Molecular Mechanisms and Physiological

Consequences of Protein Aggregation

June 21stto June 26th

Palm Beach, Florida

Organizers:

Matthew Chapman

University of Michigan, Ann Arbor, Michigan

and

Roland Riek

ETH Zurich, Switzerland

Sunday, June 21, 2015

Time / Title/Topic Event
4:00 p.m. to 9:00 p.m. / Conference Registration
Keynote Lecture / Sue Lindquist, MIT
Keynote Lecture / Virginia Lee, University of Pennsylvania
Welcome Mixer?

Monday, June 22, 2015

Time / Title/Topic Event
08:00 am to 9:00 pm / Conference Registration
08:00 am to ? / Session 1; Amyloid Structure
Session Chair and Speaker
“Micro Crystals Reveal Mega Insights into Amyloid Structure” / David Eisenberg, UCLA
Speakers
“Using Solid State NMR to Probe the Functional Amyloid State” / Christiane Ritter, Helmholtz Center for Infection Research
“High Resolution Structural Insights into Distinct Amyloid Species Derived from the Same Peptide” / Stephen Meredith, U. of Chicago
“3-Dimensional Structural Studies of Pathogenic Amyloids” / Beat Meier, ETH Zurich
coffee break
short talks selected from abstracts
Lunch
Session 2; Mechanisms of Protein Aggregation in Vitro
Session Chair and Speaker
“Molecular Insights into Cooperative Protein Folding” / Jane Clark, Cambridge
Speakers
“Protein Aggregation from Theory to Reality” / Tuomas Knowles, Cambridge
“Protein Aggregation of Beta-Microglobulin at the Atomic Level” / Sheena Radford, Leeds
”The Molecular Theory of Protein Aggregation” / RohitPappu, Washington University
short talks selected from abstracts

Tuesday, June 23, 2015

Time / Title/Topic Event
08:00 am / Session 3; Ordered Protein Aggregation and Nanotechnology
Session Chair and Speaker
“The Amyloid World Hypothesis” / Ehud Gazid, Tel Aviv University
Speakers
“Amyloid Nanotubes” / John Tovar, John Hopkins
“Replication of Amyloids in vitro and in vivo” / Claudio Soto, University of Texas at Houston
“Using Designer Gamma Bodies to Probe Amyloid Assembly” / Peter Tessier, RPI
coffee break
short talks selected from abstracts
Lunch
Session 4; Functional Amyloid
Session Chair and Speaker
“Putting Yeast Prions to Work” / Tricia Serio, University of Arizona
Speakers
“Diversity and Biogenesis of Microbial Amyloids” / Daniel Otzen, Aarhus University
“Long Term Memory Potentiation” / Eric Kandel, Columbia University
“The Biology of Hydrophobins” / Margaret Sunde, University of Sidney
short talks selected from abstracts

Wednesday, June 24, 2015

Time / Title/Topic Event
08:00 am to ? / Session 5; Proteotoxicity and Aging
Session Chair and Speaker
“What Goes Wrong in Amyloid-Related Toxicity” / Ralf Langen, USC
Speakers
“Toxicity of Cellular Protein Aggregates” / Bill Balch, Scripps Research Institute
“The Mechanism of Toxicity of Mammalian Prions” / Adriano Aguzzi, University of Zurich
“In vivo NMR of α-synuclein Reveals Structure and Toxicity Relationships” / Phil Selenko, FMP Berlin
coffee break
short talks selected from abstracts
Lunch
Session 6; Mechanisms of In VivoAmyloidogenesis
Session Chair and Speaker
“In vivo Amyloid Formation” / HilalLasheuel, ETH Zurich
Speakers
“Amyloid-Induced Proteostatic Meltdown” / Rick Morimoto, Northwestern University
“Mass Spectrometry on Living Cells” / Paula Picotti, ETH Zurich
“How Protein Aggregates are Cleared by the Autophagy System” / Ron Kopito, Stanford
short talks selected from abstracts

Thursday, June 25, 2015

Time / Title/Topic Event
08:00 am to 9:00 pm / Conference Registration
08:00 am to ? / Session 7; Cellular Response and Pathogenesis
Session Chair and Speaker
“Cellular Responses to Protein Aggregation” / Andy Dillin, UC Berkeley
Speakers
“Flavenoids can Reset Protein Homeostasis in Aging” / Pam Maher, Salk Institute
“Interaction Maps of the Protein Network” / Jonathan Weissman, UCSF
“Cellular Checkpoints in the Protein Folding Network” / Lila Gierasch, University Mass Amherst
coffee break
short talks selected from abstracts
Lunch
Session 8; Mechanisms of In Vivo Amyloidogenesis
Session Chair and Speaker
“Toxicity of α-Synuclein to Membranes” / Andrew Miranker, Yale University
Speakers
“Moving Amyloid Deposits Between Cells” / Marc Diamond, Washington University
“Fighting Fire with Fire: Amyloid Interruption of Amyloid Formation” / Joel Buxbaum, Scripps Research Institute
“Extracellular Amyloids Produced by Staph cause Membrane Toxicity” / Blaise Boles, University of Iowa
short talks selected from abstracts

Friday, June 26, 2015

Time / Title/Topic Event
08:00 am to ? / Session 9; Therapeutic Interventions
Session Chair and Speaker
“Chemical and Biological Strategies that Adapt the Proteostasis Network to Ameliorate Amyloid Toxicity” / Jeff Kelly, Scripps Research Institute
Speakers
“Mechanism of Amyloid Beta Aggregation and the Role of Natural Inhibitors” / Sara Linse, Lund University
“Small Molecules that Inhibit Amyloid Formation” / David Schubert, Salk Institute
“Rational Design of Small Molecules that Ameliorate α-synuclein Toxicity” / Fredrik Almqvist, Umea University
coffee break
short talks selected from abstracts

END OF CONFERENCE

For additional information contact:

FASEB Science Research Conferences

9650 Rockville Pike

Bethesda, MD 20814

30 October 2018