SUPPLEMENTARY MATERIALS FOR WEB

(E)T-1. The characteristics of patients with multiple or single infarct with recurrent stroke

Age/sex / No. of lesions
on DWI / Location / Site of recurrence / AF / Relevant MCA Stenosis
47/M / 5 / L. Corona radiata L.posterior BZ / same / N / Y
70/M / 4 / L. temporal, L. frontal / R. parietal / N / N
90/F / 8 / L. frontal, L. parietal / L. brain stem / N / N
60/M / 3 / L. parietal, L. internal BZ / same / N / Y
71/M / 5 / R. anterior, posterior and internal BZ / same / N / Y
62/F / 4 / R. cerebellum, R. midbrain / R. corona radiata and frontal / Y / N
78/F / 5 / L. frontal, L. parietal / same / N / N
58/M / 1 / R. cerebellum / same / N / N
69/M / 1 / R. MCA territory / L MCA territory / N / N
76/M / 1 / L. Basal ganglia / same / N / Y
80/F / 1 / L. Thalamus / same / N / N
69/F / 1 / L. frontal / same / N / Y
69/M / 1 / R. temporal / L. parietal / N / Y
65/M / 1 / R. pons / same / Y / N
93/F / 1 / L. frontal / same / N / N

L=left; R= right; BZ= border zone; MCA= middle cerebral artery; AF= atrial fibrillation.

(E)T-2. Relationship between clinical and imaging characteristics and further vascular events / death or stroke recurrence

Variable / N=119 / Patients with further vascular events/death (%) /

p

/ Patients with stroke recurrence (%) /

p

Gender / 0.31 / 0.56
Male / 57 / 13 (22.8) / 8 (14.0)
Female / 62 / 10 (16.1) / 7 (11.3)
Age / 0.44 / 0.21
>70y / 64 / 11 (17.2) / 6 (9.4)
<=70y / 55 / 12 (21.8) / 9 (16.4)
Hypertension / 0.13 / 0.09
Yes / 78 / 12 (15.4) / 7 (9.0)
No / 41 / 11 (26.8) / 8 (19.5)
Diabetes / 0.12 / 0.11
Yes / 37 / 4 (10.8) / 2 (5.4)
No / 82 / 19 (23.2) / 13 (15.9)
Hyperlipidemia / 0.47 / 0.55
Yes / 77 / 15 (19.5) / 10 (13.0)
No / 42 / 8 (25.0) / 5 (16.7)
Atrial fibrillation / 0.95 / 0.93
Yes / 14 / 3 (21.4) / 2 (14.3)
No / 105 / 20 (19.0) / 13 (12.4)
Prior stroke or TIA / 0.89 / 0.34
Yes / 28 / 5 (17.9) / 5 (17.9)
No / 91 / 18 (19.8) / 10 (11.0)
Smoking / 0.66 / 0.65
Yes / 57 / 12 (21.1) / 8 (14.0)
No / 62 / 11 (17.7) / 7 (11.3)
Stroke subtypes / 0.037* / 0.19
Large-artery disease / 39 / 11 (28.2) / 7 (17.9)
Cardioembolism / 14 / 3 (21.4) / 2 (14.3)
Small-vessel disease / 30 / 0 / 0
Other cause / 2 / 1(50) / 0
Undetermined cause / 34 / 8 (23.5) / 6 (17.6)
DWI findings on initial scan / 0.0007* / 0.0003*
Single infarct / 99 / 14 (14.1) / 8 (8.08)
Multiple infarcts / 20 / 9 (45) / 7 (35)

p = statistical significance of log-rank test in groups stratified by each variable;

TIA=transient ischemic attack; DWI= diffusion-weighted imaging; * p< 0.05.


(E)F-1. An example of multiple infarcts in the anterior and posterior borderzones.