Institute of Chemistry Timisoara of Romanian Academy
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Brief history
Institute of Chemistry of Romanian Academy was set up in 2003 by the fusion of the Inorganic Chemistry Laboratory of the Romanian Academy with Institute of Chemistry Timisoara.
The roots of the institute are bound with the formation of some research groups in the Chemistry Faculty of Polytechnical Institute Timisoara, in 1948. These groups were the basic nucleus of the Chemistry Department of the Romanian Academy – Timisoara Branch in 1958, which further became an independent institute, namely Centre of Chemistry Timisoara (CCT). The promoter of this development was Academician Coriolan Dragulescu (1907-1977), who became the Center’s first director. CCT was organized in three sections: Inorganic Chemistry, Organic-dyes Chemistry and Organic-phosforic Chemistry departments until 1990 when Inorganic Chemistry Laboratory became a department of the Romanian Academy – Timisoara Branch and organic laboratories formed the Institute of Chemistry Timisoara.
Picture of the instituteAddress: 24, Bul. Mihai Viteazul
300223 Timisoara
Romania
Phone: + 40 256 491818
Fax: + 40 256 491824
Picture of the directorDirector:
Dr. Otilia Costisor
()
Deputy director:
Dr. Ludovic Sayti
()
Scientific secretary:
Dr. Georgeta Simu
( @acad-icht.tm.edu.ro)
Structure:
Departments : 3
Programmes: 4
Human resources:
Scientific researchers I: 17
Scientific researchers II: 5
Scientific researchers III: 12
Scientific researchers: 11.5
Assistants: 19
Technical personnel: 17
Various statistical data:
Number of ISI papers / year (average value for the period 2002-2004): 77:3=26
Number of peer reviewed / year (average value for the period 2002-2005): 6:3=2
Research directions
Fundamental research in chemistry is the main activity but the scientific research has a wide scope, ranging from a fundamental form to concrete forms of applied research.
The institute was intended to carry out both basic research and applications, the latter consisting mainly on compounds with biological relevance and as potential advanced materials. This basic idea was implemented by bringing together chemists with strong background in inorganic, organic and computational chemistry.
Presentation of the research programmes
1. Molecular design assisted by computer
2. Organic and element-organic compounds of fluorine, nitrogen and phosphor. New bioactive compounds.
3. Structure and reactivity of some inorganic compounds with special properties.
4. Catalytic activity of hetero-polyoxometallates compounds of Keggin type in oxidation and dehydrogenation reactions
Research laboratories
Picture of a research teamINORGANIC CHEMISTRY
LABORATORY TEAM
1. Coordination chemistry.
Coordinator : Dr. Otilia Costisor
Homo- and heteropolynuclear metal complexes as precursors for:
a. Advanced materials:
- Vanadium - copper complex polysulfides;
- Liquid crystals. Metallomesogenes: First row metal complexes containing Schiff bases as ligands;
- Polynuclear metal complexes containing oxalate as ligand.
b. Supramolecular systems with relevance in biological systems as models, antiviral, antimicrobial or cytostatic compounds and contrast agents for MRI :
- Design and synthesis of Mannich bases as ligands;
- Mono- and polymetallic metal complexes containing Mannich bases as ligands.
2. Oxidic Compunds and Salts Chemistry
Coordinator : Dr. Cecilia Savii, C. S. I
a. Nanocomposite systems exhibiting peculiar optical and magnetic properties
- sol-gel derived silica nanoporous matrices;
- sol-gel derived nonionic hybrid organic-inorganic silica matrices, (polyvinyl alcohol as organic moiety);
- monolith, powder, and thin film (transition metallic oxides, iron oxide or ferrite-silica) nanocomposites obtained in situ or by impregnation.
b. Manganese activated willemite type phosphors
- Synthesis methods optimization (ultrasound field assisted ceramic methods, and sol-gel processing);
- Luminescence intensity and emission properties correlation with synthesis parameters.
Coordinators: Dr. Lidia Taubert, C. S. I, and Dr. Ludovic Sayti, C. S .I
c. Optimized technologies for magnesium and calcium oxides and carbonates
- Molecular modeling on crystallites growing process;
- Ecologic processing of indigene row materials;
- Potential applications of obtained salts/oxides: rubber and plastics, pharmaceutical industry and as nutrients additives for animal’s food.
3. Chemical catalysis and kinetics
Coordinator: Dr. eng. Viorel Sasca, C. S. II
a. Solid state reactions and heterogenic catalytic reactions kinetics:
- reactant pulse technique used in the inferior alcohols oxidation/dehydrogenation reactions;
- reactant continuous flux method in the reactor of integral type.
b. Oxide catalysts – design, synthesis and characterization
c. Design and construction of Laboratory equipments in order to prepare and evaluate acid-basic properties and respectively catalytic activity and redox properties of oxide compounds
PictureOf a research team
COMPUTATIONAL CHEMISTRY TEAM
4. Computational chemistry
Coordinator: Prof. Dr. Zeno Simon, correspondent member of the Romanian Academy
a. Applications of QSAR, QSPR and computational chemistry techniques in the area of biologically active compounds with desired target properties
Coordinator: Dr. eng. Simona Funar-Timofei, C. S. I
- Applications of QSPR (QSAR) and other modern computational techniques to obtain chemical compounds with target properties (dyes, drugs);
- MTD-PLS variant for receptor binding site mapping;
- Biological interactions design.
b. Molecular modelling for characterization of chemical compounds.
Coordinator: Dr. Maria Mracec, C. S. I
- Applications of molecular modeling methods on biologic active ligands;
- Theoretical study of the interactions between GPCR and agonists or antagonists ligands;
- Studies on structural characterization and reactivity of chemical compounds.
PictureOf a research team afara
Organic Chemistry Department Team
5. Organic chemistry
Coordinator: Dr. eng. Gheorghe Ilia, C.S.I.
a. Phosphorus, nitrogen and fluorine compounds
Coordinator: Dr. eng. Gheorghe Ilia, C.S.I.
- Green Chemistry concept in the synthesis of phosphates, phosphinates and phosphoramidates in multiphase systems;
- Structure, reactivity and properties of perfluorurated compounds;
- 1,4,2-benzoxaza or benzodiaza-phosphorin-2-oxides and nitrogen macrocycles from meso-tetraphenyl porfirines class;
- Organic salts of ethanolamine with orto-substituted benzoic acids;.
- Heterobenzenes with elements from the fifth main group;
b. Macromolecular compounds with controlled and oriented properties.
Coordinators: Dr. eng. Smaranda Iliescu C.S.I. and Dr. eng. Adriana Popa C. S. I
- Polymers with phosphorus and/or nitrogen in main chain;
- Polymers with pendant functional groups with phosphorus and/or nitrogen and oxygen.
c. Dyes and dyes precursors chemistry
Coordinator: Dr. eng. Simu Georgeta C.S.II
- Direct azo dyes and azo containing compounds;
- Monoazo dyes based on ohydroxy carboxylic acid arylamides;
- Dyes interactions with macromolecular and biological substrates;
- Dyes with special applications.
PictureOf a research team coloranti
d. Carbohydrates chemistry
Coordinator: Chem. Sisu Ioana, C.S.III.
- Functionalization reactions at the anomeric centre of carbohydrates;
- Thioribofuranosides synthesis.
e. Analytical and preparative HPLC
Coordinator: Dr. chem. Szabadai Zoltan, C.S.I.
- Photochemical kinetic analysis of photosensitive drugs in photo degradation process.
Picture of one or more laboratoriesResearch results (between 2002-2004)
- 1 books published abroad
- 6 books published with other Romanian publishing houses
- 6 papers published in peer-reviewed international journals ( 11 ISI papers)
- 23 papers published in the journals of the Romanian Academy
- 54 papers published in other journals
- 316 scientific communications (163 at international meetings)
ISI papers (since 2002)
L. Taubert, L. Sayti and M. Milos: Magnesium Carbonates Cristallisation in presence of surface-active substances, Magnesium Res., 2001, 14, 321-323.
O. Costisor, R. Tudose I.Pantenburg, and G.Meyer: A New Copper(II) Complexes with N,N’-Bis(anti piryl – 4 - methyl) - piperazne (BAMP) Ligand, Z. Naturforschung, 2002, 57B, 1454.
S. Timofei, L. Kurunczi, W. Schmidt and Z. Simon: Steric and electrostatic effects in dye-cellulose interactions by the MTD and CoMFA approaches, SAR & QSAR Environ. Res., 2002, 13 (2), 219-226.
L. Kurunczi, S. Timofei and S. Iliescu: Structure of the polymer obtained from bisphenol-a and Cl2P(O)CH3, Phosphorus Sulfur, 2002, 177 (6-7), 1713-1716.
G. Dehelean, G. Ilia, S. Iliescu, A. Popa, L. Macarie and A. Pascariu: The influence of the molar ratio SPCl3:phenol on the formation of the disubstituted secondary products in the liquid-liquid PTC synthesis of aryltiophosphoric acid diclorides, Phosphorus Sulfur, 2002, 177:8-9, 2193-2194.
S. Iliescu, G. Ilia, G. Dehelean, A. Popa, L. Macarie, L. Pacureanu and A. Pascariu: New polyphosphonates obtained by vapor-liquid interfacial polycondensation, Phosphorus Sulfur, 2002, 177:8-9, 2051-2052.
G. Ilia, S. Iliescu, G. Dehelean, A. Popa, L. Pacureanu, L. Macarie and A. Pascariu: Synthesis of mixed dialkylphosphates by phase transfer catalysis method, Phosphorus Sulfur, 2002, 177:8-9, 2049-2050.
S. Iliescu, G. Ilia, G. Dehelean and A. Popa: New polyphosphonates obtained by vapor-liquid interfacial polycondensation, Polym. Bull., 2002, 48, 451- 456.
A. Popa, A. Trif, V. G. Curtui, G. Dehelean, S. Iliescu and G. Ilia: Synthesis and toxicological characterization of poly(oxyethylene)s functionalized with quaternary phosphonium end groups, Phosphorus Sulfur, 2002, 177, 2195-2196.
E. Sisu, M. Sollogoub, J. M. Mallet and P. Sinaÿ: Cycloheptanic sugar mimetics, bridging the gap in the homologous series of carbocyclic analogues, Tetrahedron, 2002, 58, 10189-10196.
I. Ciucanu, A. Chiriac and A. Caprita: Continuous permetion of analytes through a thin poly(dimethylsiloxane) membrane followed by sorbent trapping for their gas chromatographic monitoring, J. Chromatogr, 2002, 964, 1-9.
M. Grozav, G. Ilia, I. Neamtiu, M. Mercea and M. Laichici: Some nitro-acenaphthenephosphonic acids as potential plant-growth regulators, Phosphorus Sulfur, 2002, 77 (8-9), 2053.
O. Costisor, I. Pantenburg, G. Meyer and R. Tudose: synthesis, characterization of new copper(II) complexes containing N,N’-Bis(antipiryl- 4- methyl)-piperazne ligand, Z. Naturforsch., 2002, 58B, 1024-1035.
O. Costisor, P. Weinberger, M. Stefanescu, I.Labadi, A. Meghea, W.Linert and M. Brezeanu: New polynuclear complexes in the vanadium-copper system, Synth. React. Inorg. Met -Org. Chem. (New York), 2002, 32(5), 923-937.
E. Princz, I Szilagyi, K. Mogyorosy and I. Labadi: Lanthanide complexes of ethylenediamine-tetramethylenephos phonic acid, J. Therm. Anal. Calor., 2002, 69, 427-439.
C. Savii, M. Popovici, C. Enache, J. Subrt, D. Niznansky, S. Bakardjeva, C. Cauzer and I. Hrianca:
Fe2O3–SiO2 composites obtained by sol-gel synthesis, Solid State Ionics (Elsevier), 2002, 8731, 1242-1256.
M. Caldararu, C. Hornoiu, G. Postole, M. Carata, A. L. Petre, V. Sasca, N. I. Ionescu and N. J. Jaeger: The effect of hydration/dehydration on the AC electrical conductivity of H4PVMo11O40 and some of its cesium salts used as catalysts, React. Kinet. Catal. Lett., 2002, 76(2), 235-242.
E. Seclaman, A. Sallo, F. Elenes, E. Crasmareanu, C. Wikete, S. Timofei and Z. Simon: Hydrophobicity, protolytic equilibrium and chromatographic behaviour of some monoazoic dyes, Dyes Pigments, 2002, 55, 69-77.
G. Balea, E. Sallo, A. Sallo, L. Sayti and M. Milos: The behaviour of perturbed Belousov-Zhabotinsky systems II, Rev. Rom. Chim., 2002, (4), 527-531.
M. V. Putz, A. Chiriac and M. Mracec: Foundations for a theory of the chemical field. II. The integrated electronegatvity, Rev. Roum. Chim., 2002, 47, 201-206.
S. Iliescu, G. Ilia, G. Dehelean, A. Popa, E. Fagadar-Cosma, L. Macarie, and L. Pacureanu: The study of the liquid-liquid interfacial polycondensation of the cyclohexylphosphonic dichloride with bisphenol A 2. The influence of organic phase, Rev. Roum. Chim., 2002, 47(5), 461-464 .
N. Dinca, E. Sisu, I. Sisu, I. Oprean, C. Csunderlik and M. Mracec: GC-MS and Differential Mass Spectrometry analysis of 3- and 4-nitrobenzophenone dimethyl acetals, Rev. Roum. Chim., 2002, 47 (3-4), 379-385.
O. Costisor, M. Mracec I. Labadi, and W. Linert: New copper(I) and cobalt(II) binuclear complexes with mercaptobenzothiazole and Mannich base ligands: A spectroscopic characterization, Rev. Roum. Chim., 2002, 47(10-11), 1155-1163.
E. Sisu, I. Sisu, N. Dinca, C. Csunderlik, I. Oprean, V. Rusu and M. Mracec: Nitrobenzophenones and their derivatives. 31 new acetals of mono- and dinitrobenzophenones, Rev. Roum. Chim., 2002, 47 (3-4), 339-342.
S. Funar-Timofei, T. Suzuki, J. A. Paier, A. Steinreiber, K. Faber and M. F. Fabian: Quantitative Structure – Activity Relationships for the enantioselectivity of oxirane ring opening catalyzed by epoxide hydrolases, J. Chem. Inf. Comput. Sci., 2003, 43(3), 934-940.
G. Schüürmann and S. Funar-Timofei: Multilinear Regression and Comparative Molecular Field Analysis (CoMFA) of azo dye- fibre affinities II: Inclusion of solution-phase molecular orbital descriptors, J. Chem. Inf. Comput. Sci., 2003, 43(5), 1502-1515.
O. Popescu, I. Checiu, P. Gherghel, Z. Simon and G.N. Misevics: Quantitative and qualitative approach to glycan-glycan interactions in marine sponges, Biochim. (Biochemistry), 2003, 85 (1-2), 181-188.
A. Popa, C. M. Davidescu, R. Trif, G. Ilia, S. Iliescu and G. Dehelean: Study of quaternary onium salts grafted on polymers: Antibacterial activity of quaternary phosphonium salts grafted on gel-type styrene-divinylbenzene copolymers, React. Funct. Polym., 2003, 55(2), 151-158.
G. Ilia, A. Popa, S. Iliescu, A. Bora, G. Dehelean and A. Pascariu: Synthesis of mixed alkylphosphites and alkylphosphates, Phosphorus Sulfur, 2003, 178(7), 1513-1519.
S. Iliescu, G. Ilia, A. Popa, L. Kurunczi and G. Dehelean: The vapor-liquid polycondensation of cyclohexylphosphoric dichloride with hydroquinone,
Phosphorus Sulfur, 2003, 178(8), 1759-1769.
G. Ilia, A. Bora, S. Iliescu, A. Popa and G. Dehelean: Synthesis of phosphorus derivatives from 1,3-Dioxolan-2-one, Phosphorus Sulfur, 2003, 178(11), 2491-2496.
I. Ciucanu, A. Caprita, A. Chiriac, and R. Barna:
Helical sorbent microtrap for continuous sampling by a membrane and trap interface for on-line gas chromatographic monitoring of volatile organic compounds, Anal. Chem., 2003, 75 (4), 736-741.
E. Sisu, S. Tripathy, J. M. Mallet, P. A. Driguez, J. P. Hérault, P. Sizun, J. M. Herbert, Maurice Petitou and P. Sinay: Synthesis of new conformationally constrained pentasaccharides as molecular probes to investigate the biological activity of heparin, Biochim., 2003, 85, 91-99.
M. Simon, C. Csunderlik, P.J. Jones, I. Neda and A. Fischer: Bis(p-nitrophenzl)carbonate-benzene, Acta Cryst., 2003, E59, 91-92.
M. Simon, C. Csunderlik, P.J. Jones, I. Neda and A. Fischer: A second polymorph of bis(o-nitrophenyl)carbonate, Acta Cryst., 2003, E59, 688-690.
M. Simon, C. Csunderlik, P.J. Jones, I. Neda and A. Tarta-Micle: N,N-Disuccinimidyl carbonate, Acta Cryst., 2003, E59, 63-65.
P. C. Fannin, C. N. Marin, V. Socoliuc, G. M. Istratuca and A. T. Giannitsis: The effect of magnetic field induced instability on ferrimagnetic resonance in magnetic liquids, J. Phys. D: Appl. Phys., 2003, 36, 1227.
L. Cseh, I. Pantemburg, C. Csunderlik, G. Meyer and O. Costisor: Synthesis, crystal structure, and spectral properties of a cobalt(II) complex with N-salicylidene-p-toluidine, Z. Anorg. Allg. Chem., 2003, 629 No. 6, 985-988.
C. Caizer, M. Popovici and C. Savii: Spherical (Zn Ni1- Fe2O4) nanoparticles in an amorphous (SiO2)1- matrix, prepared with the sol–gel method, Acta Mater., 2003, 51(12) 3607-3616.