Table 2 electronic supplement. Characteristics of AKI non-survivors and surviving AKI patients with complete, partial or absent recovery (* in patients with available baseline) (p1 for comparison of survivors versus non-survivors, p2 for comparison of recovery groups in survivors). Abbreviations: Screat = serum creatinine, eGFR = estimated GFR, CKD = chronic kidney disease, HD = hemodynamic support, MV = mechanical ventilation

Non-survivors / Surviving with complete recovery / Surviving with partial recovery / Surviving with
no recovery / P1 / P2
n (% of total population) / 333 (25.4) / 776 (59.2) / 105 (8) / 96 (7.3)
n (% of survivors) / 776 (79.4) / 105 (10.7) / 96 (9.8)
Demographics
Age (y)
(median IQR) / 72.1
(61.2-79.4) / 68.0
(57.1-76.3) / 69.4
(57.2-77.9) / 68.2
(57.1-76.2) / <0.0001 / 0.62
Male gender - n (%) / 208 (62.5) / 492 (63.4) / 59 (56.2) / 48 (50) / 0.71 / 0.022
Comorbidity
Diabetes - n (%) / 82 (24.6) / 148 (19.1) / 27 (25.7) / 27 (28.1) / 0.13 / 0.055
Malignancy - n (%) / 96 (28.8) / 192 (24.7) / 20 (19.1) / 17 (17.7) / 0.049 / 0.15
Baseline Screat mg/dL
(median IQR) / 0.96
(0.74-1.11) / 0.98
(0.77-1.15) / 0.82
(0.74-1.0) / 0.79
(0.64-1.11) / 0.54 / <0.0001
Imputed baseline -n (%) / 117 (35.1) / 201 (25.9) / 57 (54.3) / 28 (29.2) / 0.047 / <0.0001
Baseline Screat mg/dL *
(median IQR) / 0.94
(0.70-1.24) / 0.97
(0.73-1.25) / 0.76
(0.58-1.04) / 0.77
(0.56-1.28) / 0.97 / 0.0003
Baseline eGFR *
(median IQR) / 70.8
(49.7-99.2) / 70.7
(49.5-96.4) / 97.4
(64.6-124.6) / 85.8
(45.2-123.4) / 0.79 / 0.0009
CKD * - n (%) / 81 (24.3) / 207 (26.7) / 10 (9.5) / 22 (22.9) / 0.96 / 0.0002
Acute illness
Emergency admission n (%) / 263 (79) / 447 (57.6) / 86 (81.9) / 58 (60.4) / <0.0001 / <0.0001
Surgical admission - n (%) / 217 (65.2) / 650 (83.8) / 83 (79.1) / 82 (85.4) / <0.0001 / 0.42
Sepsis on admission - n (%) / 182 (54.7) / 277 (35.7) / 50 (47.6) / 35 (36.5) / <0.0001 / 0.064
Apache II score
(median IQR) / 37
(27-42.5) / 28
(20-36.8) / 36
(27.5-39) / 30
(20-37) / <0.0001 / <0.0001
Max lactate d1 mmol/L
(median IQR) (n=1271) / 2.7
(1.7-4.8) / 2.2
(1.5-3.4) / 2.4
(1.6-3.9) / 2.1
(1.4-3.1) / <0.0001 / 0.24
Need for HD support -n (%) / 318 (95.5) / 689 (88.8) / 90 (85.7) / 81 (84.4) / <0.0001 / 0.36
Need for MV - n (%) / 325 (97.6) / 728 (93.8) / 95 (93.1) / 91 (91.9) / 0.0023 / 0.74
Characteristics AKI
AdmScreat mg/dL
(median IQR) / 1.48
(1.07-2.23) / 1.36
(0.96-1.87) / 1.95
(1.20-2.88) / 1.22
(0.85-2.14) / 0.033 / <0.0001
AKI on admission – n (%) / 181 (54.4) / 352 (45.4) / 77 (73.3) / 49 (51) / 0.032 / <0.0001
AKImax – n (%) / <0.0001 / <0.0001
Stage 1 0.3 / 18 (5.4) / 138 (17.8) / 4 (4)
Stage 1 50% / 53 (15.9) / 320 (41.2) / 52 (52.5)
Stage 2 / 44 (13.2) / 136 (17.5) / 25 (24.5) / 8 (8.1)
Stage 3 no RRT / 51 (15.3) / 74 (9.5) / 36 (35.3) / 3 (3)
Stage 3 RRT / 167 (50.1) / 108 (13.9) / 44 (41.9) / 29 (30.2)
Outcome
ICU stay
(median IQR) / 15
(7-31) / 7
(4-17) / 11
(6-21.5) / 6
(3-17) / <0.0001 / 0.0016
Hospital stay
(median IQR) / 20
(9-41.5) / 27
(16-49) / 33
(22.5-57) / 26
(17-59) / <0.0001 / 0.038

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