Platelet Rich Plasma(P-PRP-ACP, ACS, L-PRP)

References- October 2012

Platelet Rich Plasma(p-PRP-ACP, ACS, L-PRP)

1.)Anitua E, Sanchez M, Nurden AT, Zalduendo MM, de La Fuente M, Azofra J, Andia I. Platelet Released Growth Factors Ehnace the Secretion of Hyaluronic Acid and Induce Hepatocyte Growth factor in Ostoarthritic Patients. Rheumatology. 2007 Dec. 46(12)

PRP increases hyaluronic acid production by synovial cells but does not halt the effects of IL-1beta(+)

2.)Baboldashti NZ,*1"* MSc, Raewyn C. Poulsen,* PhD, Sarah L. Franklin,* PhD,

Mark S. Thompson,1"* MEng, PhD, and Philippa A. Hulley,* PhD. Platelet-Rich Plasma Protects Tenocytes From Adverse Side Effects of Dexamethasone and Ciprofloxacin. American Journal of Sports Medicine, Vol. 39, No. 9

Ciprofloxacin can cause tenocyte cell death, dexamethasone can cause tenocyte senescence- PRP protects(+)

3.)Baltzer AWA M.D.f, C. Moser M.D.f, S. A. Jansen M.D.§ and R. Krauspe M.D4. Autologous conditioned serum (Orthokine) is an effective treatment for knee Osteoarthritis. Osteoarthritis and Cartilage (2009) 17,152-160

Autologous conditioned serum (ACS) was developed inthe mid-1990s in an attempt to generate an injectablematerial enriched in endogenous IL-1 Ra as a novel therapeuticfor OA. Meijer eta/.27 noted that exposure of bloodto glass beads elicits a vigorous, rapid increase in thesynthesis of several anti-inflammatory cytokines, includingll_-1Ra. This observation is the basis for producing ACS,which is injected into the affected joint in a series of six intra-articular injections given twice a week for 3 Weeks-, 2 year follow-up(+)

4.)Barber AF, M.D., Scott A. Harnack, M.D., Stephen J. Snyder, M.D., and OnurHapa, M.D. Rotator Cuff Repair Healing Influenced by Platelet-Rich Plasma Construct Augmentation. Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 27, No 8 (August), 2011: pp 1029-1035

Lower re-tear rates(+)

5.)Beck J, Evans D, Tonino P, Yong S, Callaci JJ. The Biomechanical and Histologic Effects of Platelet-Rich Plasma on Rat Rotator Cuff Repairs. Am J Sports Med. Vol. 40 No. 9, 2012

Notes non PRP groups had higher failure strain at 7 days, PRP higher at 21 days, PRP had higher fibroblastic response and vascular response at each time and PRP had more linear aligned fibers at 21 days(+), aids in being cautious for the first 3 weeks with post-op therapy(+)

6.)Bergeson AG,* MD, Robert Z. Tashjian,*1" MD, Patrick E, Greis,* MD,JuliaCrim;* MD, Gregory J. Stoddard,* MPH, and Robert T. Burks,** MD. Effects of Platelet-Rich Fibrin Matrix on Repair Integrity of At-Risk Rotator Cuff Tears. American Journal of Sports Medicine, Vol. 40, No. 2

PRFM(Cascade) did not help re-tear rates and did not increase functional outcome(-)

7.)Carofino B, M.D., David M. Chowaniec, B.S., Mary Beth McCarthy, B.S.,James P. Bradley, M.D., Steve Delaronde, M.P.H., M.S.W., Knut Beitzel, M.D.,Mark P. Cote, P.T., D.P.T., Robert A. Arciero, M.D., and Augustus D. Mazzocca, M.S., M.D. Corticosteroids and Local Anesthetics Decrease Positive Effectsof Platelet-Rich Plasma: An In Vitro Study on HumanTendon Cells. Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 28, No 5 (May), 2012: pp 711-719

local anesthetics and steroids decrease cell proliferation and viability of tenocytes with prp(neutral)

8.)Castillo TN,* Michael A. Pouliot,* MD, HyeonJoo Kim,* PhD, and Jason L. Dragee,*1" MD. Comparison of Growth Factor and Platelet Concentration From Commercial Platelet-Rich Plasma Separation Systems. American Journal of Sports Medicine, Vol. 39, No. 2

Various systems make various concentration(neutral)

9.)Castricini R,* MD, Umile Giuseppe Longo,1" MD, MSc, Massimo De Benedetto,* MD,NicolaPanfoli,* MD, PiergiorgioPirani,* MD, Raul Zini,* MD,Nicola Maffulli,§11 MD, MS, PhD, FRCS(Orth), and Vincenzo Denaro,1 MD. Platelet-Rich Plasma Augmentation for Arthroscopic Rotator Cuff Repair. e American Journal of Sports Medicine, Vol. 39, No. 2

PRFM did not improve healing of rotator cuff repair(-)

10.)de Almeida AM, MD, MS, Marco Kawamura Demange, MD, PhD,MarcelFaracoSobrado, Marcelo Bordalo Rodrigues, MD, Andre Pedrinelli MD, PhD, and Arnaldo Jose Hernandez MD, PhD. Patellar Tendon Healing With Platelet-Rich Plasma. American Journal of Sports Medicine, Vol. 40, No, 6

PRP, 7x baseline, showed decreased pain, better healing of patellar ligament donor site for ACL(+)

11.)de Jonge S,*1"* MD, Robert J. de Vos,* MD, PhD, Adam Weir,* MD, Hans T. M. van Schie,t§ DVM, PhD, Sita M. A. Bierma-Zeinstra^11 PhD, Jan A. N. Verhaar,1" MD, PhD, Harrie Weinans,1"11 PhD, and Johannes L Tol,* MD, PhD. One-Year Follow-up of Platelet-Rich Plasma

Treatment in Chronic Achilles Tendinopathy.American Journal of Sports Medicine, Vol. 39, No.

Biomet PRP, no difference in outcomes and ultrasonography_subjective(-)

12.)DeLong MJ, B.Sc., Ryan P. Russell, M.A., and Augustus D. Mazzocca, M.S., M.D. Platelet-Rich Plasma: The PAW Classification System. Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 28, No 7 (July), 2012: pp 99S-I009

Classification includes platelet numbers, activation and white blood cell count(Neutral)

13.)Dragoo JL,*1" MD, Hillary J. Braun. Comparison of the Acute Inflammatory ! Response of Two Commercial Platelet-RichPlasma Systems in Healthy Rabbit Tendons. The American Journal of Sports Medicine, Vol. 40, No.

5 days after injections L-PRP more inflammation than Cascade, at 14 days the same(-/+)

14.)Ehrenfest DMD, Lars Rasmusson and Tomas Albrektsson. Classification of platelet concentrates:

from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRP). Trends in Biotechnology Vol.27 No.3, 2009

Classification System of PRP(neutral)

15.)Fallouh L, MD, PhD, Koichi Nakagawa, MD, PhD, TakahisaSasho, MD, PhD, Momoko Aral, ME,

SotaKitahara, MD, PhD, Yuichi Wada, MD, PhD, Hideshige Moriya, MD, PhD, Kazuhisa Takahashi, MD, PhD. Effects of Autologous Platelet-Rich Plasma on Cell Viability and Collagen Synthesis inInjured Human Anterior Cruciate Ligament. J Bone Joint Surg Am. 2010;92:2909-16

PRP enhanced cell viability , number and ACL extracellular collagen(+)

16.)Filardo G, Kon E. Platelet Rich Plasma Injections for Degenerative Cartilage lesions and Osteoarthritis.KneeSurg Sports Traumatology, 2011 19:528-535

PRP effective in alleviating symptoms up to 24 months, fell off around 9-12 months(+)

17.)Foster TE, *f MD, Brian L Puskas,1" MD, Bert R. Mandelbaum,* MD, Michael B. Gerhardt,* MD, and Scott A, Rodeo,§ MD. Platelet-Rich Plasma From Basic Science to Clinical Applications. American Journal of Sports Medicine, Vol. 37, No. 11, 2009

Review- initially anti-doping agencies against but now have switched(+)

18.)Fratalocchi F, PHT, Alessandra Milani, MS, and Franco Postacchini,

Hyunchul Jo C,*1" MD, JiEun Kim,1" MS, Kang Sup Yoon,1 MD, and Sue Shin,* MD. Platelet-Rich Plasma Stimulates Cell Proliferation and Enhances Matrix Gene Expression and Synthesis in TenocytesFrom Human Rotator Cuff Tendons With Degenerative Tears. American Journal of Sports Medicine, Vol. 40, No. 5

PRP stimulated tenocyte cell proliferation and production of tendon extracellular matrix(+)

19.)Getgood A, Henson F, Skelton C, herrara E, Brooks R, Fortier L, Rushton N. The Augmentation of a Collagen/Glycosaminoglycan Biphasic Osteochondral Scaffold with Platelet-Rich Plasma and Concentrated Bone Marrow Aspirate for Osteochondral Defect Repair in Sheep. Cartilage 3(4), 2012 351-363

PRP creates better hyaline-like cartilage than controls, PRP/BMAC better hyaline-like cartilage than controls and less subchondral bone cyst formation(+)

20.)Gosens T,*"1" MD, PhD, Joost C. Peerbooms,* MD, Wilbert van Laar,* and Brenda L, den Oudsten,1". Ongoing Positive Effect of Platelet-Rich Plasma Versus Corticosteroid Injection in Lateral Epicondylitis. American Journal of Sports Medicine, Vol. 39, No. 6, 2011

PRP better than cortisone even at 2 years(+)

21.)Gumrna S, MD, PhD, Vincenzo Campagna, MD, Giancarlo Ferrazza, MD, Giuseppe Giannicola, MD. Use of Platelet-Leukocyte Membrane in Arthroscopic.Repair of Large Rotator Cuff Tears. J BoneJointSurgAm. 2D12;94:1345

PRP improves repair integrity(+)

22.)Harrison S,* Patrick Vavken,* MD, Sherwin Kevy,f MD, May Jacobson,* PhD, David Zurakowski,* PhD, and Martha M, Murray,** MD. Platelet Activation by Collagen Provides Sustained Release of Anabolic Cytokines. AJSM, 2011

Collagen sustains a release, thrombin immediate(neutral)

23.)Kisiday JD, C., Wayne Mcllwraith, William G. Rodkey, David D. Frisbie, J.Richard Steadman. Effects of Platelet-Rich Plasma Composition on Anabolic and Catabolic Activities inEquine Cartilage and Meniscal Explants. Cartilage.3(3) 245-254

Suggests that Leukocytes may not be good for joints- IL-1beta its effect? Not solid study-in vitro(?)

24.)Majewski,*1" MD, Peter E. Ochsner,* MD, Fanjun Liu,§ PhD, Rudolf Fluckiger,§ PhD,

and Christopher H. Evans,§ PhD. Accelerated Healing of the Rat Achilles

Tendon in Response to Autologous

Conditioned Serum AM J Sports Med, Vol. 37 No. 11, 2009

ACS makes tendon stronger(+)

25.)Mazzocca AD,*f MS, MD, Mary Beth R. McCarthy,1" BS, David M. Chowaniec,f Evan M. Dugdale,f Derek Hansen,1" MD, Mark P. Cote,1 DPT, James P. Bradley,* MD,Anthony A. Romeo,§ MD, Robert A. Arciero,1" MD, and Knut Beitzel,1" MA, MD. The Positive Effects of DifferentPlatelet-Rich Plasma Methods onHuman Muscle, Bone, and Tendon Cells. American Journal of Sports Medicine, Vol. 40, No. 8

Various PRP concentration can affect different cell targets

Osteoblasts. Proliferation was significantly increased by addition of PK.PLP compared with all controls (FBS low, FBS high, Blood) (P < .05) (Figure 1). Addition of PRPDSto osteoblasts led to significantly increased proliferation compared with all controls, native blood, and PRPfjp (P <.05). Proliferation was less when PRPjp was compared with PRPLp but did not reach statistical significance (P >.05). PRPHP showed significantly less proliferation compared with PRPDs CP < -05).

Myocytes. Proliferation was significantly increased by addition of PR?LP compared with, native blood (P !< .05)(Figure 2). Adding PRPos or PRPHp to myocytesshowedno significant increase in proliferation compared with the controls or the other separations.

Tenocytes. Proliferation was significantly increased by addition of PR?LP compared with all controls (FBS low,FBS high, Blood) (P < .05) (Figure 3). There was no differencein the proliferation of tenocytes comparing all 3 PRP types. Addition of PRPDs showed a significant increase compared with the controls and native blood. For tenocytes,there was a significant increase (P < .05) seen when PRPHp was added compared with the controls and native "blood but not compared with the other separations(+)

26.)Mazzocca AD, MS, MD, Mary Beth R. McCarthy, BS, David M. Chowaniec, BS, Mark P. Cote, DPT, Anthony A. Romeo, MD, James P. Bradley, MD, Robert A. Arciero, MD, and Knut Beitzel, MD. Platelet-Rich Plasma Differs According to Preparation Method and Human Variability. J Bone Joint Surg Am. 2012;94:308-16

Preparation methods varied with content and multiple samples from same patient showed significant variability(neutral)

27.)McCarrel T, Minas T, Fortier L. Optimization of Leukocyte Concentration in Platelet-Rich Plasma for the Treatment of Tendinopathy. J B J S(Am) 2012, 94, 143, 1-8

Suggest that PRP without leukocytes is a better choice for creating a lower catabolic cytokine environment and better stimulate cell proliferation and extracellular matrix production than high leukocyte PRP preparations, could be true, yet did not indicate whether IL-1beta and mmp-13 were measured immediately or after 72 hour culture.(+)

28.)Mei-Dan O,*1" MD, Michael R. Garment,* FRCS(Tr&Orth), Lior Laver,1" MD,Gideon Mann;t§ MD, Nicola Maffulli,11 MD, MS, PhD, FRCS(Orth), and Meir Nyska,1" MD. Platelet-Rich Plasma or Hyaluronatein the Management of Osteochondral Lesions of the Talus. American Journal of Sports Medicine, Vol. 40, No. 3

PRP worked better than hyaluronic acid in ankle lesions(+)

29.)Milano G, M.D., Laura Deriu, M.D., EraldoSannaPassino, D.V.M., Gerolamo Masala, D.V.M., Andrea Manunta, M.D., Roberto Postacchini, M.D., Maristella F. Saccomanno, M.D., and Carlo Fabbriciani, M.D. Repeated Platelet Concentrate Injections Enhance Reparative Response of Microfractures in the Treatment of Chondral Defects of the Knee: An Experimental Study in an AnimalModel. Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 28, No 5 (May), 2012: pp 688-701

PRP when added to microfracture makes better cartilage(+)

30.)Narita A, M.D., Ph.D., Masatoshi Takahara, M.D., Ph.D., Daisuke Sato, M.D., Toshihiko Ogino, M.D., Ph.D., Shigenobu Fukushima, M.D., Yu Kimura, MJBng., Yasuhiko Tabata. Biodegradable Gelatin Hydrogels Incorporating Fibroblast Growth Factor 2 Promote Healing of Horizontal Tears

in Rabbit Meniscus. Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 28, No 2 (February), 2012: pp 255-263

GHs incorporating FGF-2 significantly stimulated proliferationand inhibited the death of meniscal cells until 4 weeks, thereby increasing meniscal cell densityand enhancing meniscal repair in a rabbit model

31.)Peerbooms JC,* MD, Jordi Sluimer,1" MD, Daniel J. Bruijn,* PhD, and Taco Go-sens,1* PhD. Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial. American Journal of Sports Medicine, Vol. 38, No. 2, 2010

PRP better than cortisone injections for tenniselbow(+)

32.)Provenzano PP, Adriana L Alejandro-Osorio2, Kelley W Grorud1'3, Daniel A Martinez4'5, Arthur C Vailas5, Richard E Grindeland6 Ray Vanderby Jr. Systemic administration of IGF-I enhances healing in collagenous extracellular matrices: evaluation of loaded and unloaded ligaments. &MC Physiology 2007, 7:

Systemic HGH and IGF1 improved healing of collagen tissue(Hormone+)

33.)Radice F, M.D., Roberto Yanez, M.D., Vicente Gutierrez, M.D., Julio Resales, M.D.,

Miguel Pinedo, M.D., and Sebastian Coda, M.D. Comparison of Magnetic Resonance Imaging Findings inAnterior Cruciate Ligament Grafts With and Without Autologous Platelet-Derived Growth Factors. Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 26, No 1 (January), 2010: pp 50-57

ACL grafts mature on MRI at 179 versus 369 days with PRP compared to without(+)

34.)Randelli P, MDa'*, Paolo Arrigoni, MDa, VincenzaRagone, MEnga, Alberto Aliprandi, MDb, Paolo Cabitza, MDa J. Platelet rich plasma in arthroscopic rotator cuff repair: A prospective RCT study, 2-year follow-up. Shoulder Elbow Surg (2011) 20, 517

•Decreased pain and positively affected rotator cuff healing.(+)

35.)Sanchez M, Ph.D., Nicolas Fiz, Ph.D., Juan Azofra, Ph.D., Jaime Usabiaga, Ph.D., EnmanuelAdurizRecalde, Ph.D., Antonio Garcia Gutierrez, Ph.D., Javier Albillos, Ph.D.,RamonGarate, Ph.D., Jose Javier Aguirre, Sabino Padilla, Ph.D.,GorkaOrive, Ph.D., and Eduardo Anitua, M.D., D.D.S., Ph.D. A Randomized Clinical Trial Evaluating Plasma Rich in Growth Factors (PRGF-Endoret) Versus Hyaluronic Acid in the Short-Term Treatment of Symptomatic Knee Osteoarthritis. Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 28, No S (August), 2012: pp J070-1078

PRP was better than Hyaluronic Acid injections in mild and moderate osteoarthritis of the knee(+)

36.)Sanchez M, M.D., Eduardo Anitua, M.D., Juan Azofra, M.D., Roberto Prado, Ph.D.,FranciscoMuruzabal, Ph.D., and Isabel Andia, Ph.D.Ligamentization of Tendon Grafts Treated With an Endogenous Preparation Rich in Growth Factors: Gross Morphology and Histology. Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 26, No 4 (April}, 2010: pp 470-480

PRP provides for better graft remodeling(+)

37.)Sanchez M, Anitua E, Azofra J, Aguiree JJ, Andia A. Intra-Articular Injection of an Autologous Preparation Rich in growth Factors for the Treatment of Osteoarthritis. Clinical Experimental Rheumatology, 2008, 26, 910-913

PRP provides pain relief in Osteoarthritic Knees(+)

38.)Sheth U, BHSc, Nicole Simunovic, MSc, Guy Klein, DO, Freddie Fu, MD, Thomas A. Einhorn, MD, Emil Schemitsch, MD, Olufemi R. Ayeni, MD, and MohitBhandari, MD, PhD. Efficacy of Autologous Platelet-Rich Plasma Use for Orthopaedic Indications: A Meta-Analysis. J Bone Joint Surg Am. 2012;94:298-

Studies lack standardization of preparations and outcomes(neutral)

39.)Thanasas C,*1" MD, George Papadimitriou,* MD, CharalambosCharalambidis,* MD, llias Paraskevopoulos,* MD, and AthanasiosPapanikolaou,* MD, PhD. Platelet-Rich Plasma Versus Autologous Whole Blood for the Treatment of Chronic Lateral Elbow Epicondylitis. American Journal of Sports Medicine, Vol. 39, No. 10,2011

PRP better than blood for tennis elbow(+)

40.)Vavken.P M.D., M.Sc.EZl. Patrick Sadoqhi. M.D.. Martha M. Murray. M.The Effect of Platelet Concentrates on Graft Maturation and Graft -Bone Interface Healing in Anterior Cruciate Ligament Reconstruction in Human Patients: A Systematic Review of Controlled Trials. 2011 Arthroscopy Association of North America.

ACL, PRP positive on graft maturation(+)

41.)West DWD; Stuart M. Phillips, PhU, FACSM. Anabolic Processes in Human Skeletal Muscle:

Restoring the Identities of Growth.Hormone and Testosterone. THE PHYSICIAN AND SPOKTSMEDICINE* ISSN -0091-3847,October 2010, No.3. Volume 38

Growth Hormone stimulates connective tissue production and lean body mass(+)

42.)Zhang J, Wang J. Platelet-Rich Releasate Promotes Differentiation of Tendon Stem cells in Tendon Cells. Am J Sports Med, Vol. 38, No. 12, 2010

PRP Clot Releasate pushes tendon stem cells to differentiate and produce extracellular matrix(+)

31 Positive Articles !

3 Negative !

7 Informative/Classification or Neutral !

By Body Part

Shoulder

1.)Randelli P, MDa'*, Paolo Arrigoni, MDa, VincenzaRagone, MEnga, Alberto Aliprandi, MDb, Paolo Cabitza, MDa J. Platelet rich plasma in arthroscopic rotator cuff repair: A prospective RCT study, 2-year follow-up. Shoulder Elbow Surg (2011) 20, 517

•Decreased pain and positively affected rotator cuff healing.(+)

2.)Gumrna S, MD, PhD, Vincenzo Campagna, MD, Giancarlo Ferrazza, MD, Giuseppe Giannicola, MD. Use of Platelet-Leukocyte Membrane in Arthroscopic.Repair of Large Rotator Cuff Tears. J BoneJointSurgAm. 2D12;94:1345

PRP improves repair integrity(+)

3.)Castricini R,* MD, Umile Giuseppe Longo,1" MD, MSc, Massimo De Benedetto,* MD,NicolaPanfoli,* MD, PiergiorgioPirani,* MD, Raul Zini,* MD,Nicola Maffulli,§11 MD, MS, PhD, FRCS(Orth), and Vincenzo Denaro,1 MD. Platelet-Rich Plasma Augmentation for Arthroscopic Rotator Cuff Repair. e American Journal of Sports Medicine, Vol. 39, No. 2

PRFM did not improve healing of rotator cuff repair(-)

4.)Bergeson AG,* MD, Robert Z. Tashjian,*1" MD, Patrick E, Greis,* MD,JuliaCrim;* MD, Gregory J. Stoddard,* MPH, and Robert T. Burks,** MD. Effects of Platelet-Rich Fibrin Matrix on Repair Integrity of At-Risk Rotator Cuff Tears. American Journal of Sports Medicine, Vol. 40, No. 2

PRFM(Cascade) did not help re-tear rates and did not increase functional outcome(-)

5.)Beck J, Evans D, Tonino P, Yong S, Callaci JJ. The Biomechanical and Histologic Effects of Platelet-Rich Plasma on Rat Rotator Cuff Repairs. Am J Sports Med. Vol. 40 No. 9, 2012

6.)Barber AF, M.D., Scott A. Harnack, M.D., Stephen J. Snyder, M.D., and OnurHapa, M.D. Rotator Cuff Repair Healing Influenced by Platelet-Rich Plasma Construct Augmentation. Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 27, No 8 (August), 2011: pp 1029-1035

Lower re-tear rates(+)

Knee

1.)Vavken.P M.D., M.Sc.EZl. Patrick Sadoqhi. M.D.. Martha M. Murray. M.The Effect of Platelet Concentrates on Graft Maturation and Graft -Bone Interface Healing in Anterior Cruciate Ligament Reconstruction in Human Patients: A Systematic Review of Controlled Trials. 2011 Arthroscopy Association of North America.

ACL, PRP positive on graft maturation(+)

2.)Sanchez M, Anitua E, Azofra J, Aguiree JJ, Andia A. Intra-Articular Injection of an Autologous Preparation Rich in growth Factors for the Treatment of Osteoarthritis. Clinical Experimental Rheumatology, 2008, 26, 910-913

PRP provides pain relief in Osteoarthritic Knees(+)

3.)Sanchez M, M.D., Eduardo Anitua, M.D., Juan Azofra, M.D., Roberto Prado, Ph.D.,FranciscoMuruzabal, Ph.D., and Isabel Andia, Ph.D. Ligamentization of Tendon Grafts Treated With an Endogenous Preparation Rich in Growth Factors: Gross Morphology and Histology. Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 26, No 4 (April}, 2010: pp 470-480

PRP provides for better graft remodeling(+)

4.)Sanchez M, Ph.D., Nicolas Fiz, Ph.D., Juan Azofra, Ph.D., Jaime Usabiaga, Ph.D., EnmanuelAdurizRecalde, Ph.D., Antonio Garcia Gutierrez, Ph.D., Javier Albillos, Ph.D.,RamonGarate, Ph.D., Jose Javier Aguirre, Sabino Padilla, Ph.D., GorkaOrive, Ph.D., and Eduardo Anitua, M.D., D.D.S., Ph.D. A Randomized Clinical Trial Evaluating Plasma Rich in Growth Factors (PRGF-Endoret) Versus Hyaluronic Acid in the Short-Term Treatment of Symptomatic Knee Osteoarthritis. Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 28, No S (August), 2012: pp J070-1078