Table S1: Gene expression summary

Dataset / No. of transcripts before removing duplicates / No. of unique genes after removing duplicates
Up regulated / 1221 / 906
Down regulated / 293 / 253
Total No. of DEGs / 1514 / 1159

Table S2: nsSNPs of HCLS1 gene in human predicted to be damaging/deleterious/affect protein function by Polyphen2, PROVEAN and SIFT. Overall 51 out of total 68 nsSNPs in human HCLS1 gene were found to be deleterious, damaging or affect protein function.At least 26 nsSNPs (in bold) were commonly predicted to be tolerated by these three tools whereas the nsSNPs that were predicted to be tolerated by any one of the software are shown in italics.

SNP ID / AA Change / PPH2_Prob / PPH2 / PROVEAN Score / PROVEAN (cutoff= -2.5) / SIFT Score / SIFT (cutoff=0.05)
  1. rs150386736
/ 7 G A / 1 / Probably Damaging / -4.789 / Deleterious / -4.789 / Damaging
  1. rs372797954
/ 19 D E / 0.999 / Probably Damaging / -3.437 / Deleterious / -3.437 / Damaging
  1. rs148254045
/ 21 W C / 1 / Probably Damaging / -11.321 / Deleterious / -11.321 / Damaging
  1. rs201978006
/ 44 E K / 0.997 / Probably Damaging / -1.996 / Neutral / -1.996 / Tolerated
  1. rs114739036
/ 48 R H / 0.104 / Benign / 0.959 / Neutral / 0.959 / Tolerated
  1. rs146539124
/ 54 I T / 0.986 / Probably Damaging / -3.533 / Deleterious / -3.533 / Damaging
  1. rs368720242
/ 59 N H / 0.251 / Benign / -0.687 / Neutral / -0.687 / Damaging
  1. rs374566386
/ 61 V I / 0.874 / Possibly Damaging / -0.822 / Neutral / -0.822 / Damaging
  1. rs376707994
/ 68 L I / 0.217 / Benign / -0.318 / Neutral / -0.318 / Tolerated
  1. rs199972787
/ 80 S A / 0.365 / Benign / -2.57 / Deleterious / -2.57 / Damaging
  1. rs386479629
/ 128 R S / 0.775 / Possibly Damaging / -0.53 / Neutral / -0.53 / Tolerated
  1. rs371758156
/ 155 R C / 0.999 / Probably Damaging / -2.749 / Deleterious / -2.749 / Damaging
  1. rs142478875
/ 160 R Q / 0.999 / Probably Damaging / -1.615 / Neutral / -1.615 / Damaging
  1. rs372191150
/ 163 V L / 0.971 / Probably Damaging / -2.684 / Deleterious / -2.684 / Damaging
  1. rs34767273
/ 166 D H / 1 / Probably Damaging / -5.588 / Deleterious / -5.588 / Damaging
  1. rs144275149
/ 181 T M / 1 / Probably Damaging / -2.589 / Deleterious / -2.589 / Damaging
  1. rs147129061
/ 184 H Y / 1 / Probably Damaging / -5.782 / Deleterious / -5.782 / Damaging
  1. rs368893881
/ 184 H Q / 1 / Probably Damaging / -7.69 / Deleterious / -7.69 / Damaging
  1. rs36104070
/ 200 I T / 0.908 / Possibly Damaging / -3.216 / Deleterious / -3.216 / Damaging
  1. rs143408084
/ 203 D E / 0.891 / Possibly Damaging / -3.417 / Deleterious / -3.417 / Damaging
  1. rs370995398
/ 205 V M / 0.642 / Possibly Damaging / 1.443 / Neutral / 1.443 / Tolerated
  1. rs202020296
/ 211 G S / 0.977 / Probably Damaging / -2.55 / Deleterious / -2.55 / Damaging
  1. rs368885768
/ 211 G A / 0.881 / Possibly Damaging / -3.231 / Deleterious / -3.231 / Tolerated
  1. rs61749596
/ 218 P L / 0.97 / Probably Damaging / -2.595 / Deleterious / -2.595 / Damaging
  1. rs144589441
/ 225 T M / 1 / Probably Damaging / -3.399 / Deleterious / -3.399 / Damaging
  1. rs373119014
/ 226 T M / 0.993 / Probably Damaging / 0.392 / Neutral / 0.392 / Tolerated
  1. rs2070179
/ 235 T A / 0 / Benign / 0.754 / Neutral / 0.754 / Tolerated
  1. rs150713543
/ 240 A V / 0.998 / Probably Damaging / -3.167 / Deleterious / -3.167 / Damaging
  1. rs145735987
/ 249 K N / 0.013 / Benign / 0.819 / Neutral / 0.819 / Tolerated
  1. rs140445778
/ 252 R Q / 0.07 / Benign / -0.755 / Neutral / -0.755 / Tolerated
  1. rs373015540
/ 252 R G / 0.835 / Possibly Damaging / -3.38 / Deleterious / -3.38 / Tolerated
  1. rs375272596
/ 258 A S / 0.996 / Probably Damaging / -1.188 / Neutral / -1.188 / Tolerated
  1. rs371572740
/ 268 R Q / 0.499 / Possibly Damaging / 0.202 / Neutral / 0.202 / Tolerated
  1. rs142437444
/ 269 K Q / 0.828 / Possibly Damaging / 0.409 / Neutral / 0.409 / Tolerated
  1. rs141595315
/ 283 I L / 0.009 / Benign / 0.12 / Neutral / 0.12 / Tolerated
  1. rs145562548
/ 291 P L / 0.984 / Probably Damaging / -2.73 / Deleterious / -2.73 / Damaging
  1. rs147706872
/ 291 P S / 0.688 / Possibly Damaging / -1.359 / Neutral / -1.359 / Tolerated
  1. rs140124715
/ 306 V A / 0 / Benign / -0.084 / Neutral / -0.084 / Tolerated
  1. rs138443230
/ 315 E K / 0.003 / Benign / -0.887 / Neutral / -0.887 / Tolerated
  1. rs139020299
/ 323 H R / 0 / Benign / 0.503 / Neutral / 0.503 / Tolerated
  1. rs150723074
/ 335 P L / 0.004 / Benign / -2.346 / Neutral / -2.346 / Tolerated
  1. rs145987912
/ 339 E G / 0.967 / Probably Damaging / -2.318 / Neutral / -2.318 / Tolerated
  1. rs369551744
/ 339 E K / 0.75 / Possibly Damaging / -1.057 / Neutral / -1.057 / Tolerated
  1. rs2070180
/ 361 E Q / 0.131 / Benign / -0.803 / Neutral / -0.803 / Tolerated
  1. rs149387044
/ 373 E K / 0.021 / Benign / -1.057 / Neutral / -1.057 / Damaging
  1. rs376083217
/ 374 P S / 0.9 / Possibly Damaging / -1.1 / Neutral / -1.1 / Tolerated
  1. rs367896416
/ 381 V I / 0.027 / Benign / -0.302 / Neutral / -0.302 / Tolerated
  1. rs77852202
/ 388 E K / 0.047 / Benign / -0.982 / Neutral / -0.982 / Tolerated
  1. rs368236790
/ 402 E K / 0.977 / Probably Damaging / -0.398 / Neutral / -0.398 / Tolerated
  1. rs370406484
/ 403 P R / 0.856 / Possibly Damaging / -1.757 / Neutral / -1.757 / Damaging
  1. rs375796675
/ 403 P A / 0.295 / Benign / -1.337 / Neutral / -1.337 / Tolerated
  1. rs141075247
/ 405 D E / 0 / Benign / 0.337 / Neutral / 0.337 / Tolerated
  1. rs370437286
/ 409 S P / 0 / Benign / -0.005 / Neutral / -0.005 / Tolerated
  1. rs147742489
/ 419 P L / 0.062 / Benign / -1.135 / Neutral / -1.135 / Damaging
  1. rs199584417
/ 427 V G / 0.824 / Possibly Damaging / 0.868 / Neutral / 0.868 / Damaging
  1. rs368506277
/ 430 G W / 1 / Probably Damaging / -5.551 / Deleterious / -5.551 / Damaging
  1. rs147125943
/ 434 V M / 0.81 / Possibly Damaging / -1.945 / Neutral / -1.945 / Damaging
  1. rs376245237
/ 441 G V / 1 / Probably Damaging / -2.85 / Deleterious / -2.85 / Damaging
  1. rs201252242
/ 451 P L / 1 / Probably Damaging / -9.08 / Deleterious / -9.08 / Damaging
  1. rs202175021
/ 452 D N / 0.997 / Probably Damaging / -3.99 / Deleterious / -3.99 / Damaging
  1. rs142545513
/ 453 D N / 1 / Probably Damaging / -4.19 / Deleterious / -4.19 / Damaging
  1. rs145436824
/ 458 I V / 0.993 / Probably Damaging / -0.908 / Neutral / -0.908 / Damaging
  1. rs377000996
/ 464 G A / 1 / Probably Damaging / -5.148 / Deleterious / -5.148 / Damaging
  1. rs78618042
/ 467 R Q / 0.999 / Probably Damaging / -3.049 / Deleterious / -3.049 / Damaging
  1. rs139834889
/ 469 R C / 0.996 / Probably Damaging / -0.949 / Neutral / -0.949 / Tolerated
  1. rs146030198
/ 469 R H / 0.009 / Benign / -0.552 / Neutral / -0.552 / Tolerated
  1. rs374286282
/ 476 L P / 1 / Probably Damaging / -6.108 / Deleterious / -6.108 / Damaging
  1. rs142693789
/ 479 A E / 0.998 / Probably Damaging / -4.51 / Deleterious / -4.51 / Damaging

Table S3: nsSNPs of SLC15A3 gene in humans predicted to be damaging/deleterious/affect protein function by Polyphen2, PROVEAN and SIFT. Overall 41 out of total 60 nsSNPs in human SLC15A3 gene were found to be deleterious, damaging or affect protein function.At least 26 nsSNPs (in bold) were commonly predicted to have a damaging effect by these three tools whereas the nsSNPs that were predicted to be tolerated by any one of the software are shown in italics.

SNP ID / AA Change / PH2_Prob / PPH2 / PROVEAN Score / PROVEAN (cutoff=-2.5) / SIFT Score / SIFT (cutoff=0.05)
  1. rs182547368
/ 16 R P / 0.016 / Benign / -2.01 / Neutral / 0.017 / Damaging
  1. rs377584250
/ 51 G R / 0.991 / Probably Damaging / -4.34 / Deleterious / 0.002 / Damaging
  1. rs150370599
/ 78 V I / 0.001 / Benign / 0.18 / Neutral / 0.505 / Tolerated
  1. rs200982819
/ 90 G V / 0.02 / Benign / -5.43 / Deleterious / 0.005 / Damaging
  1. rs199743083
/ 93 L P / 0.994 / Probably Damaging / -4.74 / Deleterious / 0.001 / Damaging
  1. rs201623464
/ 187 V G / 1 / Probably Damaging / -6.04 / Deleterious / 0 / Damaging
  1. rs140918009
/ 191 G C / 0.992 / Probably Damaging / -7.49 / Deleterious / 0 / Damaging
  1. rs142952480
/ 197 R H / 1 / Probably Damaging / -3.35 / Deleterious / 0.007 / Damaging
  1. rs367882663
/ 206 I V / 0.63 / Possibly Damaging / -0.77 / Neutral / 0.007 / Damaging
  1. rs377073448
/ 213 S L / 1 / Probably Damaging / -4.21 / Deleterious / 0.002 / Damaging
  1. rs147928255
/ 217 V L / 0.008 / Benign / -1.44 / Neutral / 0.013 / Damaging
  1. rs375591770
/ 221 Q L / 0.014 / Benign / -5.68 / Deleterious / 0.001 / Damaging
  1. rs368616172
/ 254 K R / 1 / Probably Damaging / -1.45 / Neutral / 0.296 / Tolerated
  1. rs140942899
/ 256 P L / 0.999 / Probably Damaging / -5.93 / Deleterious / 0.002 / Damaging
  1. rs147368970
/ 258 G D / 1 / Probably Damaging / -5.28 / Deleterious / 0 / Damaging
  1. rs149694525
/ 269 L P / 0.979 / Probably Damaging / -2.16 / Neutral / 0.119 / Tolerated
  1. rs376068707
/ 275 Q R / 0 / Benign / 0.76 / Neutral / 1 / Tolerated
  1. rs183899877
/ 281 S L / 0.002 / Benign / -0.77 / Neutral / 0.411 / Tolerated
  1. rs190794276
/ 285 R G / 0 / Benign / -0.08 / Neutral / 0.431 / Tolerated
  1. rs370679611
/ 289 R P / 0.004 / Benign / 0 / Neutral / 0.268 / Tolerated
  1. rs141782055
/ 294 E K / 0.04 / Benign / -0.46 / Neutral / 0.896 / Tolerated
  1. rs77943698
/ 303 P Q / 0.041 / Benign / -0.55 / Neutral / 0.415 / Tolerated
  1. rs373404805
/ 318 P L / 1 / Probably Damaging / -6.64 / Deleterious / 0.003 / Damaging
  1. rs138688557
/ 319 V I / 0.343 / Benign / -0.61 / Neutral / 0.081 / Tolerated
  1. rs372172597
/ 327 W R / 1 / Probably Damaging / -11.75 / Deleterious / 0.004 / Damaging
  1. rs34738190
/ 337 Y C / 0.998 / Probably Damaging / -7.53 / Deleterious / 0 / Damaging
  1. rs17855607
/ 349 I F / 0.817 / Possibly Damaging / -1.78 / Neutral / 0.023 / Damaging
  1. rs200292846
/ 353 N K / 0.095 / Benign / -1.45 / Neutral / 0.141 / Tolerated
  1. rs199700410
/ 354 P R / 0.78 / Possibly Damaging / -2.18 / Neutral / 0.029 / Damaging
  1. rs149165643
/ 360 A S / 0.322 / Benign / -0.36 / Neutral / 0.331 / Tolerated
  1. rs78193365
/ 365 G V / 0.174 / Benign / -0.84 / Neutral / 0.34 / Tolerated
  1. rs376050411
/ 365 G R / 0.001 / Benign / -1 / Neutral / 0.536 / Tolerated
  1. rs188010920
/ 369 T M / 0.983 / Probably Damaging / -3.17 / Deleterious / 0.021 / Damaging
  1. rs201019779
/ 371 P L / 1 / Probably Damaging / -8.64 / Deleterious / 0.001 / Damaging
  1. rs144904455
/ 379 N S / 0.994 / Probably Damaging / -2.12 / Neutral / 0.013 / Damaging
  1. rs150414083
/ 380 V L / 0.64 / Possibly Damaging / -1.72 / Neutral / 0.06 / Tolerated
  1. rs140596697
/ 392 R C / 0.99 / Probably Damaging / -4.74 / Deleterious / 0.005 / Damaging
  1. rs201995321
/ 395 D N / 1 / Probably Damaging / -2.21 / Neutral / 0.292 / Tolerated
  1. rs140945002
/ 400 R W / 0.518 / Possibly Damaging / -4.65 / Deleterious / 0.027 / Damaging
  1. rs182999629
/ 400 R Q / 0.854 / Possibly Damaging / -2.28 / Neutral / 0.024 / Damaging
  1. rs199509067
/ 405 P S / 1 / Probably Damaging / -4.34 / Deleterious / 0.025 / Damaging
  1. rs201776822
/ 420 T I / 0.351 / Benign / 0.37 / Neutral / 0.244 / Tolerated
  1. rs372267601
/ 424 V A / 0.122 / Benign / 0.17 / Neutral / 0.885 / Tolerated
  1. rs376670301
/ 435 Y C / 0.999 / Probably Damaging / -1.55 / Neutral / 0.124 / Tolerated
  1. rs142111240
/ 464 Q R / 1 / Probably Damaging / -3.54 / Deleterious / 0 / Damaging
  1. rs377527454
/ 471 S G / 1 / Probably Damaging / -3.54 / Deleterious / 0 / Damaging
  1. rs148648672
/ 473 I T / 0.998 / Probably Damaging / -3.85 / Deleterious / 0.002 / Damaging
  1. rs377256065
/ 481 E Q / 0.999 / Probably Damaging / -2.63 / Deleterious / 0 / Damaging
  1. rs143864458
/ 488 P L / 1 / Probably Damaging / -9.1 / Deleterious / 0 / Damaging
  1. rs367924777
/ 489 R C / 1 / Probably Damaging / -4.81 / Deleterious / 0.001 / Damaging
  1. rs369243035
/ 531 G E / 1 / Probably Damaging / -5.26 / Deleterious / 0 / Damaging
  1. rs146262615
/ 533 I M / 0.998 / Probably Damaging / -1.7 / Neutral / 0.002 / Damaging
  1. rs374216372
/ 537 R W / 0.996 / Probably Damaging / -3.22 / Deleterious / 0.023 / Damaging
  1. rs199844407
/ 552 T M / 0.999 / Probably Damaging / -3.56 / Deleterious / 0.002 / Damaging
  1. rs369720330
/ 552 T A / 0.013 / Benign / -2.27 / Neutral / 0.243 / Tolerated
  1. rs371994103
/ 562 R C / 1 / Probably Damaging / -3.57 / Deleterious / 0.001 / Damaging
  1. rs201852183
/ 566 A V / 0.001 / Benign / 0.21 / Neutral / 0.668 / Tolerated
  1. rs200335334
/ 572 S T / 0.067 / Benign / -0.43 / Neutral / 0.085 / Tolerated
  1. rs141888730
/ 575 R H / 0.244 / Benign / -0.78 / Neutral / 0.221 / Tolerated
  1. rs150575712
/ 575 R C / 0 / Benign / -0.03 / Neutral / 0.08 / Tolerated

Table S4: nsSNPs of HCK gene in humans predicted to be damaging/deleterious/affect protein function by Polyphen2, PROVEAN and SIFT. Overall 29 out of total 48nsSNPs in human HCK gene were found to be deleterious, damaging or affect protein function.At least 16 nsSNPs (in bold) were commonly predicted to have a damaging effect by these three tools whereas the nsSNPs that were predicted to be tolerated by any one of the software are shown in italics.

SNP ID / AA Change / PH2_Prob / PPH2 / PROVEAN Score / PROVEAN (cutoff =-2.5) / SIFT Score / SIFT (cutoff=0.05)
  1. rs151045621
/ 15 N S / 0 / Benign / -0.34 / Neutral / 0.637 / Tolerated
  1. rs80138575
/ 18 S L / 0 / Benign / -1.33 / Neutral / 0.31 / Tolerated
  1. rs6089165
/ 20 T I / 0 / Benign / -0.68 / Neutral / 0.285 / Tolerated
  1. rs56029200
/ 24 A T / 0.001 / Benign / 0.24 / Neutral / 0.623 / Tolerated
  1. rs147906206
/ 26 P A / 0 / Benign / -0.25 / Neutral / 0.271 / Tolerated
  1. rs141638027
/ 29 P A / 0 / Benign / -0.99 / Neutral / 0.175 / Tolerated
  1. rs146996549
/ 32 V L / 0.047 / Benign / -0.79 / Neutral / 0.533 / Tolerated
  1. rs369611440
/ 32 V A / 0.563 / Possibly Damaging / -0.73 / Neutral / 0.37 / Tolerated
  1. rs372621598
/ 39 I L / 0 / Benign / 0.03 / Neutral / 1 / Tolerated
  1. rs138094245
/ 41 P L / 0 / Benign / -1.16 / Neutral / 0.234 / Tolerated
  1. rs149121640
/ 42 G E / 0.001 / Benign / -0.56 / Neutral / 0.278 / Tolerated
  1. rs34513177
/ 44 N K / 0.019 / Benign / -0.83 / Neutral / 0.298 / Tolerated
  1. rs184537004
/ 45 S R / 0.035 / Benign / -0.92 / Neutral / 0.15 / Tolerated
  1. rs148264751
/ 47 N S / 0 / Benign / -0.18 / Neutral / 1 / Tolerated
  1. rs369294499
/ 51 P Q / 0.554 / Possibly Damaging / -2.05 / Neutral / 0.025 / Damaging
  1. rs373209595
/ 72 I V / 0 / Benign / -0.13 / Neutral / 0.54 / Tolerated
  1. rs201087116
/ 75 E Q / 0.06 / Benign / -1.01 / Neutral / 0.04 / Damaging
  1. rs6089166
/ 78 S I / 0.138 / Benign / -3.84 / Deleterious / 0.002 / Damaging
  1. rs55722810
/ 85 M L / 0 / Benign / 0.02 / Neutral / 1 / Tolerated
  1. rs200519132
/ 98 R Q / 0.003 / Benign / -1.35 / Neutral / 0.205 / Tolerated
  1. rs182852728
/ 103 R Q / 0.001 / Benign / -0.39 / Neutral / 0.014 / Damaging
  1. rs375313782
/ 115 R C / 0.009 / Benign / -3.85 / Deleterious / 0.009 / Damaging
  1. rs199725229
/ 120 E Q / 0.992 / Probably Damaging / -1.23 / Neutral / 0.646 / Tolerated
  1. rs199815006
/ 125 F C / 1 / Probably Damaging / -6.34 / Deleterious / 0 / Damaging
  1. rs199854883
/ 167 Y C / 0.001 / Benign / -3.01 / Deleterious / 0.062 / Tolerated
  1. rs372761182
/ 168 D N / 0.999 / Probably Damaging / -3.61 / Deleterious / 0.002 / Damaging
  1. rs376025420
/ 170 R G / 0 / Benign / -0.31 / Neutral / 0.388 / Tolerated
  1. rs200896933
/ 186 G R / 1 / Probably Damaging / -7.13 / Deleterious / 0 / Damaging
  1. rs202001086
/ 193 R Q / 0.936 / Possibly Damaging / -3.13 / Deleterious / 0.001 / Damaging
  1. rs199531584
/ 212 G R / 0.996 / Probably Damaging / -7.01 / Deleterious / 0 / Damaging
  1. rs189947820
/ 239 R W / 1 / Probably Damaging / -6.86 / Deleterious / 0 / Damaging
  1. rs370473046
/ 246 K Q / 0.2 / Benign / -2.08 / Neutral / 0.077 / Tolerated
  1. rs200867413
/ 257 W R / 1 / Probably Damaging / -12.37 / Deleterious / 0 / Damaging
  1. rs200178250
/ 271 T M / 0.973 / Probably Damaging / -4.89 / Deleterious / 0 / Damaging
  1. rs372166561
/ 317 A V / 0.232 / Benign / -2.41 / Neutral / 0.03 / Damaging
  1. rs151054795
/ 339 I T / 0.981 / Probably Damaging / -3.86 / Deleterious / 0.029 / Damaging
  1. rs114505022
/ 350 A T / 0.983 / Probably Damaging / -3.52 / Deleterious / 0.001 / Damaging
  1. rs181577847
/ 364 A S / 0.36 / Benign / -2.51 / Deleterious / 0.105 / Tolerated
  1. rs145632103
/ 384 R W / 1 / Probably Damaging / -7.46 / Deleterious / 0 / Damaging
  1. rs377468533
/ 392 T M / 0.554 / Possibly Damaging / -3.83 / Deleterious / 0.022 / Damaging
  1. rs140392783
/ 397 A S / 0.012 / Benign / -2.22 / Neutral / 0.029 / Damaging
  1. rs202169601
/ 413 S F / 0.94 / Possibly Damaging / -2.26 / Neutral / 0.026 / Damaging
  1. rs137871205
/ 435 R W / 1 / Probably Damaging / -6.94 / Deleterious / 0 / Damaging
  1. rs374360915
/ 435 R Q / 0.993 / Probably Damaging / -3.2 / Deleterious / 0.001 / Damaging
  1. rs369369487
/ 452 R H / 0.076 / Benign / -2.31 / Neutral / 0.159 / Tolerated
  1. rs200005064
/ 467 Y H / 1 / Probably Damaging / -2.72 / Deleterious / 0.464 / Tolerated
  1. rs142491977
/ 470 M V / 0.773 / Possibly Damaging / -3.13 / Deleterious / 0.001 / Damaging
  1. rs17093828
/ 482 P Q / 1 / Probably Damaging / -7.15 / Deleterious / 0 / Damaging

Table S5: nsSNPs of LY96 gene in humans predicted to be damaging/deleterious/affect protein function by Polyphen2, PROVEAN and SIFT. Overall 9 out of total 13 nsSNPs in human LY96 gene were found to be deleterious, damaging or affect protein function.At least 5nsSNPs (in bold) were commonly predicted to have a damaging effect by these three tools whereas the nsSNPs that were predicted to be tolerated by any one of the software are shown in italics.

SNP ID / AA Change / PPH2_Prob / PPH2 / PROVEANScore / PROVEAN (cutoff=-2.5) / SIFT Score / SIFT (cutoff=0.05)
  1. rs185479794
/ 4 F I / 0.447 / Benign / -2.81 / Deleterious / 0.06 / Tolerated
  1. rs141631661
/ 12 S C / 0.997 / Probably Damaging / -3.04 / Deleterious / 0.003 / Damaging
  1. rs199978698
/ 29 D N / 1 / Probably Damaging / -2.54 / Deleterious / 0 / Damaging
  1. rs147043603
/ 42 Y C / 0.967 / Probably Damaging / -1.71 / Neutral / 0.065 / Tolerated
  1. rs149129453
/ 68 R K / 0.994 / Probably Damaging / -2.11 / Neutral / 0.282 / Tolerated
  1. rs142571384
/ 70 D Y / 1 / Probably Damaging / -7.36 / Deleterious / 0.002 / Damaging
  1. rs199845476
/ 84 T S / 0 / Benign / 2.16 / Neutral / 1 / Tolerated
  1. rs143608308
/ 85 M I / 0 / Benign / -0.5 / Neutral / 0.587 / Tolerated
  1. rs199848357
/ 96 R Q / 0.5 / Possibly Damaging / -1.33 / Neutral / 0.058 / Tolerated
  1. rs367973351
/ 99 D H / 0.999 / Probably Damaging / -4.5 / Deleterious / 0.004 / Damaging
  1. rs141759642
/ 142 P L / 0.027 / Benign / -1.33 / Neutral / 0.056 / Tolerated
  1. rs202107994
/ 143 E A / 0.962 / Probably Damaging / -2.85 / Deleterious / 0 / Damaging
  1. rs11466004
/ 157 P S / 0.021 / Benign / -2.47 / Neutral / 0.175 / Tolerated

Supplementary Figure 1: Genes with highest node degree as hubs and their first neighbors or interacting partners.(a)HCLS1 (b) SLC15A3(c)HCK (d) LY96. The hub genes are shown as purple diamonds.

a)

b)

c)

d)