Appendix B:Inclusion and Exclusion Criteria

Inclusion criteria

1.Patientswas 20 years old

2.Patients suitable for percutaneous coronary intervention(PCI)

3.Patients with signed informed consent

4.Patients judged suitable to receive anti-platelet drugs in principle for at least 6 months after procedure, and ideally up to 12 months in patients who were not at high risk of bleeding

5.Patients with up to 3 lesions (with 50% of stenosis) in the maximum of 2 targeted vessels to be treated at once

6.Patients with reference vessel diameter of each lesion ≥ 2.5 mm and ≤ 3.75 mm by visual observation

7.Patients with length of each lesions up to ≤ 46 mm by visual observation

8.Patients eligible for implantation of drug-eluting stent

Exclusion criteria

1.Patients with any planned treatment in the targeted vessel with a drug-eluting stent other than in this study

2.Patients with Acute Myocardial Infarction (including non-ST segment elevation Myocardial Infarction) developed within 7 days before the procedure

3.Patients participating in a currently ongoing registry or clinical study, or receiving a treatment which may affect the endpoints of this study

4.Patients of childbearing potential with a positive pregnancy test within 14 days before the procedure, or lactating

5. Patients who had a history of allergy against Sirolimus, Paclitaxel, polymers or stainless steel

  1. Patients who had a history of side-effect,with anti-platelet drugs or anti-coagulation drugs
  2. Patients with serious hepatic dysfunction
  3. Patients with left ventricular ejection fraction of 35% or less
  4. Patients with three target vessels in need of PCI treatment
  5. Patients with serious renal dysfunction (serum creatinine value 2mg/dl or higher)
  6. Patients currently receiving artificial dialysis
  7. Patients with a malignant tumor (cancer) diagnosed within 5 years before the procedure
  8. Patients who had received PCI treatment within the past 1 year
  9. Patients with chronic total occlusion or TIMI flow of 2 or less
  10. Patients with 50% stenosis in left main coronary artery
  11. Patients with 50% stenosis in side branch ostial for which stenting in the side branch lesion is required
  12. Patients with in-stent restenosis in the garget lesion implanted with a bare-metal or drug-eluting stent
  13. Patients whose target lesion was in the saphenous vein graft
  14. Patients judged non-eligible by the physician in charge