EN
Annex 11
Horizon 2020
8. Health, demographic change and wellbeing
DISCLAIMERThis draft has not been adopted or endorsed by the European Commission. Any views expressed are the preliminary views of the Commission services and may not in any circumstances be regarded as stating an official position of the Commission. The information transmitted is intended only for the Member State or entity to which it is addressed for discussions and may contain confidential and/or privileged material.
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Horizon 2020 – Vs 5.3 for PC- CONFIDENTIAL
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Table of contents
Introduction 6
Call - Better Health and care, economic growth and sustainable health systems 10
Overall mission statement 10
1.1 Personalised medicine 10
SC1-BHC-01-2019: Understanding causative mechanisms in co- and multimorbidities 11
SC1-BHC-02-2019: Systems approaches for the discovery of combinatorial therapies 12
SC1-BHC-03-2018: Exploiting research outcomes and application potential of the human microbiome for personalised prediction and prevention of disease 13
SC1-BHC-04-2018: Rare Disease European Joint Programme Co-Fund 14
SC1-BHC-05-2018: International flagship collaboration with Canada for human data storage, integration and sharing to enable personalised medicine approaches 17
SC1-HCO-01-2018-2019-2020: Actions in support of the International Consortium for Personalised Medicine 19
SC1-HCO-02-2018: Data integration and data-driven in-silico models for enabling personalised medicine - a European standardization framework 21
SC1-HCO-04-2018: ERA-NET to support the Joint Programming in Neurodegenerative Diseases strategic plan (JPND) 23
1.2 Innovative health and care industry 24
SC1-BHC-07-2019: Regenerative medicine: from new insights to new applications 25
SC1-BHC-09-2018: Innovation platforms for advanced therapies of the future 26
SC1-BHC-10-2019: Innovation Procurement: Next generation sequencing (NGS) for routine diagnosis 27
SC1-HCO-05-2018: Strengthen Regulatory Sciences and support for regulatory Scientific Advice 28
1.3 Infectious diseases and improving global health 29
SC1-BHC-13-2019: Mining big data for early detection of infectious disease threats driven by climate change and other factors 30
SC1-BHC-14-2019: Stratified host-directed approaches to improve prevention, treatment and/or cure of infectious diseases 32
SC1-BHC-15-2018: New anti-infective agents for prevention and/or treatment of neglected infectious diseases (NID) 33
SC1-BHC-16-2018: Global Alliance for Chronic Diseases (GACD) 1 35
SC1-BHC-18-2019: EU-CELAC collaboration for research on non-communicable diseases 35
SC1-BHC-19-2019: Implementation research for maternal and child health 36
SC1-BHC-21-2018: Research on HIV, tuberculosis and/or hepatitis C in patients with mono-, co-infections or comorbidities in the contest of the collaboration between the European Union and the Russian Federation 38
SC1-HCO-06-2018: Establishment of an International Network of Research Centres addressing governance challenges in the research response to infectious threats 40
SC1-HCO-08-2019: Creation of a European wide sustainable clinical research network for infectious diseases 42
SC1-HCO-09-2018: Building international efforts on population and patient cohorts 43
SC1-HCO-10-2018: Coordinating European brain research and developing global initiatives 44
SC1-HCO-11-2018: Strategic collaboration in health and care research and innovation between EU and China 46
1.4. Innovative health and care systems - Integration of care 46
SC1-BHC-22-2019: Mental health in the workplace 47
SC1-BHC-23-2018: Novel patient-centred approaches for survivorship, palliation and/or end-of-life care 48
SC1-BHC-25-2019: Demonstration pilots for implementation of personalised medicine in health care 50
SC1-BHC-26-2018: HTA research to support evidence-based healthcare 51
SC1-HCO-12-2018: Innovation in health care - a CSA towards using pre-commercial procurement and public procurement of innovative solutions in health care systems 53
1.5 Decoding the role of the environment for health and well-being 55
SC1-BHC-27-2018: New testing and screening methods to identify endocrine disrupting chemicals 56
SC1-BHC-28-2019: The Human Exposome Project: a toolbox for assessing and addressing the impact of environment on health 57
SC1-HCO-13-2018: Setting the priorities for a European environment and health research agenda 59
Conditions for the Call - Better Health and care, economic growth and sustainable health systems 60
Call - Digital transformation in Health and Care 64
Overall mission statement 64
SC1-DTH-01-2019: Big data and Artificial Intelligence for monitoring health status and quality of life after the cancer treatment 64
SC1-DTH-03-2018: Adaptive smart working and living environments supporting active and healthy ageing 66
SC1-DTH-05-2019: Large scale implementation of digital innovation for health and care in an ageing society 67
SC1-DTH-07-2018: Exploiting the full potential of in-silico medicine research for personalised diagnostics and therapies in cloud-based environments 70
SC1-DTH-08-2018: Prototyping a cloud-based standardised Personal Health Record/Electronic Health Record for Europe 71
SC1-DTH-09-2019: Scaling up the univocal Identification of Medicinal Products 74
SC1-DTH-10-2019-2020: Digital health and care services 77
SC1-DTH-11-2019: Large Scale pilots of personalised & outcome based integrated care 79
SC1-HCC-01-2018: Supporting investment in smart living environments for ageing well through certification 81
SC1-HCC-02-2019: Support for the large scale uptake of open service platforms in the Active and Healthy Ageing domain 83
SC1-HCC-03-2018: Support to further development of international cooperation in digital transformation of health and care 84
SC1-HCC-04-2018: Digital health and care services – support for policy, strategy and (early) adoption 86
SC1-HCC-05-2018: Support to a Digital Health and Care Innovation initiative in the context of Digital Single Market strategy 88
Conditions for the Call - Digital transformation in Health and Care 90
Call - Trusted digital solutions and Cybersecurity in Health and Care 92
Overall mission statement 92
DT-ICT-12-2019-: Smart and healthy living at home 92
SU-TDS-01-2018: Toolkit for assessing and reducing cyber risks in hospitals and care centres to protect privacy/data/infrastructures 94
SU-TDS-02-2018: Raising awareness and developing training schemes on cybersecurity in hospitals 95
Conditions for the Call - Trusted digital solutions and Cybersecurity in Health and Care 96
Other Actions 2018-2019 97
1. Subscription fee: Human Frontier Science Programme Organisation 97
2. Studies, activities of the Scientific Panel for Health, conferences, events and outreach activities 97
3. External expertise 98
4. Grant to the Global Alliance for Chronic Diseases 98
5. Fostering transnational cooperation between National Contact Points (NCP) in the area of health, demographic change and well-being: follow-up project 98
6. Expert group for the impact assessment of the planned Commission communication on infectious diseases 100
7. Expert groups for the assessment of scenarios for public-public and public-private partnerships 100
8. Subscription fee: World RePORT international health research database 100
9. Mobilisation of research funds in case of Public Health Emergencies 101
CALLS and OTHER ACTIONS for 2020 103
Call - Better Health and care, economic growth and sustainable health systems (continued in 2020) 104
Draft content for 2020 104
Other Actions for 2020 105
1. Subscription fee: Human Frontier Science Programme Organisation 105
2. Horizon Prize on novel solutions to reduce the spread of AMR in the environment 105
3. Surgical care in resource-poor settings 105
4. Exemplary application of personalised medicine approaches at a local or regional level 106
5. Novel tool(s) to limit the use of test animals in biomedical sciences and safety testing 106
6. Implantation of smart medical devices to (re-) establish neural &/or neuronal function 106
7. Mobilisation of research funds in case of Public Health Emergencies 106
Call - Digital Transformation in Health and Care 107
Draft content for 2020 107
Call - Trusted digital solutions and Cybersecurity in Health and Care 108
Draft content for 2020 108
Budget 109
Introduction
Policy drivers
The specific objective of the 'Health, demographic change and well-being' societal challenge 1 (SC1) is to improve the lifelong health and well-being of all. Lifelong health and well-being for all - children, adults and older people - high-quality, economically sustainable and innovative health and care systems, as part of welfare systems, and opportunities for new jobs and growth are the aims of the support provided to research and innovation in response to this challenge. SC1 implements several Commission priorities, including:
· The pursuit of the 2030 Agenda for Sustainable Development and its Sustainable Development Goals (SDGs), in particular the SDG3 on 'Good Health and Well-being'. All activities developed in this work programme will support the SDGs;
· The agreement reached during COP21[1] and future COP agreements and the goals of the Ostrava declaration on environment and health. Several actions of this work programme will contribute to the climate action;
· The Digital Single Market, and its relevance for the digital transformation of health and care. The Digital Single Market will support in particular patient-centred integrated care and personalised medicine, leveraging the potential of digital technologies and data analysis to improve detection of health risks, early diagnosis and treatment of rare and chronic diseases, as well as advance early detection of infectious diseases outbreaks, and faster drug development;
· The implementation of the expected new EU Action Plan on Antimicrobial Resistance;
· The support and implementation of the expected legislative initiative on Health Technology Assessment
Beyond well-being, health is also instrumental in social policies and socio-economic sustainability.
The contribution to Focus Areas will be EUR 186.50 million for 'Digitisation' and EUR 71 million for 'Security Union'.
Challenges and opportunities
Europe faces rising and potentially unsustainable health and care costs, mainly due to the increasing prevalence of chronic diseases, to an ageing population requiring more diversified care and to increasing societal demands. Health research and innovation also face new challenges stemming from the emergence of new research paradigms and methodologies to address increasingly complex medical and health challenges, including growing awareness of the influence of external environmental factors, and in view of worldwide competition. The world, including Europe, is confronted with increasing migration, climate change and new threats of emerging infectious diseases. Furthermore, health inequalities and access to health and care also constitute major challenges for our societies. Europe needs to innovate to develop smart, scalable and sustainable solutions in order to overcome these challenges and must grasp every opportunity for leadership. Technology and innovation continue to offer such opportunities at an accelerating pace.
Diseases need to be addressed at global level. Therefore the many SC1 research priorities include an international dimension, mainly through multi-lateral initiatives (such as in the areas of rare diseases, chronic diseases and infectious diseases). In this regard, recent outbreaks infectious diseases such as Ebola, Zika, SARS and MERS-CoV demonstrated that cross-border epidemics are a major threat for the health and prosperity across the world. Threats need to be swiftly identified and at a much earlier stage, before developing into a public health emergency (PHE). Under WP 2018-2020, research investment in measures that better detect and foresee these potential epidemics will be stepped up so that preparedness and surveillance can further improve. This includes the swift mobilisation of research funds to address a public health emergency independently recognised by the Commission[2].
Social sciences and humanities research is employed, and sex differences and gender aspects are addressed where relevant. SC1 integrates the principle of responsible research and innovation, including ethics, in all its activities.
In line with the 'Three Os' strategy of promoting Open Science, Open Innovation and being Open to the World' and with the European Open Science Cloud initiative, this work programme promotes an 'Open Science' approach in all topics. Grant beneficiaries under this work programme part will engage in research data sharing by default, as stipulated under Article 29.3 of the Horizon 2020 Model Grant Agreement (including the creation of a Data Management Plan). Participants may however opt out of these arrangements, both before and after the signature of the grant agreement. More information can be found under General Annex L of the work programme. Above and beyond the default requirements on Open Access to Research Data in Article 29.3 of the Model Grant Agreement, applicants are encouraged to demonstrate plans for data management and in particular FAIR (findable, accessible, interoperable and reusable) data sharing.
Applicants are required to include specifications in their proposal on how timely data sharing will be ensured to allow for an appropriate use in public health and research. This is of particular relevance for projects related to emerging infections and public health emergencies. Public health emergencies may include, but are not limited to the following: Public Health Emergencies of International Concern (PHEIC) according to the World Health Organization, public health emergencies under Decision 1082/2013/EU or under applicable national frameworks and regulations.
For clinical studies, the 'Open Science' approach requires (i) the registration of the study prior to the enrolment of the first patient in a registry that is part of the WHO Registry Network[3], and (ii) in line with the WHO 'Joint statement on public disclosure of results from clinical trials'[4] the disclosure of the study results by posting to the results section of the registry and by journal publication within 12 months from primary study completion.
The use of European health research infrastructures (including e-infrastructures) is also encouraged when appropriate, e.g. research infrastructures established as a European Research Infrastructure Consortium (ERIC) or identified on the roadmap of the European Strategy Forum on Research Infrastructures (ESFRI). Projects submitting a data management plan are invited to identify the existing European research data infrastructures that may be used and how these may be mobilised, in particular for long-term data curation and preservation.
The programme should allow for further building of clinical research infrastructure and evidence with regard to efficient and validated models of organisation of complex networks such as European Reference Networks of healthcare providers established by Article 12 of Directive 2011/24/EU[5].
Actions included in this work programme may also gain more impact and scope by envisaging synergies with the European Structural and Investment Funds (ESIF) in this field. It is therefore recommended, where relevant, to seek concrete synergies with ESIF in smart specialisation priorities within the EU regions.
Funding schemes
In order to address these objectives and challenges, societal challenge 1 (SC1) implements a comprehensive strategy covering the whole innovation cycle. SC1 supports multidisciplinary and translational approaches, aiming at the integration of new knowledge generated in pre-clinical, clinical and public health settings. It deploys all Horizon 2020 instruments:
· Research and Innovation Actions (RIA)
· Innovation Actions (IA)
· Coordination and Support Actions (CSA)