Title: Inflammation and Insulin Resistance Exert Dual Effects on Adipose Tissue Tumor Protein

Title: Inflammation and insulin resistance exert dual effects on adipose tissue tumor protein 53 (p53) expressions

Authors: Francisco J Ortega et al.

SupplementaRY Information (sI)

Table S1

% of variation assessed by surgery-induced weight loss [(post-surgery induced weight loss*100/ baseline)-100]
Subject / Age / Fat mass / BMI / Glucose / Insulin / HOMA-IR / M value / P53 / MDM2 / IRS1 / GLUT4 / LEP / IL-6 / CD14
1 / 35 / -52.2 / -39.8 / -23.5 / -5.9 / -27.9 / 297.2 / -1.0 / 6.8 / 26.7 / 122.7 / -75.1 / -83.9 / -80.7
2 / 47 / -46.9 / -35.2 / -15.5 / -77.1 / -80.6 / 303.7 / 103.5 / -35.6 / 576.6 / -47.3 / -81.1 / -97.9 / -25.6
3 / 52 / -62.3 / -45.0 / -11.5 / -75.7 / -78.3 / 226.5 / 118.9 / 13.3 / 13.8 / 186.8 / -53.0 / -100.0 / -26.6
4 / 48 / -55.0 / -43.4 / -19.6 / -43.9 / -55.0 / 286.3 / 273.2 / -6 / 160.9 / 86.6 / -59.1 / -44.3 / -85.8
5 / 26 / -60.5 / -42.6 / -10.2 / -60.0 / -63.9 / 151.2 / -30.3 / -25.8 / 95.9 / 56.9 / 1245.4 / -98.8 / -70.5
6 / 31 / -53.5 / -45.8 / -14.1 / -82.9 / -85.2 / 121.5 / 27.5 / 2.1 / 145.9 / 334.7 / -47.9 / -98.6 / -69.7
7 / 54 / -54.2 / -38.9 / -16.7 / -34.3 / -45.1 / 308.5 / 34.7 / 22.3 / 33.3 / 93.2 / -50.7 / -99.2 / -20.4
Mean / 42 / -52.3 / -41.7 / -15.9 / -58.9 / -65.3 / 219.9 / 44.9 / -6.3 / 99.1 / 89.9 / -55.3 / -89 / -54.2
P-value / <0.0001 / <0.0001 / <0.0001 / 0.008 / 0.004 / <0.0001 / 0.029 / ns / 0.007 / 0.01 / 0.024 / 0.036 / 0.02

BMI, body mass index; HOMA-IR, homeostasis model assessment of insulin resistance value, calculated in all subjects as [glucose (mmol/l) × insulin (mU/l)/ 22.5]; p53,tumor protein 53, MDM2, mouse double minute 2; IRS1, insulin receptor soluble 1;GLUT4, glucose transporter type 4;LEP, leptin; IL-6, interleukin-6; CD14, cluster differentiation molecule 14.