets Journal

6. Frontiers in Neurology

7. Therapeutic advances in neurological disorders

8. International Archives of Medicine

Editorial experience:

2011 – Present Editorial Board, International archives of Medicine (IAM).

2014 Editorial board, Pharmacologia

2014. Editorial board, Frontiers in Neurology

Research Support

Ongoing Research Support

German Arab Research Partnership (DAAD), Mohamed Salama (PI) 2013-2015

Title: Parkinson’s Susceptibility

Goal: Studying the interplay between genes and environment in the development of PD among Egyptian patients

Through recruiting Egyptian PD patients (both high risk and low risk exposure to pesticides) we were able to obtain samples from 500 patients so far who are exposed to different types of genetic study and epidemiologic studies. I applied my experience in neurodegenerative diseases research trying to answer this question.

IBRO/ISN/Mansoura University competitive projects, Mohamed Salama (PI) 2014-2015

Title: Peripheral biomarkers for brain injury (Mansoura/Duke Collaboration)

Goal: Validation of peripheral biomarkers for chemical induced brain injury.

As a neurotoxicologist, I applied my experience to isolate patients chronically exposed to pesticides and examine them clinically then through western blot technique we are trying to find easy and simple way to diagnose the impact of OPs on their brains.

Mansoura University competitive projects, Mohamed Salama (PI) 2014-2015

Title: Assessment of impact of SSRI on osteogenic differentiation on Mesenchymal stem cells

Goal: Studying the impact of novel SSRI on osteogenic differentiation of mesenchymal stem cells

Through this grant we will try to find out the impact of new antidepressants on osteogenesis. Through my experience in stem cell research i will manage to answer this question.

Parkinson’s and movement disorders foundation (PMDF) research grant, Mohamed Salama (PI), 2015

Title: siRNA based silencing of Mammalian target of rapamycin (mTOR): Implications for Tauopathy.

Goal: Studying the effect of blocking mTOR on tauopathy in LUHMES cell line.

Through my experience in invitro research, i will try to unravel the role of mTOR on neurodegeneration and suggest potential new therapeutic targets.

International Development Research Centre (IDRC): Ramzi Salloum (PI) 2015-2016

Title: Waterpipe and nicotine addiction in Arab world: A multicenter study

Goal: The goal of this study is to identify the liability of WP and nicotine addiction among Arab people with exploring ways for prevention.

Cultural Dialogue with Islamic World, DAAD: Mohamed Salama (PI) 2016-2018

Title: Genetic Factors for Inherited Neurodegenerative Diseases in Egyptian Regions. (GeneFINDER)

Goal: The goal of this study is to identify genes responsible for different neurodegenerative disorders in Egyptian population.

Mansoura University competitive projects, Mohamed Salama (PI) 2015-2016

Title: siRNA blocking of mitochondiral complex I assembly factors: Implications for Tauopathy

Goal: studying the putative role of CI assembly factors in developing Tauopathy

JESOR Grant,Academy of scientific Research and Technology (ASRT): Mohamed Salama (PI) 2016-2017

Title: Developing new serum biomarkers for diagnosis of Parkinson’s disease (PD)

Goal: developing new biomarkers from sera of PD patients..

STDF: Basic and Applied Research Grant: Mohamed Salama (PI) 2016-2017

Title: siRNA induced blocking of mTOR in animal model of Tauopathy

Goal: studying the impact of silencing mTOR as a therapeutic approach for transgenic animal mode of tauopathy

Completed Projects:

German Egyptian Research Fund (GERF): Mohamed Salama (PI) 2012-2013

Title: Model Fusion of Systemic Exposure of Environmental Toxins in Transgenic Mice Inducing a Progressive Model of Parkinsonism.

Goal: Establishing new animal model for PD

This big EGY/GER research fund needed a good coordination between different researchers from Egypt and Germany. I succeeded to coordinate this project to establish a new model that recapitulate the pathology of PD through combining environmental agents and genetic mutations.

MERC Research Grants: Mohamed Salama (PI) 2012-2013

Title: Novel neuroprotectants for PD

Goal: developing new neuroprotectants against PD.

I managed, with my team, to develop new agents to treat PD. Through collaboration between different team members including students, technicians and postdocs, we managed to reach to promising new agents that can help in the fight against PD.

Research Interests:

My research focus is in the role of environmental pollutants and their role in inducing neurodegeneration. The most important area in pathogenesis of neurodegenerative disorders e.g PD and tauopathy is the interplay between environment and genes. This is my main interest.

Previous teaching experiences:

Thirteen years of teaching to Medical students of Mansoura Medical School. I taught the course of Medical Toxicology.

Four years for teaching Medical students course of biomedical research basics in the Medical Experimental Research Center.

I assisted in teaching activities in Duke University (Pharmacology Department) and Philipps University Marburg, Germany (Neuroscience course).

I have further qualification in Health education through DHPE, where i have good experience in Problem Based Learning (PBL) and other recent modalities of medical education.

Teaching Faculty in the IBRO neuroscience School, Khouribga, Morrocco, 2015

Relevant Experience:

1- Working in Mansoura University Hospitals (MUHs) as a clinical toxicologist in Toxicology Unit – Emergency hospital

2- Working in Medical Experimental Research Center (MERC) of Mansoura University on stem cells in Parkinson disease models in animals.

3- Working in the Experimental Neurology Unit, Biomedical Research Center (BMFZ) of Philipps University, Marburg as a part of PhD thesis through DAAD scholarship on variable techniques for inducing Parkinson Disease in animals and the analysis of therapeutic approaches for these models.

4- Research Fellowship to the (BMFZ), Marburg University (1-6-2012) through GERF project.

5- Research Fellowship to Pharmacology and Cancer Biology Dept., Duke University USA (03/2013).

6- Research Fellowship to Pharmacology and Cancer Biology Dept., Duke University USA (11/2014).

Specific and Technical skills:

- Stereotactic surgeries on rodents including toxin injections, viral vector injections and fetal cell transplantation.

- Toxic models of neurodegenerative disorders especially PD using MPTP, Paraquat and Rotenone.

- Behavioural testing on rodents, including Cylinder test, Stepping test, Staircase test, Rotation tests (spontaneous- and drug-induced), dyskinesia test and open-field.

- Histological analyses, including autoradiograph (in situ hybridization and DAT binding) and immunohistochemisty.

- Morphological analyses including un-biased stereology (CAST) and fiber-density measurements, image analysis (e.g. imageJ ) and confocal laser microscopy (CLM).

- Cell culture techniques especially stem cells isolation, culture and differentiation.

- Analysis of chemicals in various tissues using TLC, HPLC and GC-MS techniques.

- Quality specialist in the field of quality control, implementation and improvement programs in hospitals and teaching institutes.

B. Publications

PhD Thesis:

Evaluation of stem cell therapies in MPTP induced toxic parkinsonism in mice

Theses supervision:

1-Mitochondrial complex I inhibition role in Neurodegenerative disorders. 2011[MSc.]

2-Isolation and characterization of mesenchymal stem cells from adipose tissue in mice, 2012 [MSc.]

3-Neural Stem Cells (NSCs) as a predictive toxicology system: malathion effects 2012.[MSc.]

4- Molecular studies on the role of neurospheres in developmental neurotoxicity (2015) [MSc.]

5- Effect of SSRI on Mesencyhmal stem cells (MSCs) osteogenesis (2015) [PhD]

6- Impact of Malathion on dopaminergic System, an experimental study in mice (2015) [PhD]

7- Environmental factors of Parkinson’s disease (2015) [PhD]

BOOKs:

Oscar Arias Carrion, Mohamed Salama and Sergio Machado. Coenzyme Q10 treating neurological disorders. LAP, 2012.

Chapter [food Additives] in (Mammalian Toxicology) Ed: MB Abou Donia, Wiley , 2015.

Recent relevant Journal articles

A)  Publications with peer review process:

1.  Shalash A, Roesler T, Muller, S, Salama M, Hopfner, F, Kulenbaumer G, Duschel G, Hoeglinger G. Genetic variants in SPR and DHFR in an Egyptian family with dopa-responsive dystonia. (Sumitted).

2.  Abou Donia MB, Salama M, Elgamal M, Elkholi I, Wang Q. 2016. Organophosphorus Flame Retardants (OPFRs): Neurotoxicity. J Environ Health Sci 2(1):1-30.

3.  Salama M and Mohamed W. Tau protein: A possible forensic tool?. Appl Transl Genom, 9:20-22.

4.  Abou-Donia MB, Salama M. and Abdel-Rahman A. Propetamphos Enhances Chlorpyrifos-Induced Organophosphate-Induced Delayed Neurotoxicity (OPIDN) in Hens: A role for Plasma Butyrylcholinesterase. Toxicological and Environmental Chemistry (Accepted).

5.  Salama M, Sobh M, Emam M, Abdalla A, Sabry D, El-Gamal M, Lotfy A, El-Husseiny M, Sobh M. Intranasal Stem cell Administration Rescues Nigrostriatal System in Parkinson’s Disease Mouse Model. Experimental and Therapeutic Medicine.(Accepted).

6.  Salama M, Lotfy A, Fathy K, Makar M, El-emam M, El-gamal A, El-gamal M, Badawy A, Mohamed WMY, Sobh M. 2015. Deveopmental Neurotoxic Effects of Malathion on 3D Neurospheres System. Appl Transl Genom 7:13-18.

7.  Salama M. and Mohamed WMY. 2015.NDUFA12L mitochondrial complex-I assembly factor: Implications for tauopathies. Appl Transl Genom. 5:37-39.

8.  Salama M. 2015. Aberrant cell retro-programming; a possible mechanism for neurodegeneration. Medical hypotheses 84(5):526

9.  Matthias Höllerhage, Roman Deck, Anderson De Andrade, Gesine Respondek, Hong Xu, Thomas W. Rösler, Mohamed Salama, Thomas Carlsson, Elizabeth S. Yamada, Seham A. Gad El Hak, Michel Goedert, Wolfgang H. Oertel, Günter U. Höglinger. 2015. Piericidin A aggravates tau pathology in P301S transgenic mice. PLOS one 9(12):e113557.

10.  Salama M, Elgamal M, Abdelaziz A, Ellithy M, Magdy D, Ali L, Fekry E, Mohsen Z, Mostafa M, Elgamal H, Sheashaa H and Sobh M. 2015. Toll like receptors 4 blocker as potential antidote of acetaminophen induced Organ Failure in mice. Experimental and Therapeutic Medicine. 10: 241-246

11.  Lotfy A, Salama M, Zahran F, Jones E, Badawy A and Sobh M. 2014. Characterization of mesenchymal stem cells derived from rat bone marrow and adipose tissue: A comparative study. Int J Stem Cells. 7(2): 135–142.

12.  Oscar Arias-Carrión, Eric Murillo-Rodríguez, Sergio Machado, Mohamed Salama, Manuel Menéndez-González, Antonio Egidio Nardi. 2014. Orquestic regulation of neurotransmitters on reward-seeking behavior. Int Arch Med. 16;7:29.

13.  Salama M, El Morsy D, El Gamal M, Shabka O, Mohamed W. 2014. Mitochondrial comple I inhibition as a possible mechanism of chlorpyrifos induced neurotoxicity. Ann Neurosci. ;21(3):85-89.

14.  Yamada ES, Respondek G, Müssner S, de Andrade A, Höllerhage M, Depienne C, Rastetter A, Tarze A, Friguet B, Salama M, Champy P, Oertel WH, Höglinger GU. 2014. Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phophorylation of tau in the brain of FTDP-17 transgenic mice. Exp Neurol. 253C:113-125

15.  Abou-Donia MB, Salama M. and Islam M. 2013. Autoantibodies against Cytoskeletal Neuronal Proteins in Sera of Arsenic-Exposed Subjects Correlate with Neurological Symptoms. Toxicological and Environmental Chemistry DOI: 10.1080/02772248.2013.796787.

16.  Salama M, Yuan TF, Machado S, Murillo-Rodríguez E, Vega JA, Menéndez-González M, Nardi AE, Arias-Carrión O. 2013. Co-Enzyme Q10 to Treat Neurological Disorders: Basic Mechanisms, Clinical Outcomes, and Future Research Direction. CNS Neurol Disord Drug Targets. 12(5):641-64.

17.  Salama M, Farrag, S, Abulasrar, S, Amin, M, Abdelaziz, A, Sheashaa H, Sobh, M. and Arias-Carrion O. 2013. Up-Regulation of TLR-4 in the Brain after Ischemic Kidney- Induced Encephalopathy in the Rat. CNS Neurol Disord Drug Targets. 12(5):583-6.