Thatcher, SE
CURRICULUM VITAE ~ Sean E. Thatcher
CONTENT ORGANIZATION
I. GENERAL INFORMATION
Office Address, Email, Telephone, Fax
II. EDUCATION
Undergraduate, Professional/Graduate, Continuing
III. PROFESSIONAL EXPERIENCES
IV. ACADEMIC APPOINTMENTS
Faculty, Visiting Professorships
V. CONSULTING ACTIVITIES
Local, State/Regional, National/International
VI. TEACHING ACTIVITIES
University Faculty, Professional Faculty
VII. ADVISING ACTIVITIES
Student Advising, Directed Student Learning, Thesis & Dissertation, Referee for Academic Appointment, Promotion or Tenure
VIII. SPECIAL ASSIGNMENTS
IX. HONORS & AWARDS
X. PROFESSIONAL ACTIVITIES, PUBLIC SERVICE & PROFESSIONAL DEVELOPMENT
Memberships, Positions Held, Advisory Groups, Review Panels, Editorial Boards,
Journal Peer-Reviewing, Media Contributions, Professional Development
XI. SPEAKING ENGAGEMENTS
Local, State/Regional, National/International
XII. RESEARCH & INTELLECTUAL CONTRIBUTIONS
Publications, Abstract Presentations, Sponsored Research Projects, Grant & Contract Activities, Non-Sponsored Research Projects, Other Creative Activities
XIII. OTHER ACTIVITIES
Date Prepared: February 15, 2017
CURRICULUM VITAE
Sean E. Thatcher, PhDAssistant Professor,
Research Title Series
Department of Pharmacology & Nutritional Sciences
University of Kentucky
College of Medicine
UK HealthCare /
Thatcher, SE
I. GENERAL INFORMATION
Office Address 900 South Limestone Street, CTW Bldg, Rm. 593
Lexington, KY 40536
Telephone 859-218-4001
Fax 859-257-3565
II. EDUCATION
Undergraduate
Morehead State University
Morehead, KY
08/1994-05/1998 BS in Biology, Chemistry Minor
Professional/Graduate
Morehead State University
Morehead, KY
08/1998-05/2001 MS in Biology, mentor: Dr. Craig Tuerk, PhD
Marshall University
Huntington, WV
08/2001-05/2007 PhD in Physiology, mentor: Dr. Gary Wright, PhD
Post-Graduate
University of Kentucky, Department of Pharmacology & Nutritional Sciences
Lexington, KY
06/2007-06/2012 F32 Post-doctoral fellow, mentor: Dr. Lisa Cassis, PhD
III. PROFESSIONAL EXPERIENCES
University of Kentucky
Lexington, KY
07/2012-present Assistant Professor, Research Title Series, Department of Pharmacology & Nutritional Sciences, full-time non-tenure track position
IV. ACADEMIC APPOINTMENTS [specify tenure/non-tenure track, academic/non-academic, full-time or part-time]
Faculty
University of Kentucky
Lexington, KY
07/2012-present Assistant Professor of Pharmacology & Nutritional Sciences, Research
Title Series, non-tenure-track, academic, full-time
V. CONSULTING ACTIVITIES
Local
Spherix Inc.
Lexington, KY
01/2010-12/2013 Scientist, analysis of data concerning atherosclerosis in mice
VI. TEACHING ACTIVITIES
University Faculty
Morehead State University
Morehead, KY
08/2000-05/2001 BIOL171/Lab instructor [10-20 undergraduate students, 10 labs]
Marshall University
Huntington, WV
01/2006-05/2007 PHYS629/Medical Physiology [50-60 medical students, 2 hours, topics were the study of MLCK and vascular contractility of smooth muscle]
University of Kentucky
Lexington, KY
01/2014-present IBS608/Research Topics in Nutrition [8-12 graduate students, 1.5 hours, use of EchoMRI, blood pressure by tail-cuff, and blood glucose measures in mice]
01/2013-present NS602/Integrated Nutritional Sciences II [graduate students, 5 hours, understanding of the essential nutrients, magnesium, fluoride, vitamin K, folic acid, vitamin B12, biotin, iron, and iodine]
VII. ADVISING ACTIVITIES
Student Advising
Kentucky State University
Frankfort, KY
06/2012-08/2012 Mentor/Thomas Gardner/undergraduate/summer internship
University of Puerto Rio
San Juan, PR
05/2013-08/2013 Mentor/Griselle Travasco Martinez/undergraduate/summer internship
University of Kentucky
Lexington, KY
2014-2015 Mentor/Shannon Woody/undergraduate/winner of Ag-tech Biology Award
Sayre High School
Lexington, KY
05/2015-08/2015 Mentor/Nicole Bacha/student/summer internship
Directed Student Learning
University of Kentucky
Lexington, KY
08/2012-05/2013 Mentor/Gyeong-Ok Kim/graduate/Nutritional Sci/NS782/6 hrs [ACE2 in atherosclerosis]
University of Kentucky
Lexington, KY
09/2012-12/2012 Mentor/James Sledziona/graduate/IBS rotation/3 hrs [adipocyte angiotensinogen and atherosclerosis]
Thesis & Dissertation
University of Kentucky
Lexington, KY
2012-2013 Committee member/Gyeong-Ok Kim/Master’s in Nutritional Sci.
University of Kentucky
Lexington, KY
2013-present Committee member/Yasir AlSiraj/Doctorate in Pharm. & Nutr. Sci.
VIII. SPECIAL ASSIGNMENTS
2014 Gordon Research Seminar Series
Was nominated by colleagues to chair the Gordon Research Seminar Series in Angiotensin II (conference held every 2 years). My position was to generate funds for the conference and to create a program that contained the top 2% of young scientists in the international community. The conference was held in Lucca (Barga), Italy and had over 100 attendees.
2017 Methods in Molecular Biology Series, Protocols on the Renin-Angiotensin-Aldosterone System (RAAS), Springer Publishing
Was selected to edit a protocol book on the RAAS and new, cutting-edge research techniques in studying the RAAS. Contacted scientists from around the world to contribute chapters and then edited the chapters with help from Springer publishing.
IX. HONORS AWARDS
04/2007 “Best Scientific Talk”/Marshall University Research Day/Marshall University
10/2008 1st place prize at annual Saha Cardiovascular Research Day/University of Kentucky/(poster session)
04/2009 2nd place prize at annual Post-doctoral poster competition/Society for Post-doctoral fellows & scholars/University of Kentucky (campus-wide)
05/2009 Travel award at national AHA meeting/Council for Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)
10/2009 1st place prize at annual Saha Cardiovascular Research Day/University of Kentucky/(poster session)
03/2012 1st place prize in young investigator competition at Gordon Research Conference (Angiotensin)/(oral session)
X. PROFESSIONAL ACTIVITIES, PUBLIC SERVICE & PROFESSIONAL DEVELOPMENT
Memberships
2004-2007 Member, American Physiological Society
2007-present Member, American Heart Association, ATVB Council
2015-present Member, Organizational Society for Sex Differences (OSSD)
X. PROFESSIONAL ACTIVITIES, PUBLIC SERVICE & PROFESSIONAL DEVELOPMENT - continued
Editorial Boards
2013-present Cardiobiology/Avens publishing/(Associate editor)
Journal Peer-Reviewing
2013-present Atherosclerosis (Springer publishing)
Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)(AHA)
Bioassays (Wiley publishing)
Current Pharmaceutical Design (Bentham Science)
EBioMedicine (Elsevier publishing)
Journal of Cardiovascular Pharmacology (Wolters Kluwer)
Scientific Reports (Springer publishing)
Vascular Pharmacology (Elsevier publishing)
Professional Development
UK Center for the Enhancement of Learning and Teaching (CELT)
10/26/2016 New Faculty Teaching Academy: Teaching Portfolios, Lex., KY 1 CEU
11/21/2016 UK Center for the Enhancement of Learning and Teaching (CELT)
New Faculty Teaching Academy: Teacher and Course Evaluations, Lex., KY 1 CEU
1/18/2017 eLearning training workshop, Getting Started with Canvas (via Zoom)
University of Kentucky, Lexington, KY
XI. SPEAKING ENGAGEMENTS
Local
University of Kentucky
Lexington, KY
2009 GCNS Seminar Series: “Effects of angiotensin-converting enzyme 2 deficiency on hypercholesterolemia-induced atherosclerosis”
2013 GCNS Seminar Series: “ACE2/Ang-(1-7)/MasR and its therapeutic potential in cardiovascular disease”
State/Regional
Morehead State University
Morehead, KY
2006 Department of Biology, Seminar Series: “Myosin Light Chain Kinase and Actin Interactions in A7r5 Smooth Muscle Cells”
Marshall University
Huntington, WV
2007 MUSOM Research Day: “MMP localization to the podosome and inhibition of podosome formation by galardin”
2015 Keynote speaker, MUSOM retreat: “Possibilities and Pitfalls: stories of an early career investigator ”
National/International
ATVB National meeting
Washington DC
2009 “Angiotensin-converting enzyme 2 in bone marrow-derived cells decreases atherosclerosis in Ldlr-/- mice”
High Blood Pressure Research Council, AHA Hypertension National meeting
Orlando, FL
2011 “Bone marrow deficiency of ACE2 promotes macrophage infiltration into adipose tissue and disrupts glucose homeostasis”
2012 Gordon Research Conference International meeting (GRC)(Angiotensin)
Ventura, CA
“ACE2 decreases atherosclerosis and abdominal aortic aneurysms through distinct mechanisms”
XII. RESEARCH & INTELLECTUAL CONTRIBUTIONS
A. PUBLICATIONS (* represents shared first-authorship)
Peer-Reviewed Original Research in Professional, Scientific or Educational Journals
1) Thatcher SE. Effects of butyrate feeding on glucose tissue metabolism in exercised mice. Morehead State University Press, 2001.
2) Wang HH, Tanaka H, Qin X, Zhao T, Ye L, Okagaki T, Katayama T, Nakamura A, Ishikawa R, Thatcher SE, Wright GL, and Kohama K. Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells through breaking the interaction between myosin II and actin. Am J Physiol.-Heart Circ Physiol. 294(5):H2060-8, 2008. PMID 18296570
3) Li S, H Tanaka, H Wang, S Yoshiyama, H Kumagai, A Nakamura, D Brown, SE Thatcher, GL Wright, and K Kohama. Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells following sphingosylphosphorylcholine stimulation. Am J Physiol.-Heart Circ Physiol. 291:H1262-H1272, 2006. PMID 16899767
4) Brown D, A Dykes, J Black, SE Thatcher, ME Fultz, and GL Wright. Differential actin isoform reorganization in the contracting A7r5 smooth muscle cell. Can J Physiol. Pharmacol. 84(8-9):867- 875, 2006. PMID 17111031
5) Cassis LA, S Police, F Yiannikouris, and SE Thatcher. Local adipose tissue renin-angiotensin system. Current Hypertension Reports, 10(2):93-8, 2008. PMCID 2702858
6) Gupte M, CM Boustany-Kari, K Bharadwaj, S Police, SE Thatcher, MC Gong, VL English, and LA Cassis. ACE2 expression in adipocytes: regulation by a high fat diet in relation to the development of obesity hypertension. Am J Physiol.-Endocrine and Metabolic Dis. 295:R781-R788, 2008. PMCID 2536864
7) Black J, A Dykes, D Brown, SE Thatcher, and GL Wright. FRET analysis of actin/myosin interaction in contracting aortic smooth muscle. Can J Physiol. Pharmacol., 87(5):327-36, 2009. PMID 19448730
8) Thatcher SE, F Yiannikouris, M Gupte and LA Cassis. The adipose renin-angiotensin system: role in cardiovascular disease. J Mole and Cell Endocrinology, 302(2):111-7, 2009. PMCID 2748818
9) Police SB, SE Thatcher, R Charnigo, A Daugherty, and LA Cassis. Obesity promotes inflammation in peri-aortic adipose tissue and angiotensin-II induced abdominal aortic aneurysm formation. ATVB, 29(10): 1458-64, 2009. PMID 19608970
10) Police SB, K Putnam, SE Thatcher, F Yiannikouris, A Daugherty, and LA Cassis. Weight loss in obese C57BL/6 mice limits adventitial expansion of established angiotensin II-induced abdominal aortic aneurysms, AJP-Heart Circ Physiol., 298(6):H1932-8, 2010. PMID 20304811
11) Watanabe M, M Yumoto, H Tanaka, HH Wang, T Katayama, S Yoshiyama, J Black, SE Thatcher, K Kohama. Blebbistatin, a myosin II inhibitor, suppresses contraction and disrupts contractile filament organization of skinned taenia cecum from guinea pig. AJP-Cell Physiology, 298(5):C1118-26, 2010. PMID 20164381
12) Thatcher SE, X Zhang, DA Howatt, H Lu, SB Gurley, A Daugherty, and LA Cassis. ACE2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in LDL receptor -/- mice. ATVB. 31:758-765, 2011. PMID:21252069
13) Thatcher SE, ME Fultz, H Tanaka, H Hagiwara, HL Zhang, Y Zhang, K Hayakawa, S Yoshiyama, A Nakamura, HH Wang, T Katayama, M Watanabe, Y Lin, GL Wright, and K Kohama. MLCK/Actin interaction in the phorbol-dibutyrate stimulated smooth muscle cell. Japanese Journal of Pharmacol., 116(1):116-27, 2011. PMID 21551973
14) Thatcher SE, M Gupte, N Hatch, and LA Cassis. Deficiency of ACE2 in bone marrow-derived cells increases expression of TNF-α in adipose stromal cells and augments glucose intolerance in obese C57BL/6 mice. International Journal of Hypertension, special issue, article ID 762094, November 2011.
15) Gupte M*, SE Thatcher*, CM Boustany-Kari, R Shoemaker, F Yiannikouris, X Zhang, M Karounos, and LA Cassis. Angiotensin-converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice. ATVB. 32 (6):1392-9, 2012. PMID 22460555
16) Zhang X, SE Thatcher, DL Rateri, D Bruemmer, R Charnigo, A Daugherty, and LA Cassis. Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms. Circ. Res. 110(11):e73-85, 2012. PMID 22539767
17) Yiannikouris F, Gupte M, Putnam K, Thatcher SE, Charnigo R, Rateri DL, Daugherty A, and Cassis LA. Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice. Hypertension, accepted October 2012. PMID: 23108647
18) Metts B, S Thatcher, E Lewis, M Karounos, L Cassis, R Smith, RA Lodder. DDDAS Design of drug interventions for the treatment of dyslipidemia in apoE-/- mice. J Dev Drugs, 2(2):1-17, 2013. PMID 25866829.
19) Zhang X, C Wu, SE Thatcher, A Daugherty, and LA Cassis. Castration of male mice prevents the progression of established angiotensin II-induced abdominal aortic aneurysms, J Vas Surg. Jan 15. 2014 PMID: 24439319
20) Thatcher SE, Xuan Zhang, DA Howatt, F Yiannikouris, SB Gurley, T Ennis, JA Curci, A Daugherty, and LA Cassis. ACE2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms. ATVB, 34(12): 2617-23, 2014 PMID: 25301841
21) Wang Y, R Shoemaker, SE Thatcher, F Batifoulier-Yiannikouris, VL English, and LA Cassis. Administration of 17beta-estradiol to ovariectomized obese female mice reverses obesity-hypertension through an ACE2-dependent mechanism. AJP-Endocrinol Metab. 308(12):E1066-75, 2015. PMID: 26078188
22) Thatcher SE, X Zhang, S Woody, Y Wang, Y Alsiraj, R Charnigo, A Daugherty, and LA Cassis. Exogenous 17-beta estradiol administration blunts progression of established angiotensin II-induced abdominal aortic aneurysms in female ovariectomized mice. Bio Sex Diff. 6:12, 2015. PMID:26131353
23) Tanaka H, H.H. Wang, SE Thatcher, H Hagiwara, H Takano-Ohmuro, K Kohama. Electron microscopic examination of podosomes induced by phorbol 12,13 dibutyrate on the surface of A7r5 cells. J. Pharm. Sci. 128:78-82, 2015. PMID:25986486
24) Shoemaker R, F Yiannikouris, SE Thatcher, and LA Cassis. ACE2 deficiency reduces beta-cell mass and impairs beta-cell proliferation in obese C57BL/6 mice. Am J Physiol Endocrinol. Metab. 309(7):E621-31. PMID:26389599
25) Alsiraj Y, Thatcher SE, Charnigo R, Kuey C, Blalock E, Daugherty A, Cassis LA. Female mice with an XY sex chromosome complement develop severe angiotensin II-induced abdominal aortic aneurysms. Circulation. 135(4):379-391, 2017. PMID: 27815372
26) Vasam G, Joshi S, Thatcher SE, Bartelmez SH, Cassis LA, Jarajapu YP. Reversal of bone marrow mobilopathy and enhanced vascular repair by angiotensin-(1-7) in diabetes. Diabetes. 66(2):505-518, 2017. PMID: 27856608
27) Wang Y, Shoemaker R, Powell D, Su W, Thatcher SE, Cassis LA. Differential effects of mas receptor deficiency on cardiac function and blood pressure in obese male and female mice. Am J Physiol Heart Circ Physiol. Accepted, December 16, 2016. PMID: 27986659
Non-Peer-Reviewed Articles, Editorials, Reviews in Professional, Scientific or Educational Journals
1) Commentary for International Atherosclerosis Society: Angiotensin Converting-Enzyme 2 (ACE2): a New Target in the Treatment of Atherosclerosis, 2012. Website: www.athero.org/commentaries/comm1102.asp
2) Commentary for Atherosclerosis: Clancy, P et al., ARBs and ERK activation: new insights on human atherosclerosis. Atherosclerosis, 236(1): 131-2, 2014. PMID:25036239
3) Commentary for EBioMedicine: TGF-β Signaling: New Insights into Aortic Aneurysms. EBioMedicine, October 3, 2016 in press.
XII. RESEARCH & INTELLECTUAL CONTRIBUTIONS - continued
C. SPONSORED RESEARCH PROJECTS, GRANT CONTRACT ACTIVITIES
Active
Project Title: Angiotensin-A link between obesity and hypertension
Project Number: R01HL073085
Principal Investigator(s): Lisa Cassis, PhD
Role in Project: Co-I
Effort: 30%
Institution/University: University of Kentucky
Source of Funding: NHLBI
Duration of Project: 5/2014-4/2017
Total Award: $1,209,893
Grant Number: Account #3048111520
Project Title: Sex differences in angiotensin II-induced vascular diseases
Project Number: R01HL107326
Principal Investigator(s): Lisa Cassis, PhD
Role in Project: Co-I
Effort: 36%
Institution/University: University of Kentucky
Source of Funding: NHLBI
Duration of Project: 3/16-3/20