Prof Anna-Mart Engelbrecht

Curriculum Vitae

1. BIOGRAPHICAL SKETCH

1.1 GENERAL INFORMATION
Surname / Engelbrecht
First names / Anna-Mart
Citizenship / South African / Title / Prof / Female / X / Male
Place of Birth / Pretoria / Date of birth / 01/05/1968
Population group / White South African
Organisation / Stellenbosch University
Faculty / Natural Science / Position / Professor
Telephone number / 021-8084573 / Direct telefax number / 021-8083145
E-mail address /
Date of appointment / 2010

1.2 ACADEMIC QUALIFICATIONS OBTAINED

Degree/
Diploma / Field of study / Higher education institution / Year
BSc / Physiology & Biochemistry / Stellenbosch University / 1989
BSc (Hons) / Physiology / Stellenbosch University / 1990
MMedSc – cum laude (part time) / Medical Biochemistry / University of the Free State / 1997
PhD (part time) / Medical Physiology / Stellenbosch University / 2005

1.3 WORK EXPERIENCE TO DATE

Name of employer / Capacity and/or type of work / Period
University of the Free State / Research Assistant / 1991-1992
University of the Free State / Junior Lecturer / 1993-1996
Stellenbosch University / Research Assistant / 1998-1999
Stellenbosch University / Junior Lecturer / 2000-2005
Stellenbosch University / Lecturer / 2005-2006
Stellenbosch University / Senior Lecturer / 2007-2010
Stellenbosch University
Stellenbosch University
Stellenbosch University / Associate Professor
Professor
Head of Department / 2010-2013
2014-
2016-

2. TEACHING ACTIVITIES

2.1 COURSES PRESENTED
Course / Level / Self Developed
Histology / 2nd and 3rd year / I have restructured the Histology course by writing new study guides and exercise manuals when I started lecturing at US
2.2. Other education and pedagogic courses presented
Course / Year / Institution
Physiology 176: Hematology, Immunology, Cardiovascular Physiology, Sense Organs / 2000-2006 / Stellenbosch University
Physiology 278: Sense Organs / 2000-2006 / Stellenbosch University
Physiology 378: Immunology, Temperature regulation, Cellular signaling / 2000-2006 / Stellenbosch University
Physiology 314: Endocrinology / 2007-current / Stellenbosch University
Physiology 344: Cellular Signaling / 2007--2012 / Stellenbosch University
Physiology 324: Cancer / 2009-curent / Stellenbosch University
Honours: Physiological Sciences: 6 week mini course on cell signaling and apoptosis / 2004-current / Stellenbosch University

3. TEACHING OUTPUTS

3.1 EDUCATIONAL PUBLICATIONS
3.1.1 Books
X-kit Undergraduate Physiology, Pearson Maskew Miller Longman (Pty) Ltd, 2006, ISBN: 978-1-86891-378-7: Chapter 6: The Urinary System and Chapter 8: Blood and Lymphatic System

4. OTHER TEACHING CONTRIBUTIONS

4.1Invited to lecture in Honours courses of other departments at Stellenbosch University:

Dept of Wine Biotechnology (2005)

Dept of Biochemistry (2006)

Dept of Biomedical Sciences at Medical Faculty (2006-current)

5. RESEARCH ACTIVITIES

5.1 FORMER SUPERVISION OR CO-SUPERVISION (Completed)
Name of Student / Degree / Title of dissertation / thesis and date / Supervisor / Co-supervisor / Duration of study
MSc
Jacqueline Faure (female, white) / The effects of repeated stress on the behavior and neurochemistry of the adult rat./ April 2006 / Prof Willie Daniels / Dr A-M Engelbrecht / 2 years
Joe-Lin du Toit (cum laude) (female, white) / The modulation of various signal transduction pathways by docosahexaenoic acid in a colon carcinoma cell line./ Dec 2006 / Dr A-M Engelbrecht / 1 year
Benjamin Loos (cum laude) (male, white) / Signaling mechanisms involved in TNF-alpha mediated cytoprotection during ischaemic injury in a C2C12 muscle cell line. / Dec 2006 / Dr A-M Engelbrecht / 1 year
Louise Odendaal (female, white) / The effect of dietary red palm oil on the functional recovery and the PI3-Kinase pathway in the ischaemic/reperfused isolated rat heart. / Dec 2007 / Dr A-M Engelbrecht / Prof Jacques van Rooyen / 2 years
Balindiwe Sishi (female, black) / An investigation into the PI3-Kinase signaling pathway in TNF-alpha induced muscle proteolysis in L6 myotubes. / Dec 2008 / Dr A-M Engelbrecht / 1 year
Mark Thomas (cum laude) (male, white) / Hypoxia-induced apoptosis in cultured skeletal muscle cells: The role of the phosphatidylinositol 3-kinase signaling pathway. / Dec 2008 / Dr A-M Engelbrecht / 2 years
Martine van den Heever (female, white) / The effect of Curcumin treatment on apoptosis, necrosis and autophagy in the MCF-7 breast carcinoma cell line / April 2009 / Dr A-M Engelbrecht / 2 years
Michelle Vermeulen (cum laude) (female, white) / The role of MKP-1 in myocardial ischaemia/reperfusion (I/R) injury / Prof A-M Engelbrecht / Prof A Lochner / 1.5 years
Justin Mills (cum laude) (male, white) / The relationship between HIF-1 alpha and autophagic activity in the hypoxic environment of breast cancer. / Prof A-M Engelbrecht / Dr Ben Loos / 2 years
Heloise le Roux (cum laude) (female, white) / The role of MKP-1 in doxorubicin resistance in human breast cancer cells. / Prof A-M Engelbrecht / 2 years
Yogeshni Govender (female, Indian) / The role of short-term starvation in sensitizing breast cancer to doxorubicin-induced cell death. / Prof A-M Engelbrecht / Dr Ben Loos / 1 year
Megan Mitchell (cum laude) / Circadian autophagy rhythms in novel chemotherapeutic strategies for breast cancer. / Prof A-M Engelbrecht / 2 years
PhD
Ben Loos (male, white) / Cell death in severe hypoxic injury – signaling mechanisms and dynamics in the decision making process / Dr A-M Engelbrecht / 3 years
Mark Thomas (male, white) / Therapeutic nutrient starvation and breast cancer: The effect of increased basal autophagy on doxorubicin treatment regimes. / Prof A-M Engelbrecht / 3 years
Balindiwe Sishi (black female) / Anthracycline-induced cardiotoxicity- role of the ubiquitin-proteasome pathway( UPP) and autophagy / Prof A-M Engelbrecht / Dr B Loos, Prof J van Rooyen / 3 years
Gina Leisching (female, white) / An investigation into the various modes of cell death in the progressive stages of cervical carcinoma / Prof A-M Engelbrecht / Dr Ben Loos / 3 years
Derick van Vuuren (male, white) / The role of protein phosphatase 2A (PP2A) in myocardial ischaemia / reperfusion injury. / Prof A Lochner / Prof A-M Engelbrecht / 5 years
Suzél Hattingh / Ischaemic preconditioning: An investigation of the patterns of kinase activation and protein expression profiles during reperfusion in the rat heart / Prof S du Plessis / Prof A-M Engelbrecht, Dr R Salie
Mashudu Mudau (female, black) / Oxidative and nitrooxidative stress response of the endothelium to insult: does endothelial heterogeneity play a role in in vitro cell models? / Prof JG Strijdom / Prof A-M Engelbrecht / 4 years
5.2 CURRENT POST-GRADUATE STUDENTS
Name of Student / Degree / Title of dissertation / thesis / Supervisor / Co-supervisor / Year of Regis-tration
Honours
Daleen Conradie / BSc (Hons) / The cytotoxic effect of the Dodonaea viscosa plant extract on human breast cancer cells. / Prof A-M Engelbrecht / 2016
Claudia Christowich / BSc (Hons) / Investigation into the mechanismsof the tumour-promoting effects of doxorubicin in a murine breast cancer model. / Prof A-M Engelbrecht / 2016
Robert Henning / BSc (Hons) / Can melatonin inhibit doxorubicin induced atrophy in a murine breast cancer model? / Prof A-M Engelbrecht / 2016
MSc
PhD
Yogeshni Govender (indian, female) / PhD / Can melatonin counter-act the detrimental effects of doxorubicin-induced cardiotoxicity in a mouse xenograft model? / Prof A-M Engelbrecht / Dr Ben Loos / 2013
Ashwin Isaacs
(male, coloured) / PhD / Effect of melatonin on doxorubicin-induced skeletal muscle atrophy in a cancer model. / Prof A-M Engelbrecht / Dr Ben Loos, Prof Kathy Myburgh / 2013
Tanja Davis / PhD / Can melatonin prevent the onset of breast cancer in a mouse xenograft model? / Prof A-M Engelbrecht / Dr Ben Loos / 2013
Gustavus Van Niekerk / PhD / An investigation into the role of various cytokine polymorphisms in predicting cancer tolerance and resistance in an immune competent mouse model. / Prof A-M Engelbrecht / 2013
Zaakiyah Emjedi / PhD / An evaluation melatonin in an obese tumour-bearing mice model. / Prof A-M Engelbrecht / Dr B Loos / 2014
Yolandi Espach / PhD / An investigation into the importance of the ATM protein in the myocardial pathology associated with insulin resistance and type 2 diabetes. / Prof B Huisamen / Prof A-M Engelbrecht
Prof Hans Strijdom / 2013
Megan Mitchell / PhD / Metabolic reprograming and cancer resistance: An investigation into the metabolic control of cancer-associated fibroblasts on breast cancer cell survival / Prof A-M Engelbrecht / 2015
Marguerite Blignaut / PhD / An investigation into the role of ATM protein in the mitochondrial defects associated with the cardiovascular pathology resulting from insulin resistance. / Prof Barbara Huisamen / Prof A Lochner
Prof A-M Engelbrecht / 2016
Thandi Mcqoco / PhD / Chemoresistance and breast cancer sensitization in a 3D model. / Prof A-M Joubert (UP) / Dr B Stander (UP)
Prof A-M Engelbrecht / 2015
5.3 RESEARCH FUNDING
Origin of research funds / Title of research project or programme / Duration / Money allocated (R)
Promising Young Investigator (Vise-rector) / 2005-2007 / R150000.00
NRF Thuthuka programme / TNF-alpha induced signaling in mycytes / 2005 / R 291000.00
” / “ / 2006 / R 312000.00
“ / “ / 2007 / R 401720.00
“ / “ / 2008 / R 228000.00
Brenno-Kem (Pty) Ltd / The efficacy of grape-seed extract on cancer cell viability and the signaling mechanisms involved. / 2006 / R 50000.00
MRC (Collaboration with Prof Louise Louw, Free State University) / Adenomatous Colon Cancer: A lipid model and Mitogen-activated protein kinase signaling pathways / 2003-2006 / R150000.00/y
Sub Committee B and Dean US / Running expenses for projects / 2009 / R 80000.00
NUFU (Norway – South collaboration) / Anthracyclin-induced cardiotoxicity (collaboration Prof Jonassen and Prof van Rooyen) / 2009 / 211.580,00 NOK
MRC / Antracycline-induced cardiotoxicity- role of the ubiquitin-proteasome pathway (UUP) and autophagy / 2010-2012 / R130000.00 /y
CANSA / Therapeutic nutrient starvation and breast cancer. The effect of increased basal autophagy on doxorubicin treatment regimes. / 2010-2012 / R120000.00/y
SGKN-Trust / The role of MKP-1 in doxorubicin resistance in breast cancer cells. / 2011 / R40000.00
Discretionary Fund: Vice Rector / Active targeting in anti-tumour drug delivery – with Prof Bert Klumperman. / 2011 / R200000.00
(R100000.00 into my cost point)
CANSA / Can melatonin prevent the onset of breast cancer in a mouse xenograft model? / 2013-2015 / R200000.00/y
for 3 years
MRC / An evaluation of the intracellular mechanisms and apoptosis-inducing potential of punicic acid in breast cancer cell lines and in a tumour-bearing mice model. / 2014-2016 / R200000.00/y for 3 years
NRF / Bioinformatics and Functional Genomics: Cancer tolerance, Resistance, Pathogenicity and Virulence – deconstructing the disease state. / 2015-2016 / R200000.00 per year
NRF / Unraveling the mechanisms of resistance in breast cancer therapy / 2016-2018 / R329000.00
R394000.00
R345000.00

6. RESEARCH OUTPUTS

6.1Publications in peer-reviewed or refereed SCI journals

  1. The importance of linoleic acid in the total fatty acid composition of benign and malignant neurological tumors. L Louw, A-M Engelbrecht, F Cloete, JP van der Westhuizen G Joubert. Adv Exp Med Biol 1997. 400B: 919-924 [IF – 2.02]
  2. Linoleic acid levels in cutaneous tumors with different growth patterns as an additional sensitive diagnostic feature. L Louw, A-M Engelbrecht, F Cloete, JP van der Westhuizenm G Joubert. Adv Exp Med Biol 1997. 400B: 911-917 [IF – 2.02]
  3. Impairment in the fatty acid composition of keloids. L Louw, A-M Engelbrecht, F Cloete, JP van der Westhuizenm G Joubert. Adv Exp Med Biol 1997. 400B: 905-910 [IF – 2.02]
  4. Comparison of the fatty acids compositions of intraepithelial and infiltrating lesions of the cervix. I – The total fatty acid profiles. L Louw, A-M Engelbrecht and F Cloete. Prostaglandins Leukotrienes and Essential Fatty Acids 1998. 59 (4): 247-251 [IF – 2.361]
  5. Comparison of the fatty acids compositions of intraepithelial and infiltrating lesions of the cervix. II – The free fatty acid profiles. A-M Engelbrecht, L Louw and F Cloete. Prostaglandins Leukotrienes and Essential Fatty Acids 1998. 59 (4): 253-257 [IF – 2.361]
  6. Comparison of the fatty acids compositions of intraepithelial and infiltrating lesions of the cervix. III – Saturated and unsaturated fatty acid profiles. L Louw, A-M Engelbrecht and F Cloete. Prostaglandins Leukotrienes and Essential Fatty Acids 1998. 59: (4): 259-264 [IF – 2.361]
  7. p38-MAPK and JNK have distinct regulatory functions on hypoxia/reoxygenation-induced apoptosis in cardiomyocytes. Engelbrecht A-M, Niesler C, Page C and Lochner A. Basic Research in Cardiology 2004, 99:308-314 [IF – 5.973]
  8. Long-chain polyunsaturated fatty acids protect the heart against ischaemia/reperfusion-induced injury via a MAPK dependent pathway.Engelbrecht A-M, Engelbrecht P, Genade S, Niesler C, Page C, Smuts M and Lochner A, Molecular and Cellular Cardiology 2005, 39: 940-954 [IF – 4.965]
  9. p38-MAPK and PKB/Akt, possible role players in red palm oil-induced protection of the isolated perfused rat heart? A-M Engelbrecht, J Esterhuyse, EF du Toit, A Lochner, J van Rooyen, Journal of Nutritional Biochemistry 2006, 17(4): 265-271 [IF – 4.288]
  10. Ex vivo study of MAPK profiles correlated with parameters of apoptosis during cervical carcinogenesis. Engelbrecht A-M, Gebhardt S, Louw L, Cancer Letters 2006, 235(1): 93-99 [IF – 3.741]
  11. Dietary Red Palm Oil (RPO) reduces ischaemia/reperfusion injury in a hypercholesterolemic diet. Kruger M, Engelbrecht A-M, Esterhuyse J, du Toit EF, Van Rooyen J, British Journal of Nutrition, 2007, 97:653-660. [IF – 3.446]
  12. Proanthocyanidin from grape seeds inactivated the PI3-Kinase/PKB pathway and induces apoptosis in a colon cancer cell line. Engelbrecht AM, Mattheyse M, Ellis B, et al., Cancer Letters, 2007, 258: 144-153. [IF – 3.741]
  13. Apoptosis is mediated by cytosolic phospholipase A2 during simulated ischaemia/reperfusion-induced injury in neonatal cardiac myocytes. Engelbrecht AM, Ellis B, Prostaglandins Leukotrienes and Essential Fatty Acids, 2007, 77: 37-43. [IF – 2.361]
  1. Ischaemic preconditioning and TNF-alpha mediated preconditioning are associated with a differential cPLA2 translocation pattern in early ischaemia. B Loos, R Smith, AM Engelbrecht, Prostaglandins Leukotrienes and Essential Fatty Acids, 2008, 78(6):403-413. [IF – 2.361]
  2. Differential induction of apoptosis and inhibition of the PI3-Kinase pathway by saturated-, monounsaturated- and polyunsaturated fatty acids in a colon cancer cell model. AM Engelbrecht, J-L du Toit, L Louw. Apoptosis, 2008, 13(11):1368-1377. [IF – 4.066]
  3. Health benefits of a natural carotenoid rich oil: a proposed mechanism of protection against ischaemia/reperfusion injury (review). Van Rooyen J, Esterhuyse AJ, Engelbrecht AM, du Toit EF, Asia Pac J Clin Nutr, 2008, 17(1):316-319 [IF – 1.214]
  4. Cell death: A dynamic response concept.Loos B, Engelbrecht AM. Autophagy. 2009, Jul 17;5(5). [IF – 12.04]
  5. The effect of dietary Red Palm Oil on the functional recovery of the ischaemic/reperfused isolated rat heart: The involvement of the PI3-kinase signaling pathway.Anna-Mart Engelbrecht, Louise Odendaal, Eugene F. Du Toit, Kristina Kupai,Tamás Csont, Peter Ferdinandy, Jacques van Rooyen. Lipids in Health and Disease, 2009, 29;8:18. [IF – 2.141]
  6. Docosahexaenoic acid induces apoptosis in colorectal carcinoma cells by modulating the PI3 kinase and p38 MAPK pathways. Toit-Kohn JL, Louw L, Engelbrecht AM. JNutr Biochem. 2009 Feb;20(2):106-14. [IF- 4.288]
  7. Daily brief restraint stress alters signaling pathways and induces atrophy and apoptosis in rat skeletal muscle. Anna-Mart Engelbrecht, Carine Smith, Ian Neethling, Mark Thomas, Beverly Ellis, Mary Mattheyse, Kathryn Myburgh. STRESS, The International Journal on the Biology of Stress, 2010; 13(2): 132-141. [IF – 3.205]
  8. Diet-induced obesity alters signaling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model. Balindiwe Sishi, Ben Loos, Wayne Smith, Joss du Toit, Anna-Mart Engelbrecht. Experimental Physiology, 2011; 96(2):179-193. [IF- 3.168]
  9. Tumor Necrosis Factor Alpha (TNF-) inactivates the PI3-Kinase/PKB pathway and induces atrophy and apoptosis in L6 myotubes. Balindiwe Sishi, Anna-Mart Engelbrecht. Cytokine, 2011; 54(2):173-184. [IF - 3.125].
  10. At the core of survival: Autophagy delays the onset of both apoptotic and necrotic cell death in a model of ischemic cell injury. Loos B, Genade S, Ellis B, Lochner A, Engelbrecht A-M. Exp Cell Res, 2011; 317(10): 1437-1453.[IF - 3.580]
  11. Autophagy in heart disease: A strong hypothesis for an untouched metabolic reserve. Loos B, Lochner A, Engelbrecht A-M. Med Hypothesis, 2011: Jul77(1):52-57.[IF - 1.150]
  12. Dietary red palm oil protects the heart against the cytotoxic effects of anthracycline. Wergeland A, Bester DJ, Sishi BJ, Engelbrecht A-M, Jonassen AK, Van Rooyen J. Cell Biochem Funct, 2011; Jul29(5):356-364.[IF - 1.771]
  13. Daunorubicin therapy is associated with upregulation of E3 ubiquitin ligases in the heart. Sishi BJ, Bester D, Wergeland, A, Loos B, Jonassen A, van Rooyen J, Engelbrecht A-M. Experimental Biology and Medicine, 2012: 237:219-226.[IF- 2.526]
  14. Guidelines for the use and interpretation of assays for monitoring autophagy. Klionsky DJ, et al., Engelbrecht A-M. Autophagy, 2012: 8(4):1-100.[IF –12.04]
  15. Inhibition of Akt attenuates RPO-induced cardioprotection. Katengua-Thamahane E, Engelbrecht A-M, Esterhuyse AJ, van Rooyen J. Cardiology Research and Practice, 2012: 392457. Published online 2012 October 3 (doi:0.1155/2012/392457).
  16. Phosphatidylinositol-3-kinase (PI3K) activity decreases in C2C12 myotubes during acute simulated ischemia at a cost to their survival. Thomas MP, Mills J, Engelbrecht AM. Life Sci. 2012 Jul 26;91(1-2):44-53.[IF - 2.527]
  17. Autophagy upregulation promotes survival and attenuates doxorubicin-induced cardiotoxicity. BJN Sishi, B Loos, J van Rooyen, AM Engelbrecht. Biochemical Pharmacology 2013, 85:124-134.[IF - 4.405]
  18. Doxorubicin induces protein ubiquitination and inhibits proteasome activity during cardiotoxicity. BJN Sishi, B Loos, J van Rooyen, A-M Engelbrecht. Toxicology 2013, 309:23-29.[IF - 3.681]
  19. The variability of autophagy and cell death susceptibility – unanswered questions. B Loos, A-M Engelbrecht, D Klionsky, R Lockshin, Z Zakeri. Autophagy2013, 9(9):1-16.[IF – 12.04]
  20. AHNAK: The giant jack of all trades. Davis T, Loos B, Engelbrecht A-M. Cell Signal 2014, 26(12):2683-2693.[IF: 4.471]
  21. Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin. Govender J, Loos B, Marais E, Engelbrecht A-M.J Pineal Res 2014, 57(4): 367-380.[IF: 7.812].
  22. A Commentary on “A common origin for immunity and digestion”. Van Niekerk G and Engelbrecht A (2015). Front. Microbiol.6:531. doi: 10.3389/fmicb.2015.00531[IF: 3.9]
  23. On the evolutionary origin of the adaptive immune system-The adipocyte hypothesis. van Niekerk G, Engelbrecht AM. Immunol Lett. 2015 Apr;164(2):81-87. doi: 10.1016/j.imlet.2015.02.002. Epub 2015 Feb 16. Review.[IF: 2.367]
  24. A nontoxic concentration of cisplatin induces autophagy in cervical cancer: selective cancer cell death with autophagy inhibition as an adjuvant treatment.Leisching G, Loos B, Botha M, Engelbrecht AM. Int J Gynecol Cancer. 2015 Mar;25(3):380-8. doi: 10.1097/IGC.0000000000000365.[IF: 1.94]
  25. Melatonin: A protective role against doxorubicin-induced cardiotoxicity? Govender J, Loos B, Engelbrecht A-M. Future Oncology, July 2015[IF:2.611 ]
  26. Intermittent insulin treatment mimics ischemic postconditioning via MitoK-ATP channels, ROS and RISK. Helgeland E, Breivik L, Sishi B, Engelbrecht A-M, Jonassen AK. Scandinavian Cardiovascular Journal, 2015. Doi:10.3109/14017431.2015.1071494.[IF:1.104]
  27. Sutherlandia frutescens treatment induces apoptosis and modulates the PI3-kinase pathway in colon cancer cells. Leisching G, Loos B, Nell T, Engelbrecht A-M. South African Journal of Botany, 2015; 100, 20-26. [IF:0.978]
  28. The role of mTOR during cisplatin treatment in an in vitro and ex vivo model of cervical cancer. Leisching GR, Loos B, Botha MH, Engelbrecht A-M. Toxicology, 2015,
  29. Circadian Rhythms and Breast Cancer: The role of Per2 in Doxorubicin-induced cell death. Megan Mitchell, Anna-Mart Engelbrecht. Journal of Toxicology, 2015,
  30. Van Niekerk G, Davis T, Engelbrecht A-M. Was the evolutionary road towards adaptive immunity paved with endothelium? Biol Direct, 2015 Sept4; 10(1):47. DOI: 10.1186/S13062-015-0079-0. [IF:4.658]
  31. Leisching G, Loos B, Botha M, Engelbrecht A-M. Bcl-2 confers survival in cisplatin treated cancer cells: circumventing cisplatin dose-dependent toxicity and resistance. Journal of Translational Medicine, 2015 13:328. DOI 10.1186/s12967-015-0689-4.[IF: 3.694]
  32. van Niekerk G, Davis T, Engelbrecht AM. Bone marrow fat: What is it good for? Semin Arthritis Rheum. 2016 Apr;45(5):e14. doi: 10.1016/j.semarthrit.2015.09.011. Epub 2015 Oct 3.[IF: 3.946]
  33. van Niekerk G, Hattingh SM, Engelbrecht AM. Invertebrates: Why No Adaptive Immune System?Scand J Immunol. 2016 Feb;83(2):160-1. doi: 10.1111/sji.12400. [IF: 2.27]
  34. Klionsky DJ, et al., Engelbrecht A-M, et al.Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy. 2016 Jan 2;12(1):1-222. [IF: 12.04]
  35. van Niekerk G, Loos B, Nell T, Engelbrecht AM. Cancer tolerance, resistance, pathogenicity and virulence: deconstructing the disease state.Future Oncol. 2016 Mar 31. [Epub ahead of print][IF: 2.129]
  36. van Niekerk G, Loos B, Nell T, Engelbrecht AM. Autophagy-A free meal in sickness-associated anorexia.Autophagy. 2016 Apr 2;12(4):727-34. doi:10.1080/15548627.2016.1147672.[IF: 12.04]
  37. van Niekerk G, Isaacs A, Nell T, Engelbrecht A-M.Sickness-Associated Anorexia: Mother Nature’s Idea of Immunonutrition?Mediators of Inflammation, Volume 2016, Article ID 8071539, 12 pages, [IF: 3.236]

Bottom of Form

Google Scholar

Citation indices / All / Since 2011
Citations / 4747 / 4036
h-index / 17 / 15
i10-index / 25 / 21

Average Impact Factor of Journals:4.07

Average Impact Factor of Journals for past 5 years: 4.79

6.2Books and / or chapters in books

6.2.1Books

6.2.2Chapters in books (7)

FATTY ACIDS AND CANCER: AN OVERVIEW OF THIRTY YEARS OF RESEARCH

  • Part I: The epidemiological evidence, Contributing authors: J-L du Toit, T Nell, A-M Engelbrecht, Dept of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa
  • Part II: The modulation of signaling pathways and the induction of apoptosis by fatty acids, A-M Engelbrecht, Dept of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa
  • Part III: An overview on clinically relevant fatty acids and rationale for adjuvant fatty acid therapy, L Louw, University of the Free State, Bloemfontein South Africa

In: LAP LAMBERT Academic Publishing, 2013: AV Akademikerverlag GmbH& Co. KG, Heinrich-Böcking-Str. 6-8,66121, Saarbrücken, Germany, ISBN 978-3-659-36348-1