Dr. William G. Pitt
Chemical Engineering Department (801)422-2589 (office)
350 Clyde Building (801)422-0151 (FAX)
Brigham Young University E-mail:
Provo, Utah 84602
EDUCATION
1983-1987 University of Wisconsin-Madison, Madison, WI
Ph.D. in Chemical Engineering, Minor: Materials Science
Dissertation: "Adsorption of Proteins to Polyurethanes", December 1987
1977-1983 Brigham Young University, Provo, UT
Bachelor of Science, summa cum laude, Chemical Engineering, April 1983
PROFESSIONAL EXPERIENCE
1998-present Professor, Chemical Engineering Dept., Brigham Young University
2007-2012 Pope Professor (an endowed chair), Chemical Engineering Dept., BYU
1988-present Adjunct Professorial titles, Department of Bioengineering, University of Utah
2003-present BYU Cancer Research Center, board member
2001-2002 Visiting Research Prof., Center for Biofilm Engineering, Montana State University
1993-1998 Associate Professor, Chemical Engineering Dept., Brigham Young University
1994-1995 Lasby Visiting Professor, Dept. of Oral Sciences, Univ. of Minnesota, Minneapolis
1988-1997 Faculty Research Member, Center for Biopolymers at Interfaces, University of Utah
1987-1993 Assistant Professor, Dept. of Chemical Engineering, Brigham Young University
1983-1987 Research Assistant, Teaching Assistant, Department of Chemical Engineering, University of Wisconsin-Madison, Madison, WI
1982, 1983 Project Engineer (summer intern), Terra Tek Research, Salt Lake City, UT: corrosion research, analytical chemistry
1980, 1981 Lab Technician (summer intern), Kennecott Research, Salt Lake City, UT: corrosion, reaction kinetics
PROFESSIONAL SOCIETIES (Memberships)
American Institute of Chemical Engineers (AIChE)
Society for Biomaterials
Controlled Release Society
Society for Biological Engineering
HONORS AND AWARDS
2013-2014 Karl G. Maeser Research and Creative Arts Award, Brigham Young University
2007-2012 Pope Professor of Chemical Engineering, an endowed chair, Brigham Young U.
2007 Sponsored Research Award, Brigham Young University
1999-2000 BYU College of Engineering and Technology, Special Commendation Award
1994-1995 Lasby Visiting Professor, Dept. of Oral Sciences, Univ. of Minnesota, Minneapolis
1988 Teacher of the Year, Dept. of Chemical Engineering, Brigham Young University
ACTIVITIES
2011-present Member of Board of Directors, 2ft Prosthetics, maker of low-cost prosthetic legs
2010-present Member of Editorial Board of Colloids and Surfaces B: Biointerfaces
2003-present Member of Editorial Board of Journal of Biomaterial Science, Polymer Edition
1989-present member, National Student Chapters Committee, AIChE
1989-present Chair, National Student Paper Competition, AIChE
2012-present Advisor, 2ft Prosthetics student club, Brigham Young University
2000-2012 Advisor, Biomedical Engineering student club, Brigham Young University
1989-present Regular reviewer for over 25 journals in drug delivery and biomedical engineering
PROFESSIONAL CONSULTANT in the areas of ultrasound, polymer identification, biomedical polymers, polymer degradation, polymer surfaces, polymeric drug delivery
Revised and printed April 14, 2015
Dr. William G. Pitt
PUBLICATIONS
Peer-Reviewed Journal Articles and Peer-Reviewed Book Chapters (* indicates corresponding author)
140. Javadi, M. and Pitt, W.G.*, “Insights into Ultrasonic Release from eLiposomes”, Letters in Applied NanoBioScience, 4,(1) 251-258 (2015).
139. Lattin, J.R., Javadi, M., McRae, M., and Pitt, W.G.*, “Cytosolic Delivery via the Endosome using Acoustic Droplet Vaporization, J. Drug Targeting, in press, (2015).
138. Husseini, G.A.*, Pitt, W.G., Williams, J., and Javadi, M., “Release of Calcein from eLiposomes at Different Temperatures”, J. Colloid Sci. Biotech., in press, (2015).
137. Lattin, J.R. and Pitt, W.G.*, “Factors Affecting Ultrasonic Release from eLiposomes”, in press, Journal of Pharmaceutical Science (2015).
136. Pitt*, W.G., Zhao, Y., Jack, D. R., Perez, K.X., Jones, P.W., Marelli, R., Nelson, J.L., and Pruitt, J.D., “Extended Elution of Phospholipid from Silicone Hydrogel Contact Lenses”, J. Biomaterials Sci., Polymer Edn., in press (2015). http://dx.doi.org/10.1080/09205063.2014.994947
135. Husseini, G.A.*, Kherbeck, L., Pitt, W.G., Hubbell, J.A., Christensen, D.A., and Velluto, D., “Kinetics of Ultrasonic Drug Delivery from Targeted Micelles”, J. Nanosci. Nanotechnol.15(3), 2099-2104 (2015). http://dx.doi.org/10.1166/jnn.2015.9498
134. Chung-Yin Lin*, William G. Pitt, Hai-Li Liu, and Kuo-Chin Wei, “Development of Ultrasound Sensitive eLiposomes Containing Doxorubicin for Drug Delivery”, British J Pharm Res, 4(19), 2296-2311 (2014).
133. Husseini, G.A.*, Pitt, W.G. and Javadi, M., “Investigating the Stability of eLiposomes at Elevated Temperatures”, Technol. Cancer Res. Treatment,14, 1-4 (2014). DOI: 10.1177/1533034614551480
132. Husseini, G.A.*, Pitt, W.G., and Martins, A.M., “Ultrasonically triggered drug delivery: breaking the barrier”, Colloids & Surfaces B: Biointerfaces, 123, 364-386 (2014). http://dx.doi.org/10.1016/j.colsurfb.2014.07.051
131. Tam, N.K, Pitt, W.G.*, Perez, K.X., Glenn, A., E., Chinn, J., Liu, X.M., and Maziarz, E.P. “Prevention and Removal of Lipid Deposits by Lens Care Solutions and Rubbing”, Optometry Vision Sci., 91(12), 1430-1439 (2014).
130. Tam, N.K., Pitt*, W.G., Perez, K.X., Handly, E., Glenn, A.A., Hickey, J.W. and Larsen, B.G, “The Role of Multi-Purpose Solutions in Prevention and Removal of Lipid Depositions on Contact Lenses”, Contact Lens & Anterior Eye, 37, 405-414 (2014). http://dx.doi.org/10.1016/j.clae.2014.07.003
129. Lin, C.-Y., Javadi, M., Belnap, D.M., Barrow, J.R., and Pitt, W.G.*, “Ultrasound Sensitive eLiposomes Containing Doxorubicin for Targeted Drug Therapy”, Nanomedicine: Nanotechnology, Biology, and Medicine”, 10(1), 67-76 (2014). http://dx.doi.org/10.1016/j.nano.2013.06.011
128. Pitt, W.G., Perez, K.X., Singh, R.N., Husseini, G.A., and Jack, D.R. “Phase Transitions of Perfluorocarbon Nanoemulsions Induced with Ultrasound: A Mathematical Model”, Ultrasonics Sonochemistry, 21(2) 879-891 (2014). http://dx.doi.org/10.1016/j.ultsonch.2013.08.005 http://authors.elsevier.com/sd/article/S1350417713001764
127. Lin, C.-Y., Pitt, W.G., “Acoustic Droplet Vaporization in Biology and Medicine”, BioMed Research International (Hindawi), 2013(404361), 1-13 (2013). http://dx.doi.org/10.1155/2013/404361
126. Pitt, W.G.*, Perez, K.X., Tam, N.K., Handly, E., Chinn, J., Liu, X.M., and Maziarz, E.P., “Quantitation of Cholesterol and Phospholipid Sorption on Silicone Hydrogel Contact Lenses” J. Biomedical Materials Research B: Applied Biomaterials, 101(8) 1516-1523 (2013).
125. Javadi, M., Pitt, W.G.,* Tracy, C.M., Barrow, J.R., Willardson, B.M., Hartley, J.M., and Tsosie, N.H. “Ultrasonic Gene and Drug Delivery using eLiposomes”, J. Controlled Release, 167(1) 92-100 (2013). http://dx.doi.org/10.1016/j.jconrel.2013.01.009
124. Pitt, W.G.*, Husseini, G.A., and Kherbeck, L.N., “Ultrasound-Triggered Release from Micelles”, in “Smart Materials for Drug Delivery”, vol. 1, C. Alvarez-Lorenzo, A. Concheiro, Eds., Royal Society of Chemistry, 148-178, (2013). http://dx.doi.org/10.1039/9781849736800-00148
123. Diaz de la Rosa, M.A., Pitt, W.G.*, and Husseini, G.A., “Comparing Microbubble Cavitation at 500 kHz and 70 kHz Related to Micellar Drug Delivery using Ultrasound”, Ultrasonics, 53(2), 377-386 (2013). http://dx.doi.org/10.1016/j.ultras.2012.07.004
122. Husseini, G.A.*, Velluto, D., Kherbeck, L., Pitt, W.G., Hubbell, J.A., and Christensen, D.A., “Investigating the Acoustic Release of Doxorubicin from Targeted Micelles”, Colloids Surfaces B: Biointerfaces, 101, 153-155 (2013). http://dx.doi.org/10.1016/j.colsurfb.2012.05.025
121. Diaz de la Rosa, M.A., Pitt, W.G.*, and Husseini, G.A., “Mathematical Modeling of Microbubble Cavitation at 70 kHz and the Importance of the Subharmonic in Drug Delivery from Micelles”, Ultrasonics, 53, 97-110 (2013). http://dx.doi.org/10.1016/j.ultras.2012.04.004
120. Hansen, D., Pan, Y., Stockton, J., Pitt, W.G. and Wheeler, D.R.*, “Cyclic voltammetry investigation of organic species considered for use as catalysts in direct-carbohydrate fuel cells,” J. Electrochem. Soc., 159, H834-H841 (2012).
119. Read, A., Hansen, D., Aloi, S., Pitt, W.G., Wheeler, D.R., and Watt, G.D.*, “Mono alkyl viologens are effective carbohydrate O2-oxidation catalysts for electrical energy generation by fuel cells,” Renewable Energy, 46, 218-223 (2012).
118. Marjan Javadi, William G. Pitt*, David M. Belnap, Naakaii H. Tsosie, and Jonathan M. Hartley, “Encapsulating Emulsions inside Liposomes for Drug Delivery”, Langmuir, 28(41), 14720-14729 (2012). DOI: http://dx.doi.org/10.1021/la303464v
117. Lattin, J.R., Pitt, W.G.*, Belnap, D.M., and Husseini, G.A., “Ultrasound Induced Calcein Release from eLiposomes”, Ultrasound Med. Biol., 38(12), 2163-2173 (2012). http://dx.doi.org/10.1016/j.ultrasmedbio.2012.08.001
116. Singh, R. Husseini, G.A.*, and Pitt, W.G., “Phase Transitions of Nanoemulsions Using Ultrasound: Experimental Observations”, Ultrasonics Sonochemistry, 19, 1120-1125 (2012).
115. Husseini, G.A.*, Pitt, W.G., Memmott, B.R., Jack, D.R., “Non-Viral Gene Transfection with Ultrasound: is 100% Transfection Possible?”, Advanced Science Lett, 11, 98-105 (2012).
114. Lattin, J.R., Belnap, D.M., and Pitt, W.G.*, “Formation of eLiposomes as a drug delivery vehicle”, Colloids & Surfaces B: Biointerfaces, 89, 93-100 (2012). http://dx.doi.org/10.1016/j.colsurfb.2011.08.030
113. Pitt*, W.G., Jack, D.R., Zhao, Y., Nelson, J.L., and Pruitt, J.D. “Transport of Phospholipid in Silicone Hydrogel Contact Lenses”, J. Biomat. Sci. Polym. Ed., 23, 527-541 (2012).
112. Abdel-Jabbar, N.M., Husseini*, G.A,, Mjalli, F.S., Pitt, W.G., Al-Mousa, A., “Optimizing the Use of Ultrasound to Deliver Chemotherapeutic Agents to Cancer Cells from Polymeric Micelles”, J. Franklin Inst., 348, 1276-1284 (2011).
111. Pitt*, W.G., Jack, D.R., Zhao, Y., Nelson, J.L., and Pruitt, J.D. “Loading and Release of a Phospholipid from Contact Lenses”, Optometry and Vision Science, 88(4), 502-506 (2011). http://dx.doi.org/10.1097/OPX.0b013e31820e9ff8
110. Pitt*, W.G., Husseini, G.A., Roeder, B.L., Dickinson, D., Warden, D.K., Hartley, J., and Jones, P.W., “Preliminary Results of Combining Ultrasound and Liposomal Drug Delivery to Treat Tumors in Rats”, J. Nanosci. Nanotech., 11(3), 1866-1870 (2011). http://dx.doi.org/10.1166/jnn.2011.3117
109. Lewis*, R.S., Knotts, T.A., Wilding, W.V., Pitt, W.G., and Argyle, M.D., “Results and Analysis of a Required Senior Exam to Assess Learning of Course Competencies”, Proceeding of the ASEE Annual Meeting, (2010).
108. Husseini*, G.A., Stevenson-Abouelnasr, D.,Pitt, W.G., Assaleh, K.T., Farahat, L.O., and Fahadi, J., “Kinetics and Thermodynamics of Acoustic Release of Doxorubicin from Non-stabilized polymeric Micelles”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 359, 18-24 (2010).
107. Staples, B.J., Pitt*, W.G., Roeder, B.L., Husseini, G.A., Rajeev, D., and Schaalje, G.B., “Distribution of Doxorubicin in Rats Undergoing Ultrasonic Drug Delivery”, J. Pharmaceutical Sciences, 99(7), 3122-3131 (2010).
106. Husseini*, G.A., Mjalli, F.S., Pitt, W.G., and Abdel-Jabbar, N.M., “Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles”, Tech. Cancer Res. Treatment, 8(6), 479-488 (2009).
105. Husseini*, G.A., Diaz de la Rosa, M.A., AlAqqad, E.O., Al Mamary, S., Kadimanti, Y., Al Baik, A. and Pitt, W.G., “Kinetics of Acoustic Release of Doxorubicin from Stabilized and Unstabilized Micelles and the Effect of Temperature”, J Franklin Inst., 348(1), 125-133 (2011). doi:10.1016/j.jfranklin.2009.02.007.
104. Solen*, K.A., and Pitt, W.G., “The Anomaly of Methods in Deriving Miller-Bravais Directions and Its Application to the Hexagonal Close-Packed Unit Cell” J. Materials Edu., 31(3-4), 231-238 (2009).
103. Husseini*, G.A., Pitt, W.G., Christensen, D.A. and Dickinson, D., “Degradation Kinetics of Stabilized Pluronic Micelles under the action of Ultrasound”, J. Controlled Rel., 138, 45-48 (2009).
102. Staples, B.J., Roeder, B.L., Husseini, G.A., Badamjav, O., Schaalje, G.B. and Pitt*, W.G., “Role of Frequency and Mechanical Index in Ultrasound-Enhanced Chemotherapy of Tumors in Rats”, Cancer Chemotherapy and Pharmacology, 64(3), 593-600 (2009).
101. Stringham, S.B., Viskovska, M.A., Richardson, E.S., Ohmine, S., Murray, B.K., and Pitt*, W.G., “Over-pressure suppresses ultrasonic-induced drug uptake”, Ultrasound in Medicine and Biology, 35(3), 409-415 (2009).
100. Husseini*, G.A., and Pitt, W.G., “Ultrasonic-Activated Micellar Drug Delivery for Cancer Treatment”, J. Pharm. Sci., 98(3), 795-811 (2009).
99. Husseini*, G.A., and Pitt, W.G., “Micelles and Nanoparticles for Ultrasonic Drug and Gene Delivery”, Advanced Drug Delivery Reviews, 60, 1137-1152 (2008).
98. Pitt*, W.G., and Husseini, G.A., “Ultrasound in Drug and Gene Delivery”, Advanced Drug Delivery Reviews, 60, 1095-1096 (2008). DOI: 10.1016/j.addr.2008.03.001.
97. Husseini*, G.A., and Pitt, W.G., “The Use of Ultrasound and Micelles in Cancer Treatment”, J. Nanoscience Nanotechnology, 8, 2205-2215 (2008).
96. Pitt*, W.G., and Husseini, G.A., “On Bubbles and Liposomes”, J. Controlled Release, 125, 174-177 (2008). DOI: 10.1016/j.jconrel.2007.10.004.
95. Lei, H., Wilding, W.V., and Pitt*, W.G., “Measurement of Activities of Toluene and Trichloroethylene in Polyisobutylene”, J. Chem. Eng. Data, 52, 2233-2236 (2007). DOI: 10.1021/je700255f.
94. Richardson, E.S., Woodbury, D.J., and Pitt*, W.G., “The Role of Cavitation in Liposome Formation”, Biophysical Journal, 93(12) 4100-4107 (2007). http://dx.doi.org/10.1529/biophysj.107.104042.
93. Lei, H., Pitt*, W.G., McGrath, L.K., and Ho, C.K., “Modeling carbon-black/polymer composite sensors”, Sensors & Actuators B, 125, 396-407 (2007).
92. Husseini*, G.A., Abdel-Jabbar, N.M., Mjalli, F.S., and Pitt, W.G., “Modeling and Sensitivity Analysis of Acoustic Release of Doxorubicin from Unstabilized Pluronic P105 Using an Artificial Neural Network Model”, Technol. Cancer Res. Treatment, 6(1), 1-8 (2007) [ISSN 1533-0346].
91. Stevenson-Abouelnasr, D., Husseini*, G.A., and Pitt, W.G., "Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models" Colloids & Surfaces B: Biointerfaces, 55, 59-66 (2007).
90. Husseini, G.A., Diaz de la Rosa, M.A., Gebuji, T., Zeng, Y., Christensen, D.A., and Pitt*, W.G., “Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the action of Ultrasound”, J Nanoscience Nanotechnology, 7(3), 1028-1033 (2007).
89. Lei, H., and Pitt*. W.G., “Selection of polymeric sensor arrays for quantitative analysis”, Sensors & Actuators B, 124, 278-283 (2007).
88. Runyan, C.M., Carmen, J.C., Beckstead, B.L., Nelson, J.L., Robison, R.A., and Pitt*, W.G., “Low-Frequency Ultrasound Increases Outer Membrane Permeability of Pseudomonas aeruginosa, J. Gen. Appl. Microbiology, 52(5) 1-7 (2006).
87. Parini, M.R., and Pitt*, W.G., “Dynamic Removal of Oral Biofilms by Bubbles”, Colloids & Surfaces B: Biointerfaces, 52, 39-46 (2006).
86. Zeng, Y., and Pitt*, W.G., “A polymer micelle system with a hydrolysable segment for drug delivery”, J. Biomaterial Sci Polym. Ed., 17(5) 591-604 (2006).
85. Husseini, G.A., O’Neill, K.L., and Pitt*, W.G., “The Comet Assay to Determine the Mode of Cell Death for the Ultrasonic Delivery of Doxorubicin to Human Leukemia (HL-60 cells) from Pluronic P105 Micelles”, Technol. Cancer Res. Treatment, 4(6), 707-712 (2005).
84. Parini, M.R., and Pitt*, W.G., “Removal of Oral Biofilms by Bubbles: The Effect of Bubble Trajectory and Sonic Waves”, J. Am. Dent. Assoc., 136, 1688-1693 (2005).
83. Parini, M.R., Eggett, D.L., and Pitt*, W.G., “Removal of Streptococcus mutans Biofilms by Bubbles”, J. Clin. Periodontol., 32, 1151-1156 (2005).
82. Pitt*, W.G., “Removal of Oral Biofilm by Sonic Phenomena”, Am. J. Dent., 18(5), 345-352 (2005).
81. Choi, S., Christensen, M.B., Fredin, N., and Pitt*, W.G., “Swellable Coatings for Hearing Aid Applications”, J. Biomat. Applications, 20(2), 1223-1235 (2005).
80. Ensing, G.T., Roeder, B.L., Nelson, J.L., van Horn, J.R., van der Mei, H.C., Busscher*, H.J., and Pitt, W.G., “Effect of pulsed ultrasound in combination with gentamicin on bacterial viability in biofilms on bone cements in vivo”, J. Appl. Microbiol., 99(1), 443-448 (2005).
79. Husseini, G.A., Diaz de la Rosa, M.A., Richardson, E.S., Christensen, D.A., and Pitt*, W.G., “The Role of Cavitation in Acoustically Activated Drug Delivery”, J. Controlled Release, 107(2), 253-261 (2005). http://dx.doi.org/10.1016/j.jconrel.2005.06.015
78. Zeng, Y., and Pitt*, W.G., “Poly(ethylene oxide)-b-poly(N-isopropylacrylamide) nanoparticles with crosslinked cores as drug carriers”, J. Biomaterial Sci Polym. Ed., 16(3), 371-380 (2005).
77. Carmen, J.C., Roeder, B.L., Nelson, J.L., Beckstead, B.L., Runyan, C.M., Robison, R.A., Schaalje, G.B. and Pitt*, W.G., “The Treatment of Implanted Biofilms with Low-Frequency Ultrasound and Gentamicin, Am. J. Infect. Control, 33(2), 78-82 (2005).