Table S1. Original DTP for Cohorts 1 to 3 (with cohort size of 3) with all 64 pathways without stopping early for excessive toxicity in Viola. The design will always recommend staying at the lowest dose even when high numbers of DLTs are observed at the lowest dose as no safety stopping criterion is applied.

Pathway / Cohort 1 / Cohort 2 / Cohort 3 / Cohort 4
Dose / DLT / Dose / DLT / Dose / DLT / Dose
1 / 0 / 0 / 1 / 0 / 2 / 0 / 3
2 / 0 / 0 / 1 / 0 / 2 / 1 / 2
3 / 0 / 0 / 1 / 0 / 2 / 2 / 1
4 / 0 / 0 / 1 / 0 / 2 / 3 / 0
5 / 0 / 0 / 1 / 1 / 1 / 0 / 2
6 / 0 / 0 / 1 / 1 / 1 / 1 / 0
7 / 0 / 0 / 1 / 1 / 1 / 2 / -1
8 / 0 / 0 / 1 / 1 / 1 / 3 / -2
9 / 0 / 0 / 1 / 2 / -1 / 0 / 0
10 / 0 / 0 / 1 / 2 / -1 / 1 / -1
11 / 0 / 0 / 1 / 2 / -1 / 2 / -2
12 / 0 / 0 / 1 / 2 / -1 / 3 / -2
13 / 0 / 0 / 1 / 3 / -2 / 0 / -1
14 / 0 / 0 / 1 / 3 / -2 / 1 / -2
15 / 0 / 0 / 1 / 3 / -2 / 2 / -2
16 / 0 / 0 / 1 / 3 / -2 / 3 / -2
17 / 0 / 1 / -1 / 0 / 0 / 0 / 1
18 / 0 / 1 / -1 / 0 / 0 / 1 / 0
19 / 0 / 1 / -1 / 0 / 0 / 2 / -1
20 / 0 / 1 / -1 / 0 / 0 / 3 / -2
21 / 0 / 1 / -1 / 1 / -1 / 0 / -1
22 / 0 / 1 / -1 / 1 / -1 / 1 / -2
23 / 0 / 1 / -1 / 1 / -1 / 2 / -2
24 / 0 / 1 / -1 / 1 / -1 / 3 / -2
25 / 0 / 1 / -1 / 2 / -2 / 0 / -2
26 / 0 / 1 / -1 / 2 / -2 / 1 / -2
27 / 0 / 1 / -1 / 2 / -2 / 2 / -2
28 / 0 / 1 / -1 / 2 / -2 / 3 / -2
29 / 0 / 1 / -1 / 3 / -2 / 0 / -2
30 / 0 / 1 / -1 / 3 / -2 / 1 / -2
31 / 0 / 1 / -1 / 3 / -2 / 2 / -2
32 / 0 / 1 / -1 / 3 / -2 / 3 / -2
33 / 0 / 2 / -2 / 0 / -2 / 0 / -1
34 / 0 / 2 / -2 / 0 / -2 / 1 / -2
35 / 0 / 2 / -2 / 0 / -2 / 2 / -2
36 / 0 / 2 / -2 / 0 / -2 / 3 / -2
37 / 0 / 2 / -2 / 1 / -2 / 0 / -2
38 / 0 / 2 / -2 / 1 / -2 / 1 / -2
39 / 0 / 2 / -2 / 1 / -2 / 2 / -2
40 / 0 / 2 / -2 / 1 / -2 / 3 / -2
41 / 0 / 2 / -2 / 2 / -2 / 0 / -2
42 / 0 / 2 / -2 / 2 / -2 / 1 / -2
43 / 0 / 2 / -2 / 2 / -2 / 2 / -2
44 / 0 / 2 / -2 / 2 / -2 / 3 / -2
45 / 0 / 2 / -2 / 3 / -2 / 0 / -2
46 / 0 / 2 / -2 / 3 / -2 / 1 / -2
47 / 0 / 2 / -2 / 3 / -2 / 2 / -2
48 / 0 / 2 / -2 / 3 / -2 / 3 / -2
49 / 0 / 3 / -2 / 0 / -2 / 0 / -2
50 / 0 / 3 / -2 / 0 / -2 / 1 / -2
51 / 0 / 3 / -2 / 0 / -2 / 2 / -2
52 / 0 / 3 / -2 / 0 / -2 / 3 / -2
53 / 0 / 3 / -2 / 1 / -2 / 0 / -2
54 / 0 / 3 / -2 / 1 / -2 / 1 / -2
55 / 0 / 3 / -2 / 1 / -2 / 2 / -2
56 / 0 / 3 / -2 / 1 / -2 / 3 / -2
57 / 0 / 3 / -2 / 2 / -2 / 0 / -2
58 / 0 / 3 / -2 / 2 / -2 / 1 / -2
59 / 0 / 3 / -2 / 2 / -2 / 2 / -2
60 / 0 / 3 / -2 / 2 / -2 / 3 / -2
61 / 0 / 3 / -2 / 3 / -2 / 0 / -2
62 / 0 / 3 / -2 / 3 / -2 / 1 / -2
63 / 0 / 3 / -2 / 3 / -2 / 2 / -2
64 / 0 / 3 / -2 / 3 / -2 / 3 / -2