Syllabus

CourseTitle:PracticalCell NeuroscienceSpringSemester2015

CourseNumber: ClassTime:

PCB4843C(Undergraduate)3Cr

CRN#21797 Section001

Lecture-MonlOam-11:30am-Rm-SC119

Workshop-Mon-1pm-3:50pm-Rm-SC118

Pre-requisites:GeneticsPCB 3063orequivalent,minimumgradeofB-orbetter

Instructor:KenDawson-Scully

OfficeNumber:SC214

Telephone:561-297-0337.

E-mail:

Officehours:Monday-Friday8:30am-9:30am,SC214

RequiredTextBooks:

1) FromNeurontoBrain:ACellularandMolecularApproachtotheFunctionofthe Nervous System,2001,FourthEditionbyA.RobertMartin,BruceG.Wallace, PaulA.Fuchs,andJohnG.Nicholls(SinauerAssociatesISBN-10:0878934391

ISBN-13:978-0878934393)

2) NeuronsinActionV2.TutorialsandSimulationsUsingNEURON,2007byJohn

W.MooreandAnneE.Stuart(SinauerAssociatesISBN-978-0-87893-548-2)

Coursedescription,purpose,andobjectives:Thiscoursewill bringthestudentscloserto understandingneurophysiologicalsignalingatthecellularlevel,whereonlyafewcells communicateincloseproximity.Wewilllookatsignalingfromtheperspectiveofsingle ionchannelstocellularsynaptictransmission. Theelectricalpropertiesofneuronsand theirsignalingisthebasisforallneuronalfunction.Thestudentswilllearnthroughboth theoryandpracticallaboratorytheseprinciplesandapplythemin anexperimental proposal,which theywillpresentandthenexecuteresultinginafmalreport.

MethodofInstruction:Lectures,classroomexercises,labexercises,proposalwriting,and formalmanuscriptwriting.

Topics:

1) Thecellmembrane

2) Equilibriumpotentials

3) TheNaActionPotential

4) Threshold

5) VoltageClampandCurrentClamp

6) IonChannels

7) TheCaActionPotential

8) TheNeuromuscularJunction

9) PostsynapticInhibition

10)InteractionofSynapticPotentials

11)Myelination

12)AxonDiameter

13)TemperatureandCellSignaling

PracticalCellNeuroscienceLabSyllabusSpring2015

WKSTOPICSANDASSIGNEDREADINGS

1.Jan51h,2015NOCLASS

2.Jan12th,2015A#1:Introduction/Membrane/Equilibrium

Jan19th,2015Dr.MartinLutherKing,Jr.Holiday-NOCLASS

4.Jan26th,2015A#2:TheNaAP!Threshold/CaSensitivityofNaChannel

5.Feb2nd,2015A#3:Non-UniformDensityNoltageClamping/ChatteringChannels

6.Feb91h,2015A#4: TheCaAP/TheNMJ/PostsynapticInhibition

7.Feb16th,2015A#5: InteractionsofSynapticPotentials/PassiveAxon/AxonDiameter

8.Feb23rd,2015A#6: UnmyelinatedAxon/MyelinatedAxon/PartialDemyelination

Mar2°d,2015SPRINGBREAK-NOCLASS

9.Mar 9th,2015A#7: ImpulseInitiation/SynapticIntegration/ImpulseInvasion

10.Mar16th,2015PRESENTATATIONSWORKONPROJECT

11.Mar23r< ,2015PRESENTATATIONSWORKONPROJECT

12.Mar 30th.2015WORKONPROJECT-datagraphs

13.Apr6th,2015WORKONPROJECT-datagraphs

14.Apr13th,2015WORKONPROJECT-datagraphsDUE

15.Apr201h'2015PROJECTDUEby4pm(BOTH:handinemailconfirmation)

16.Apr27th,2015FINALEXAMatlOaminSC119

AssessmentProcedures,GradingCriteria,ClassPolicies:

10%Quizzes(Quizeveryclasstoshowyoureadthelabbeforehand)

10%Participation

20%AssignmentSheets(Thesewill bedoneduringlab)

20%ProposalofFormalLab Report(aonepagereportandpresentationonyour proposedexperiment foryourFormalLab Report)

20%FormalLabReport

20%Exam(ComprehensiveExam)

A94-100% A-90-94% B+86-90%

B82-86%

B-78-82%

C+74-78%

c70-74%

C- 66-70% D+ 62-66% D 58-62% D- 54-58% F 54%

Itistheresponsibilityofthestudenttowithdrawfromthisclass,shouldthatstatusbe desired-theinstructorcannotwithdrawstudentsfromthecourse.Theinstructorwillnot givethegradeof"I"inlieuofagradeof"D"or"F".Thegradeof"I"willbeconsidered onlyinexceptionalcases(suchasseriousillness)forstudentswho arepresently performingata"C"orhigherlevelinthecourse.

Attendance.Studentsare expectedtoattendallscheduledclasses.Ifyoumissaclassyou areresponsibleforALLthematerialcoveredduringthatclass,includinglecture material andrulesandregulationsaboutthecourse(suchaspenaltiesforlateassignments,etc.). StudentswillnotbepenalizedforabsencesduetoparticipationinUniversity-approved activities,includingathleticorscholasticsteams,musicalandtheatricalperformances, anddebateactivities. Thesestudentswillbeallowedtomakeupmissedworkwithout anyreductioninthestudent'sfinalcoursegrade. Reasonableaccommodationwillalso bemadeforstudentsparticipatingin areligiousobservance

Homeworkassignmentsandpapers.Thepapersandhomeworkaredueonthedates assigned.Thesewillbeacceptedupto1weeklate,buttheywillbepenalized.Nonewill beacceptedover1weeklate.

FinalExam.Thefmalexamwillbeacomprehensiveexamonallmaterialcoveredinthis course.

Accommodationsforstudentswithdisabilities.IncompliancewiththeAmericanswith

DisabilitiesAct(ADA),studentswhorequirespecialaccommodationsduetoadisability toproperlyexecutecourseworkmustregisterwiththeOfficeforStudentswith Disabilities(OSD)locatedinBocaRaton-SU133(561-297-3880),inDavie-MODI (954-236-1222),inJupiter-SR117(561-799-8585),orattheTreasureCoast-CO128 (772-873-3305),andfollowallOSDprocedures.

HonorCode.StudentsatFloridaAtlanticUniversityareexpectedtomaintainthe highest ethicalstandards.Academicdishonesty,includingcheatingandplagiarism,isconsidered a seriousbreachoftheseethicalstandards,becauseitinterfereswiththeUniversity missiontoprovideahighqualityeducationinwhichnostudentenjoysanunfair advantageoveranyother.AcademicdishonestyisalsodestructiveoftheUniversity community,whichisgroundedinasystemofmutualtrustandplaceshighvalueon personalintegrityandindividualresponsibility.Harshpenaltiesareassociatedwith academicdishonesty.Formoreinformation,see