Medix Market Research Report

Supplementary Material: Market Research Report: Adult ADHD Resource Study:

October 2014

Article title: A cost-effectiveness analysis of lisdexamfetamine dimesylate in the treatment of adults with attention-deficit/hyperactivity disorder in the United Kingdom

Journal: The European Journal of Health Economics

Authors: Evelina A Zimovetz, Alain Joseph, Rajeev Ayyagari, Josephine A Mauskopf

Corresponding author: Evelina Zimovetz, RTI Health Solutions;

Respondent profile & project history

Specialty
Total
N / %
Psychiatry / 60 / 100%
Other / 0 / 0%
Base / 60
Location
Total
N / %
England / 50 / 83.33%
Scotland / 10 / 16.67%
Base / 60

Fieldwork dates: 23rd September – 17th October

Sample: 60 psychiatrists currently treating adult patients with ADHD.

Methodology: All respondents were invited via email and were recruited from the Medix database of healthcare professionals. Respondents were also screened prior to entering the survey to ensure that they are treating Adult ADHD (18yrs +) patients.

Are you a psychiatrist? / N / %
Yes / 60.00 / 100.00
No / 0.00 / 0.00
Total / 60.00
Where in the UK are you currently practicing? / N / %
England / 50.00 / 83.33
Scotland / 10.00 / 16.67
Wales / 0.00 / 0.00
Total / 60.00
Are you treating adult patients (18 years of age and above) with ADHD? / N / %
Yes / 60.00 / 100.00
No / 0.00 / 0.00
Total / 60.00
How many adults with ADHD (new and existing) do you see per month? / N / %
5.00 / 11.00 / 18.33
6.00 / 4.00 / 6.67
7.00 / 1.00 / 1.67
8.00 / 2.00 / 3.33
10.00 / 17.00 / 28.33
12.00 / 2.00 / 3.33
14.00 / 2.00 / 3.33
15.00 / 5.00 / 8.33
18.00 / 1.00 / 1.67
20.00 / 6.00 / 10.00
25.00 / 2.00 / 3.33
30.00 / 3.00 / 5.00
40.00 / 1.00 / 1.67
50.00 / 3.00 / 5.00
Mean / Std-deviation
(Total) Scotland + England / 14.45 / 11.16
Base / 60.00
1) What percentage of your adult patients who are receiving treatment for ADHD are on pharmacotherapy? / N / %
8.00 / 1.00 / 1.67
20.00 / 1.00 / 1.67
25.00 / 2.00 / 3.33
33.00 / 1.00 / 1.67
35.00 / 2.00 / 3.33
40.00 / 3.00 / 5.00
50.00 / 1.00 / 1.67
57.00 / 1.00 / 1.67
60.00 / 1.00 / 1.67
65.00 / 1.00 / 1.67
70.00 / 2.00 / 3.33
75.00 / 2.00 / 3.33
80.00 / 8.00 / 13.33
85.00 / 5.00 / 8.33
90.00 / 11.00 / 18.33
95.00 / 3.00 / 5.00
99.00 / 1.00 / 1.67
100.00 / 14.00 / 23.33
Mean / Std-deviation
(Total) Scotland + England / 77.70 / 0.25
Base / 60.00
2) What percentage of your adult patients who are diagnosed with ADHD are not receiving any form of treatment at all? / N / %
0% / 23.00 / 38.33
3% / 2.00 / 3.33
5% / 13.00 / 21.67
7% / 2.00 / 3.33
10% / 10.00 / 16.67
14% / 1.00 / 1.67
20% / 3.00 / 5.00
25% / 2.00 / 3.33
30% / 1.00 / 1.67
50% / 2.00 / 3.33
67% / 1.00 / 1.67
Mean / Std-deviation
(Total) Scotland + England / 8.00 / 13.00
Base / 60.00
3) When you are initiating pharmacotherapy for an average adult patient with ADHD, in what percentage of patients do you only prescribe one drug (versus a combination therapy of two drugs)? / N / %
20% / 1.00 / 1.67
25% / 1.00 / 1.67
35% / 1.00 / 1.67
40% / 2.00 / 3.33
50% / 1.00 / 1.67
58% / 2.00 / 3.33
60% / 3.00 / 5.00
65% / 2.00 / 3.33
70% / 1.00 / 1.67
75% / 6.00 / 10.00
80% / 7.00 / 11.67
89% / 1.00 / 1.67
90% / 7.00 / 11.67
95% / 2.00 / 3.33
97% / 1.00 / 1.67
99% / 3.00 / 5.00
100% / 19.00 / 31.67
Mean / Std-deviation
(Total) Scotland + England / 82.21 / 21.00
Base / 60.00
3b) On average, what percentage of patients who are receiving pharmacotherapy for the first time (first line) are indicated on which drug and what is the average dose used for these patients? Methylphenidate / N / %
0.00 / 2 / 3.33
5.00 / 1 / 1.67
10.00 / 3 / 5.00
15.00 / 1 / 1.67
20.00 / 1 / 1.67
25.00 / 3 / 5.00
33.00 / 1 / 1.67
35.00 / 2 / 3.33
40.00 / 2 / 3.33
45.00 / 3 / 5.00
50.00 / 5 / 8.33
55.00 / 2 / 3.33
60.00 / 7 / 11.67
70.00 / 8 / 13.33
75.00 / 3 / 5.00
80.00 / 5 / 8.33
85.00 / 2 / 3.33
90.00 / 2 / 3.33
95.00 / 1 / 1.67
100.00 / 6 / 10.00
Mean / Std-deviation
57.88 / 27.96
Base / 60.00
3b) On average, what percentage of patients who are receiving pharmacotherapy for the first time (first line) are indicated on which drug and what is the average dose used for these patients? Methylphenidate / N / %
0.00 / 4 / 6.67
10.00 / 4 / 6.67
15.00 / 2 / 3.33
18.00 / 2 / 3.33
20.00 / 4 / 6.67
30.00 / 9 / 15.00
36.00 / 4 / 6.67
40.00 / 6 / 10.00
45.00 / 2 / 3.33
50.00 / 6 / 10.00
54.00 / 7 / 11.67
56.00 / 1 / 1.67
60.00 / 5 / 8.33
72.00 / 3 / 5.00
100.00 / 1 / 1.67
Mean / Std-deviation
38.00 / 20.79
Base / 60.00
3b) On average, what percentage of patients who are receiving pharmacotherapy for the first time (first line) are indicated on which drug and what is the average dose used for these patients? Atomoxetine / N / %
0.00 / 8 / 13.33
1.00 / 1 / 1.67
5.00 / 1 / 1.67
10.00 / 7 / 11.67
12.00 / 2 / 3.33
15.00 / 2 / 3.33
20.00 / 11 / 18.33
25.00 / 7 / 11.67
30.00 / 3 / 5.00
34.00 / 1 / 1.67
35.00 / 1 / 1.67
40.00 / 4 / 6.67
45.00 / 4 / 6.67
50.00 / 2 / 3.33
70.00 / 1 / 1.67
85.00 / 1 / 1.67
90.00 / 3 / 5.00
100.00 / 1 / 1.67
Mean / Std-deviation
(Total) Scotland + England / 27.48 / 24.68
Base / 60.00
3b) On average, what percentage of patients who are receiving pharmacotherapy for the first time (first line) are indicated on which drug and what is the average dose used for these patients? Atomoxetine / N / %
0.00 / 9.00 / 15.00
15.00 / 1.00 / 1.67
30.00 / 2.00 / 3.33
40.00 / 14.00 / 23.33
50.00 / 1.00 / 1.67
60.00 / 5.00 / 8.33
65.00 / 1.00 / 1.67
72.00 / 1.00 / 1.67
80.00 / 22.00 / 36.67
100.00 / 4.00 / 6.67
Mean / Std-deviation
(Total) Scotland + England / 54.70 / 30.70
Base / 60.00
3b) On average, what percentage of patients who are receiving pharmacotherapy for the first time (first line) are indicated on which drug and what is the average dose used for these patients? Lisdexamphetamine / N / %
0.00 / 38.00 / 63.33
3.00 / 4.00 / 6.67
5.00 / 1.00 / 1.67
10.00 / 9.00 / 15.00
15.00 / 1.00 / 1.67
20.00 / 3.00 / 5.00
25.00 / 2.00 / 3.33
30.00 / 2.00 / 3.33
Mean / Std-deviation
(Total) Scotland + England / 4.87 / 8.25
Base / 60.00
3b) On average, what percentage of patients who are receiving pharmacotherapy for the first time (first line) are indicated on which drug and what is the average dose used for these patients? Lisdexamphetamine / N / %
0.00 / 38.00 / 63.33
30.00 / 6.00 / 10.00
40.00 / 3.00 / 5.00
50.00 / 6.00 / 10.00
51.00 / 1.00 / 1.67
60.00 / 2.00 / 3.33
70.00 / 4.00 / 6.67
Mean / Std-deviation
(Total) Scotland + England / 17.52 / 24.77
Base / 60.00
3b) On average, what percentage of patients who are receiving pharmacotherapy for the first time (first line) are indicated on which drug and what is the average dose used for these patients? Dexamphetamine / N / %
0.00 / 27.00 / 45.00
2.00 / 2.00 / 3.33
5.00 / 6.00 / 10.00
9.00 / 1.00 / 1.67
10.00 / 13.00 / 21.67
15.00 / 4.00 / 6.67
20.00 / 2.00 / 3.33
25.00 / 2.00 / 3.33
30.00 / 1.00 / 1.67
33.00 / 1.00 / 1.67
35.00 / 1.00 / 1.67
Mean / Std-deviation
(Total) Scotland + England / 24.77 / 8.97
Base / 60.00
3b) On average, what percentage of patients who are receiving pharmacotherapy for the first time (first line) are indicated on which drug and what is the average dose used for these patients? Dexamphetamine / N / %
0.00 / 27.00 / 45.00
5.00 / 2.00 / 3.33
10.00 / 5.00 / 8.33
15.00 / 5.00 / 8.33
20.00 / 2.00 / 3.33
30.00 / 5.00 / 8.33
40.00 / 13.00 / 21.67
50.00 / 1.00 / 1.67
Mean / Std-deviation
(Total) Scotland + England / 14.92 / 16.94
Base / 60.00
3b) On average, what percentage of patients who are receiving pharmacotherapy for the first time (first line) are indicated on which drug and what is the average dose used for these patients? Other / N / %
0.00 / 52.00 / 86.67
5.00 / 4.00 / 6.67
15.00 / 2.00 / 3.33
20.00 / 1.00 / 1.67
95.00 / 1.00 / 1.67
Mean / Std-deviation
(Total) Scotland + England / 2.75 / 12.70
Base / 60.00
3b) On average, what percentage of patients who are receiving pharmacotherapy for the first time (first line) are indicated on which drug and what is the average dose used for these patients? Other / N / %
0.00 / 52.00 / 86.67
15.00 / 1.00 / 1.67
40.00 / 3.00 / 5.00
50.00 / 3.00 / 3.33
100.00 / 1.00 / 1.67
Mean / Std-deviation
(Total) Scotland + England / 8.08 / 25.58
Base / 60.00
3c) On average, what percentage of patients who are 2nd line patients are you prescribing which drug and what is the average dose used for these patients? Methylphenidate / N / %
0.00 / 4.00 / 6.67
5.00 / 1.00 / 1.67
10.00 / 4.00 / 6.67
15.00 / 4.00 / 6.67
20.00 / 9.00 / 15.00
25.00 / 3.00 / 5.00
30.00 / 6.00 / 10.00
33.00 / 3.00 / 5.00
35.00 / 1.00 / 1.67
40.00 / 10.00 / 16.67
45.00 / 1.00 / 1.67
50.00 / 4.00 / 6.67
60.00 / 3.00 / 5.00
80.00 / 2.00 / 3.33
90.00 / 1.00 / 1.67
100.00 / 4.00 / 6.67
Mean / Std-deviation
(Total) Scotland + England / 35.82 / 25.86
Base / 60.00
3c) On average, what percentage of patients who are 2nd line patients are you prescribing which drug and what is the average dose for these patients? Methylphenidate / N / %
0.00 / 5.00 / 8.33
10.00 / 4.00 / 6.67
20.00 / 4.00 / 6.67
30.00 / 10.00 / 16.67
36.00 / 1.00 / 1.67
40.00 / 4.00 / 6.67
45.00 / 1.00 / 1.67
50.00 / 2.00 / 3.33
54.00 / 11.00 / 18.33
56.00 / 1.00 / 1.67
60.00 / 10.00 / 16.67
72.00 / 3.00 / 5.00
80.00 / 1.00 / 1.67
90.00 / 1.00 / 1.67
100.00 / 2.00 / 3.33
Mean / Std-deviation
(Total) Scotland + England / 43.28 / 24.21
Base / 60.00
3c) On average, what percentage of patients who are 2nd line patients are you prescribing which drug and what is the average dose used for these patients? Atomoxetine / N / %
0.00 / 5.00 / 8.33
5.00 / 1.00 / 1.67
10.00 / 1.00 / 1.67
15.00 / 3.00 / 5.00
20.00 / 4.00 / 6.67
25.00 / 5.00 / 8.33
30.00 / 6.00 / 10.00
35.00 / 1.00 / 1.67
37.00 / 1.00 / 1.67
40.00 / 7.00 / 11.67
45.00 / 1.00 / 1.67
50.00 / 5.00 / 8.33
53.00 / 2.00 / 3.33
60.00 / 6.00 / 10.00
66.00 / 1.00 / 1.67
67.00 / 1.00 / 1.67
70.00 / 4.00 / 6.67
80.00 / 2.00 / 3.33
90.00 / 2.00 / 3.33
95.00 / 1.00 / 1.67
100.00 / 1.00 / 1.67
Mean / Std-deviation
(Total) Scotland + England / 41.77 / 25.47
Base / 60.00
3c) On average, what percentage of patients who are 2nd line patients are you prescribing which drug and what is the average dose for these patients? Atomoxetine / N / %
0.00 / 7.00 / 11.67
10.00 / 1.00 / 1.67
15.00 / 1.00 / 1.67
20.00 / 1.00 / 1.67
30.00 / 1.00 / 1.67
40.00 / 13.00 / 21.67
60.00 / 3.00 / 5.00
65.00 / 1.00 / 1.67
70.00 / 1.00 / 1.67
80.00 / 24.00 / 40.00
90.00 / 1.00 / 1.67
100.00 / 5.00 / 8.33
Mean / Std-deviation
(Total) Scotland + England / 59.00 / 31.78
Base / 60.00
3c) On average, what percentage of patients who are 2nd line patients are you prescribing which drug and what is the average dose used for these patients? Lisdexamphetamine / N / %
0.00 / 39 / 65.00
2.00 / 1.00 / 1.67
10.00 / 7.00 / 11.67
15.00 / 3.00 / 5.00
20.00 / 3.00 / 5.00
25.00 / 1.00 / 1.67
30.00 / 6.00 / 10.00
Mean / Std-deviation
(Total) Scotland + England / 6.37 / 10.23
Base / 60.00
3c) On average, what percentage of patients who are 2nd line patients are you prescribing which drug and what is the average dose for these patients? Lisdexamphetamine / N / %
0.00 / 39.00 / 65.00
5.00 / 1.00 / 1.67
20.00 / 1.00 / 1.67
30.00 / 4.00 / 6.67
40.00 / 2.00 / 3.33
50.00 / 7.00 / 11.67
60.00 / 1.00 / 1.67
70.00 / 5.00 / 8.33
Mean / Std-deviation
(Total) Scotland + England / 16.42 / 24.93
Base / 60.00
3c) On average, what percentage of patients who are 2nd line patients are you prescribing which drug and what is the average dose used for these patients? Dexamphetamine / N / %
0.00 / 31.00 / 51.67
1.00 / 1.00 / 1.67
5.00 / 2.00 / 3.33
10.00 / 6.00 / 10.00
14.00 / 1.00 / 1.67
15.00 / 3.00 / 5.00
20.00 / 8.00 / 13.33
25.00 / 1.00 / 1.67
35.00 / 1.00 / 1.67
50.00 / 3.00 / 5.00
75.00 / 1.00 / 1.67
80.00 / 1.00 / 1.67
85.00 / 1.00 / 1.67
Mean / Std-deviation
(Total) Scotland + England / 12.33 / 20.25
Base / 60.00
3c) On average, what percentage of patients who are 2nd line patients are you prescribing which drug and what is the average dose for these patients? Dexamphetamine / N / %
0.00 / 31.00 / 51.67
10.00 / 5.00 / 8.33
15.00 / 3.00 / 5.00
20.00 / 3.00 / 5.00
25.00 / 1.00 / 1.67
30.00 / 7.00 / 11.67
40.00 / 3.00 / 5.00
45.00 / 1.00 / 1.67
50.00 / 3.00 / 5.00
60.00 / 3.00 / 5.00
Mean / Std-deviation
(Total) Scotland + England / 14.75 / 19.03
Base / 60.00
3c) On average, what percentage of patients who are 2nd line patients are you prescribing which drug and what is the average dose used for these patients? Other / N / %
0.00 / 47.00 / 78.33
10.00 / 4.00 / 6.67
14.00 / 2.00 / 3.33
20.00 / 4.00 / 6.67
25.00 / 3.00 / 5.00
Mean / Std-deviation
(Total) Scotland + England / 3.72 / 7.63