Table S2. Adenocarcinoma cohort characteristics stratified by smoking status.

Cohort* / Nbr patients / % Heavy smokers / % EGFR mutations / % KRAS mutations / % Females / % Males / % Stage I / % Stage II / % Stage III / % Stage IV
Genomic cohort
NS / 277 / - / 49 / 9 / 81 / 19 / 56 / 16 / 23 / 5
S / 1121 / 22 / 11 / 35 / 47 / 53 / 56 / 19 / 20 / 5
CS / 391 / 24 / 9 / 35 / 56 / 44 / 49 / 21 / 24 / 6
FS / 567 / 20 / 12 / 36 / 49 / 51 / 59 / 16 / 20 / 5
Okayama et al.
NS / 115 / - / 58 / 9 / 85 / 15 / 82 / 18 / 0 / 0
S / 111 / - / 54 / 9 / 21 / 79 / 67 / 33 / 0 / 0
Chitale U133A
NS / 17 / - / 35 / 6 / 71 / 29 / 47 / 35 / 18 / 0
S / 73 / 21 / 12 / 12 / 52 / 48 / 62 / 19 / 19 / 0
CS / 13 / 23 / 0 / 15 / 54 / 46 / 46 / 31 / 23 / 0
FS / 60 / 21 / 15 / 12 / 52 / 48 / 65 / 17 / 18 / 0
Chitale U133 2plus
NS / 19 / - / 74 / 16 / 84 / 16 / 79 / 0 / 21 / 0
S / 83 / 28 / 12 / 40 / 53 / 47 / 66 / 12 / 16 / 6
CS / 12 / 17 / 0 / 50 / 75 / 25 / 42 / 42 / 16 / 0
FS / 71 / 30 / 14 / 38 / 49 / 51 / 70 / 7 / 16 / 7
Fouret et al.
NS / 63 / - / 69 / 5 / 86 / 14 / 54 / 13 / 33 / 0
S / 40 / - / 18 / 38 / 83 / 17 / 65 / 5 / 30 / 0
Landi et al.
NS / 16 / - / - / - / 81 / 19 / 38 / 25 / 31 / 6
S / 42 / - / - / - / 24 / 76 / 38 / 40 / 17 / 5
CS / 24 / - / - / - / 33 / 67 / 42 / 42 / 8 / 8
FS / 18 / - / - / - / 11 / 89 / 33 / 39 / 28 / 0
Shedden et al.
NS / 33 / - / - / - / 82 / 18 / 75 / 13 / 12 / 0
S / 229 / - / - / - / 46 / 54 / 62 / 26 / 12 / 0
CS / 20 / - / - / - / 60 / 40 / 60 / 30 / 10 / 0
FS / 209 / - / - / - / 45 / 55 / 62 / 25 / 13 / 0
TCGA
NS / 65 / - / 29 / 11 / 72 / 28 / 51 / 31 / 12 / 6
S / 358 / 17 / 11 / 30 / 50 / 50 / 56 / 21 / 18 / 5
CS / 102 / 21 / 8 / 21 / 41 / 59 / 51 / 27 / 17 / 5
FS / 256 / 15 / 12 / 34 / 54 / 46 / 58 / 19 / 18 / 5
Der et al.
NS / 23 / - / - / - / 78 / 22 / 87 / 13 / - / -
S / 92 / - / - / - / 41 / 59 / 69 / 31 / - / -
CS / 36 / - / - / - / 33 / 67 / 67 / 33 / - / -
FS / 56 / - / - / - / 46 / 54 / 70 / 30 / - / -
Tarca et al.
NS / 19 / - / - / - / 90 / 10 / 58 / 42 / - / -
S / 51 / - / - / - / 10 / 90 / 51 / 49 / - / -
CS / 40 / - / - / - / 13 / 87 / 60 / 40 / - / -
FS / 11 / - / - / - / 0 / 100 / 18 / 82 / - / -

* NS: Never-smoker, S: Smoker, CS: Current-smoker, FS: Former-smoker.