For identification of acetylsalicylic acid chemist used dilute sodium hydroxide solution R. After boiling and next cooling he added dilute sulphuric acid R. What product of reaction is formed?

  1. Smoke
  2. Opalescense
  3. Green precipitate
  4. Brown gas
  5. White precipitate

ANSWER: E

The method of assay for salicylamide is:

  1. Iodometry, direct titration
  2. Cerymetry, back titration
  3. Permanganatometry
  4. Argentometry, back titration
  5. Modified Keldal method

ANSWER: E

Salicylanilide use as agent:

  1. Purgative
  2. Anaestetic
  3. Keratolytic
  4. Analgesic and antipyretic
  5. Antibacterial

ANSWER: E

The molar weight of equivalent (Em) at assay of acetylsalicylic acid by means of acidimetry after saponification alcoholic solution (back titration) equals:

  1. М m.
  2. М m./4
  3. 2М. M.
  4. М m./3
  5. М m./2

ANSWER: E

What functional groups are available in a molecule salicylamide?

  1. Keto-group, amide group
  2. Integrally connected chlorine
  3. Alcoholic hydroxyl, amino group
  4. Amino group, benzene cycle
  5. Amide group, phenolic hydroxyl

ANSWER: E

Assay of acetylsalicylic acid, according to Pharmacopoeia, makes by means of such method:

  1. Alkalimetry, back titration
  2. Argentometry
  3. Acidimetry, non-aqueous direct titration
  4. Alkalimetry in alcoholic solution, direct titration
  5. Acidimetry, after saponification alcoholic solution, back titration

ANSWER: E

The pharmacopoeial method of assay for furazolidone is:

  1. Cerimetry
  2. Chelatometry
  3. Thin-layer chromatography
  4. UV-spectrophotometry
  5. Argentometry

ANSWER: D

The characters of furazolidone, according to Pharmacopoeia, is:

  1. A white crystalline powder, very soluble in water, soluble in alcohol
  2. A white or almost white, crystalline powder, soluble in water and in ethanol
  3. A yellow, crystalline powder or yellow crystals, odourless or almost odourless, very lightly soluble in water and in alcohol, soluble in dimethylformamide
  4. A yellow, crystalline powder, very slightly soluble in water and in ethanol (96%); practically insoluble in ether
  5. A yellow or brownish-yellow, crystalline powder, very slightly soluble in water, slightly soluble in alcohol

ANSWER: D

In the medical practice nitrofurantoin use as agent:

  1. Diuretic
  2. Membrane-promoting
  3. Expectorant
  4. Anaesthetic
  5. Antibacterial

ANSWER: E

The initial substance for synthesis nitrofurantoin is:

  1. Oxadiazole
  2. Oxazole
  3. Thiophene
  4. Pyrrole
  5. 5-Nitrofurfurol

ANSWER: E

The pharmacopoeial method of assay for nitrofurazone is:

  1. Refractometry
  2. Thin-layer chromatography
  3. IR-spectroscopy
  4. Photocolorimetry
  5. UV-spectrophotometry

ANSWER: E

At interaction solution of nitrofurazone in the dimethylformamide with alcoholic potassium hydroxide solution can be observed:

  1. Formation of a white precipitate
  2. Ammonia allocation
  3. Yellow colouring, which passes in the violet
  4. Violet-red colour of solution
  5. Brown colour of solution

ANSWER: D

As antioxidant in medical practice use:

  1. Piracetam
  2. Furazolidone
  3. Nitrofurantoin
  4. Nitrofural
  5. Thiotriazolinum

ANSWER: E

The chemist makes pyrolysis of Thiotriazolinum dry substance (burning substance in crucible) with the next revealing of sulphides-ions by means of filter paper moistened by solution of:

  1. Starch
  2. Barium chloride
  3. Potassium iodide
  4. Lead acetate
  5. Water

ANSWER: D

The pharmacopoeial method of assay for clonidine hydrochloride is:

  1. lkalimetry, back titration
  2. Acidimetry, back titration
  3. Acidimetry direct non-aqueous titration
  4. Alkalimetry in the alcohol medium, direct titration
  5. Acidimetry, direct titration

ANSWER: D

Clonidine hydrochloride is derivative of such heterocyclic compound:

  1. Pyridine
  2. Pyrimidine
  3. Imidazoline
  4. Imidazole
  5. Furan

ANSWER: C

What analytical effect of reaction furazolidone with dimethylformamide and alcoholic potassium hydroxide?

  1. White colour
  2. Ammonia allocation
  3. *Blue colour
  4. Red gas
  5. Brown colour

ANSWER: C

For synthesis furazolidone can be used condensation of 5-nitrofurfurol with:

  1. Aniline
  2. Morpholine
  3. 3-aminooxazolidone-2
  4. 1-Aminohydantoin
  5. Semicarbazide

ANSWER: C

Alkalimetry, non-aqueous titration – is a method of assay for nitrifurantoin. As titrant in his method use standard solution of:

  1. Perchloric acid in the presents of ice acetic acid
  2. Sodium methylate in the presents of DMFA (dimethylformamide)
  3. Potassium hydroxide in the presents of ethanol and benzene
  4. Sodium hydroxide in the presents of benzene and methylene
  5. Water solution of sodium hydroxide

ANSWER: B

What characters of nitrifurantoin, according to Pharmacopoeia?

  1. A white crystalline powder, very soluble in water, soluble in alcohol
  2. A white or almost white, crystalline powder, soluble in water and in ethanol
  3. A yellow, crystalline powder, very slightly soluble in water and in ethanol (96%); practically insoluble in ether
  4. A yellow or brownish-yellow, crystalline powder, very slightly soluble in water, slightly soluble in alcohol
  5. A yellow, crystalline powder or yellow crystals, odourless or almost odourless, very slightly soluble in water and in alcohol, soluble in dimethylformamide

ANSWER: E

For identification of nitrifurazone can be used reaction with:

  1. Perhydrol in the alkaline medium
  2. Nesler reagent
  3. 10 % copper sulphate solution
  4. Water solution of alkali
  5. Dimethylformamide and alcoholic potassium hydroxide solution

ANSWER: E

The chemical name of nitrifurazone is:

  1. morpholine 3-methyl-1,2,4-triazolyl-5-thioacetate
  2. 2,6-dichloro-N-(imidazolidin-2-ylidene)aniline
  3. 2-[(5-nitrofuran-2-yl)methylene]diazanecarboxamide
  4. 3-(5-nitrofurfurylideneamino)oxazolidin-2-one
  5. 1-[[(5-nitrofuran-2-yl)methylene]amino]imidazolidine-2,4-dione

ANSWER: C

The chemical name 3-methoxy-4-oxybenzylidenehydrazide pyridine-4-carboxylic acid hydrate is for a preparation:

  1. Nicodine
  2. Isoniazid
  3. Cordiamine
  4. Nikethamide
  5. Phthivazid

ANSWER: E

Tocopherol acetate has the following chemical name:

  1. Pregnane–4-ol-21-dione-3,20-21 acetate
  2. Pregnene–4-diol-17-2,21-trione-3,11,20-21 acetate
  3. Pregnene–4-triol-11,17, 21-dione-3,20-21 acetate
  4. Trans-9,13-dimethyl-7-(1,1,5-trimethyl-cyclogen-5-yl-6)nontetraene-7,9,11,13-one–15 acetate
  5. (+)-2,5,7,8,-tetramethyl-2-(4',8',12'-trimethyltridecyl)-6-acetoxychromane

ANSWER: E

Routine is present in the following tablets content:

  1. Papazol
  2. No-spa
  3. Ascoroutine
  4. Reoperin
  5. Citramone

ANSWER: C

Steroid cycle in the molecules of cardiac glycosides is revealed by the reaction of:

  1. Lieberman - Burhardt
  2. Legal
  3. Raymond
  4. Baljet
  5. Keller-Kilian

ANSWER: A

Pentamerous lactone cycle in the molecules of cardiac glycosides is revealed by the reaction of:

  1. Raymond
  2. Legal
  3. Lieberman - Burhardt
  4. Keller-Kilian
  5. Baljet

ANSWER: B

Source of obtaining cardiac glycosides are different types of:

  1. Belladonna
  2. Poppy
  3. Digitalis
  4. Hemp
  5. Ephedrine

ANSWER: C

Quantitative determination of cardiac glycosides according to the procedures DF X is carried out by the method of:

  1. Photocolorimetry
  2. Acidimetry
  3. Infrared spectroscopy
  4. Alkalimetry
  5. Biological method

ANSWER: E

What monosaccharide is nonspecific for cardiac glycosides?

  1. Digitoxose
  2. D-cymarose
  3. L-rhamnose
  4. Oleandroze
  5. Fructose

ANSWER: E

The aglycone structure of the cardiac glycosides, which are called cardenolides, is formed of such lactone cycle:

  1. Pentamerous
  2. 6-membered
  3. Heptatomic
  4. 4-membered
  5. Octatomic

ANSWER: A

Bufadienolides are the part of:

  1. Digitalis
  2. Hellebore
  3. Adonis
  4. Lily of the valley
  5. Strophanthus

ANSWER: B

2-deoxysaccharides in the molecule of cardiac glycosides is revealed by the reaction of:

  1. Legalov
  2. Pezets
  3. Raymond
  4. Baleta
  5. Lieberman – Burhardt

ANSWER: B

Which of the saccharides is included in the structure of the ouabain molecule?

  1. Lactose
  2. Digitoxose
  3. D-Cymarose
  4. L-Rhamnose
  5. D-Oleandroze

ANSWER: D

Aglycone in the celanidum molecule is :

  1. Strofantidine
  2. Gitoxigenin
  3. Digitoxigenin
  4. Digoxigenine
  5. Oleandrogenine

ANSWER: D

The bearer of the biological activity in the cardiac glycosides is:

  1. Saccharic part
  2. Pentamerous lactone cycle
  3. Aglycone
  4. Radical in the position of the 10th aglycone
  5. OH-group in the position of the 14th aglycone

ANSWER: C

Six-membered lactone cycle in the molecule of cardiac glycosides may be detected with a solution:

  1. FeCl3
  2. H2SO4
  3. AlCl3
  4. SbCl3
  5. CuSO4

ANSWER: D

Steroid cycle in the molecules of cardiac glycosides is revealed by the reaction of:

  1. Rosenheim
  2. Legalov
  3. Keller-Kilian
  4. Pezets
  5. Balet

ANSWER: A

Pentamerous lactone cycle in the molecules of cardiac glycosides is revealed by the reaction of:

  1. Lieberman-Burhardt
  2. Raymond
  3. Rosenheim
  4. Keller-Kilian
  5. Pezets

ANSWER: B

2-deoxysaccharides in the molecule of cardiac glycosides is revealed by the reaction of:

  1. Legalov
  2. Raymond
  3. Pezets
  4. Rosenheim
  5. Lieberman-Burhardt

ANSWER: C

According to their chemical structure cardiac glycosides belong to:

  1. Heterocyclic carboxylic acids
  2. Aromatic amines
  3. Esters
  4. Ethers
  5. Polyhydric alcohols

ANSWER: C

Cardiac glycosides are extracted from various plants, one of which is:

  1. Belladonna
  2. Snakewood (Rauvolfia serpentina)
  3. Senecio platyphyllos
  4. Spring Adonis(Adonis vernalis)
  5. Henbane (Hyoscyamus niger L)

ANSWER: D

Which of the saccharides does not belong to the cardiac glycosides structure?

  1. Lactose
  2. Digitoxose
  3. D-cymarose
  4. L-rhamnose
  5. D-oleandroze

ANSWER: A

Bufadienolidy are the part of:

  1. Digitalis
  2. Adonis
  3. Lily of the valley
  4. Sea onion (Urginea maritima)
  5. Strophanthus

ANSWER: D

Saccharic component, which is attached at position 3 to the cardiac glycoside aglycone, affects:

  1. Medical product form
  2. The duration of drug action
  3. Directions for use
  4. Specific action of cardiac glycosides
  5. Side effects

ANSWER: B

Cardiac glycosides of the cardenolide group include in their molecule:

  1. Steroid cycle
  2. Double bond between C atoms
  3. Triple bond between C atoms
  4. Six-membered lactone cycle
  5. Pentamerous lactone cycle

ANSWER: E

Quantitative determination of cardiac glycosides is carried out by the method of:

  1. Photocolorimetry
  2. Acidimetry
  3. UV- spectroscopy
  4. Alkalimetry
  5. Precipitation titration

ANSWER: C

Cardiac glycosides genins are derived from:

  1. Cyclohexane
  2. Cholesterol
  3. Cyclopentaneperhydrophenanthrene
  4. Adrostan
  5. Ergocalciferol

ANSWER: C

In the digitoxin molecule the aglycone is:

  1. Strophantidine
  2. Gitoksigenine
  3. Digitoxigenin
  4. Digoxigenine
  5. Oleandrogenine

ANSWER: C

Cardiac glycosides aglycones are the derivatives of:

  1. Cholesterol
  2. Steranes
  3. Cyclopentaneperhydrophenanthrene
  4. Androstane
  5. Pregnenolone

ANSWER: C

Pentamerous lactone cycle in the cardiac glycosides molecule is revealed by the reaction of:

  1. Raymond
  2. Sakagush
  3. Lugol
  4. Ovchinnikov
  5. Rosenkheim

ANSWER: A

Steroid cycle in the structure of cardiac glycosides is revealed by the reaction of:

  1. Legalov
  2. Raymond
  3. Balet
  4. Lieberman-Burhardt
  5. Keller-Kilian

ANSWER: D

Aglycone in the digoxin molecule is:

  1. Strophantidine
  2. Gitoksigenine
  3. Digitoxigenin
  4. Digoxigenine
  5. Oleandrogenine

ANSWER: D

Konvalyatoksin the medical product of cardiac glycosides is extracted from such plant:

  1. Strophanthus Combe
  2. Strophanthus gratus
  3. Convallaria majalis
  4. Erysimum diffuse
  5. Digitalis lanata

ANSWER: C

Cardenolides are identified by the maximum absorption at  = 220 nm, comparing with the standard sample of preparation. Specify which physicochemical method is used then

  1. Refractometry
  2. Fluorometry
  3. Polarimetry
  4. Spectrophotometry
  5. Polarography

ANSWER: D

Saccharid part in the cardiac glycosides molecules may be detected after acid hydrolysis by the reaction of:

  1. Formation of silver mirror
  2. Dragendorf reagent
  3. Lieberman-Burhardt reagent
  4. Pezets reagent
  5. Schiff

ANSWER: A

The drug ouabain is also known as:

  1. Strophanthin-G
  2. Strophanthin-K
  3. Korglikon
  4. Adonisid
  5. Kardiovalen

ANSWER: A

Saccharic part of the digitalis secondary glycosides consists of three molecules:

  1. D-Glucose
  2. Digitoxose
  3. D-Cymarose
  4. L-Rhamnose
  5. D-Oleandroze

ANSWER: B

By the chemical structure glucose is related to:

  1. Polysaccharides
  2. Disaccharides
  3. Monosaccharides
  4. Ketopentose
  5. Aldopentose

ANSWER: C

Indicate starch formula:

  1. C12H22O11
  2. C5H10O5
  3. (C6H10O5)n
  4. C6H14O7
  5. C6H12O7

ANSWER: C

Sucrose aqueous solution heating generates:

  1. Beet sugar
  2. Cane sugar
  3. Lactose
  4. Invert sugar
  5. Tautorotation sugar

ANSWER: D

What analytical reaction effect is observed during the interaction of glucose with the Feling reagent?

  1. Crimson-violet formations
  2. A yellow sediment
  3. Formations of violet colour
  4. Formations of red sediment
  5. CO2 bubbles separation with the subsequent identification

ANSWER: D

One of the methods of glucose quantitative determination is the method of:

  1. Acidimetry
  2. Alkalimetry
  3. Iodinometry
  4. Permanganatometry
  5. Complexometry

ANSWER: C

Which of the following saccharides relates to non-restorable glycosacchara:

  1. Glucose
  2. Lactose
  3. Maltose
  4. Sucrose
  5. Fructose

ANSWER: D

Which molecule property results the optical activity of the glucose solution?

  1. The tautomery characteristic
  2. Changing of the solution refraction angle
  3. The ability to rotate the polarized light plane as it passes through the solution
  4. Inversion phenomenon
  5. Changes in the EMF solution

ANSWER: C

By its chemical structure the starch belongs to the group of:

  1. Disaccharides
  2. Monosaccharides
  3. Proteoglycans
  4. Polysaccharides
  5. Peptidoglycans

ANSWER: D

What chemical compound when it’s heated forms caramel?

  1. Glucose
  2. Lactose
  3. Starch
  4. Sucrose
  5. Amylose

ANSWER: D

In medical practice sucrose is used:

  1. For the treatment of shock
  2. For trituration manufacturing
  3. For the manufacture of syrups
  4. For collapse
  5. For the treatment of radiation sickness

ANSWER: C

Which hydrocarbon belongs to the hexose class?

  1. Starch
  2. D-Ribose
  3. Sucrose
  4. Lactose
  5. D-glucose

ANSWER: E

Indicate the sucrose formula:

  1. C5H10O5
  2. C5H12O5
  3. C6H12O6
  4. (C6H10O5)n
  5. C12H22O11

ANSWER: E

What monosaccharide is in the lactose molecule?

  1. D-(+)-mannose
  2. D-(-)-ribose
  3. D-galactose
  4. D-fructose
  5. L-fucose

ANSWER: C

What glucose properties determine the reaction with ammonia solution of silver nitrate:

  1. The ability to rotate the polarization plane of polarized light
  2. Regenerative
  3. Oxidative
  4. The ability to polymerization
  5. The ability to absorb light in the UV-area spectrum

ANSWER: B

Pharmacist-analyst conducts quantitative determination of glucose by the iodinometry method. What is the molar mass of equivalent?

  1. 1/3 М.m.
  2. ¼ М.m.
  3. ½ М. m.
  4. М.m.
  5. 1,5 M.m.

ANSWER: B

What of the following succharides is characterized by the inversion phenomenon?

  1. Maltose
  2. Cellobiose
  3. Lactose
  4. Sucrose
  5. Glucose

ANSWER: D

The interaction of glucose with mineral acids at time of heating forms:

  1. Furfural
  2. Acetone
  3. Benzol
  4. Methylolfurfural
  5. Toluene

ANSWER: D

Determine the type of reaction which is used for the glucose identification:

  1. Recovery
  2. Polymerization
  3. Polycondensation
  4. Oxidation
  5. Expansions

ANSWER: D

Angle measurement of the 10% glucose solution conversion is carried out by:

  1. UV-spectrophotometer
  2. Refractometer
  3. Infrared spectrophotometer
  4. Polarimeter
  5. Photoelectrocolorimeter

ANSWER: D

Sucrose is used in medical practice:

  1. As a means of enveloping
  2. To slow down the absorption of drugs
  3. For the trituration preparation
  4. Antidote to heavy metal poisoning
  5. Auxiliary for the preparation of medicines

ANSWER: E

Due to its chemical structure glucose belongs to:

  1. Aldopentoses
  2. Ketopentoses
  3. Aldogeksoses
  4. Desoxisaccharides
  5. Ketogexoses

ANSWER: C

Indicate the lactose formula:

  1. C5H10O5
  2. C5H12O5
  3. C6H12O6
  4. C12H22O11
  5. (C6H10O5)n

ANSWER: D

Which monosaccharide is a component of sucrose?

  1. alpha-D-galactose
  2. Amylose
  3. beta-D-fructose
  4. Amylopectin
  5. D-digitoxose

ANSWER: C

In the interaction with which reagent glucose constitutes osasone?

  1. Nessler reagent
  2. Tollens reagent
  3. Phenylhydrazine
  4. Sorrel acid
  5. Feling reagent

ANSWER: D

One of the glucose identification reactions held by rapid analysis method is the interaction with:

  1. Sodium to sodium, weak chloride acid
  2. Alkaline beta-naphthol solution
  3. Thorium nitrate
  4. Thymol, concentrated sulphate acid
  5. Milon basis

ANSWER: D

With what reagent solution lactose aqueous solution while heated is painted in red?

  1. Vanillin
  2. Dimethylaminobenzaldehyde
  3. Sodium nitroprusside
  4. Ammoniac
  5. Resorcin

ANSWER: E

Glucose is characterized by the phenomenon of:

  1. Inversion
  2. Dismutation
  3. Polymerization
  4. Gelatinization
  5. Tautorotation

ANSWER: C

What glucose molecule fragment conditioned its property to rotate the polarized light plane?

  1. Aldehyde group
  2. Alcoholic hydroxyls
  3. Chirality centers
  4. Carbon backbone chain
  5. Tautomeric groups

ANSWER: C

One of the lactose identification reactions is the interaction with the reagent of:

  1. Marky
  2. Fisher
  3. Copper-tartrate
  4. Dragendorf
  5. Molish

ANSWER: B

The quantitative content of glucose in solutions for injection is carried out by:

  1. UV-spektoskopy
  2. Refractometry
  3. Photoelectrocolorimetry
  4. Infared spectroscopy
  5. Potentiometry

ANSWER: C

Chemical name of 2-Chlor-10-(3'-Dimethylaminopropyl)-Phenothiazine Hydrochloride is:

  1. Trifluoroperazine hydrochloride
  2. Promethazine hydrochloride
  3. Promazine hydrochloride
  4. Chlorpromazine hydrochloride
  5. Perphenazine hydrochloride

ANSWER: D

What reagent can be used for organic bounded sulfur in the bicillin-1 molecule?

  1. Pb(CH3COO)2
  2. NaOH solution
  3. HNO3 conc.
  4. HNO3 dil.
  5. NaOH (solid), Pb(CH3COOH)2

ANSWER: E

Which of the following antibiotics has hygroscopic properties?

  1. Bicillin-1, phenoxymethylpenicillin
  2. Ampicillin sodium salt, benzylpenicillin sodium salt
  3. Benzylpenicillin potassium salt, benzylpenicillin sodium salt
  4. Cefazolin, ceftriaxone
  5. Bicillin-5, benzylpenicillin Novocain salt

ANSWER: C

Biological activity of the natural penicillins is be expressed in:

  1. DUA
  2. RUA
  3. CUA
  4. UA
  5. FUA

ANSWER: D

Which of the following antibiotics can be detected with ninhydrine solution?

  1. Ampicillin, oxacillin
  2. Amoxicillin, benzylpenicillin sodium salt
  3. Ampicillin, amoxicillin
  4. Cefalotin, cefalexin
  5. Amoxiclav, bicillin-1

ANSWER: C

To the penicillins of the third generation the following preparation belongs:

  1. Ceftriaxone
  2. Amoxicillin
  3. Amoxiclav
  4. Ampicillin sodium salt
  5. Oxacillin sodium salt

ANSWER: C

To the cephalosporin’s derivatives of 7-ADAC the following antibiotic belongs:

  1. Cefalotin
  2. Cephapirin
  3. Cefuroxime
  4. Cefaloridine
  5. Cefaloglycine

ANSWER: D

Amoxiclav consists of:

  1. Ampicillin, clavulanic acid
  2. Amoxicillin, clavulanic acid
  3. Amoxicillin, tienam
  4. Amoxicillin, imipenem
  5. Clavulanic acid, tienam

ANSWER: B

What reagent can be used for the carboxylic group detection?

  1. NaOH
  2. NH4OH
  3. NaHCO3
  4. Felling liquid
  5. K3KFe(CN)6F

ANSWER: C

Antibiotic kefzol can be also named as:

  1. Bicilllin-1
  2. Bicillin-5
  3. Cefazolin
  4. Cefalexin
  5. Cefaloridine

ANSWER: C

Which of the following preparations does belong to antibiotics-glycosides?

  1. Gentamycin sulfate
  2. Monomycin sulfate
  3. Neomycin sulfate
  4. Doxorubicin hydrochloride
  5. Streptomycin sulfate

ANSWER: D

Medical drug amikacin sulfate belongs to the following antibiotic’s type:

  1. beta-lactamide
  2. Aminoglycoside
  3. Macrolide
  4. Polypeptide
  5. Polyene

ANSWER: B