Supplementary Table S2 Linear regression modelsa showing the associations between overall brain levels of CPX1 and/or CPX2, and their interaction with Braak stagingb (as predictors), and global cognitive function (as the outcome)

Model terms / Reference / Model 1 / Model 2 / Model 3 / Model 4
Adj. R2 or B / P value / Adj. R2 or B / P value / Adj. R2 or B / P value / Adj. R2 or B / P value / Adj. R2 or B / P value
Model adj. R2 / 0.3996 / 0.4100 / 0.4083 / 0.4102 / 0.4427
Sex / -0.1330 / 0.1198 / -0.1379 / 0.1038 / -0.1463 / 0.0854 / 0.0717 / 0.0912 / -0.1760 / 0.0416*
Age at death / –0.0246 / 0.0004* / –0.0232 / 0.0007* / –0.0229 / 0.0009* / –0.0227 / 0.0009* / –0.0200 / 0.0069*
Education / 0.0236 / 0.1001 / 0.0226 / 0.1118 / 0.0239 / 0.0931 / 0.0231 / 0.1045 / 0.0312 / 0.0140*
PMI / 0.0060 / 0.5067 / 0.0066 / 0.4608 / 0.0080 / 0.3716 / 0.0075 / 0.4041 / 0.0069 / 0.0087*
Macroinfarcts / –0.3334 / <.0001* / –0.3235 / 0.0001* / –0.3406 / <.0001* / –0.3304 / <.0001* / –0.3361 / 0.0809
Lewy bodies / –0.1834 / 0.0722 / –0.1789 / 0.0769 / –0.1916 / 0.0586 / –0.1846 / 0.0682 / –0.1959 / 0.0993
Hipp sclerosis / –0.6479 / <.0001* / –0.5727 / 0.0001* / –0.5897 / <.0001* / –0.5652 / 0.0001* / –0.6051 / 0.1445
b-amyloid / –0.0814 / 0.0207* / –0.0741 / 0.0340* / –0.0746 / 0.0330* / –0.0728 / 0.0374* / –0.0144 / 0.0369*
Phosphotau / –0.0667 / <.0001* / –0.0649 / <.0001* / –0.0664 / <.0001* / –0.0653 / <.0001* / –0.0522 / 0.0070*
Synapse densityc / –0.0228 / 0.6090 / –0.0761 / 0.1128 / –0.0829 / 0.0957 / –0.0914 / 0.0676 / –0.0832 / 0.0487*
CPX1 / – / – / 0.1531 / 0.0046* / – / – / 0.1054 / 0.1285 / – / –
CPX2 / – / – / – / – / 0.1393 / 0.0085* / 0.0740 / 0.2761 / – / –
Braak [1–0]d / – / – / – / – / – / – / – / – / –0.1421 / 0.2048
Braak [2–0]d / – / – / – / – / – / – / – / – / –0.5525 / 0.0022*
Marginal effectse
CPX1 / Braak [0] / – / – / – / – / – / – / – / – / 0.4843 / 0.0027*
Braak [1] / – / – / – / – / – / – / – / – / 0.0829 / 0.3808
Braak [2] / – / – / – / – / – / – / – / – / –0.1054 / 0.3987
CPX2 / Braak [0] / – / – / – / – / – / – / – / – / –0.2002 / 0.2501
Braak [1] / – / – / – / – / – / – / – / – / –0.0055 / 0.9521
Braak [2] / – / – / – / – / – / – / – / – / 0.4210 / 0.0012*

a Models 1–4 were constructed sequentially by adding the indicated terms to the reference model. Whole model adjusted R2, individual unstandardized coefficients (B) and P values are reported

b Braak stages were collapsed into three levels corresponding to Braak 0–II [0], III–IV [1], and V–VI [2]. Shown estimates and P values correspond to between-level thresholds

c Synapse density was estimated as the overall brain levels of the three SNARE proteins (syntaxin-1, SNAP-25 and VAMP) averaged

d Terms represent average effects on cognition for the corresponding Braak stage transitions for hypothetical CPX2 = CPX1 = 0 values

e Calculated from the corresponding CPX1/2 × Braak [1–0] or Braak [2–0] interaction terms as previously described (Brambor et al., Political Analysis 2005)

* Statistically significant