Supplementary Table S1. GOBPs represent epigenomesin which H3K9me3 occupancyis significantly elevated in R6/2 mice, and the H3K9me3 occupancy is reduced by nogalamycin administration in R6/2 mice. Count indicates the number of the genes involved in the GOBP.

GO ID / Description / P-value / Count / Genes
GO:0044267 / cellular protein metabolic process / 0.00 / 125 / Gabarapl2; Usp2; Wars; Ctnnb1; Hspe1; Cnot1; Anapc2; Sars2; Pan2; Arih1; Nanos1; Tceb2; Mocs1; Adarb1; Gpx1; Gan; Pigs; Macrod1; 5430437P03Rik; Rnf5; Smarca4; Eef2; Cdk5r1; Wdr82; Mrpl49; Exosc1; Rad23a; Cdc25b; Dnajc7; Dnajc3; Il34; Csnk1e; Wdyhv1; Itgb1bp1; D1Bwg0212e; Poldip3; Hexb; Dab2ip; Pick1; Dars2; Pias4; Irak2; Psmb6; Atat1; Rps6ka2; Ngdn; Psmb10; Prmt2; H2-Ke2; Plg; Sae1; Bbs12; Mapk12; Mlst8; Skp1a; Hexim1; Nek2; Pfdn1; Galntl4; 1200011M11Rik; Ppp1ca; Egr1; Parp1; Fkbp4; Mettl21a; Apoa1; Mt3; Ezh1; Clu; Hsp90ab1; Mrpl14; Epha4; Smad3; Cog3; Prkcsh; Dusp18; Ccnt1; Dusp13; Mink1; Dpagt1; Bag6; Rnf103; Bag5; H2-DMa; Ang; Tssk2; Cln6; Arrb2; Prkar1a; Ube2v2; Mapk8ip3; B3gnt1; Rpsa; Spred2; Dusp8; Usp28; Dusp1; Dennd3; Asb1; Sik3; Phb; Rbm4b; Herc2; Map2k6; Wsb2; Il23a; Hyal2; Ufc1; Prkcz; Cish; Usp32; Fem1b; Osbpl7; Usp36; Sphk1; Tpst2; Ncbp2; Rpl27; Anapc11; Cry1; Eif2c2; Dvl2; Nars2; Ppp2r5b; Setd6
GO:0009894 / regulation of catabolic process / 0.00 / 32 / Gabarapl2; Mt3; Tbc1d2; Dab2ip; Psmd3; Clu; Cnot1; Asap1; Epha4; Hif1a; Smad3; Hsp90ab1; Ldlr; Tnnc1; Mlst8; Ptprn2; Bag6; Arfgap1; Sln; Gtpbp1; Crk; Serpinb1b; Osbpl7; Bcr; Ppp1ca; Rad23a; Eif2c2; Csnk1e; Arfgap3; Apoc1; Ube2v2; Itgb1bp1
GO:0009057 / macromolecule catabolic process / 0.00 / 39 / Gabarapl2; Usp2; Dab2ip; Usp28; Clu; Cnot1; Dnajc3; Plg; Anapc2; Ncbp2; Psmb10; Psmd3; Smad3; Hsp90ab1; Ldlr; Herc2; Rnf103; Rnf5; Bag6; Pan2; Hyal2; Skp1a; Gtpbp1; Usp32; Serpinb1b; Osbpl7; Usp36; Wdyhv1; Arih1; Ppp1ca; Psmb6; Rad23a; Eif2c2; Dennd3; Cln6; Chi3l4; Ube2v2; 1200011M11Rik; Csnk1e
GO:0035556 / intracellular signal transduction / 0.00 / 81 / Rab27a; Lphn1; Cnih2; Ccdc109a; Cnih4; Mink1; Epha4; Eef1d; 2810002N01Rik; Dab2ip; Pick1; Spred2; Ctnnb1; Arl10; Dgkh; Dusp8; Pias4; Usp28; Irak2; Clu; Dusp1; Dgkd; Ryk; Rfxank; Asb1; Bag6; Il23a; Rasd1; Arf3; Arhgef25; Rab1b; Hif1a; Gpx1; Arl5c; Rab3c; Rab43; Rab3a; Rabif; Arrb2; Arl4d; Mlst8; Mt3; Aif1; Arl4a; Mc1r; Ift27; Ypel1; Slc9a1; Rasl10b; Cep63; Hyal2; Nisch; Rps6ka2; Pde2a; Prkcz; Cish; Nfkbil1; Ndrg2; Crk; F10; Cradd; Bcr; Rab25; Sphk1; Map2k6; Sos1; Rabl2; Gpr183; Dock6; Dvl2; Prmt2; Itpkb; Rhobtb2; Plcd3; Wsb2; Mt1; Telo2; Itgb1bp1; Apoa1; Rab17; Mapk8ip3
GO:1901361 / organic cyclic compound catabolic process / 0.00 / 33 / Rab27a; Dpysl2; Mt3; Tbc1d2; Dab2ip; Pick1; Cnot1; Asap1; Pan2; Hsd17b14; Epha4; Comt; Tnnc1; Mlst8; Smarca4; Eef2; Arl4a; Ptprn2; BC048355; Pde2a; Sln; Gtpbp1; Crk; Bcr; Ncbp2; Enpp5; Eif2c2; Ywhah; Arfgap3; Arfgap1; Ube2v2; 1200011M11Rik; Itgb1bp1
GO:0030163 / protein catabolic process / 0.00 / 30 / Gabarapl2; Usp2; Dab2ip; Usp28; Psmb6; Anapc2; Plg; Arih1; Psmb10; Clu; Psmd3; Smad3; Hsp90ab1; Ldlr; Herc2; Rnf103; Rnf5; Bag6; Pan2; Skp1a; Usp32; Serpinb1b; Osbpl7; Usp36; Rad23a; Dnajc3; Dennd3; Csnk1e; Ube2v2; Wdyhv1
GO:0044265 / cellular macromolecule catabolic process / 0.00 / 31 / Gabarapl2; Usp2; Dab2ip; Usp28; Psmb6; Cnot1; Dnajc3; Plg; Anapc2; Ncbp2; Psmb10; Clu; Hsp90ab1; Herc2; Rnf103; Rnf5; Bag6; Pan2; Skp1a; Gtpbp1; Usp32; Osbpl7; Usp36; Arih1; Rad23a; Eif2c2; Dennd3; Cln6; Csnk1e; Ube2v2; 1200011M11Rik
GO:0015031 / protein transport / 0.00 / 53 / Tomm6; Rab27a; Tomm40l; Pacs1; Cabp1; Gabarapl2; Cog3; Mt3; Vps4a; Dab2ip; Pick1; Tmed1; Tap2; Dusp18; Chmp1b; Gabarap; Myrip; Gnptab; Rab1b; Ywhah; Smad3; Rab3c; Rab43; Nup155; Atg4d; Snx27; Arfgap3; Pttg1ip; Vamp2; Rab3a; Nup133; H2-DMa; Rabif; Nup85; Tmed9; Pde2a; Prkcz; Cdk5r1; Snx3; Gosr1; Rab25; Sphk1; Ang; Arfgap1; Ramp2; Arf3; Hyal2; Arrb2; Yif1a; Tomm20; Itgb1bp1; Apoa1; Rab17
GO:0050821 / protein stabilization / 0.00 / 8 / Bag6; Cog3; Mt3; Usp2; Smad3; Clu; Apoa1; Nckap1
GO:0006405 / RNA export from nucleus / 0.00 / 6 / Rpsa; Nup133; Nup155; Ncbp2; Thoc3; Ddx39
GO:0046434 / organophosphate catabolic process / 0.00 / 25 / Rab27a; Tbc1d2; Dab2ip; Pick1; Mtmr7; Asap1; Epha4; Ldlr; Tnnc1; Mlst8; Smarca4; Eef2; Arl4a; Ptprn2; Arfgap1; BC048355; Pde2a; Sln; Gtpbp1; Crk; Bcr; Enpp5; Arfgap3; Apoc1; Itgb1bp1
GO:0034655 / nucleobase-containing compound catabolic process / 0.00 / 28 / Rab27a; Tbc1d2; Dab2ip; Pick1; Cnot1; Asap1; Pan2; Ncbp2; Epha4; Tnnc1; Mlst8; Smarca4; Eef2; Arl4a; Ptprn2; BC048355; Pde2a; Sln; Gtpbp1; Crk; Bcr; Enpp5; Eif2c2; Arfgap3; Arfgap1; Ube2v2; 1200011M11Rik; Itgb1bp1
GO:0044270 / cellular nitrogen compound catabolic process / 0.00 / 29 / Rab27a; Dpysl2; Tbc1d2; Dab2ip; Pick1; Cnot1; Asap1; Pan2; Ncbp2; Epha4; Tnnc1; Mlst8; Smarca4; Eef2; Arl4a; Ptprn2; BC048355; Pde2a; Sln; Gtpbp1; Crk; Bcr; Enpp5; Eif2c2; Arfgap3; Arfgap1; Ube2v2; 1200011M11Rik; Itgb1bp1
GO:0046700 / heterocycle catabolic process / 0.00 / 29 / Rab27a; Dpysl2; Tbc1d2; Dab2ip; Pick1; Cnot1; Asap1; Pan2; Ncbp2; Epha4; Tnnc1; Mlst8; Smarca4; Eef2; Arl4a; Ptprn2; BC048355; Pde2a; Sln; Gtpbp1; Crk; Bcr; Enpp5; Eif2c2; Arfgap3; Arfgap1; Ube2v2; 1200011M11Rik; Itgb1bp1
GO:0007403 / glial cell fate determination / 0.00 / 2 / Ctnnb1; Smarca4
GO:0019439 / aromaticcompound catabolic process / 0.00 / 29 / Rab27a; Tbc1d2; Dab2ip; Pick1; Cnot1; Asap1; Pan2; Ncbp2; Epha4; Comt; Tnnc1; Mlst8; Smarca4; Eef2; Arl4a; Ptprn2; BC048355; Pde2a; Sln; Gtpbp1; Crk; Bcr; Enpp5; Eif2c2; Arfgap3; Arfgap1; Ube2v2; 1200011M11Rik; Itgb1bp1
GO:0002478 / antigen processing and presentation of exogenous peptide antigen / 0.00 / 4 / H2-DMa; Fcer1g; Tap2; H2-Aa
GO:0048617 / embryonic foregut morphogenesis / 0.00 / 3 / Ctnnb1; Nckap1; Smad3
GO:0009308 / amine metabolic process / 0.01 / 9 / Aoc2; Sptlc1; Comt; Chka; Ldlr; Pnpla6; Apoc1; Ache; Apoa1
GO:0055086 / nucleobase-containing small molecule metabolic process / 0.01 / 35 / Rab27a; Dpysl2; Tbc1d2; Dab2ip; Pick1; Crk; Asap1; Atp5g2; Coasy; Epha4; Mpi; Gng7; Tnnc1; Macrod1; Mlst8; Smarca4; Eef2; Arl4a; Ptprn2; Mc1r; Arfgap1; BC048355; Pde2a; Sln; Gtpbp1; Gnmt; Bcr; Prpsap1; Shpk; Enpp5; Ramp2; Dtymk; Arfgap3; Slc25a25; Itgb1bp1
GO:0050807 / regulation of synapse organization / 0.01 / 6 / Lphn1; Oxt; Dab2ip; Ube2v2; Anapc2; Rab17
GO:0018158 / protein oxidation / 0.01 / 2 / Gpx1; Apoa1
GO:0001835 / blastocyst hatching / 0.01 / 2 / Grn; Smarca4
GO:0006796 / phosphate-containing compound metabolic process / 0.01 / 82 / Rab27a; Rimbp2; Mink1; Mt3; Tbc1d2; Hexb; Dab2ip; Pick1; Spred2; Rps6ka2; Chka; Mtmr7; Smad3; Ppp2r5b; Irak2; Mpi; Dusp1; Asap1; Atp5g2; Arl4a; Coasy; Dusp13; Nek2; Sik3; Arfgap1; Gnptab; Epha4; Mocs1; Adarb1; Gng7; Ldlr; Pigs; Tnnc1; Mapk12; Sptlc1; Ccnt1; Arrb2; Ccdc8; Mlst8; Smarca4; Ramp2; Eef2; Pnpla6; Ptprn2; Mc1r; Pla2g16; Il23a; Hyal2; Mapk8ip3; Slc25a25; BC048355; Prkar1a; G6pc3; Pde2a; Hexim1; Sln; Prkcz; Cdk5r1; Tssk2; Crk; Bcr; Prpsap1; Shpk; Ppp1ca; Rrp1b; Cdc25b; Enpp5; Dusp18; Dnajc3; Dvl2; Prmt2; Il34; Map2k6; Dtymk; Arfgap3; Apoc1; Gtpbp1; 1200011M11Rik; Itgb1bp1; Apoa1; Csnk1e; Dusp8
GO:1901565 / organonitrogen compound catabolic process / 0.01 / 27 / Rab27a; Dpysl2; Tbc1d2; Hexb; Dab2ip; Pick1; Asap1; Epha4; Comt; Ldlr; Tnnc1; Mlst8; Smarca4; Eef2; Arl4a; Ptprn2; Hyal2; Arfgap1; Pde2a; Sln; Gtpbp1; Crk; Bcr; Chi3l4; Arfgap3; Apoc1; Itgb1bp1
GO:0009116 / nucleoside metabolic process / 0.01 / 24 / Rab27a; Tbc1d2; Dab2ip; Pick1; Asap1; Atp5g2; Coasy; Epha4; Tnnc1; Macrod1; Mlst8; Smarca4; Eef2; Arl4a; Ptprn2; Arfgap1; Sln; Gtpbp1; Crk; Bcr; Gnmt; Arfgap3; Slc25a25; Itgb1bp1
GO:0035050 / embryonic heart tube development / 0.01 / 7 / C2cd3; Hif1a; Smad3; Ctnnb1; Dll1; Foxh1; Nckap1
GO:0019048 / virus-host interaction / 0.01 / 6 / Epor; Hyal2; Smad3; Banf1; Pias4; Thoc3
GO:1901136 / carbohydrate derivative catabolic process / 0.01 / 21 / Ptprn2; Rab27a; Epha4; Smarca4; Hyal2; Tbc1d2; Eef2; Dab2ip; Pick1; Pde2a; Chi3l4; Gtpbp1; Arfgap3; Hexb; Arfgap1; Crk; Mlst8; Itgb1bp1; Asap1; Bcr; Arl4a
GO:0065003 / macromolecular complex assembly / 0.01 / 44 / Ccdc109a; Rpsa; Dab2ip; Pick1; Tubg1; Dgkh; Angptl4; Clu; Cnot1; Dgkd; Tubb2b; Pomp; Scara5; H2-Ke2; Arpc5; Smad3; Bbs12; Ndufs8; Ache; P2rx6; Smarca4; Aif1; Myh11; Vamp2; Mlst8; Tspyl1; Cep63; H2-DMa; Med24; Kcnab2; Prkcz; Slc9a1; Insig1; Nip7; Nek2; Kctd3; Ang; Gnmt; Kcnc3; Fkbp4; Hist1h1d; Itgb1bp1; Apoa1; Ppp2r5b
GO:0070848 / response to growth factor stimulus / 0.01 / 19 / Chst11; Zfyve27; Ltbp3; Fos; Fez1; Hyal2; Amhr2; Dab2ip; Hif1a; Pde2a; Ctnnb1; Smad3; Tmem204; Mt3; Dtymk; Foxh1; Itgb1bp1; Ramp2; Ppp2r5b
GO:0010646 / regulation of cell communication / 0.01 / 80 / Chst11; Cnih2; Dpysl2; Ryk; Mink1; Mt3; Eef1d; Dab2ip; Spred2; Gm98; Ctnnb1; Dll1; Ccdc109a; Dusp8; Pias4; 2810002N01Rik; Irak2; Clu; Cnot1; Gpr183; Dusp1; Asap1; Gpx1; Anapc2; Myrip; Pld2; Kcnc3; Prmt2; Phb; Epha4; Arhgef25; Hif1a; Smad3; Hsp90ab1; Csnk1e; Map2k6; Rab3a; Ndrg2; Mlst8; Smarca4; Tbc1d2; C2cd3; Mc1r; Ypel1; Slc9a1; Rasl10b; Oxt; Hyal2; Nisch; Prkcz; Cdk5r1; Cish; Nfkbil1; Crk; F10; Tert; Fem1b; Cradd; Bcr; Nr1d1; Sphk1; Sos1; Ppp1ca; Tmem204; Egr1; Wnt9a; Ramp2; Dvl2; Grk6; Itpkb; Arrb2; Arfgap3; Arfgap1; Il23a; Telo2; Foxh1; Itgb1bp1; Apoa1; Ppp2r5b; Mapk8ip3
GO:0036211 / protein modification process / 0.01 / 86 / Usp2; Ctnnb1; Anapc2; Arih1; Tceb2; Adarb1; Gpx1; Gan; Pigs; Macrod1; 5430437P03Rik; Rnf5; Smarca4; Cdk5r1; Wdr82; Cdc25b; Dnajc3; Il34; Csnk1e; Wdyhv1; Itgb1bp1; Cog3; Dab2ip; Pick1; Pias4; Irak2; Atat1; Rps6ka2; Prmt2; Sae1; Mapk12; Mlst8; Skp1a; Hexim1; Galntl4; 1200011M11Rik; Ppp1ca; Egr1; Parp1; Fkbp4; Wsb2; Apoa1; Mt3; Ezh1; Clu; Nek2; Epha4; Smad3; Prkcsh; Dusp18; Ccnt1; Dusp13; Mink1; Dpagt1; Bag6; Rnf103; Bag5; Tssk2; Arrb2; Prkar1a; Mapk8ip3; B3gnt1; Spred2; Dusp8; Usp28; Dusp1; Asb1; Sik3; Phb; Herc2; Map2k6; Mettl21a; Il23a; Hyal2; Ufc1; Prkcz; Cish; Usp32; Fem1b; Sphk1; Tpst2; Anapc11; Cry1; Dvl2; Ppp2r5b; Setd6
GO:0060179 / male mating behavior / 0.01 / 2 / Oxt; Hexb
GO:0060431 / primary lung bud formation / 0.01 / 2 / Ctnnb1; Rdh10
GO:0031175 / neuron projection development / 0.01 / 27 / Epha4; B3gnt1; Mt3; Gprin1; Dab2ip; Nfasc; Nrp2; Ryk; Zfyve27; Fez1; Ntn3; Kidins220; Prkcsh; Rab3a; Ache; Mink1; Rtn4r; Cdk5r1; Trpv2; Ppp2r5b; Fkbp4; Ywhah; Nptxr; Ube2v2; Apoa1; Rab17; Mapk8ip3
GO:0044106 / cellular amine metabolic process / 0.01 / 8 / Sptlc1; Comt; Apoa1; Ldlr; Pnpla6; Apoc1; Ache; Chka
GO:0043412 / macromolecule modification / 0.01 / 89 / Usp2; Ctnnb1; Anapc2; Arih1; Tceb2; Adarb1; Gpx1; Gan; Pigs; Macrod1; 5430437P03Rik; Rnf5; Smarca4; Cdk5r1; Rpusd1; Wdr82; Cdc25b; Dnajc3; Il34; Csnk1e; Wdyhv1; Itgb1bp1; Wdr4; Cog3; Dab2ip; Pick1; Pias4; Irak2; Atat1; Rps6ka2; Prmt2; Sae1; Zfp57; Mapk12; Mlst8; Skp1a; Hexim1; Galntl4; 1200011M11Rik; Ppp1ca; Egr1; Parp1; Fkbp4; Wsb2; Apoa1; Mt3; Ezh1; Clu; Nek2; Epha4; Smad3; Prkcsh; Dusp18; Ccnt1; Dusp13; Mink1; Dpagt1; Bag6; Rnf103; Bag5; Tssk2; Arrb2; Prkar1a; Mapk8ip3; B3gnt1; Spred2; Dusp8; Usp28; Dusp1; Asb1; Sik3; Phb; Herc2; Map2k6; Mettl21a; Il23a; Hyal2; Ufc1; Prkcz; Cish; Usp32; Fem1b; Sphk1; Tpst2; Anapc11; Cry1; Dvl2; Ppp2r5b; Setd6
GO:0060074 / synapse maturation / 0.01 / 3 / Lphn1; Anapc2; Dab2ip
GO:2000243 / positive regulation of reproductive process / 0.01 / 6 / Rad23a; Oxt; Adarb1; Ctnnb1; Smarca4; Top2a
GO:0050790 / regulation of catalytic activity / 0.01 / 48 / Aph1c; Rimbp2; Mt3; Tbc1d2; Dab2ip; Spred2; Angptl4; Serpinf1; Dusp8; 2810002N01Rik; Irak2; Smad3; Dusp1; Asap1; Epha4; Hif1a; Adarb1; Gng7; Tnnc1; Ccnt1; Ccdc8; Mlst8; Prkar1a; Ptprn2; Il23a; Bag5; Hyal2; Arfgap1; Sln; Cdk5r1; Wnt9a; Crk; Fem1b; Cradd; Bcr; Ang; Rrp1b; Cdc25b; Dnajc3; Dvl2; Hexim1; Arfgap3; Apoc1; Map2k6; 1200011M11Rik; Itgb1bp1; Apoa1; Mapk8ip3
GO:0043086 / negative regulation of catalytic activity / 0.01 / 21 / Ptprn2; Rimbp2; Bag5; Rrp1b; Hyal2; Dusp1; Dab2ip; Spred2; Adarb1; Angptl4; Serpinf1; Dusp8; Wnt9a; Apoc1; Hexim1; Ccdc8; Dnajc3; Itgb1bp1; Apoa1; Mt3; Prkar1a
GO:0072521 / purine-containing compound metabolic process / 0.01 / 28 / Rab27a; Tbc1d2; Dab2ip; Pick1; Asap1; Atp5g2; Coasy; Epha4; Gng7; Tnnc1; Macrod1; Mlst8; Smarca4; Eef2; Arl4a; Ptprn2; Mc1r; Arfgap1; Pde2a; Sln; Gtpbp1; Crk; Bcr; Gnmt; Ramp2; Arfgap3; Slc25a25; Itgb1bp1
GO:0035382 / sterol transmembrane transport / 0.01 / 2 / Ldlr; Apoa1
GO:0000096 / sulfur amino acid metabolic process / 0.01 / 4 / Ggt1; Gnmt; Comt; Mri1
GO:0006753 / nucleoside phosphate metabolic process / 0.01 / 32 / Rab27a; Tbc1d2; Dab2ip; Pick1; Asap1; Atp5g2; Coasy; Epha4; Mpi; Gng7; Tnnc1; Mlst8; Smarca4; Eef2; Arl4a; Ptprn2; Mc1r; Arfgap1; BC048355; Pde2a; Sln; Gtpbp1; Crk; Bcr; Prpsap1; Shpk; Enpp5; Ramp2; Dtymk; Arfgap3; Slc25a25; Itgb1bp1
GO:0002495 / antigen processing and presentation of peptide antigen via MHC class II / 0.02 / 3 / H2-DMa; Fcer1g; H2-Aa
GO:0006891 / intra-Golgi vesicle-mediated transport / 0.02 / 3 / Cog3; Pacs1; Gabarapl2
GO:0034121 / regulation of toll-like receptor signaling pathway / 0.02 / 4 / Arrb2; Nr1d1; Dab2ip; Nfkbil1
GO:1901658 / glycosyl compound catabolic process / 0.02 / 17 / Ptprn2; Rab27a; Epha4; Smarca4; Tbc1d2; Eef2; Dab2ip; Pick1; Gtpbp1; Arfgap3; Arfgap1; Crk; Mlst8; Itgb1bp1; Asap1; Bcr; Arl4a
GO:0071822 / protein complex subunit organization / 0.02 / 40 / Ccdc109a; Dab2ip; Pick1; Tubg1; Dgkh; Angptl4; Clu; Dgkd; Tubb2b; Pomp; Scara5; H2-Ke2; Arpc5; Smad3; Bbs12; Ndufs8; Ache; P2rx6; Aif1; Myh11; Vamp2; Mlst8; Nup133; Cep63; H2-DMa; Med24; Kcnab2; Prkcz; Kank3; Slc9a1; Insig1; Nek2; Kctd3; Ang; Gnmt; Kcnc3; Fkbp4; Ppp2r5b; Itgb1bp1; Gas2l1
GO:0007399 / nervous system development / 0.02 / 61 / Faim2; Szt2; Lphn1; Ntn3; Dpysl2; B3gnt1; Fos; Mt3; Hexb; Dab2ip; Gm98; Ctnnb1; Dll1; Nfasc; Dpf1; Serpinf1; Ryk; Bag6; Anapc2; Atat1; Nrp2; Tubb2b; Dvl2; Zfyve27; Fez1; Epha4; Kidins220; Hif1a; Shroom3; Prkcsh; Nckap1; Rab3a; Ache; Ndrg2; Smarca4; Zfp57; C2cd3; Mink1; Gprin1; Ypel1; Oxt; Nrxn3; Rtn4r; Cdk5r1; Wnt9a; Bcr; Trpv2; Pfdn1; Sphk1; Ang; Ppp2r5b; Epor; Fkbp4; Ywhah; Nptxr; Wdr62; Ube2v2; Foxh1; Apoa1; Rab17; Mapk8ip3
GO:0009966 / regulation of signal transduction / 0.02 / 70 / Chst11; Cnih2; Nr1d1; Ryk; Mink1; Mt3; Eef1d; Dab2ip; Spred2; Ctnnb1; Dll1; Dusp8; Pias4; 2810002N01Rik; Irak2; Clu; Cnot1; Gpr183; Dusp1; Asap1; Gpx1; Pld2; Prmt2; Phb; Epha4; Arhgef25; Hif1a; Smad3; Hsp90ab1; Csnk1e; Map2k6; Ndrg2; Mlst8; Smarca4; Tbc1d2; C2cd3; Mc1r; Ypel1; Slc9a1; Il23a; Hyal2; Prkcz; Cdk5r1; Cish; Nfkbil1; Crk; F10; Tert; Fem1b; Cradd; Bcr; Sphk1; Sos1; Ppp1ca; Tmem204; Egr1; Wnt9a; Ramp2; Dvl2; Grk6; Itpkb; Arrb2; Arfgap3; Arfgap1; Telo2; Foxh1; Itgb1bp1; Apoa1; Ppp2r5b; Mapk8ip3
GO:0001558 / regulation of cell growth / 0.02 / 14 / Sphk1; Gas2l1; Ryk; Wisp3; BC048355; Smad3; Sbf1; Phb; Hyal2; Cdk5r1; Slc9a1; Mt3; Smarca4; Trpv2
GO:0051648 / vesicle localization / 0.02 / 8 / Rab27a; Vamp2; Dpysl2; Myrip; Tmed9; Ctnnb1; Rab3a; Rab17
GO:0051788 / response to misfolded protein / 0.02 / 2 / Clu; Rnf5
GO:0032886 / regulation of microtubule-based process / 0.02 / 8 / Fkbp4; Nek2; Stmn4; Ctnnb1; Cdk5r1; 1700054N08Rik; Gas2l1; Atat1
GO:0051726 / regulation of cell cycle / 0.02 / 28 / Gas2l1; Hinfp; Usp2; Dab2ip; Ctnnb1; Usp28; Smad3; Sin3b; Top2a; Rps6ka2; Prmt2; Adarb1; Mapk12; Ccnt1; 5430437P03Rik; Aif1; Pla2g16; Cep63; Hexim1; Wnt9a; Fem1b; Cradd; Bcr; Tubg1; Sphk1; Cdc25b; Ywhah; Ppp2r5b
GO:0045926 / negative regulation of growth / 0.02 / 11 / Gas2l1; Ryk; Lgmn; Hyal2; Mt1; Hif1a; Smad3; Phb; Cdk5r1; Mt3; Smarca4
GO:0044321 / response to leptin stimulus / 0.02 / 2 / Prmt2; Mt3
GO:0000083 / regulation of transcription involved in G1/S phase of mitotic cell cycle / 0.02 / 2 / E2f6; Hinfp
GO:0030522 / intracellular receptor signaling pathway / 0.02 / 9 / Prmt2; Phb; Safb; Med24; Fkbp4; Ywhah; Cnot1; Foxh1; Smarca4
GO:0008202 / steroid metabolic process / 0.02 / 13 / Ywhah; Ddx20; Hsd17b14; Cln6; Mt3; Insig1; Comt; Sf1; Cyp17a1; Ldlr; Apoc1; Apoa1; Hsd17b6
GO:1901616 / organichydroxy compound catabolic process / 0.03 / 5 / Mtmr7; Mt3; Ldlr; Comt; Apoc1
GO:0015914 / phospholipid transport / 0.03 / 3 / Ldlr; Apoa1; Apoc1
GO:0071310 / cellular response to organic substance / 0.03 / 43 / Chst11; Gas2l1; Fos; Mt3; Amhr2; Dab2ip; Ctnnb1; Irak2; Nr1d1; Eif2c2; Dusp1; 2010002M12Rik; Rps6ka2; Ltbp3; Fez1; Phb; Hif1a; Smad3; Hsp90ab1; Ramp2; Rnf5; Aif1; Vamp2; Hyal2; Nup85; Pde2a; Prkcz; Tmem204; Nfkbil1; Zfyve27; Osbpl7; Alpl; Sphk1; Shpk; Egr1; Parp1; Dnajc3; Prmt2; Dtymk; Foxh1; Itgb1bp1; Apoa1; Ppp2r5b
GO:0015748 / organophosphate ester transport / 0.03 / 4 / Ldlr; Apoa1; G6pc3; Apoc1
GO:0030048 / actin filament-based movement / 0.03 / 4 / Sun2; Frmd6; Tnnc1; Myrip
GO:0036230 / granulocyte activation / 0.03 / 3 / Fcer1g; Bcr; Pi4k2a
GO:0060341 / regulation of cellular localization / 0.03 / 29 / Rab27a; Dpysl2; Dab2ip; Ctnnb1; Ccdc109a; Nek2; Myrip; Ncbp2; Kcnc3; Hif1a; Smad3; Rab3c; Tnnc1; Rab3a; Vamp2; Rasl10b; Oxt; Hyal2; Sphk1; Cabp1; Pde2a; Prkcz; Cdk5r1; Insig1; Bcr; Fcer1g; Ang; Itgb1bp1; Apoa1
GO:0043902 / positive regulation of multi-organism process / 0.03 / 4 / Adarb1; Smarca4; Rad23a; Top2a
GO:0042135 / neurotransmitter catabolic process / 0.03 / 2 / Ache; Comt
GO:0003143 / embryonic heart tube morphogenesis / 0.03 / 5 / C2cd3; Dll1; Foxh1; Hif1a; Smad3
GO:0016482 / cytoplasmic transport / 0.03 / 24 / Rpsa; Cog3; Mt3; Dab2ip; Ncbp2; Smad3; Dusp18; Nup155; Thoc3; Pacs1; Pttg1ip; Vamp2; Nup133; Hyal2; Cabp1; Pde2a; Insig1; Gosr1; Sphk1; Ddx39; Trak1; Snx27; Dennd3; Tomm20
GO:0051028 / mRNA transport / 0.03 / 6 / Ddx39; Nup133; Nup85; Nup155; Ncbp2; Thoc3
GO:0048659 / smooth muscle cell proliferation / 0.03 / 5 / Ctnnb1; Ndrg2; Ang; Aif1; Comt
GO:0007416 / synapse assembly / 0.03 / 5 / Oxt; Ache; Ube2v2; Nrxn3; Rab17
GO:0016042 / lipid catabolic process / 0.03 / 12 / Pafah2; Pld2; Hsd17b14; Mt3; Clps; Hexb; Ywhah; Ldlr; Plcd3; Apoc1; Pla2g16; Pnpla6
GO:0008333 / endosome to lysosome transport / 0.03 / 3 / Dennd3; Trak1; Snx27
GO:0080134 / regulation of response to stress / 0.03 / 28 / Dab2ip; Spred2; Pias4; Nr1d1; Clu; 2010002M12Rik; Hsp90ab1; Epha4; Smad3; Gpx1; 5430437P03Rik; Mink1; Il23a; Hyal2; Plg; Pde2a; Ggt1; Nfkbil1; Fem1b; Bcr; Fcer1g; Shpk; Dvl2; Arrb2; Ube2v2; Mapk8ip3; Apoa1; Setd6
GO:0007492 / endoderm development / 0.04 / 5 / Bptf; Ctnnb1; Dusp1; Nckap1; Smad3
GO:0040013 / negative regulation of locomotion / 0.04 / 9 / Ryk; Hyal2; Nisch; Dab2ip; Adarb1; Abhd2; Itgb1bp1; Aif1; Bcr
GO:0051129 / negative regulation of cellular component organization / 0.04 / 16 / Gas2l1; Ryk; Mt3; Epha4; Dab2ip; Fkbp4; Ywhah; Prkcz; Cdk5r1; Kank3; Insig1; Apoc1; Clu; Itgb1bp1; Apoa1; Prkcsh
GO:0000902 / cell morphogenesis / 0.04 / 35 / Fam161a; Ntn3; B3gnt1; Upk3a; Mt3; Hexb; Dab2ip; Ctnnb1; Nfasc; Ryk; Asap1; Nrp2; Myl12b; Psmb10; Epha4; Kidins220; Hif1a; Smad3; Shroom3; Rab3a; Ache; Atp6v0d1; Smarca4; C2cd3; Mink1; Loxl3; Rtn4r; Cdk5r1; Trpv2; Ywhah; Frmd6; Itgb1bp1; Apoa1; Nbeal2; Mapk8ip3
GO:0019226 / transmission of nerve impulse / 0.04 / 23 / Lphn1; Dpysl2; Hexb; Dab2ip; Pick1; Gm98; Ctnnb1; Nfasc; Anapc2; Kcnc3; Comt; Rab3a; Ache; Mink1; Vamp2; Ypel1; Oxt; Nisch; Nrxn3; Prkcz; Arrb2; Ube2v2; Rab17
GO:0060768 / regulation of epithelial cell proliferation involved in prostate gland development / 0.04 / 2 / Ctnnb1; Serpinf1
GO:0048703 / embryonicviscerocranium morphogenesis / 0.04 / 2 / Chst11; Rdh10
GO:0043116 / negative regulation of vascular permeability / 0.04 / 2 / Ramp2; Pde2a
GO:0031344 / regulation of cell projection organization / 0.04 / 14 / Ryk; Fez1; Mt3; Epha4; Dab2ip; Fkbp4; Ywhah; Prkcsh; Cdk5r1; Ppp2r5b; Ache; Ube2v2; Rab17; Trpv2
GO:0007268 / synaptic transmission / 0.04 / 19 / Mink1; Lphn1; Vamp2; Dpysl2; Kcnc3; Oxt; Nrxn3; Nisch; Dab2ip; Comt; Pick1; Ctnnb1; Prkcz; Arrb2; Rab3a; Ache; Ube2v2; Anapc2; Rab17
GO:0048675 / axon extension / 0.04 / 5 / Mt3; Cdk5r1; Ryk; Nrp2; Trpv2
GO:0006022 / aminoglycanmetabolic process / 0.04 / 6 / Chst11; B3gnt1; Hyal2; Hexb; Cln6; Chi3l4
GO:0032612 / interleukin-1 production / 0.04 / 4 / Sphk1; Arrb2; Apoa1; Smad3
GO:0006954 / inflammatory response / 0.04 / 20 / Fcer1g; Il23a; Shpk; Hyal2; Ggt1; Dab2ip; Tpsb2; Hif1a; Pde2a; Gpx1; Sphk1; Il34; Chi3l4; Il25; Prkcz; Apoa1; Smad3; Aif1; Bcr; Setd6
GO:0019693 / ribose phosphate metabolic process / 0.04 / 24 / Rab27a; Tbc1d2; Dab2ip; Pick1; Asap1; Atp5g2; Coasy; Epha4; Gng7; Mlst8; Smarca4; Eef2; Arl4a; Ptprn2; Mc1r; Arfgap1; Pde2a; Gtpbp1; Crk; Bcr; Ramp2; Arfgap3; Slc25a25; Itgb1bp1
GO:0072657 / protein localization to membrane / 0.04 / 7 / Zfyve27; Pick1; Ramp2; Gpr179; Prkcz; Itgb1bp1; Pacs1
GO:0032402 / melanosome transport / 0.04 / 2 / Rab27a; Rab17
GO:0060767 / epithelial cell proliferation involved in prostate gland development / 0.04 / 2 / Ctnnb1; Serpinf1
GO:0080090 / regulation of primary metabolic process / 0.05 / 140 / Pcgf3; Gabarapl2; Usp2; Gm98; Ctnnb1; Serpinf1; Nr1d1; Cnot1; Asap1; Top2a; Prr13; Nanos1; Tceb2; Ldlr; Adarb1; Hsp90ab1; Tnnc1; 5430437P03Rik; Smarca4; Nfic; D1Bwg0212e; Kdm4b; Cdk5r1; Gnmt; Zfp9; Rad23a; Cdc25b; Zfp112; Dnajc3; Zfp41; Il34; Csnk1e; Apoc1; Foxh1; Itgb1bp1; Hinfp; Fos; Poldip3; Sap30l; Eef1d; Hexb; Dab2ip; Dll1; Angptl4; Pias4; Irak2; Hif3a; Rps6ka2; Ngdn; Rbfox3; Prmt2; Safb; Zfp775; Gng7; Il25; Zfp57; Mapk12; Camta2; Mlst8; Hivep3; C2cd3; Etv3; Hexim1; Nfkbil1; 1200011M11Rik; Ppp1ca; Celf6; Egr1; Parp1; Ywhah; Apoa1; Zfp60; Epha4; Mt3; Tfip11; Ezh1; Psmd3; Clu; Sin3b; Rfxank; Rasd1; Ntn3; Comt; Hif1a; Smad3; Zscan29; Ccnt1; Tbc1d2; E2f6; Loxl3; Bag6; Bag5; Sphk1; Pde2a; Sln; Sf1; Crk; Serpinb1b; Ang; Cln6; Narfl; Prkar1a; Ube2v2; Mapk8ip3; Ptprn2; Zfp276; Aire; Thap7; Npas2; Spred2; Zfp516; Dpf1; Dusp8; Ramp2; Dusp1; Ddx20; Ncbp2; Phb; Rbm4b; Map2k6; Rgmb; Mc1r; Il23a; Hyal2; Med24; Prkcz; Gtpbp1; Insig1; Fem1b; Osbpl7; Bcr; Chd3; Arrb2; Cry1; Eif2c2; Dvl2; Arfgap3; Arfgap1; Ppp2r5b; Setd6
GO:0006066 / alcohol metabolic process / 0.05 / 13 / Sphk1; Dpagt1; Mt3; Sptlc1; Chka; Cln6; Ldlr; Pnpla6; Insig1; Apoc1; Mtmr7; Ache; Apoa1
GO:0048705 / skeletal system morphogenesis / 0.05 / 11 / Chst11; Ltbp3; Ryk; Sik3; Hyal2; Smad3; Ctnnb1; Rdh10; Wnt9a; Insig1; Alpl
GO:0043433 / negative regulation of sequence-specific DNA binding transcription factor activity / 0.05 / 7 / Pias4; Prmt2; Dab2ip; Nfkbil1; Irak2; Foxh1; Setd6
GO:0051336 / regulation of hydrolase activity / 0.05 / 26 / Rimbp2; Mt3; Tbc1d2; Dab2ip; Angptl4; Serpinf1; 2810002N01Rik; Asap1; Epha4; Smad3; Tnnc1; Ccdc8; Mlst8; Ptprn2; Arfgap1; Sln; Wnt9a; Crk; Cradd; Bcr; Ang; Rrp1b; Arfgap3; Apoc1; Itgb1bp1; Apoa1
GO:0006605 / protein targeting / 0.05 / 16 / Pttg1ip; Rab27a; Sphk1; Hyal2; Dab2ip; Pick1; Cabp1; Pde2a; Cdk5r1; Tomm20; Nup155; Mt3; Smad3; Itgb1bp1; Pacs1; Dusp18
GO:0043038 / amino acid activation / 0.05 / 4 / Sars2; Nars2; Dars2; Wars

Supplementary Table S2. The biological pathways from Reactome and KEGG representepigenomesin which H3K9me3 occupancyis significantly elevated in R6/2 mice, andthe H3K9me3 occupancy is reduced bynogalamycin administration in R6/2 mice. Count indicates the number of the genes involved in the pathway.

Source / Pathway / P-value / Count / Genes
Reactome / Signaling by Wnt / 0.00 / 7 / Snx3; Ppp2r1b; Skp1a; Ctnnb1; Wnt9a; Ppp2r5e; Ppp2r5b
Reactome / Degradation of beta-catenin by the destruction complex / 0.00 / 5 / Ctnnb1; Ppp2r5e; Ppp2r1b; Skp1a; Ppp2r5b
Reactome / Glutamate Neurotransmitter Release Cycle / 0.00 / 4 / Vamp2; Gls2; Rab3a; Slc38a2
Reactome / Gene Expression / 0.00 / 37 / Rpsa; D1Bwg0212e; Lsm4; Eef1d; Parp1; Edc4; Nr1d1; Cnot1; Smad3; Snrpe; Ddx23; Pan2; Ddx20; Ncbp2; Tceb2; Wars; Adarb1; Gtf3c1; Dars2; Nup155; Ccnt1; Eef2; Nfic; Sars2; Nup133; Nup85; Med24; Polr2e; Polr2a; Exosc1; Rpl27; Nr2c2ap; Eif2c2; Sf3a1; Nars2; 1200011M11Rik; Cpsf3
Reactome / Beta-catenin phosphorylation cascade / 0.00 / 4 / Ctnnb1; Ppp2r5e; Ppp2r1b; Ppp2r5b
Reactome / Mitotic Anaphase / 0.00 / 11 / Ppp2r1b; Cenpl; Nup133; Cenpf; Nudc; Nup85; Banf1; Ppp2r5e; Anapc2; Ppp2r5b; Spc24
Reactome / Mitotic Metaphase and Anaphase / 0.00 / 11 / Ppp2r1b; Cenpl; Nup133; Cenpf; Nudc; Nup85; Banf1; Ppp2r5e; Anapc2; Ppp2r5b; Spc24
Reactome / Hyaluronan uptake and degradation / 0.00 / 3 / Hyal2; Hexb; Slc9a1
KEGG / Oocyte meiosis - Mus musculus (mouse) / 0.00 / 10 / Rps6ka2; Ppp1ca; Ppp2r1b; Anapc11; Skp1a; Ywhah; Mapk12; Ppp2r5e; Anapc2; Ppp2r5b
KEGG / Circadian rhythm - Mus musculus (mouse) / 0.00 / 5 / Npas2; Nr1d1; Csnk1e; Cry1; Skp1a
KEGG / Dopaminergic synapse - Mus musculus (mouse) / 0.00 / 11 / Ppp2r1b; Ppp1ca; Kif5a; Kcnj9; Fos; Comt; Gng7; Arrb2; Mapk12; Ppp2r5e; Ppp2r5b
Reactome / Deadenylation-dependent mRNA decay / 0.00 / 6 / Pan2; D1Bwg0212e; Lsm4; Edc4; Cnot1; Exosc1
Reactome / Hyaluronan metabolism / 0.00 / 3 / Hyal2; Hexb; Slc9a1
Reactome / Developmental Biology / 0.00 / 19 / Myh11; Rps6ka2; Dpysl2; Myl12b; Sos1; Gdf1; Ntn3; Col9a3; Smad3; Hsp90ab1; Nfasc; Cdk5r1; Ctnnb1; Mapk12; Cdh15; Med24; Foxh1; Rgmb; Nrp2
Reactome / Separation of Sister Chromatids / 0.00 / 10 / Ppp2r1b; Cenpl; Nup133; Cenpf; Nudc; Nup85; Ppp2r5e; Anapc2; Ppp2r5b; Spc24
Reactome / Resolution of Sister Chromatid Cohesion / 0.00 / 9 / Ppp2r1b; Cenpl; Nup133; Cenpf; Nudc; Nup85; Ppp2r5e; Ppp2r5b; Spc24
Reactome / CDO in myogenesis / 0.00 / 4 / Ctnnb1; Ntn3; Cdh15; Mapk12
Reactome / Myogenesis / 0.00 / 4 / Ctnnb1; Ntn3; Cdh15; Mapk12
Reactome / Disease / 0.00 / 31 / Aph1c; Chst11; B3gnt1; Hexb; Dll1; Coasy; Sos1; Rdh5; Mocs1; Hif1a; Smad3; Prkar2a; Ldlr; Slc25a32; Ccnt1; Rdh10; Atp6v0d1; Mlst8; Gsto2; Slc9a1; Hyal2; Skp1a; Prkcz; Bcr; Ppp1ca; Clps; Parp1; Slc26a1; Arrb2; Prkar1a; Apoa1
Reactome / snRNP Assembly / 0.01 / 6 / Ddx20; Ncbp2; Nup133; Nup85; Nup155; Snrpe
Reactome / Metabolism of non-coding RNA / 0.01 / 6 / Ddx20; Ncbp2; Nup133; Nup85; Nup155; Snrpe
Reactome / LDL-mediated lipid transport / 0.01 / 2 / Plg; Ldlr
Reactome / Regulation of Gene Expression by Hypoxia-inducible Factor / 0.01 / 2 / Hif3a; Hif1a
Reactome / Mitotic Prometaphase / 0.01 / 9 / Ppp2r1b; Cenpl; Nup133; Cenpf; Nudc; Nup85; Ppp2r5e; Ppp2r5b; Spc24
Reactome / Circadian Clock / 0.01 / 3 / Csnk1e; Cry1; Npas2
Reactome / Circadian Clock / 0.01 / 3 / Csnk1e; Cry1; Npas2
Reactome / DARPP-32 events / 0.01 / 4 / Prkar2a; Ppp2r1b; Prkar1a; Ppp1ca
Reactome / Chaperonin-mediated protein folding / 0.01 / 5 / Pfdn1; Sphk1; Tubb2b; H2-Ke2; Kifc3
Reactome / M Phase / 0.01 / 12 / Ppp2r1b; Cenpl; Nup133; Cenpf; Nudc; Nup85; Banf1; Nup155; Ppp2r5e; Anapc2; Ppp2r5b; Spc24
Reactome / Transport of Mature mRNA Derived from an Intronless Transcript / 0.01 / 5 / Nup133; Cpsf3; Nup85; Ncbp2; Nup155
KEGG / Antigen processing and presentation - Mus musculus (mouse) / 0.01 / 7 / Rfxank; Tap2; Lgmn; H2-DMa; H2-Aa; Hsp90ab1; Psme2
Reactome / Formation of RNA Pol II elongation complex / 0.01 / 5 / Polr2e; Ccnt1; Polr2a; Ncbp2; Tceb2
Reactome / RNA Polymerase II Transcription Elongation / 0.01 / 5 / Polr2e; Ccnt1; Polr2a; Ncbp2; Tceb2
Reactome / Transport of Mature mRNAs Derived from Intronless Transcripts / 0.01 / 5 / Nup133; Cpsf3; Nup85; Ncbp2; Nup155
KEGG / mRNA surveillance pathway - Mus musculus (mouse) / 0.01 / 8 / Ppp2r1b; Ncbp2; Ppp1ca; Pabpc4; Wdr82; Ppp2r5e; Cpsf3; Ppp2r5b
KEGG / Hippo signaling pathway - Mus musculus (mouse) / 0.01 / 11 / Dvl2; Ppp2r1b; Itgb2; Ppp1ca; Smad3; Ctnnb1; Ywhah; Prkcz; Wnt9a; Frmd6; Csnk1e
Reactome / mRNA Splicing - Minor Pathway / 0.01 / 5 / Polr2e; Ddx23; Polr2a; Ncbp2; Snrpe
Reactome / Lipid digestion, mobilization, and transport / 0.01 / 5 / Plg; Clps; Ldlr; Apoa1; Ppp1ca
KEGG / Proteasome - Mus musculus (mouse) / 0.01 / 5 / Psmb6; Pomp; Psme2; Psmd3; Psmb10
Reactome / Metabolism of RNA / 0.01 / 15 / Pan2; Exosc1; Ddx20; Rpsa; Ncbp2; D1Bwg0212e; Lsm4; Rpl27; Nup85; Edc4; Nup133; Cnot1; 1200011M11Rik; Nup155; Snrpe
Reactome / Protein folding / 0.01 / 5 / Pfdn1; Sphk1; Tubb2b; H2-Ke2; Kifc3
Reactome / Neurotransmitter Clearance In The Synaptic Cleft / 0.01 / 2 / Ache; Comt
Reactome / mRNA Processing / 0.01 / 11 / Ddx23; Nup133; Ncbp2; Nup85; Adarb1; Polr2e; Polr2a; Sf3a1; Nup155; Cpsf3; Snrpe
Reactome / Processing of Capped Intron-Containing Pre-mRNA / 0.02 / 10 / Ddx23; Nup133; Ncbp2; Nup85; Polr2e; Polr2a; Sf3a1; Nup155; Cpsf3; Snrpe
Reactome / Neurotransmitter Release Cycle / 0.02 / 4 / Vamp2; Rab3a; Gls2; Slc38a2
Reactome / Elongation arrest and recovery / 0.02 / 4 / Polr2e; Ccnt1; Polr2a; Tceb2
Reactome / MAP kinase activation in TLR cascade / 0.02 / 5 / Irak2; Map2k6; Ppp2r1b; Rps6ka2; Fos
Reactome / Signaling by NODAL / 0.02 / 3 / Gdf1; Foxh1; Smad3
Reactome / Cell Cycle, Mitotic / 0.02 / 18 / Ppp2r1b; Cenpl; Nek2; Actr1a; Nup133; Cdc25b; Nudc; Nup85; Skp1a; Tubg1; Banf1; Csnk1e; Nup155; Cenpf; Ppp2r5e; Anapc2; Ppp2r5b; Spc24
KEGG / Staphylococcus aureus infection - Mus musculus (mouse) / 0.02 / 5 / Cfb; H2-DMa; Itgb2; H2-Aa; Plg
KEGG / Glycerophospholipid metabolism - Mus musculus (mouse) / 0.02 / 7 / Pla2g16; Pld2; Dgkh; Pnpla6; Ache; Chka; Dgkd
Reactome / Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha / 0.02 / 3 / Hif3a; Tceb2; Hif1a
Reactome / CTLA4 inhibitory signaling / 0.02 / 3 / Ppp2r5e; Ppp2r1b; Ppp2r5b
Reactome / Mitotic M-M/G1 phases / 0.03 / 12 / Ppp2r1b; Cenpl; Nup133; Cenpf; Nudc; Nup85; Banf1; Nup155; Ppp2r5e; Anapc2; Ppp2r5b; Spc24
Reactome / Costimulation by the CD28 family / 0.03 / 5 / Ppp2r5e; Ppp2r1b; Mlst8; H2-Aa; Ppp2r5b
Reactome / Mitochondrial tRNAaminoacylation / 0.03 / 3 / Sars2; Nars2; Dars2
Reactome / Neuronal System / 0.03 / 14 / Rps6ka2; Vamp2; Comt; Kcnk7; Kcnc3; Kcnj9; Slc38a2; Pick1; Kcnab3; Kcnab2; Gng7; Rab3a; Ache; Gls2
KEGG / Glutathione metabolism - Mus musculus (mouse) / 0.03 / 5 / Gpx1; Gstp2; Ggt1; Gsto2; Gpx8
Reactome / Mitotic Prophase / 0.03 / 5 / Nup133; Banf1; Ppp2r1b; Nup85; Nup155
Reactome / Regulation of Hypoxia-inducible Factor (HIF) by Oxygen / 0.03 / 3 / Hif3a; Tceb2; Hif1a
Reactome / Cellular response to hypoxia / 0.03 / 3 / Hif3a; Tceb2; Hif1a
Reactome / Deadenylation of mRNA / 0.03 / 3 / Pan2; Cnot1; D1Bwg0212e
Reactome / Nuclear Envelope Breakdown / 0.03 / 4 / Nup133; Banf1; Nup85; Nup155
Reactome / Transport of the SLBP independent Mature mRNA / 0.03 / 4 / Nup133; Nup85; Ncbp2; Nup155
Reactome / Acetylcholine Neurotransmitter Release Cycle / 0.03 / 2 / Vamp2; Rab3a
KEGG / Ubiquitin mediated proteolysis - Mus musculus (mouse) / 0.03 / 9 / Aire; Tceb2; Anapc11; Skp1a; Sae1; Herc2; Rhobtb2; Pias4; Anapc2
KEGG / RNA degradation - Mus musculus (mouse) / 0.03 / 6 / Pan2; Lsm4; Pabpc4; Edc4; Cnot1; Exosc1
Reactome / Transport of the SLBP Dependant Mature mRNA / 0.03 / 4 / Nup133; Nup85; Ncbp2; Nup155
Reactome / Processing of Capped Intronless Pre-mRNA / 0.03 / 3 / Cpsf3; Ncbp2; Snrpe
Reactome / Post-Elongation Processing of Intronless pre-mRNA / 0.03 / 3 / Cpsf3; Ncbp2; Snrpe
Reactome / RNA Polymerase II Pre-transcription Events / 0.03 / 5 / Polr2e; Ccnt1; Polr2a; Ncbp2; Tceb2
Reactome / Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways / 0.04 / 4 / Irak2; Hsp90ab1; Map2k6; Mapk12
Reactome / Glucose transport / 0.04 / 4 / Nup133; G6pc3; Nup85; Nup155
Reactome / SLBP independent Processing of Histone Pre-mRNAs / 0.04 / 2 / Ncbp2; Snrpe
Reactome / Norepinephrine Neurotransmitter Release Cycle / 0.04 / 2 / Vamp2; Rab3a
KEGG / Asthma - Mus musculus (mouse) / 0.04 / 3 / H2-DMa; Fcer1g; H2-Aa
Reactome / tRNAAminoacylation / 0.04 / 4 / Sars2; Nars2; Dars2; Wars
Reactome / Metabolism of carbohydrates / 0.04 / 13 / Chst11; Ppp2r1b; B3gnt1; Nup133; Nup155; Hyal2; Hexb; Nup85; G6pc3; Slc26a1; Slc9a1; Slc25a11; Slc25a10
Reactome / Transport of Mature Transcript to Cytoplasm / 0.04 / 5 / Nup133; Cpsf3; Nup85; Ncbp2; Nup155
Reactome / Hexose transport / 0.04 / 4 / Nup133; G6pc3; Nup85; Nup155
Reactome / Prefoldin mediated transfer of substrate to CCT/TriC / 0.04 / 3 / Pfdn1; H2-Ke2; Tubb2b
Reactome / NOD1/2 Signaling Pathway / 0.04 / 3 / Irak2; Map2k6; Mapk12
Reactome / G2/M Transition / 0.04 / 7 / Ppp2r1b; Nek2; Cdc25b; Skp1a; Tubg1; Csnk1e; Actr1a
KEGG / Rheumatoid arthritis - Mus musculus (mouse) / 0.04 / 6 / Itgb2; Il23a; Fos; H2-DMa; H2-Aa; Atp6v0d1
Reactome / Signaling by NOTCH1 / 0.04 / 5 / Aph1c; Dll1; Arrb2; Skp1a; Hif1a
Reactome / Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant / 0.04 / 5 / Aph1c; Dll1; Arrb2; Skp1a; Hif1a
Reactome / Signaling by NOTCH1 HD Domain Mutants in Cancer / 0.04 / 5 / Aph1c; Dll1; Arrb2; Skp1a; Hif1a
Reactome / Signaling by NOTCH1 PEST Domain Mutants in Cancer / 0.04 / 5 / Aph1c; Dll1; Arrb2; Skp1a; Hif1a
Reactome / Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer / 0.04 / 5 / Aph1c; Dll1; Arrb2; Skp1a; Hif1a
Reactome / FBXW7 Mutants and NOTCH1 in Cancer / 0.04 / 5 / Aph1c; Dll1; Arrb2; Skp1a; Hif1a
Reactome / Signaling by NOTCH1 in Cancer / 0.04 / 5 / Aph1c; Dll1; Arrb2; Skp1a; Hif1a
Reactome / SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs / 0.04 / 2 / Ncbp2; Snrpe
Reactome / Cellular responses to stress / 0.05 / 8 / Hif3a; Mink1; Rps6ka2; Fos; Tceb2; Hif1a; Map2k6; Anapc2
Reactome / Glutathione conjugation / 0.05 / 3 / Gsto2; Gstp2; Ggt1
Reactome / RNA Polymerase II Transcription / 0.05 / 7 / Ncbp2; Tceb2; Polr2e; Polr2a; Ccnt1; Cpsf3; Snrpe
Reactome / Mitotic G2-G2/M phases / 0.05 / 7 / Ppp2r1b; Nek2; Cdc25b; Skp1a; Tubg1; Csnk1e; Actr1a
Reactome / TRAF6 Mediated Induction of proinflammatory cytokines / 0.05 / 5 / Irak2; Map2k6; Ppp2r1b; Rps6ka2; Fos
KEGG / Aminoacyl-tRNA biosynthesis - Mus musculus (mouse) / 0.05 / 4 / Sars2; Nars2; Dars2; Wars