ADVANTAGES OF NEOCOTA OVER OTHER COATING SYSTEMS
AVAILABLE LOCALLY
NEOCOTA has several advantages over other Coating Systems locally available. Some of the main advantages are as follows :-
1. NEOCOTA has an unique pan geometry which facilitate uniform rolling of all the tablets in the Pan, which ultimately results into high degree of uniform coating.
2. NEOCOTA Pan has an increased perforated area when compared with other Coating Systems and so in NEOCOTA Pan increased number of Spray Guns can be accommodated, as a result faster coating can be achieved.
3. Due to increased perforated area, velocity of the drying air passing through the Pan is less. Due to this lower velocity, contact time between the tablet bed and the drying air is more and drying efficiency of the NEOCOTA Pan is higher than the other Coating Systems available. This better drying efficiency also results in minimum coating time.
4. Lower velocity of the drying air passing through the tablet bed also ensures minimum loss of coating materials.
5. NEOCOTA Pan is equipped with indigenously developed cylindrical baffles. Combined with the geometry of the Pan, this baffle design ensures thorough mixing of the tablet, uniform rolling and gentle treatment of the tablet during rolling. This results into high degree of uniformity of the coated products, elimination of damages to the tablets even having poor hardness and friability. This also eliminates chances of colour variation of the coated products.
6. NEOCOTA is equipped with unique spray system, which can perform aqueous and non-aqueous film coating without any change in the System. The air atomized spray System ensures elegant surface finish and eliminates the chances of all sorts of defects in film coated products.
7. NEOCOTA is quipped with self-diagnostic Alarm Annunciation System for easy and fast detection of any fault in the System for immediate rectification.
BRIEF HISTORY OF SIGNIFICANT ACHIEVEMENTS OF NEOMACHINE
IN THE FIELD OF DEVELOPMENT OF AUTOMATIC COATING SYSTEM
1. In the early 80s, Neomachine was pioneer to start developing Automatic Coating System to meet the urgent need of pharmaceutical industry in India offering cost-effective solution for efficient film coating of emerging pharmaceutical products.
2. Development of Pan Coating System to coat pellet products such as, Omiprazole, Nansiprazole etc. which provided tremendous boost to some of Indian pharmaceutical companies such as, Dr. Reddy’s Laboratories Ltd.
3. Design and manufacture of 1000 kgs. batch capacity Automatic Sugar Coating System for confectionary products such as, Chewing Gum etc. for Warner Lambert (India) Ltd. , Wrigleys (India) Ltd. as well as coating of chocolate
centres (Gems) for M/s. Cadbury India Ltd.
4. Exporting Automatic Coating System of various models to 30 foreign countries in Asia, Africa, Latin America, Europe etc. which are working satisfactorily for a long period of time.
5. Development of multi-pan R & D Model of Automatic Coating System having a minimum batch size of 500 gms. first time in India. Subsequently, multi-pan Coating System for pilot study as well as small volume commercial coating up to 75 kgs. batch size were also developed and supplied to many clients in India and abroad.
Multi-pan R & D Model of NEOCOTA is most popular R & D Coating System in India today.
6. Very recently, Neomachine has developed a R & D Model capable of coating a very low batch size of 50 grams of tablets at a time which has been considered as a breakthrough in pan coating technology even by renowned experts in the field of pharmaceutical coating. This miniature coating unit suitable for research and development have been offered to some of our clients for successful demonstration at our Kolkata factory and one similar unit has been bought by M/s. Johnson and Johnson Ltd., Mumbai already.
Till now, the internationally available R & D Model could coat a minimum batch size of 250 grams only.
7. Developed first time in India suitable Automatic Coating System for tablets made of potent drugs such as, hormone, onco care drugs etc. with all the provision for contamination free loading and unloading of uncoated and coated tablets along with total contamination free operation during coating to ensure safety of operator and other personnel present in the coating area. The System was also made suitable for containment of all the potent drugs coming out with the exhaust air by use of suitable cleaning system including cartridge type Bag Filter, Wet Scrubber, Buffer Chamber with Demister Pad, HEPA Filter etc. We have also supplied such critical units for coating of potent drugs including hormone to reputed companies such as Cipla Ltd., Cadila Healthcare Ltd., Johnson & Johnson Ltd. etc.
8. NEOCOTA Coating System is only reliable equipment with a track record of
successful sugar coating of various pharmaceutical products including sensitive and hygroscopic products such as multi vitamin tablets, aurvedic and herbal products for The Zandu Pharmaceuticals Ltd., Charak Pharma Pvt. Ltd., The Himalaya Drug etc.
GENERAL FEATURES OF NEOCOTA DESIGN
I. INTRODUCTION :-
NEOCOTA Coating System was designed without any effort to copy any Coating System available internationally in early eighties.
With the growing need for suitable system for efficient and cost effective FILM coating of pharma industry in India, Neomachine in Kolkata started development of Automatic Coating System through in house research to manufacture a Coating System which can meet the urgent need of Indian Pharma Industry to introduce new drugs in tablet form such as Ibuprofen, Norfloxin, Siprofloxcin, Metranidazole, Tinidazole and other products.
II. DESIGN FEATURES :-
During the inception of the basic design parameters it was realized that for efficient and uniform FILM coating of tablets the following processes and their mutually contributive factors are vitally necessary :-
i) Rolling or Tumbling of tablets of various sizes and shapes in the coating pan.
ii) Intermixing of tablets in the coating pan.
iii) Variable speed of the pan to achieve the above mentioned flexible operation during coating.
iv) Measured and appropriate spray of coating solution to the tablet bed during coating process.
v) To introduce drying air at different temperature and humidity to continuous drying of tablets by evaporating the solvent (organic or aqueous) used to prepare the coating solution.
vi) For efficient drying and maximize the use of energy spent to heat the drying air the contact time between the drying air and tablets to be increased to the maximum possible level.
vii) Due to increased drying efficiency, the coating time required is kept to a minimum which ensures less abrasion and damage to the tablet surfaces due to reduced duration of moving tablets remains inside the pan.
viii) Due to increased contact time of the drying air with the tablet bed, drying air temperature can be kept at a lower optimum level and most of the coating solution which is sprayed on the tablet bed gets dried on surfaces of the tablets rather than being sprayed dried and escape with the exhaust air which in turns minimize the loss of coating materials.
ix) Due to less coating materials in the exhaust air, cleaning of the exhaust air through a Wet Scrubber or a suitable Bag Filter becomes more easier and protection of environment from the escape of the foreign materials from the Coating System makes the coating operation more environment friendly.
x) In NEOCOTA, the built-in cleaning system (C.I.P.) is designed in such a way with the help of multi-stage high pressure water pump, strategically placed jet nozzles and inter-connecting piping, tubing, valves and fittings, that even in the case of colour change and product change the cleaning cycle remains almost same as normal cleaning cycle which is routinely followed for maintenance of the Coating Unit.
xi) Due to optimization of the spray, drying, rolling and mixing of tablets etc. not only final finishing of the tablets are more elegant reduced due to reduced demand of utilities, coating cost is kept at a minimum level.
xii) In NEOCOTA, as a design strategy the product which is taken for coating inside the pan is protected from damage under all possible enforseen events. The coating process is discontinued by use of suitable interlocks and automatic stoppage of different functions in the event of possible damage to the tablets coated inside the pan.
xiii) During the development and design of NEOCOTA, various major and minor parameters which can affect the coating performance of the System where analyzed and during design and execution of the Coating System, the parameters vital for performance and efficiency of the coating are taken into consideration. A list of those parameters is enclosed for your kind reference.
xiv) With the supply of the NEOCOTA Coating System, all the necessary documents required for validation of the System during installation, commissioning and operation are supplied in systematic manner in form of a document file. We also provide factory acceptance test format, DQ format etc. along with the comprehensive instruction for operation and maintenance of Coating System and various components used.
xv) During the installation and commissioning of the Coating System our Service Engineers impart sufficient and effective training to the operators and maintenance staff of the client factory so that, they can independently operate and maintain the Coating System during its lifetime.
NEOMACHINE MFG. CO. PVT. LTD.
39/2A, PURNA DAS ROAD
KOLKATA – 700 029
LIST OF USERS OF “NEOCOTA” THE AUTOMATIC COATING SYSTEM
SL. YEAR OF
NO. NAME OF CLIENTS SUPPLY MODEL
01. EAST INDIA PHARMACEUTICAL WORKS LTD. 1984 NEOCOTA 15A
KOLKATA
02. CIPLA LTD. 1985 NEOCOTA 24A
MUMBAI CENTRAL
03. CIPLA LTD. 1986 NEOCOTA 60A
PATALGANGA, MAHARASHTRA
04. B.I.R.I. LTD. 1986 NEOCOTA 15A
KOLKATA
05. LUPIN LABORATORIES LTD. 1987 NEOCOTA 48A
AURANGABAD
06. RANBAXY LABORATORIES LTD. 1987 NEOCOTA 24A
NEW DELHI
07. ALBERT DAVID LTD. 1988 NEOCOTA 36A
KOLKATA
08. CAREWS PHARMACEUTICALS LTD. 1989 NEOCOTA 24A
SREERAMPORE, WEST BENGAL
09. BIDDLE SAWYER LTD. 1989 NEOCOTA 36A
MUMBAI
10. NICHOLAS LABORATORIES INDIA LTD. 1989 NEOCOTA 24A
MUMBAI
11. RANBAXY LABORATORIES LTD. 1989 NEOCOTA 36A
DEWAS, M.P.
12. AMERICAN REMEDIES LTD. 1990 NEOCOTA 36A
CHENNAI
13. CYNAMID INDIA LTD. 1990 NEOCOTA 24A
GUJARAT
- 2 -
SL. YEAR OF
NO. NAME OF CLIENTS SUPPLY MODEL
14. EAST INDIA PHARMACEUTICAL WORKS LTD. 1990 NEOCOTA 36A
KOLKATA
15. TAMILNADU DADHA PHARMACEUTICALS LTD. 1990 NEOCOTA 48A
CHENNAI
16. NATIONAL LABORATORIES LTD. 1990 NEOCOTA 24A
BANGLADESH
17. TTK PHARMA LTD. 1991 NEOCOTA 36A
HYDERABAD
18. F.D.C. LTD. 1991 NEOCOTA 36A
MUMBAI
19. OSCAR HEALTH CARE PVT. LTD. 1991 NEOCOTA 36A
NEW DELHI
20. AMERICAN REMEDIES LTD. 1991 NEOCOTA 36A
CHENNAI
21. RANBAXY LABORATORIES LTD. 1992 NEOCOTA 15A
DEWAS, M.P.
22. PFIMEX INTERNATIONAL LTD. 1992 NEOCOTA 36A
HYDERABAD
23. OSCAR LABORATORIES LTD. 1992 NEOCOTA 48A
NEW DELHI
24. RECKITT & COLMAN OF INDIA LTD. 1992 NEOCOTA 36A
KOLKATA
25. PARKE-DAVIS INDIA LTD. 1992 NEOCOTA 60A
HYDERABAD
26. DOLPHIN LABORATORIES LTD. 1993 NEOCOTA 36A
KOLKATA
27. TORRENT LABORATORIES LTD. 1993 NEOCOTA 15A
AHMEDABAD
- 3 -
SL. YEAR OF
NO. NAME OF CLIENTS SUPPLY MODEL
28. DR. REDDY’S LABORATORIES LTD. 1993 NEOCOTA 48A
HYDERABAD ( for Pellet Coating )
29. COLORCON AISA LTD. 1993 NEOCOTA 15A
MUMBAI (Tablet and Pellet)
30. PARKE-DAVIS INDIA LTD. 1993 NEOCOTA 60A
HYDERABAD ( for Chiclet Coating)
31. AMERICAN REMEDIES LTD. 1993 NEOCOTA 36A
CHENNAI
32. PARKE-DAVIS INDIA LTD. 1994 NEOCOTA 60A
HYDERABAD ( for Chiclet Coating)
33. DR. REDDY’S LABORATORIES LTD. 1994 NEOCOTA 60A
HYDERABAD
34. UNICORN PHARMACEUTICALS LTD. 1994 NEOCOTA 36A
CHENNAI
35. RAM PHARMACEUTICAL INDUSTRIES 1994 NEOCOTA 15A
CO. LTD.
JORDAN
36. AMPHARCO PHARMACEUTICALS 1994 NEOCOTA 48A
U.S.A.
37. RAM PHARMACEUTICALS INDUSTRIES 1994 NEOCOTA 36A
CO. LTD.
JORDAN
38. CITYPHARM PHARMACEUTICAL 1994 NEOCOTA 36A
INDUSTRIES
SUDAN
39. RANBAXY LABORATORIES LTD. 1994 NEOCOTA 48A
NEW DELHI (FOR EXPORT TO CHINA)
40. RANBAXY LABORATORIES LTD. 1994 NEOCOTA 48A
NEW DELHI (FOR EXPORT TO CHINA)
- 4 -
SL. YEAR OF
NO. NAME OF CLIENTS SUPPLY MODEL
41. DR. REDDY’S LABORATORIES LTD. 1994 NEOCOTA 15A
HYDERABAD ( for Pellet Coating )
42. TORRENT PHARMACEUTICALS LTD. 1994 NEOCOTA 48A
AHMEDABAD ( for Pellet Coating)
43. DR. REDDY’S LABORATORIES LTD. 1994 NEOCOTA 60A
HYDERABAD
44. J. K. INDUSTRIES LTD. 1994 NEOCOTA 24A
NEW DELHI
45. LEOSCOR EXPORTS 1994 NEOCOTA 24A
MUMBAI (FOR EXPORT TO BANGLADESH)
46. U S V LIMITED 1994 NEOCOTA 48A
MUMBAI
47. DOLPHIN LABORATORIES LTD. 1994 NEOCOTA 36A
MUMBAI
48. THE ACME LABORATORIES LTD. 1994 NEOCOTA 48A
BANGLADESH
49. LYKA LABORATORIES LTD. 1994 NEOCOTA 36A
MUMBAI
50. GACO PHARMACEUTICALS LTD. 1994 NEOCOTA 36A
BANGLADESH
51. PARKE-DAVIS INDIA LTD. 1994 NEOCOTA 60A
HYDERABAD ( for Chiclet Coating)
52. TAMILNADU DADHA PHARMACEUTICALS LTD. 1994 NEOCOTA 60A
CHENNAI
53. BOOTS PHARMACEUTICALS LTD. 1994 NEOCOTA 15A
MUMBAI
54. AMERICAN REMEDIES LTD. 1995 NEOCOTA 36A
CHENNAI
- 5 -
SL. YEAR OF
NO. NAME OF CLIENTS SUPPLY MODEL
55. CADBURY INDIA LTD. 1995 NEOCOTA 60A
MUMBAI ( for Gems Coating )
56. CADBURY INDIA LTD. 1995 NEOCOTA 60A
MUMBAI ( for Gems Coating )
57. CADBURY INDIA LTD. 1995 NEOCOTA 60A
MUMBAI ( for Gems Coating )
58. CADBURY INDIA LTD. 1995 NEOCOTA 60A
MUMBAI ( for Gems Coating )
59. VISTA PHARMA LTD. 1995 NEOCOTA 36A
HYDERABAD
60. NATCO PHARMA LTD. 1995 NEOCOTA 48A
HYDERABAD
61. NATCO PHARMA LTD. 1995 NEOCOTA 48A
HYDERABAD ( for Pellet Coating )
62. HOECHST INDIA LTD. 1995 NEOCOTA 15A
MUMBAI
63. CHEMINOR DRUGS LTD. 1995 NEOCOTA 15A
HYDERABAD
64. U S V LIMITED 1995 NEOCOTA 15A
MUMBAI
65. GLOBEX PHARMACEUTICALS LTD. 1995 NEOCOTA 36A
BANGLADESH
66. HETERO DRUGS LTD. 1995 NEOCOTA 48A
HYDERABAD ( for Pellet Coating )
67. CHEMINOR DRUGS LTD. 1995 NEOCOTA 24A
HYDERABAD
68. KOPRAN LTD. 1995 NEOCOTA 36A
MUMBAI
- 6 -
SL. YEAR OF
NO. NAME OF CLIENTS SUPPLY MODEL
69. CARYL PHARMA PVT. LTD. 1995 NEOCOTA 48A BANGALORE
70. HAMDARD (WAKF) LABORATORIES LTD. 1996 NEOCOTA 48A GHAZIABAD
71. CHEMINOR DRUGS LTD. 1996 NEOCOTA 48A
HYDERABAD
72. CHEMINOR DRUGS LTD. 1996 NEOCOTA 48A
HYDERABAD