RAJIVGANDHIUNIVERSITY OF HEALTH SCIENCES,BANGALORE, KARNATAKA

PROFORMA FOR REGISTRATION OF DISSERTATION

TOPIC

“STUDY OF HISTOMORPHOLOGICAL PATTERNS

OF NEOPLASTIC AND NON-NEOPLASTIC LESIONS

OF OVARY IN KVGMEDICALCOLLEGE”

DR.T.S.SOWMYA,

POSTGRADUATE,

DEPARTMENT OF PATHOLOGY,

K.V.G.MEDICALCOLLEGE,

SULLIA.

RAJIVGANDHIUNIVERSITY OF HEALTH SCIENCES,BANGALORE KARNATAKA

ANNEXURE- II

PROFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION

1 / Name of the candidate and address(in block letters) / DR.T.S.SOWMYA,
POSTGRADUATE,
DEPARTMENT OF PATHOLOGY, K.V.G.MEDICALCOLLEGE, SULLIA
2 / Name of the institution / K.V.G.MEDICALCOLLEGE,
SULLIA,
DK-574327,
KARNATAKA.
3 / Course of study and subject / M.D. in PATHOLOGY
4 / Date of admission to course / 28/ 04/ 2008.
5 / Title of the topic / “STUDY OF HISTOMORPHOLOGICAL
PATTERNS OF NEOPLASTIC AND
NON-NEOPLASTIC LESIONS OF
OVARY IN KVGMEDICALCOLLEGE ”
6 / BRIEF RESUME OF THE INTENDED WORK:
6.1 Need for the study:Ovary is unique in the variety of lesions that can arise from it.1Ovarian diseases of surgical importance can be broadly divided into non-neoplastic cysts, inflammations and neoplasms.2
Ovarian tumors accounts for considerable proportion of clinically important tumours in females. They manifest a wide spectrum of clinical , morphological and histological features.3 Ovarian neoplasms have become increasingly important not only because of the large variety of neoplastic entities but more because they have gradually increased the mortality rate in female genital cancers.4
Non- neoplastic lesions of ovary potentially mimic ovarian neoplasm. Ovarian tumours and tumour like lesions present great challenge to the gynaecological oncologist.1
The incidence, clinical appearance and the behaviour of the different types of ovarian tumors is extremely variable.It is generally impossible to diagnose the nature of the ovarian tumour preoperatively just by clinical examination and even on exploration.Hence,one has to depend on the microscopic appearance of the tumour for further management of the ovarian neoplasm.4
Thus there is a need for the knowledge of different morphological patterns of ovarian lesions. The present study is undertaken to study the diverse histomorphological patterns of ovarian lesions. Thus, offering a specific diagnosis,is of paramount clinical significance.
6.2 Review of literature:
Ovaries are paired oval organs located on either side of the uterus close to the lateral pelvic wall .5 The main function of ovary is to produce eggs to implant after fertilization in the endometrium.6Ovarian diseases of surgical importance can be broadly divided into non neoplastic cysts, inflammations and neoplasms.2
Benign ovarian cysts affect all age groups, while malignant tumours are more frequent amoung elderly women. In addition, the distribution by age group varies according to the histological types.7
Ovary is unique in the variety of lesions that can arise from it.Tumours of ovary represent about 30% all cancers of female genital system.1Ovarian tumours are classified accordingly to the most probable tissue of origin inWorld Health Organization (WHO) histological classifications. Although, some of the specific tumours have distinctive features and are hormonally active, most are non functional and tend to produce relatively mild symptoms until they have reached a large size.8
From a histogenetic view point, ovarian cancer may develop denovo or may arise from preexisting benign epithelial tumour.9
Metastasis to the ovary are common and their nature is frequently unsuspected by gynaecologist and even by pathologist, particularly when tumours are cystic.10
The accurate histological diagnosis of ovarian neoplasm is often a critical factor in achieving an optimum clinical response for the therapeutical approach.6
The conventional approach to the pathology of ovarian tumours in discussion of all features of individual types, one by one,follow standard classification system as that of WHO. This approach is valuable as it permits one to review comprehensively the pathological features of each tumors. In addition to clinical data and operative findings, the gross features of lesions of the ovary provide important and at times decisive diagnostic clues.11
6.3 Objectives of the study:
1. To study the histomorphological diversity of various neoplastic and non-neoplastic lesions of ovary.
2. To provide a specific diagnosis based upon the histomorphological study which is of paramount clinical significance in further management of the patient.
7. / MATERIALS AND METHODS
7.1 Source of data-
Surgically resected ovarian specimens sent to the Department of Pathology, KVGMedicalCollegeHospital, Sullia, for histopathological examination.Study period is June 2008 to August 2010.
Sample size: Intended to study about 100 cases.
7.2 Method of collection of data:
All surgically resected ovarian specimens, sent for histopathological examination toKVGMedicalCollege will be studied from June 2008 to August 2010 .
After careful gross examination, representative areas will be processed for the histopathological study. Staining will be done using Haematoxylin and Eosin staining. Special stains will be done wherever it is required.
Inclusion criteria:
Ovarian lesions including non-neoplastic and neoplastic will be included in the study.
Exclusion criteria:
Inflammatory, gestational-related and developmental disorders of ovary are excluded.
7.3 Does the study require any investigations or interventions to be conducted on patients or other humans or animals? If so please describe briefly.
No investigations are required to be conducted on patients or other humans or animals.
7.4 Has ethical clearance been obtained from your institution in case of 7.3?
Yes
8 / List of References
1. . Gupta N, Bisht D, AgarwalAK, Sharma VK. Retrospective and prospective study of ovarian tumours and tumourlike lesions. Indian J Pathol Microbiol. 2007 ;50(30):525-527.
2. Rosai J, Female reproductive systemChap.19.In:Rosai and Ackerman’s Surgical Pathology.Rosai J,(Eds).vol.2. 9 th ed,St.louis:Mosby;2004.p.1649-1706.
3. Pilli GS , Suneeta KP ,Dhaded AV, Yenni VV. Ovarian tumours: study of 282 cases. J Indian Med Assoc.2002; 100(7):420-424.
4. Bhattacharya MM, ShindeSD, PurandareVN.Aclinicopathological analysis of 270 ovarian tumours. J Postgrad Med.1980;26:103-107.
5.IndT.Ovaries.chap102.In:Gray’sAnatomy.Standring S,(Eds).39thedn.Spain: Elsevier;
2005,p.1321-1322.
6. Prat J, Female reproductive system. Ch68. In: Anderson’s Pathology. Damjov I, Linder J (Eds). vol.2 . 10th edn. St.Louis: Mosby;1996.p.2278-2296.
7. DiBonito L,Patriarca S, DelendiM, Alberico S. Ovarian tumours:anatomohistopathological contribution to their interpretation. Eur J Gynaecol Oncol.1988; 9(4):324-330.
8. Crum CP, Female Genital Tract.Chap22. In: Robbins and Cotran Pathological Basis of Diseases. Kumar V, AbbasAK, Fausto N ,(Eds).7th ed.. Philadelphia:Elsevier In; 2004.p.1092-1104.
9. Bell DA, ScullyRE . Early denovo ovarian carcinoma: a study of 14 cases.
Cancer1994 ;73:1859.
10.Lash RH, HartWR. Intestinal adeno carcinomas metastatic to the ovaries: a clinicopathologic evaluation of 22 cases, Am J Surg pathol.1987; 11:114.
11. Young RH , Scully RE. Differential diagnosis of ovarian tumours based primarily on their patterns and cell types. Semin Diagn Pathol.2001;18(3):161-235.
SIGNATURE OF THE CANDIDATE:
REMARKS OF THE GUIDE :
NAME AND DESIGNATION OF THE
GUIDE: / Dr. T.M. KARIAPPA
Professor and Head ,
Department of Pathology,
K.V.G.MedicalCollege, Sullia
SIGNATURE OF THE
GUIDE:
HEAD OF THE DEPARTMENT: / Dr. T.M. KARIAPPA
Professor and Head,
Department of pathology,
K.V.G. Medical college, Sullia.
SIGNATURE OF THE HEAD OF THE
DEPARTMENT:
REMARKS OF PRINCIPAL:
SIGNATURE
ETHICAL COMMITTEE CLEARANCE
1.TITLE OF DISSERTATION / “STUDY OF HISTOMORPHOLOGICAL PATTERNS OF NEOPLASTIC AND NON-NEOPLASTIC LESIONS OF OVARY IN K.V.G.MEDICALCOLLEGE.”
2.NAME OF THE CANDIDATE / Dr.T.S.SOWMYA.
3. NAME OF THE GUIDE / Dr. T.M.KARIAPPA.
4. APPROVED / NOT APPROVED
Sri KRISHNAMURTHY ,Chairperson .
Dr. SUBBANNAYYA KOTI GADDE, Secretary.
Dr. S.GOPALRAO , Member
Dr. C.S.MOHANRAJ , Member
Dr. H.R.SHIVAKUMAR , Basic scientist
LAW EXPERT : Sri KRISHNAMURTHY , Advocate
PRINCIPAL
K.V.G.MedicalCollege and Hospital , Sullia.