Supplementary Table I: Age, sex, and vocabulary-adjusted* associations between cognitive test scores and SNPs in the CRP gene (ANCOVA p-values†)

AAA Trial
Cognitive Test / rs1205 / rs1800947 / rs1130864 / rs1417938
AVLT / 0.41 / 0.31 / 0.29 / 0.26
RAVENS / 0.88 / 0.17 / 0.42 / 0.24
VFT / 0.64 / 0.13 / 0.017 / 0.014
DST‡ / 0.57 / 0.15 / 0.92 / 0.95
ln(TMT) / 0.60 / 0.49 / 0.17 / 0.20
g / 0.83 / 0.27 / 0.44 / 0.48
ET2DS
Cognitive Test / rs1205 / rs1800947 / rs1130864
LNS / 0.80 / 0.25 / 0.17
MR / 0.91 / 0.70 / 0.84
VFT / 0.68 / 0.88 / 0.42
DST‡ / 0.13 / 0.44 / 0.083
ln(TMT) / 0.26 / 0.59 / 0.17
FACES / 0.82 / 0.41 / 0.0010
LM¶ / 0.87 / 0.70 / 0.76
g / 0.42 / 0.41 / 0.38
EAS
Cognitive Test / rs1205 / rs1130864 / rs3093077
RAVENS / 0.085 / 0.37 / 0.85
VFT / 0.65 / 0.14 / 0.73
DST‡ / 0.18 / 0.59 / 0.82
LM¶ / 0.51 / 0.21 / 0.78
g / 0.12 / 0.51 / 0.87
LBC1936
Cognitive Test / rs1205 / rs1800947 / rs1130864 / rs3093077 / rs3093068
LNS / 0.80 / 0.017 / 0.96 / 0.10 / 0.18
MR / 0.073 / 0.49 / 0.076 / 0.94 / 0.53
VFT / 0.73 / 0.93 / 0.96 / 0.32 / 0.63
DST‡ / 0.92 / 0.52 / 0.56 / 0.29 / 0.46
LM¶ / 0.39 / 0.061 / 0.31 / 0.77 / 0.70
g / 0.47 / 0.21 / 0.61 / 0.25 / 0.20

AVLT = Auditory Verbal Learning Task, RAVENS = Raven’s Standard Progressive Matrices, VFT = Verbal Fluency Test, DST = Digit Symbol Test, TMT = Trail Making Test, Part B, LM = Logical Memory, LNS = Letter Number Sequencing, MR = Matrix Reasoning, FACES = Faces and family pictures subtest

* Vocabulary adjustment used Mill Hill Vocabulary Scores for the AAA Trial and the ET2DS, National Adult Reading Test scores for the EAS, and age-11 Moray House Test No. 12 scores for the LBC1936.

† P-values less than 0.05 are highlighted in bold.

‡ The Digit Symbol Test time limit was 90 seconds in the AAA Trial and EAS but 120 seconds in the ET2DS and LBC1936

¶ Different versions of the LM were used in the ET2DS, EAS, and LBC1936.