American Red Cross Blood Services, Southern California Region

Curriculum Vitae

Joy L. Fridey, MD, MBA

American Red Cross Blood Services, Southern California Region

100 Red Cross Circle, Pomona, CA 91768

(C/O) 909.203.2988 ;

CURRENT POSITION:

2011-Present Divisional Medical Officer

American Red Cross Blood Services (ARCBS), Southern California Region

Responsibilities:

• Patient Blood Management: Lead Consultant and lecturer forSouthern California hospitals and hospital systems (eg, Providence, Scripps, Adventist, Kaiser Permanente, PRIME)
• Medical consultant for140 Regional Transfusion Services, including Recipient Complications
• Physician member and advisor – ARC Sales and Marketing Team
• Medical Director, ARC Blood Services Medical Advisory Committee
• Transfusion Medicinelecturer for hospital transfusion services
• Medical Directorand Lecturer (20 hours) for Specialist in Blood Banking(SBB) Program
• Donor Eligibilityand Complication Assessment (300,000 collections annually)
• CLIA Co-director for IRL and QC Laboratory
• Medical liaison, Regulatory Affairs

PREVIOUS POSITIONS:

2008-2011Director of Transfusion Medicine

Childrens Hospital Los Angeles

4650 Sunset Boulevard

Los Angeles, CA 90027

Responsibilities:

• Blood Donor Center
• Transfusion Service
• Hematopoietic Progenitor Cell Collection and Therapeutic Apheresis Programs

2002-2008 Director of Transfusion Medicine

City of Hope National Medical Center

1500 East Duarte Rd.

Duarte, CA 91010

Responsibilities:

Blood Donor Center

• Transfusion Service

• Laboratory Director, General Clinical Research Center

Hematopoietic Progenitor Cell Collection (Apheresis)/Processing and Therapeutic Apheresis

1991-2002: Senior Vice President of Medical Affairs

Blood Bank of San Bernardino and Riverside Counties

384 Orange Show Rd.

San Bernardino, CA 92408

Responsibilities:

General: Director, Hematopoietic Progenitor Cell Collections (Apheresis)

Member, Executive Management Group

Site Investigator, Clinical and Laboratory Research Trials

Medical Oversight, Blood Collections and Laboratory

Departmental: Clinical Program – HPC Collections (Apheresis)

Quality Assurance

Research and Development

National Marrow Donor Program

Donor Notification

1990-1991Assistant Medical Director

American Red Cross Blood Services

Los Angeles-Orange County Region

1130 South Vermont Avenue

Los Angeles, CA 90006

Please note: Current address provided above

1988-1990Director, Transfusion Services

Staff Pathologist

St. Joseph Medical Center

501 South Buena Vista

Burbank, CA 91505

1975-1976Registered Nurse, Medical/Surgical Unit

Chestnut Hill Hospital

Philadelphia, PA

EDUCATION

1998-2000Masters in Business Administration (MBA), Executive Program.

Peter Drucker Graduate School of Management

Claremont, CA. GPA: 3.9

1987-1988Transfusion Medicine Fellowship

American Red Cross Blood Services, Southern California Region, Los Angeles CA

Memorial Medical Center of Long Beach, Long Beach CA

1983-1987Anatomic and Clinical Pathology Residency

Temple University Hospital

Philadelphia, PA

1982-1983Intern, Physical Medicine and Rehabilitation

Thomas Jefferson University Hospital

Philadelphia, PA

1978-1982MD, Drexel University College of Medicine (formerly Medical College of Pennsylvania)

Philadelphia, PA

1976-1978Premedical Courses, Temple University

Philadelphia, PA

1973-1975A.A.S. (Registered Nursing), Montgomery County Community College

Blue Bell, PA

HONORS

2016Biomedical Presidential Spot Award for outstanding contribution sas Chief Editor and Author of the American Red Cross Compendium of Transfusion Practice Guidelines, 3rd Edition, 2017

2013Biomedical Presidential Spot Award for outstanding patient service (American Red Cross)

2011The President’s Award, American Association of Blood Banks

2008Owen F. Thomas, MD Award, California Blood Bank Society

2002Distinguished Service Award, American Association of Blood Banks

2000Beta Gamma Sigma (National Honor Society for Management and Business Schools)

CERTIFICATION AND LICENSURE

Board Certified, Anatomic and Clinical Pathology, American Board of Pathology

CA Medical License: G60285

DEA #BF 8182317

ACADEMIC APPOINTMENTS

2008-2011 Associate Professor of Clinical Pathology, Childrens Hospital Los Angeles and USC/Keck School of Medicine

1999-PresentAssistant Clinical Professor of Anatomy and Pathology, School of Medicine, Loma Linda University Medical Center, Loma Linda, CA.

2002-2008Associate Professor of Clinical Pathology. City of Hope National Medical Center. Duarte, CA

INVESTIGATIONS– Childrens Hospital Los Angeles

2008-2010Site Investigator, National Healthcare Safety Network AABB/CDC Biovigilance Pilot Study; Childrens Hospital Los Angeles

2010-2012Co-Investigator: Tranexamic acid reduces blood loss and transfusion associated with posterior spine fusion: A retrospective study. (Principle investigator: Patrick Ross, MD)

2010-2012Co-Investigator: Iron overload in pediatric oncology patients who have been treated with anthracyclines. (Principle investigator: David Freyer, DO)

INVESTIGATIONS - City of Hope (2002-2008): Available upon request

Blood Bank of San Bernardino and Riverside Counties (1991-2002): Available upon request

PUBLICATIONS

Fridey JL. Chief Editor, American Red Cross Compendium of Transfusion Practice Guidelines, 3rd Edition. American Red Cross, Washington. 2017

Fridey JL. The California Blood Banking Society Emergency Preparedness Plan: A Lifeline in Times of Crisis. CBBSToday. Fall Ed, 2015 (electronic version only

Fridey JL, Hernandez K. The CBBS Disaster Response Plan: Don’t leave home without it. CBBSToday, 2013;31(2) (electronic version only,

Fridey JL. The path to safer home transfusion: Standardized procedures. In: UpToDate. Tirnauer J (Ed). Wellesley, MA 2016

Fridey JL. General principles of home blood transfusion. In: UpToDate, Tirnauer J (Ed.) Wellesley, MA, 2015.

Fridey JL. Hepatitis C and transfusion: A “lookback” primer. In: UpToDate, Tirnauer J (Ed) Wellesley, MA 2017.

Kaplan AA, Fridey JL. Complications of therapeutic plasma exchange. In: UpToDate, Tirnauer J (Ed.) Wellesley, MA, 2014.

Kaplan AA, Fridey JL. Indications for therapeutic plasma exchange. In: UpToDate, Tirnauer J (Ed.) Wellesley, MA, 2014.

Ruccione KS, Mudambi K, Sposto R, Fridey J, Ghazarossian S, Freyer DR. Association of projected transfusional iron burden with treatment intensity in childhood cancer survivors. Pediatric Blood Cancer. 2011. Dec 20. doi:10.1002/pbc.24046 [Epub ahead of print].

Biswas HH, Kaidarova Z, Garratty G, Gibble JW, Newman BH, Smith JW, Ziman A, Fridey JL, Sacher RA, Murphey EL. Increase all-cause cancer mortality in HTLV-II infection. J Acquired Immune Deficiency Syndr. 2010 Jul;54(3):290-6.

Fridey, JL. Preparation for the return of Pandemic H1N1/2009 Influenza A Virus: One Hospital’s Plan. CBBS Today (California Blood Bank Society). 2009. 27(2):27-32.

Biswas HH, Engstrom JW, Kaidarova Z, Garratty G, Gibble JW, Newman BH, Smith JW, Ziman A,

Fridey JL, Sacher RA, Murphy EL. Neurological abnormalities in HTLV-I and –II infected individuals without overty HTLV-associated myelopathy. Neurology, 2009 (in press).

Fridey JL. Milestones and Pivotal Events in Donor Screening. In: Eder A, Bianco C, eds. Screening Blood Donors: Science, Reason, and the Donor History Questionnaire. Bethesda, MD: AABB Press, 2007

Fridey J, Townsend M, Kessler D, Gregory K. A question of clarity: Redesigning the AABB blood donor history questionnaire – A chronology and model for donor screening. Trans Med Rev. 2007;21(3).

Yeo T, Kaidarova Z, Gibble J, Smith J, Newman B, Garratty G, Fridey J, Sacher R, Murphy E. Long-term abnormalities of complete blood counts in Human T-Lymphotropic Virus, Types I and II (HTLV-I and –II) infections. 13th International Conference on Human Retrovirology, HTLV, and Related Viruses. 2007, Hikone, Japan. AIDS Res Hum Retrov 2007;23(4) (supplement).

Wang S, Nademanee A, Qian D, Gais A, Park HS, Fridey J, Smith E, Synder D, Bhatia R, et al. Peripheral hematopoietic stem cell mobilization and collection efficacy is not an independent prognostic factor for autologous stem cell transplantation. Transfusion, 2007. (Accepted for publication with revisions).

Kaidarova Z, Gibble J, Smith J, Newman B, Garratty G, Fridey J, Sacher R, and Murphy E. Prospective analysis of neurological abnormalities in a cohort of HTLV-I and HTLV-II infection. The 13th International HTLV Conference, May 2007, Japan

Yuan S, Wang S, Aldridge L, Almquist G, Wagman L, Fridey J. Utilization of Preoperative Autologous Blood Donations in Surgical Oncology Patients at a Major Cancer Center. 2006 AABB Annual Meeting, Oct 21-24, Miami Beach, FL

Sarkodee-Adoo CB, Stein AS, O’Donnell MR, Bhatia RM, Bolotin E, Chang KP, Kirschbaum M, Kogut N, Nademanee A, Parker P, Pullarkat V, Synder D, Spielberger R, Slovak ML, Alvarnas J, Fridey J, Schriber J, Smith E, Dagis A, Land J, Palmer J, Vora N, Forman S. Long Term Survival After ASCT for AML:

Multivariate Analysis Shows Adverse Effect of Collecting and Infusing Larger Numbers of CD 34 Positive Cells. ASH 2005 47th Annual Meeting, Dec 10-13, 2005, Atlanta, GA

Sanchez AM, Schreiber GB, Nass CC, Glynn S, Kessler D, Hirschler N, Fridey J, Bethel J, Murphy E, Busch MP. The impact of male-to-male sexual experience on risk profiles of blood donors. Transfusion. 2005. 45:404-413.

Fridey JL, Kay C. Donor Screening and Blood Collection. In Textbook of Blood Banking and Transfusion Medicine. Rudman SV, Editor, 2nd Ed. 2005, Philadelphia.

McCullough J, Vesole DN, Benjamin RJ, Slichter SJ, Pineda A, Snyder E, Stadtmauer EA, Lopez-Plaza I, Coutre C, Strauss RG, Goodnough LT, Fridey JL et al. Therapeutic Efficacy and Safety of Platelets Treated With a Photochemical Process for Pathogen Inactivation: The SPRINT Trial. Blood. 2004.104(5):1534-41.

Murphy EL, Wang B, Sacher RA, Fridey J, Smith JW, Nass CG, et al. Respiratory and urinary tract infections, arthritis, and asthma associated with HTLY-I and HTLV-II disease. Emerg Inf Dis. 2004; 10(1):109-16.

Orland JR, Engstrom J, Fridey J, Sacher RA, Smith JW, Nass CG, Garratty G. Prevalence and clinical features of HTLV neurological disease in the HTLV Outcomes Study. Neurology. 2003. 61(11):1588-94.

Wang S, Smith D, Park H, Fridey J, Tsai N, Bhatia R, Falk P, Fung H, Kogut N, Krishnan A, Nademanee A, Nakamura R, O’Donnell M, Parker P, Popplewell L, Pullarkat V, Rodriguez R, Sahebi Firoozeh, Smith E, Snyder D, Spielberger R, Stein A, Yee D, Zain J, Forman S, City of Hope National Medical Center, Duarte, CA: The Association Between Stem Cell Mobilization Efficacy and Engraftmentkinetics Among Patients with Non-Hodgkin’s Lymphoma (NHL) and Acute Myelogenous Leukemia (AML). ASH 2003 45th Annual Meeting and Exposition Abstracts, Dec 6-9, 2003

Wang S, Park H, Fridey J, Rosenthal J, Falk P, Sweetman R, Murray T, McKeman M, Aldridge L,

Forman S, City of Hope National Medical Center, Duarte, CA: Manual Red Blood Cell Exchange in Low Weight Pediatric Patients Prior to Minor ABO Mismatched Transplantation to Prevent Immediate and Delayed Hemolysis (SP161): Transfusion 2003-Vol 43, Supplement

Damesyn MA, Glynn SA, Schreiber GB, Ownby HE, Bethel J, Fridey JL, McMullen Q, Garratty G, Busch, MP, et al: Behavioral and infectious disease risks in young blood donors: implications for recruitment (for NHLBI Retrovirus Epidemiology Donor Study). Transfusion. 2003. 43(11):1596-1603.

Wang S, Smith D, Fridey J, Park H, Yee D, Forman S, Aldridge L, Bhatia R, Falk P, Fung H, Kogut N, Krishnan A, Nademanee A, Nakamura R, O’Donnell M, Parker P, Popplewell L, Pullarkat V, Rodriguez R, Rosenthal J, Snyder D, Spielberger R, Stein A, Sweetman R, Zain J, City of Hope National Medical Center, Duarte, CA: Lack of Clinical Efficacy of Therapeutic Plasma Exchange in the Treatment of Hemolytic Uremic Syndrome/Thrombotic Thrombocytopenia Purpura Associated with Bone Marrow Transplantation (SP226). Transfusion 2003 - Vol 43, Supplement

Glynn, SA, Williams AE, Nass, CC, Bethel J, Kessler D, Scott EP, Fridey JL, Kleinman SH, Schreiber GB: Attitudes toward blood donation incentives in the United States: implications for donor recruitment. Transfusion, 2003: 43:7-16.

Glynn SA, Murphy EL, Wright DJ, Sacher RA, Fridey JL, Schreiber GB. Laboratory abnormalities in Human T Lymphotropic virus type-I and-II seropositive former blood donors. Archives of Path Lab Med 2000; 124:550-555.

Fridey JL. General principles of home blood transfusion. In: UpToDate, Rose BD (Ed.) Wellesley, MA, 1999.

Murphy EL, Glynn SA, Fridey JL, Smith JW, et al. Increased incidence of infectious diseases and neurologic abnormalities during prospective follow up of HTLV-II and I infected blood donors. Arch Intern Med 1999; 159:1485-91.

Fridey JL. Hepatitis C and transfusion: A “lookback” primer. In: UpToDate, Rose BD (Ed) Wellesley, MA 1999.

Fridey JL. The path to safer home transfusions: standardized procedures. In: UpToDate, Rose BD (Ed.) Wellesley, MA 1999.

Siffert W, Forster P, Jockel H, Muere DA, Brinkman B, Naber C, Crookes R, Heyns AD, Epplen JT, FrideyJL, et al. Worldwide ethnic distribution of the G Protein B3 Subunit 825T allele and its association with obesity in Caucasian, Chinese, and black African Americans. J Am Soc Neph. 1999; 10:1921-1930.

Murphy EL, Glynn SA, Watanabe K, Fridey JL, Smith JW, Sacher R, Wright D, et al., Laboratory test differences associated with HTLV-I and HTLV-II infections. J AIDS, 1998;17:332-338.

Murphy EL, Glynn SA, Fridey JL, Sacher RA, Smith JW, Wright DJ, et al. Increased prevalence of infectious diseases and other adverse outcomes in Human T Lymphotropic virus types I and II infected blood donors. J Inf Dis, 1997; 176:1468-75.

Murphy EL, Glynn S, Fridey J, Smith J, Sacher K, Nass C, Ownby H, King F, Nemo G for the NHLBI Retrovirus Epidemiology Donor Study (REDS). Abstract: Eighth International Conference on Human Retrovirology: HTLV. June, 1997.

Kaplan AA, Fridey JL. Complications of therapeutic plasma exchange. In: UpToDate, Rose BD (Ed.) Wellesley, MA, 1997.

Kaplan AA, Fridey JL. Indications for therapeutic plasma exchange. In: UpToDate, Rose BD (Ed.) Wellesley, MA, 1997.

Gallo D, George JR, Fitchen JH, Goldstein AS, Hindahl MS, for the Orasure HIV Clinical Trials Group. Evaluation of a system using oral mucosal transudate for HIV-1 antibody screening and confirmatory testing. JAMA, 1997: 277:254-8.

Murphy EL, Fridey JL, Smith JW, Engstrom J, Sacher RA, Miller K, Armstrong K, Gibble J, et al. HTLV-associated myelopathy in a cohort of HTLV-I and HTLV-II infected blood donors. Ann Neurol, 1997; 48:315-320.

Fridey JL, Ramos M. Therapeutic hemapheresis: practical considerations. Check Sample, American Society of Clinical Pathologists, 1997; 40(1):1-22.

Fridey JL. Practical aspects of out-of-hospital transfusion. Pathology Patterns, Am J Clin Path, 1997; 107(4):564-71.

Fridey JL, Simpson MB, Eds. Component Selection: Polemics and Politics. American Association of Blood Banks, Bethesda, 1996.

Fridey JL, Kasprisin CA, Chambers LA, Rudmann SV, Eds. Numbers for Blood Bankers. American Association of Blood Banks, Bethesda, 1995.

Murphy EL, Miller K, Sacher R, Fridey JL, Smith J, Kleinman S, et al. Unexpected health effects of infection with HTLV-I and HTLV-II--The REDS Cohort. 1994, Sixth International Conference on Human Retrovirology. (Abstract D-20).

Fridey JL, Kasprisin CA, Issitt LA, Eds. Out-of-hospital Transfusion Therapy. American Association of Blood Banks, Bethesda, 1994.

Saxena S, Weiner JM, Rabinowitz A, Fridey J, Shulman IA, Carmel R. Transfusion Practice in Medical Patients. Arch Intern Med, 1993: 153:2575-2580.

Murphy EL, Fridey J, Smith JW, Armstrong K, Stevens J, Sacher RA, Miller K, Engstrom JW, Kaplan J, Khabbaz R, Kleinman S, Hansma D, Thomson R, Hollingsworth C and the NHLBI Retrovirus Epidemiology Donors Study (REDS). High prevalence of HTLV-associated myelopathy (HAM) in subjects infected with HTLV-I and -II. TRANSFUSION 1993 - Vol. 33, Supplement (Abstract).

Fridey J, Almeida M, Valdellon A: Seroprevalence of infectious disease markers in tissue donors. 1990, AABB-ISBT Joint Congress Book of Abstracts: 183.

Fridey J, Nance S, Clear J, Barnes A, Garratty G: Acute hemolysis associated with anti-Wrighta undetected by antibody screen and "immediate spin" crossmatch; 1990. AABB-ISBT Joint Congress Book of Abstracts: 153.

Fridey, JL, and Ellis K: Human T-cell Lymphotropic virus, Type 1 (HTLV-1): Disease manifestations and implications for transfusion therapy. ASCP Transfusion Medicine Check Sample, 1989; 32(1).

Ochs, RH, Carr R, Griffin TD, Fridey JL: Perinatal autopsies: A challenge for the non-pediatric pathologist. Pathology Annual, 1988; 23(2):235-256.

Fridey JL, Valente PT, Tang C-K, Harwick RD, Fantasia JE, Miller AS: Oral adenosquamous carcinoma: An aggressive tumor. Laboratory Investigation, 1987; 56(1), 25A.

Carr RF, Ochs RH, Ritter DA, Kenny JD, Fridey JL, Ming PL: Fetal cystic hygroma and Turner's syndrome. American Journal of Diseases in Childhood, 1986: 140:580-583.

Carr RF, Ochs RH, Ritter DA, Kenny JD, Fridey JL, Ming PL: Autopsy evaluation of fetal cystic hygroma. Laboratory Investigation, 1986: 54(1), 10A.

PROFESSIONAL MEMBERSHIPS

American Association of Blood Banks (AABB)

California Blood Bank Society

PROFESSIONAL ACTIVITIES

2016-Present. Alliance of Blood Operators (International). Representative, American Red Cross Blood Services

2016-Present AABB Hemovigilance Committee. Representative, American Red Cross Blood Services

2014-Present Chair, AABB Patient Blood Management Standards Accreditation Committee

2013-Present Chair, California Blood Bank Society Emergency Preparedness Committee

2012-2014 Member, Nominating Committee for AABB Board of Directors

2011-2012 President, California Blood Bank Society

2011-2012 Member, AABB Donor History Questionnaire Task Force for Hematopoietic Progenitor Cells

2009-2010 Member, Board of Directors Ad Hoc Committee on Governance, American Association of Blood Banks

2008-2010 Liaison, American Association of Blood Banks, Blood Bank/Transfusion Service Standards Committee (Liaison for AABB Donor History Questionnaire Task Force)

2010-2011 President-Elect, California Blood Bank Society

2009-2010Treasurer, Board of Directors, California Blood Bank Society

2008-2009Secretary, Board of Directors, California Blood Bank Society

2008-2011Chair, AABB Donor History Questionnaire

2006-2008Member, Board of Directors, California Blood Bank Society

2007-2008Member, AABB Task Force to Address FDA Proposed Rule for Donor Eligibility

2003-2007Member, Board of Directors, American Association of Blood Banks

2003-2009 Member, Board of Directors, American Red Cross Blood Services, Southern

California Region

2005-2006 Member, Board of Trustees, National Blood Foundation Research and Education

Trust Fund

2006-2008Member, Alliance for Harmonization of Cellular Therapy Accreditation

2004-2009Member, AABB Task Force to design a standardized allogeneic HPC donor risk factor questionnaire.

2000-2002Chair, AABB Donor History Questionnaire Task Force (Multi-organizational project to re-engineer the blood donor history questionnaire)

2001-2003Chair, AABB Standards Program Unit for Blood Banks and Transfusion Services. Standards, Edition 22

1996-2001Member, Standards Committee, American Association of Blood Banks

1996-2000Member, Transfusion-Transmitted Diseases Committee, American Association of Blood Banks

1997-1998Member, Blood Centers of California, Executive Committee

1993-1996Chair, Medical-Technical Advisory Committee, Blood Centers of California, Inc.

1995-1996Chair, Scientific Program Committee, California Blood Bank Society

1992-1993Chair, Physicians' Committee, California Blood Bank Society

1990-1991Chair, Committee on Infectious Diseases, California Blood Bank Society

1989-1996Inspector, Inspection and Accreditation Program, American Association of Blood Banks

1993-1995Member, Scientific-Technical Workshop Committee, American Association of Blood Banks

1993-1995Member, Ad Hoc Committee for the Uniform Donor Medical History Card, American Association of Blood Banks

TEACHING/LECTURES – INSTITUTIONAL AND LOCAL

2016Lecturer, American Red Cross Blood Services Transfusion Medicine Lecture Series and Fall All-Day Seminar. (Disaster Preparedness; Patient Blood Management; Infectious and Non-infectious Risks of Transfusion; Zika Virus: No Longer an Emerging Pathogen).

Clinical Practice of Transfusion Medicine: 20 hour lecture series – SBB program.

American Red Cross Compendium of Transfusion Practice Guidelines, 3rd Ed. Overview. ARCBS Fall Medical Director Symposium

Evidence-based Blood Component Therapy and Patient Blood Management. Grand Rounds. San Antonio Community Hospital, CA. October 2016

2015Patient Blood Management and Blood Component Therapy

• Kaiser Permanente LA
• Kaiser Permanente West LA
• HCA Los Robles Medical Center
• Alhambra Hospital Medical Centers
• HCA West Hills Medical Center; Whittier Hospital

Transfusion Complications. Harbor UCLA Medical Center Pathology Grand Rounds

2014Patient Blood Management and Component Therapy Lectures:

• Scripps Healthcare System presentation and consultancy, San Diego, CA
• Clinical Laboratory Management Association Webinar
• Executive Leadership, Adventist Hospital System Symposium, Roseville, CA
• Temple Community Hospital
• Encino Hospital and Sherman Oaks Hospital (pending)

2013Patient Blood Management. PRIME Hospital Systems Laboratory Managers Seminar, Ontario, CA, February.

2013Non-infectious Complications of Transfusion. American Red Cross Spring Seminar in Transfusion Medicine, Cal Poly, Pomona, March