Supplement Table 1. SNPs and their relationships to high myopia under three genetic models (dominant, additive and recessive) among cases with a strong family history.
SNP / Myopia / Genotype / P valuedominant / additive / recessive
rs2075555 / Case / GG (57) / GT (46) / TT (15) / 0.94 / 0.57 / 0.16
Control / GG (296) / GT (269) / TT (53)
rs2141279 / Case / CC (59) / CT (57) / TT (1) / N/A* / N/A* / N/A*
Control / CC (298) / CT (300) / TT (7)
rs2586494 / Case / AA (25) / AC (65) / CC (28) / 0.21 / 0.80 / 0.41
Control / AA (162) / AC (278) / CC (166)
rs2696247 / Case / AA(51) / AG (54) / GG(12) / 0.79 / 0.99 / 0.66
Control / AA (266) / AG (257) / GG(69)
rs2075559 / Case / CC (41) / CG(62) / GG (23) / 0.24 / 0.21 / 0.40
Control / CC (167) / CG (312) / GG(132)
rs2586488 / Case / GG (36) / AG(60) / AA(21) / 0.58 / 0.37 / 0.36
Control / GG (174) / AG (308) / AA(134)
rs2277633 / Case / GG (83) / AG (26) / AA (7) / 0.74 / 0.33 / 0.04
Control / GG (455) / AG (153) / AA (15)
rs2277632 / Case / AA (48) / AG (56) / GG (10) / 0.84 / 0.52 / 0.31
Control / AA (254) / AG (289) / GG (75)
rs2249492 / Case / TT (35) / CT (63) / CC(20) / 0.60 / 0.35 / 0.31
Control / TT(167) / CT (316) / CC(129)
rs1061237 / Case / AA (35) / AG (61) / GG(19) / 0.69 / 0.40 / 0.32
Control / AA (178) / AG (316) / GG (128)
* No statistical results because of not in HWE
Supplement Table 2A. SNPs and their relationships to high myopia under three genetic models (dominant, additive and recessive) among subjects with high education.
SNP / Myopia / Genotype / P valuedominant / additive / recessive
rs2075555 / Case / GG (102) / GT (110) / TT (26) / 0.47 / 0.85 / 0.47
Control / GG (59) / GT (50) / TT (17)
rs2141279 / Case / CC (121) / CT (110) / TT (1) / N/A* / N/A* / N/A*
Control / CC (72) / CT (55) / TT (0)
rs2586494 / Case / AA (61) / AC (123) / CC (54) / 0.66 / 0.89 / 0.81
Control / AA (35) / AC (61) / CC (30)
rs2696247 / Case / AA(108) / AG (103) / GG(24) / 0.36 / 0.38 / 0.68
Control / AA (49) / AG (57) / GG(14)
rs2075559 / Case / CC (76) / CG(101) / GG (60) / 0.10 / 0.40 / 0.75
Control / CC (30) / CG (66) / GG(30)
rs2586488 / Case / GG (76) / AG(108) / AA(53) / 0.35 / 0.53 / 0.95
Control / GG (35) / AG (64) / AA(29)
rs2277633 / Case / GG (181) / AG (46) / AA (7) / 0.83 / 0.82 / 0.21
Control / GG (97) / AG (29) / AA (1)
rs2277632 / Case / AA (109) / AG (98) / GG (27) / 0.12 / 0.38 / 0.56
Control / AA (48) / AG (66) / GG (12)
rs2249492 / Case / TT (73) / CT (110) / CC(54) / 0.36 / 0.61 / 0.90
Control / TT(33) / CT (65) / CC(28)
rs1061237 / Case / AA (73) / AG (110) / GG(49) / 0.38 / 0.54 / 0.95
Control / AA (34) / AG (65) / GG (27)
*No statistical results because of not in HWE
Supplement Table 2B. SNPs and their relationships to high myopia under three genetic models (dominant, additive and recessive) among subjects without high education.
SNP / Myopia / Genotype / P valuedominant / additive / recessive
rs2075555 / Case / GG (73) / GT (50) / TT (10) / 0.15 / 0.27 / 0.90
Control / GG (226) / GT (213) / TT (34)
rs2141279 / Case / CC (66) / CT (64) / TT (0) / N/A* / N/A* / N/A*
Control / CC (219) / CT (234) / TT (7)
rs2586494 / Case / AA (32) / AC (66) / CC (35) / 0.49 / 0.82 / 0.75
Control / AA (125) / AC (209) / CC (128)
rs2696247 / Case / AA(59) / AG (55) / GG(17) / 0.98 / 0.89 / 0.79
Control / AA (205) / AG (194) / GG(55)
rs2075559 / Case / CC (39) / CG(60) / GG (33) / 0.67 / 0.83 / 0.42
Control / CC (129) / CG (236) / GG(101)
rs2586488 / Case / GG (39) / AG(61) / AA(33) / 0.67 / 0.91 / 0.51
Control / GG (129) / AG (237) / AA(104)
rs2277633 / Case / GG (85) / AG (39) / AA (6) / 0.10 / 0.07 / 0.22
Control / GG (347) / AG (118) / AA (12)
rs2277632 / Case / AA (52) / AG (65) / GG (15) / 0.55 / 0.81 / 0.68
Control / AA (200) / AG (213) / GG (60)
rs2249492 / Case / TT (35) / CT (66) / CC(31) / 0.97 / 0.74 / 0.60
Control / TT(125) / CT (244) / CC(100)
rs1061237 / Case / AA (35) / AG (60) / GG(36) / 0.76 / 0.26 / 0.11
Control / AA (134) / AG (243) / GG (100)
*No statistical results because of not in HWE
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