Supplementary Table 8 A: Edge correctness scores for pairwise network alignments of protists’ metabolic pathways, with the maximum, minimum, and average score for each species.

CHO - Cryptosporidium hominis / CPV - Cryptosporidium parvum / DDI - Dictyostelium discoideum / EHI - Entamoeba histolytica / PFA - Plasmodium falciparum / TAN - Theileria annulata / TPV - Theileria parva / MAX / MIN / AVG
CHO - Cryptosporidium hominis / N/A / 75.72% / 35.48% / 39.67% / 54.03% / 66.61% / 45.8% / 75.72% / 35.48% / 52.89%
CPV - Cryptosporidium parvum / 75.72% / N/A / 36.49% / 36.49% / 60.94% / 63.5% / 48.72% / 75.72% / 36.49% / 53.64%
DDI - Dictyostelium discoideum / 35.48% / 36.49% / N/A / 30.31% / 34.11% / 39.69% / 41.38% / 41.38% / 30.31% / 36.24%
EHI - Entamoeba histolytica / 39.67% / 36.49% / 30.31% / N/A / 29.55% / 36.02% / 44.02% / 44.02% / 29.55% / 36.01%
PFA - Plasmodium falciparum / 54.03% / 60.94% / 34.11% / 29.55% / N/A / 39.38% / 39.49% / 60.94% / 29.55% / 42.92%
TAN - Theileria annulata / 66.61% / 63.5% / 39.69% / 36.02% / 39.38% / N/A / 76.72% / 76.72% / 36.02% / 53.65%
TPV - Theileria parva / 45.8% / 48.72% / 41.38% / 44.02% / 39.49% / 76.72% / N/A / 76.72% / 39.49% / 49.36%

Supplementary Table 8 B: Edge correctness scores for pairwise network alignments of fungi’s metabolic pathways, with the maximum, minimum, and average score for each species.

AGO - Ashbya gossypii (Eremothecium gossypii) / CAL - Candida albicans / CNE - Cryptococcus neoformans / ECU - Encephalitozoon cuniculi / SCE - Saccharomyces cerevisiae / SPO - Schizosaccharomyces pombe / MAX / MIN / AVG
AGO - Ashbya gossypii (Eremothecium gossypii) / N/A / 45.75% / 37.33% / 37.75% / 48.5% / 40.8% / 48.50% / 37.33% / 42.03%
CAL - Candida albicans / 45.75% / N/A / 42.09% / 41.64% / 43.16% / 45.51% / 45.75% / 41.64% / 43.63%
CNE - Cryptococcus neoformans / 37.33% / 42.09% / N/A / 43.7% / 36.5% / 43.2% / 43.70% / 36.50% / 40.56%
ECU - Encephalitozoon cuniculi / 37.75% / 41.64% / 43.7% / N/A / 36.61% / 67.96% / 67.96% / 36.61% / 45.53%
SCE - Saccharomyces cerevisiae / 48.5% / 43.16% / 36.5% / 36.61% / N/A / 43.5% / 48.50% / 36.50% / 41.65%
SPO - Schizosaccharomyces pombe / 40.8% / 45.51% / 43.2% / 67.96% / 43.5% / N/A / 67.96% / 40.80% / 48.19%