Table 1 . Detailed description of each study
Study name / Histology tumor / Nature of the lesions / Presence of metastasis / Sporadic or Syndromic / CT/MRI localized vs. non-localizedBerglund, 2001 / Pheochromocytoma / Benign/Malignant / YES / Sporadic/Syndromic / Unclear
Bhatia, 2008 / Paraganglioma / Unclear / Unclear / Sporadic/Syndromic / Localized
Chatal, 1985 / Pheochromocytoma/Paraganglioma / Benign/Malignant / Unclear / Sporadic/Syndromic / Localized
Fiebrich, 2009 / Pheochromocytoma/Paraganglioma / Benign/Malignant / Some cases / Sporadic/Syndromic / Localized
Fottner, 2010 / Pheochromocytoma/Paraganglioma / Benign / NA / Sporadic/Syndromic / Localized
Francis, 1983 / Pheochromocytoma/Paraganglioma / Benign/Malignant / Some cases / Unclear / Unclear
Greenblant,2008 / Pheochromocytoma/Paraganglioma / Benign/Malignant / Some cases / Sporadic/Syndromic / Unclear
Havekes, 2009 / Pheochromocytoma/Paraganglioma / Benign/Malignant / Some cases / Syndromic / non-localized
Hoegerle, 2001 / Pheochromocytoma / Benign / NA / Sporadic/Syndromic / Unclear
Ilias,2008 / Pheochromocytoma / Benign/Malignant / Some cases / Unclear / non-localized
Jalil, 1998 / pheochromocytoma/Paraganglioma / Benign/Malignant / Some cases / Sporadic/Syndromic / non-localized
Kaji, 2007 / Pheochromocytoma / Benign / NA / Syndromic / non-localized
Khafagi,1989 / Pheochromocytoma / Benign / NA / Syndromic / non-localized
King, 2011 / Paraganglioma / Benign / NA / Syndromic / Localized
Koopmans,2008 / Paraganglioma / Benign / NA / Sporadic/Syndromic / Localized
Kroiss, 2011 / Pheochromocytoma / Benign/Malignant / YES / Unclear / non-localized
Lumachi, 2006 / pheochromocytoma/Paraganglioma / Benign / NA / Unclear / Unclear
Luster, 2010 / Pheochromocytoma / Benign/Malignant / YES / Sporadic/Syndromic / Unclear
Mann, 2006 / Pheochromocytoma / Benign/Malignant / YES / YES / Localized
Maurea 1996 / pheochromocytoma/Paraganglioma / Benign/Malignant / YES / Unclear / non-localized
Maurice, 2012 / Paraganglioma / Malignant / YES / Sporadic/Syndromic / non-localized
Meyer-Rochow, 2010 / pheochromocytoma/Paraganglioma / Malignant / YES / Sporadic/Syndromic / Unclear
Mihai, 2008 / Pheochromocytoma / Benign / NA / Sporadic/Syndromic / Unclear
Miskulin, 2003 / pheochromocytoma/Paraganglioma / Malignant / YES / Sporadic/Syndromic / Unclear
Nielsen JT, 1996 / Pheochromocytoma / Benign / NA / YES / Localized
Rodriguez, 2008 / Pheochromocytoma / Benign / NA / Syndromic / Localized
Rufini, 2011 / Paraganglioma / Malignant / YES / Unclear / non-localized
Schmidt, 2002 / Paraganglioma / Benign / NA / Unclear / Localized
Timmers, 2012 / pheochromocytoma/Paraganglioma / Malignant / Some cases / Syndromic / non-localized
Van Gils, 1991 / pheochromocytoma/Paraganglioma / Benign / NA / Unclear / Unclear
Velchik, 1989 / Pheochromocytoma / Malignant / YES / Unclear / Unclear
Win, 2006 / pheochromocytoma/Paraganglioma / Malignant / YES / Unclear / non-localized
Ovid
Database(s): Embase 1988 to 2012 Week 24, Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) 1946 to Present, EBM Reviews - Cochrane Central Register of Controlled Trials June 2012, EBM Reviews - Cochrane Database of Systematic Reviews 2005 to May 2012
Search Strategy:
1 / exp Pheochromocytoma/ / 24126
2 / (pheochromocytoma* or "medullary chromaffinoma*" or "medullary paraganglioma*" or phaeochromocytoma* or phaeochromoblastoma* or pheochromocytosis).mp. [mp=ti, ab, sh, hw, tn, ot, dm, mf, dv, kw, nm, ps, rs, ui, tx, ct] / 34761
3 / exp paraganglioma/ / 22303
4 / (paraganglioma* or "paraganglion tumor*" or "paraganglion neoplasm*" or paraganglioneuroma*).mp. [mp=ti, ab, sh, hw, tn, ot, dm, mf, dv, kw, nm, ps, rs, ui, tx, ct] / 10481
5 / or/1-4 / 43574
6 / exp Tomography, X-Ray Computed/ / 729591
7 / exp computer assisted tomography/ / 461518
8 / ((comput* adj2 tomograph*) or "ct scan*" or "x ray ct" or "cine-ct" or "cat scan*" or "ct x-ray*" or ("electron beam" adj2 tomograph*) or tomodensitometr*).mp. [mp=ti, ab, sh, hw, tn, ot, dm, mf, dv, kw, nm, ps, rs, ui, tx, ct] / 741788
9 / exp nuclear magnetic resonance imaging/ / 426722
10 / exp Magnetic Resonance Imaging/ / 698167
11 / (mri or mris or "magnetic resonance imaging*" or (nmr adj tomograph*) or (mr adj tomograph*) or "chemical shift imaging*" or "tomograph* proton spin*" or nmr or nmrs or "proton spin tomograph*" or zeugmatograph* or fmri or fmris or "magnetization transfer imaging*" or "mr imaging*").mp. [mp=ti, ab, sh, hw, tn, ot, dm, mf, dv, kw, nm, ps, rs, ui, tx, ct] / 980516
12 / or/6-11 / 1690863
13 / exp Tomography, Emission-Computed, Single-Photon/ / 63990
14 / exp scintigraphy/ / 121413
15 / ("functional imaging*" or spect or "single photon emission ct" or "single photon emission comput* tomograph*" or "single photon emission comput* assisted tomograph*" or "single photon emission cat" or "single photon emission radionuclide comput* tomograph*").mp. [mp=ti, ab, sh, hw, tn, ot, dm, mf, dv, kw, nm, ps, rs, ui, tx, ct] / 78480
16 / (scintigraph* or laminoscintigraphy or "perfusion imaging*" or scintigram* or scintillation or scintillograph* or scintiphotograph* or "scintiscan recording*" or "gamma camera imaging*" or "scanning radioisotope*" or "radionuclide imaging*" or "radioisotope scanning" or "radioisotope imaging*").mp. [mp=ti, ab, sh, hw, tn, ot, dm, mf, dv, kw, nm, ps, rs, ui, tx, ct] / 139581
17 / or/13-16 / 260384
18 / exp 3-Iodobenzylguanidine/ / 4638
19 / ("3-iodobenzylguanidine" or "m iodobenzylguanidine" or "meta-iodobenzylguanidine" or "123-I-MIBG" or iobenguane or "131i benzylguanidine" or "123-I-MIBG" or iobenguane or metaiodobenzylguanidine).mp. [mp=ti, ab, sh, hw, tn, ot, dm, mf, dv, kw, nm, ps, rs, ui, tx, ct] / 5955
20 / exp octreotide/ / 20688
21 / (octreotide or "san 201-995" or "san 201995" or "sms 201-995" or "sms 201995" or "sandoz 201995" or "sandoz 201 995" or "compound 201-995" or "compound 201995" or sandostatine or sandostatin or "sm 201 995" or "sm 201995").mp. [mp=ti, ab, sh, hw, tn, ot, dm, mf, dv, kw, nm, ps, rs, ui, tx, ct] / 24647
22 / or/18-21 / 31166
23 / 17 and 22 / 6855
24 / exp positron emission tomography/ / 90251
25 / ("pet scan*" or "positron emission tomograph*" or "positron tomograph*").mp. [mp=ti, ab, sh, hw, tn, ot, dm, mf, dv, kw, nm, ps, rs, ui, tx, ct] / 120075
26 / 24 or 25 / 120075
27 / exp fluorodeoxyglucose f 18/ / 41851
28 / (fluorodesoxyglucose or fludeoxyglucose or "fluoro-2-deoxyglucose" or "18f fdg" or 18fdg).mp. [mp=ti, ab, sh, hw, tn, ot, dm, mf, dv, kw, nm, ps, rs, ui, tx, ct] / 13025
29 / Fluorodopamine.mp. / 465
30 / exp 6 fluorodopamine f 18/ or exp 6 fluorodopamine/ / 140
31 / exp 6 fluorodopa f 18/ or exp 6 fluorodopa/ / 745
32 / (Fluorodopa or fluorolevodopa).mp. [mp=ti, ab, sh, hw, tn, ot, dm, mf, dv, kw, nm, ps, rs, ui, tx, ct] / 1965
33 / or/27-32 / 45731
34 / 26 and 33 / 38169
35 / ("FDG PET" or "fluorodopamine PET" or "fluorodopa PET").mp. [mp=ti, ab, sh, hw, tn, ot, dm, mf, dv, kw, nm, ps, rs, ui, tx, ct] / 25967
36 / 23 or 34 or 35 / 52390
37 / 36 or "functional imaging".mp. [mp=ti, ab, sh, hw, tn, ot, dm, mf, dv, kw, nm, ps, rs, ui, tx, ct] / 64364
38 / 5 and 12 and 37 / 1145
39 / exp comparative study/ / 2292409
40 / exp controlled study/ / 3857692
41 / compar$.mp. / 7724368
42 / exp cohort analysis/ / 1398456
43 / cohort.mp. / 545605
44 / exp Cohort Studies/ / 1398456
45 / exp retrospective study/ / 689783
46 / ((clinical or control$ or randomized) adj2 (study or studies or trial or trials)).mp. [mp=ti, ab, sh, hw, tn, ot, dm, mf, dv, kw, nm, ps, rs, ui, tx, ct] / 6539402
47 / exp "systematic review"/ / 50334
48 / systematic review$.mp. / 114064
49 / exp clinical trial/ / 1561292
50 / ((retrospective or cohort or cohorts) and (study or studies or studied or trial or trials or analysis or analyses)).mp. / 1334899
51 / or/39-50 / 12842118
52 / 38 and 51 / 463
53 / from 38 keep 686-1140 / 455
54 / limit 53 to (clinical trial, all or clinical trial, phase i or clinical trial, phase ii or clinical trial, phase iii or clinical trial, phase iv or clinical trial or comparative study or controlled clinical trial or randomized controlled trial) [Limit not valid in Embase,CCTR,CDSR; records were retained] / 87
55 / 52 or 54 / 463
56 / limit 55 to (editorial or erratum or letter or note or addresses or autobiography or bibliography or biography or dictionary or directory or interactive tutorial or lectures or legislation or news or newspaper article or patient education handout or periodical index or portraits or published erratum or video-audio media or webcasts) [Limit not valid in Embase,Ovid MEDLINE(R),Ovid MEDLINE(R) In-Process,CCTR,CDSR; records were retained] / 6
57 / from 56 keep 1-5 / 5
58 / 55 not 57 / 458
59 / remove duplicates from 58 / 306
Scopus
1 TITLE-ABS-KEY(pheochromocytoma* or "medullary chromaffinoma*" or "medullary paraganglioma*" or phaeochromocytoma* or phaeochromoblastoma* or pheochromocytosis or paraganglioma* or "paraganglion tumor*" or "paraganglion neoplasm*" or paraganglioneuroma*)
2 TITLE-ABS-KEY((comput* W/2 tomograph*) or "ct scan*" or "x ray ct" or "cine-ct" or "cat scan*" or "ct x-ray*" or ("electron beam" W/2 tomograph*) or tomodensitometr* or mri or mris or "magnetic resonance imaging*" or (nmr W/1 tomograph*) or (mr W/1 tomograph*) or "chemical shift imaging*" or "tomograph* proton spin*" or nmr or nmrs or "proton spin tomograph*" or zeugmatograph* or fmri or fmris or "magnetization transfer imaging*" or "mr imaging*")
3 TITLE-ABS-KEY("functional imaging*" or spect or "single photon emission ct" or "single photon emission comput* tomograph*" or "single photon emission comput* assisted tomograph*" or "single photon emission cat" or "single photon emission radionuclide comput* tomograph*" or scintigraph* or laminoscintigraphy or "perfusion imaging*" or scintigram* or scintillation or scintillograph* or scintiphotograph* or "scintiscan recording*" or "gamma camera imaging*" or "scanning radioisotope*" or "radionuclide imaging*" or "radioisotope scanning" or "radioisotope imaging*")
4 TITLE-ABS-KEY("3-iodobenzylguanidine" or "m iodobenzylguanidine" or "meta-iodobenzylguanidine" or "123-I-MIBG" or iobenguane or "131i benzylguanidine" or "123-I-MIBG" or iobenguane or metaiodobenzylguanidine or octreotide or "san 201-995" or "san 201995" or "sms 201-995" or "sms 201995" or "sandoz 201995" or "sandoz 201 995" or "compound 201-995" or "compound 201995" or sandostatine or sandostatin or "sm 201 995" or "sm 201995")
5 3 and 4
6 TITLE-ABS-KEY("pet scan*" or "positron emission tomograph*" or "positron tomograph*")
7 TITLE-ABS-KEY(fluorodesoxyglucose or fludeoxyglucose or "fluoro-2-deoxyglucose" or "18f fdg" or 18fdg or fluorodopamine or Fluorodopa or fluorolevodopa)
8 6 and 7
9 TITLE-ABS-KEY("FDG PET" or "fluorodopamine PET" or "fluorodopa PET" or "functional imaging")
10 5 or 8 or 9
11 1 and 2 and 10
12 PMID(0*) OR PMID(1*) OR PMID(2*) OR PMID(3*) OR PMID(4*) OR PMID(5*) OR PMID(6*) OR PMID(7*) OR PMID(8*) OR PMID(9*)
13 11 and not 12
14 DOCTYPE(le) OR DOCTYPE(ed) OR DOCTYPE(bk) OR DOCTYPE(er) OR DOCTYPE(no) OR DOCTYPE(sh)
15 13 and not 14
16 TITLE-ABS-KEY(compar* or ((retrospective or cohort or cohorts) and (study or studies or studied or trial or trials or analysis or analyses)) or (clinical W/2 study) or (control$ W/2 study) or (randomized W/2 study) or(clinical W/2 studies) or (control$ W/2 studies) or (randomized W/2 studies) or (clinical W/2 trial) or (control$ W/2 trial) or (randomized W/2 trial) or (clinical W/2 trials) or (control$ W/2 trials) or (randomized W/2 trials) or (systematic* W/3 review*))
17 15 and 16